EE03221B1 - Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks - Google Patents

Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks

Info

Publication number: EE03221B1
Authority: EE; Estonia
Prior art keywords: inhalation; preparation; inhaler; pharmaceutical formulations; insulin
Prior art date: 1993-06-24

Application number

EE9400429A

Other languages

English (en)

Inventor

G�ran Erik B�ckstr�m Kjell

Magnus Olof Dahlb�ck Carl

Charlotte Birgit Johansson Ann

Edman Peter

Original Assignee

Astra Aktiebolag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-24

Filing date

1994-11-23

Publication date

1999-10-15

1993-06-24 Priority claimed from SE9302198A external-priority patent/SE9302198D0/xx

1994-02-04 Priority claimed from SE9400370A external-priority patent/SE9400370L/xx

1994-11-23 Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag

1999-10-15 Publication of EE03221B1 publication Critical patent/EE03221B1/et

Links

238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
238000010521 absorption reaction Methods 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
210000002345 respiratory system Anatomy 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Otolaryngology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pulmonology (AREA)
Zoology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

EE9400429A 1993-06-24 1994-11-23 Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks EE03221B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9302198A SE9302198D0 (sv)	1993-06-24	1993-06-24	Powder preparation for inhalation
SE9400370A SE9400370L (sv)	1994-02-04	1994-02-04	Terapeutisk komposition för inhalation

Publications (1)

Publication Number	Publication Date
EE03221B1 true EE03221B1 (et)	1999-10-15

Family

ID=26661778

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9400429A EE03221B1 (et)	1993-06-24	1994-11-23	Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks

Country Status (31)

Country	Link
US (3)	US5518998C1 (et)
EP (1)	EP0706382B1 (et)
JP (2)	JP3874789B2 (et)
KR (1)	KR100372673B1 (et)
CN (1)	CN1110301C (et)
AT (1)	ATE183920T1 (et)
AU (1)	AU692780B2 (et)
BR (1)	BR9406907A (et)
CA (1)	CA2166108C (et)
CZ (1)	CZ287314B6 (et)
DE (1)	DE69420412T2 (et)
DK (1)	DK0706382T3 (et)
EE (1)	EE03221B1 (et)
EG (1)	EG20599A (et)
ES (1)	ES2138087T3 (et)
FI (1)	FI111688B (et)
GR (1)	GR3031974T3 (et)
HU (1)	HU228129B1 (et)
IL (1)	IL110084A (et)
IS (1)	IS1768B (et)
MX (1)	MX9404761A (et)
MY (1)	MY112098A (et)
NO (1)	NO313657B1 (et)
NZ (1)	NZ268137A (et)
PL (1)	PL178403B1 (et)
RU (1)	RU2148398C1 (et)
SA (1)	SA94150030B1 (et)
SK (1)	SK283145B6 (et)
TW (1)	TW402506B (et)
UA (1)	UA49794C2 (et)
WO (1)	WO1995000127A1 (et)

