ECSP11010980A - Compuestos heteroaromáticos espirocíclicos fusionados para el tratamiento de infecciones bacterianas - Google Patents

Compuestos heteroaromáticos espirocíclicos fusionados para el tratamiento de infecciones bacterianas

Info

Publication number
ECSP11010980A
ECSP11010980A EC2011010980A ECSP11010980A ECSP11010980A EC SP11010980 A ECSP11010980 A EC SP11010980A EC 2011010980 A EC2011010980 A EC 2011010980A EC SP11010980 A ECSP11010980 A EC SP11010980A EC SP11010980 A ECSP11010980 A EC SP11010980A
Authority
EC
Ecuador
Prior art keywords
bacterial infections
fusioned
treatment
heteroaromatic compounds
spirocyclic
Prior art date
Application number
EC2011010980A
Other languages
English (en)
Inventor
Sheila Irene Hauck
Fei Zhou
Gregory Steven Basarab
Kevin Barvian
Madhusudhan Reddy Gowravaram
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP11010980A publication Critical patent/ECSP11010980A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de Fórmula (I); a sales farmacéuticamente aceptables de estos, a métodos de utilización de estos para tratar infecciones bacterianas y a métodos para su preparación.
EC2011010980A 2008-10-14 2011-04-14 Compuestos heteroaromáticos espirocíclicos fusionados para el tratamiento de infecciones bacterianas ECSP11010980A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10518908P 2008-10-14 2008-10-14

Publications (1)

Publication Number Publication Date
ECSP11010980A true ECSP11010980A (es) 2011-05-31

Family

ID=41668347

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011010980A ECSP11010980A (es) 2008-10-14 2011-04-14 Compuestos heteroaromáticos espirocíclicos fusionados para el tratamiento de infecciones bacterianas

Country Status (24)

Country Link
US (1) US8658641B2 (es)
EP (1) EP2350077B1 (es)
JP (2) JP5749169B2 (es)
KR (1) KR101676886B1 (es)
CN (2) CN104086565A (es)
AR (1) AR073862A1 (es)
AU (1) AU2009305203B2 (es)
BR (1) BRPI0920180B1 (es)
CA (1) CA2736335C (es)
CL (1) CL2011000838A1 (es)
CO (1) CO6382126A2 (es)
CR (1) CR20110195A (es)
CU (1) CU20110083A7 (es)
DO (1) DOP2011000102A (es)
EA (1) EA201100613A1 (es)
EC (1) ECSP11010980A (es)
ES (1) ES2565611T3 (es)
HK (1) HK1203483A1 (es)
IL (1) IL211728A0 (es)
MX (1) MX2011003598A (es)
TW (1) TW201020258A (es)
UY (1) UY32174A (es)
WO (1) WO2010043893A1 (es)
ZA (1) ZA201103533B (es)

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US20140057303A1 (en) 2012-08-21 2014-02-27 Janssen Pharmaceutica Nv Antibodies to Olanzapine Haptens and Use Thereof
PL3663317T3 (pl) 2012-08-21 2023-06-05 Janssen Pharmaceutica Nv Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie
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EP2888263B1 (en) 2012-08-21 2018-05-09 Janssen Pharmaceutica NV Haptens of risperidone and paliperidone
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EA033459B1 (ru) 2014-05-29 2019-10-31 Entasis Therapeutics Ltd Конденсированные спироциклические гетероароматические соединения для лечения бактериальных инфекций
JP6540971B2 (ja) * 2014-08-25 2019-07-10 日産化学株式会社 Ｓｏｃパターン上でのパターン反転のための被覆用組成物
AU2015342883B2 (en) 2014-11-06 2020-07-02 Bial - R&D Investments, S.A. Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders
CN107001379B (zh) 2014-11-06 2022-11-01 Bial研发投资股份有限公司 取代的吡唑并[1,5-a]嘧啶以及它们在治疗医学障碍中的用途
WO2016073889A1 (en) 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
WO2016126721A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. 3-aryl-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors
WO2016126726A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors
TW201643138A (zh) 2015-04-17 2016-12-16 佛瑪治療公司 作為組蛋白脫乙醯基酶（ｈｄａｃ）抑制劑之３－螺－７－異羥肟酸四氫萘
WO2017024455A1 (zh) * 2015-08-07 2017-02-16 苏州大学张家港工业技术研究院 一种螺环羟吲哚咪唑啉并氧氮杂卓化合物及其合成方法
CN105152962B (zh) * 2015-09-30 2017-06-16 淄博亿丰高分子材料科技股份有限公司 N‑异丙基羟胺的制备方法
AU2016372069A1 (en) 2015-12-17 2018-06-07 Saladax Biomedical Inc. Antibodies to risperidone and use thereof
WO2017106508A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to quetiapine and use thereof
WO2017176960A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
WO2017176962A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics, Inc. Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
US10787454B2 (en) 2016-04-06 2020-09-29 BIAL—BioTech Investments, Inc. Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
MX389579B (es) 2016-05-05 2025-03-20 Bial R&D Invest S A IMIDAZO[1,2-b]PIRIDAZINAS SUSTITUIDAS, IMIDAZO[1,5-b]PIRIDAZINAS SUSTITUIDAS, COMPUESTOS RELACIONADOS Y SU USO EN EL TRATAMIENTO DE TRASTORNOS MÉDICOS
WO2017192931A1 (en) 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
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CN107827887B (zh) * 2017-11-21 2019-01-08 上海博栋化学科技有限公司 具有抗细菌活性的三氮唑甲酯链接螺环类化合物及其制备方法和应用
KR102790878B1 (ko) 2018-08-09 2025-04-02 앤타바이오 에스에이에스 세린 베타-락타마제의 억제제로서 다이아자바이사이클로옥타논
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AU2009305203B2 (en) * 2008-10-14 2013-03-07 Entasis Therapeutics Limited Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections

Also Published As

Publication number Publication date
CO6382126A2 (es) 2012-02-15
CN102245605B (zh) 2016-01-27
CN102245605A (zh) 2011-11-16
DOP2011000102A (es) 2011-05-15
CR20110195A (es) 2011-06-08
EA201100613A1 (ru) 2011-12-30
ES2565611T3 (es) 2016-04-05
AU2009305203A1 (en) 2010-04-22
WO2010043893A1 (en) 2010-04-22
KR101676886B1 (ko) 2016-11-16
HK1160127A1 (zh) 2012-08-10
EP2350077B1 (en) 2016-01-27
TW201020258A (en) 2010-06-01
ZA201103533B (en) 2012-01-25
BRPI0920180B1 (pt) 2021-10-26
CA2736335A1 (en) 2010-04-22
CN104086565A (zh) 2014-10-08
BRPI0920180A2 (pt) 2020-12-29
AR073862A1 (es) 2010-12-09
MX2011003598A (es) 2011-04-27
US8658641B2 (en) 2014-02-25
CL2011000838A1 (es) 2011-10-21
JP5749169B2 (ja) 2015-07-15
HK1203483A1 (en) 2015-10-30
AU2009305203B2 (en) 2013-03-07
US20110245224A1 (en) 2011-10-06
JP2012505261A (ja) 2012-03-01
CA2736335C (en) 2017-05-09
UY32174A (es) 2010-05-31
CU20110083A7 (es) 2013-05-31
EP2350077A1 (en) 2011-08-03
KR20110090895A (ko) 2011-08-10
IL211728A0 (en) 2011-06-30
JP2015178510A (ja) 2015-10-08

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