Families Citing this family (216)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6645504B1 (en)	1987-06-24	2003-11-11	Autoimmune Inc.	Bystander suppression of type I diabetes by oral administration of glucagon
US5645820A (en) *	1987-06-24	1997-07-08	Autoimmune, Inc.	Treatment of autoimmune diseases by aerosol administration of autoantigens
IL99699A (en) *	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
US6582728B1 (en)	1992-07-08	2003-06-24	Inhale Therapeutic Systems, Inc.	Spray drying of macromolecules to produce inhaleable dry powders
US6509006B1 (en)	1992-07-08	2003-01-21	Inhale Therapeutic Systems, Inc.	Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
ES2179831T3 (es)	1992-09-29	2003-02-01	Inhale Therapeutic Syst	Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana.
US6131567A (en) *	1993-01-29	2000-10-17	Aradigm Corporation	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US7448375B2 (en) *	1993-01-29	2008-11-11	Aradigm Corporation	Method of treating diabetes mellitus in a patient
US6024090A (en) *	1993-01-29	2000-02-15	Aradigm Corporation	Method of treating a diabetic patient by aerosolized administration of insulin lispro
EP1607086A1 (en) *	1993-01-29	2005-12-21	Aradigm Corporation	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US6794357B1 (en) *	1993-06-24	2004-09-21	Astrazeneca Ab	Compositions for inhalation
US5830853A (en) *	1994-06-23	1998-11-03	Astra Aktiebolag	Systemic administration of a therapeutic preparation
US20010003739A1 (en) *	1993-06-24	2001-06-14	Astrazeneca Ab	Systemic administration of a therapeutic preparation
US6632456B1 (en) *	1993-06-24	2003-10-14	Astrazeneca Ab	Compositions for inhalation
IS1796B (is) *	1993-06-24	2001-12-31	Ab Astra	Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
TW402506B (en) *	1993-06-24	2000-08-21	Astra Ab	Therapeutic preparation for inhalation
US5747445A (en) *	1993-06-24	1998-05-05	Astra Aktiebolag	Therapeutic preparation for inhalation
GB9322014D0 (en)	1993-10-26	1993-12-15	Co Ordinated Drug Dev	Improvements in and relating to carrier particles for use in dry powder inhalers
NZ281112A (en)	1994-03-07	1998-04-27	Inhale Therapeutic Syst	Powdered insulin delivered as an aerosol
US6051256A (en) *	1994-03-07	2000-04-18	Inhale Therapeutic Systems	Dispersible macromolecule compositions and methods for their preparation and use
US6165976A (en)	1994-06-23	2000-12-26	Astra Aktiebolag	Therapeutic preparation for inhalation
US6586006B2 (en)	1994-08-04	2003-07-01	Elan Drug Delivery Limited	Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en)	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
EP0806940B1 (en)	1994-12-22	2003-04-09	AstraZeneca AB	Aerosol drug formulations
SE9404468D0 (sv) *	1994-12-22	1994-12-22	Astra Ab	Powder formulations
US6524557B1 (en)	1994-12-22	2003-02-25	Astrazeneca Ab	Aerosol formulations of peptides and proteins
CA2206657C (en)	1994-12-22	2009-05-19	Astra Aktiebolag	Therapeutic preparation for inhalation containing parathyroid hormone, pth
GB9501841D0 (en)	1995-01-31	1995-03-22	Co Ordinated Drug Dev	Improvements in and relating to carrier particles for use in dry powder inhalers
US5612053A (en)	1995-04-07	1997-03-18	Edward Mendell Co., Inc.	Controlled release insufflation carrier for medicaments
GB9508691D0 (en) *	1995-04-28	1995-06-14	Pafra Ltd	Stable compositions
US6428771B1 (en) *	1995-05-15	2002-08-06	Pharmaceutical Discovery Corporation	Method for drug delivery to the pulmonary system
US5669973A (en) *	1995-06-06	1997-09-23	David Sarnoff Research Center, Inc.	Apparatus for electrostatically depositing and retaining materials upon a substrate
US5714007A (en) *	1995-06-06	1998-02-03	David Sarnoff Research Center, Inc.	Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US5654007A (en) *	1995-06-07	1997-08-05	Inhale Therapeutic Systems	Methods and system for processing dispersible fine powders
GB9515182D0 (en) *	1995-07-24	1995-09-20	Co Ordinated Drug Dev	Improvements in and relating to powders for use in dry powder inhalers
US5642727A (en) *	1995-07-25	1997-07-01	David Sarnoff Research Center, Inc.	Inhaler apparatus using a tribo-electric charging technique
US20020052310A1 (en)	1997-09-15	2002-05-02	Massachusetts Institute Of Technology The Penn State Research Foundation	Particles for inhalation having sustained release properties
US5985309A (en) *	1996-05-24	1999-11-16	Massachusetts Institute Of Technology	Preparation of particles for inhalation
USRE37053E1 (en)	1996-05-24	2001-02-13	Massachusetts Institute Of Technology	Particles incorporating surfactants for pulmonary drug delivery
US5855913A (en) *	1997-01-16	1999-01-05	Massachusetts Instite Of Technology	Particles incorporating surfactants for pulmonary drug delivery
US6503480B1 (en)	1997-05-23	2003-01-07	Massachusetts Institute Of Technology	Aerodynamically light particles for pulmonary drug delivery
US5874064A (en) *	1996-05-24	1999-02-23	Massachusetts Institute Of Technology	Aerodynamically light particles for pulmonary drug delivery
US6254854B1 (en)	1996-05-24	2001-07-03	The Penn Research Foundation	Porous particles for deep lung delivery
US6652837B1 (en)	1996-05-24	2003-11-25	Massachusetts Institute Of Technology	Preparation of novel particles for inhalation
US5857456A (en) *	1996-06-10	1999-01-12	Sarnoff Corporation	Inhaler apparatus with an electronic means for enhanced release of dry powders
US5871010A (en)	1996-06-10	1999-02-16	Sarnoff Corporation	Inhaler apparatus with modified surfaces for enhanced release of dry powders
US20030203036A1 (en) *	2000-03-17	2003-10-30	Gordon Marc S.	Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US6043214A (en) *	1997-03-20	2000-03-28	Novo Nordisk A/S	Method for producing powder formulation comprising an insulin
US6310038B1 (en)	1997-03-20	2001-10-30	Novo Nordisk A/S	Pulmonary insulin crystals
ZA984697B (en) *	1997-06-13	1999-12-01	Lilly Co Eli	Stable insulin formulations.
US7052678B2 (en)	1997-09-15	2006-05-30	Massachusetts Institute Of Technology	Particles for inhalation having sustained release properties
US6565885B1 (en)	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
US6309623B1 (en)	1997-09-29	2001-10-30	Inhale Therapeutic Systems, Inc.	Stabilized preparations for use in metered dose inhalers
US6946117B1 (en) *	1997-09-29	2005-09-20	Nektar Therapeutics	Stabilized preparations for use in nebulizers
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6433040B1 (en)	1997-09-29	2002-08-13	Inhale Therapeutic Systems, Inc.	Stabilized bioactive preparations and methods of use
US20020017295A1 (en) *	2000-07-07	2002-02-14	Weers Jeffry G.	Phospholipid-based powders for inhalation
US20010007853A1 (en) *	1998-01-08	2001-07-12	Dimarchi Richard Dennis	Method for administering monomeric insulin analogs
US7070799B1 (en) *	1998-02-10	2006-07-04	Generex Pharmaceuticals, Inc.	Method for administering insulin to the buccal region
US6221378B1 (en)	1998-02-10	2001-04-24	Generex Pharmaceuticals Incorporated	Mixed micellar delivery system and method of preparation
DE29923847U1 (de) *	1998-05-27	2001-04-12	Euroceltique S.A., Luxemburg/Luxembourg	Präparate zur Anwendung von entzündungshemmenden, insbesondere antiseptischen Wirkstoffen und/oder die Wundheilung fördernden Wirkstoffen in den unteren Atemwegen
US6149774A (en)	1998-06-10	2000-11-21	Delsys Pharmaceutical Corporation	AC waveforms biasing for bead manipulating chucks
US6451349B1 (en)	1998-08-19	2002-09-17	Quadrant Healthcare (Uk) Limited	Spray-drying process for the preparation of microparticles
US6956021B1 (en) *	1998-08-25	2005-10-18	Advanced Inhalation Research, Inc.	Stable spray-dried protein formulations
US6294153B1 (en)	1998-12-21	2001-09-25	Generex Pharmaceuticals, Inc.	Aerosol pharmaceutical formulation for pulmonary and nasal delivery
US20040214747A1 (en) *	1999-01-06	2004-10-28	Dimarchi Richard Dennis	Method for administering monomeric insulin
AU2879100A (en) *	1999-02-12	2000-08-29	Miles A. Libbey Iii	Formulation and system for intra-oral delivery of pharmaceutical agents
US7658938B2 (en)	1999-02-22	2010-02-09	Merrion Reasearch III Limited	Solid oral dosage form containing an enhancer
US6350432B1 (en)	1999-03-19	2002-02-26	Generex Pharmaceuticals Incorporated	Pressurized container having an aerosolized pharmaceutical composition
US6923979B2 (en) *	1999-04-27	2005-08-02	Microdose Technologies, Inc.	Method for depositing particles onto a substrate using an alternating electric field
JP2003501404A (ja)	1999-06-04	2003-01-14	デルルックスファーマシューティカルコーポレイション	薬剤の脱水粒子からなる製剤およびこれの調製方法
US7169889B1 (en) *	1999-06-19	2007-01-30	Biocon Limited	Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6858199B1 (en)	2000-06-09	2005-02-22	Advanced Inhalation Research, Inc.	High efficient delivery of a large therapeutic mass aerosol
US9006175B2 (en) *	1999-06-29	2015-04-14	Mannkind Corporation	Potentiation of glucose elimination
ES2569916T3 (es) *	1999-06-29	2016-05-13	Mannkind Corporation	Formulaciones farmacéuticas que comprenden insulina complejada con una dicetopiperazina
US6749835B1 (en)	1999-08-25	2004-06-15	Advanced Inhalation Research, Inc.	Formulation for spray-drying large porous particles
US7678364B2 (en)	1999-08-25	2010-03-16	Alkermes, Inc.	Particles for inhalation having sustained release properties
AU763041B2 (en) *	1999-08-25	2003-07-10	Alkermes, Inc.	Modulation of release from dry powder formulations
US20010036481A1 (en) *	1999-08-25	2001-11-01	Advanced Inhalation Research, Inc.	Modulation of release from dry powder formulations
AU2001226029A1 (en) *	2000-01-10	2001-07-24	Dura Pharmaceuticals, Inc.	Pharmaceutical formulation and method for pulmonary and oral delivery
JP2001240558A (ja) *	2000-02-29	2001-09-04	Nippon Suisan Kaisha Ltd	多価不飽和脂肪酸を経粘膜吸収促進剤として含有する固形製剤。
GB0004827D0 (en) *	2000-02-29	2000-04-19	Quadrant Holdings Cambridge	Compositions
GB0008660D0 (en)	2000-04-07	2000-05-31	Arakis Ltd	The treatment of respiratory diseases
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
ES2525087T5 (es)	2000-05-10	2018-06-28	Novartis Ag	Polvos basados en fosfolípidos para administración de fármacos
US8404217B2 (en)	2000-05-10	2013-03-26	Novartis Ag	Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
GB0011807D0 (en) *	2000-05-16	2000-07-05	Quadrant Holdings Cambridge	Formulation for inhalation
US7575761B2 (en) *	2000-06-30	2009-08-18	Novartis Pharma Ag	Spray drying process control of drying kinetics
US6444619B1 (en)	2000-09-28	2002-09-03	Rohm And Haas Company	Delivery system for cyclopropenes
US6953540B2 (en)	2000-09-29	2005-10-11	Rohm And Haas Company	Continuous process for the preparation of encapsulated cyclopropenes
IL145476A (en)	2000-09-29	2006-07-05	Rohm & Haas	Cyclopropene release systems that require less water
IT1319201B1 (it) *	2000-10-12	2003-09-26	Nicox Sa	Farmaci per il diabete.
WO2002043703A1 (fr) *	2000-11-29	2002-06-06	Itoham Foods Inc.	Preparations pulverulentes et son procede de production
EP2283818B1 (en)	2000-11-30	2017-08-02	Vectura Limited	Method of making particles for use in a pharmaceutical composition
EP2168571B1 (en) *	2000-11-30	2018-08-22	Vectura Limited	Particles for use in a Pharmaceutical Composition
US20030054015A1 (en) *	2000-12-25	2003-03-20	Shinichiro Haze	Sympathetic-activating perfume composition
WO2002053190A2 (en)	2000-12-29	2002-07-11	Advanced Inhalation Research, Inc.	Particles for inhalation having sustained release properties
US20020141946A1 (en) *	2000-12-29	2002-10-03	Advanced Inhalation Research, Inc.	Particles for inhalation having rapid release properties
US6867183B2 (en) *	2001-02-15	2005-03-15	Nobex Corporation	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) *	2001-02-15	2006-06-13	Nobex Corporation	Methods of treating diabetes mellitus
JP2004533438A (ja) *	2001-05-04	2004-11-04	ファイザー・プロダクツ・インク	エーロゾル化したインスリンによる２型糖尿病の予防法
US6835802B2 (en) *	2001-06-04	2004-12-28	Nobex Corporation	Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) *	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en)	2001-06-04	2010-05-11	Biocon Limited	Calcitonin drug-oligomer conjugates, and uses thereof
US6713452B2 (en)	2001-06-04	2004-03-30	Nobex Corporation	Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) *	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) *	2001-06-04	2005-02-22	Nobex Corporation	Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
GB0114033D0 (en) *	2001-06-09	2001-08-01	Innovata Biomed Ltd	Process
RU2299743C2 (ru) *	2001-07-05	2007-05-27	Транслэйшнл Рисерч Лтд.	Композиции инсулина для носового введения
GB0208742D0 (en)	2002-04-17	2002-05-29	Bradford Particle Design Ltd	Particulate materials
US7166571B2 (en) *	2001-09-07	2007-01-23	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en)	2001-09-07	2004-08-03	Nobex Corporation	Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) *	2001-09-07	2005-07-05	Nobex Corporation	Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) *	2001-09-07	2006-04-18	Nobex Corporation	Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7196059B2 (en) *	2001-09-07	2007-03-27	Biocon Limited	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) *	2001-09-07	2007-12-25	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
WO2003037303A1 (en)	2001-11-01	2003-05-08	Nektar Therapeutics	Spray drying methods and compositions thereof
AU2002346472A1 (en) *	2001-11-20	2003-06-10	Advanced Inhalation Research, Inc.	Particulate compositions for improving solubility of poorly soluble agents
CA2465675C (en) *	2001-11-20	2008-06-10	Advanced Inhalation Research, Inc.	Improved particulate compositions for pulmonary delivery
JP2005514393A (ja)	2001-12-19	2005-05-19	ネクターセラピューティクス	アミノグリコシドの肺への供給
FR2834212B1 (fr) *	2001-12-27	2004-07-09	Besins Int Belgique	Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques
US6923175B2 (en)	2002-03-20	2005-08-02	Mannkind Corporation	Inhalation apparatus
US7582284B2 (en)	2002-04-17	2009-09-01	Nektar Therapeutics	Particulate materials
DE60302454T2 (de) *	2002-04-19	2006-08-17	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Beta-agonisten-verbindungen mit stickoxid-donatoren-gruppen und reaktionsfähige sauerstoffspezies-fängergruppen und ihre verwendung bei der behandlung von atemwegsstörungen
GB0216562D0 (en) *	2002-04-25	2002-08-28	Bradford Particle Design Ltd	Particulate materials
US9339459B2 (en)	2003-04-24	2016-05-17	Nektar Therapeutics	Particulate materials
AU2003236521A1 (en) *	2002-06-13	2003-12-31	Nobex Corporation	Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
DE10234165B4 (de) *	2002-07-26	2008-01-03	Advanced Micro Devices, Inc., Sunnyvale	Verfahren zum Füllen eines Grabens, der in einem Substrat gebildet ist, mit einem isolierenden Material
WO2004030659A1 (en) *	2002-09-30	2004-04-15	Acusphere, Inc.	Sustained release porous microparticles for inhalation
US20060247216A1 (en) *	2002-10-25	2006-11-02	Haj-Yehia Abdullah I	Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
US6962006B2 (en) *	2002-12-19	2005-11-08	Acusphere, Inc.	Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040121003A1 (en) *	2002-12-19	2004-06-24	Acusphere, Inc.	Methods for making pharmaceutical formulations comprising deagglomerated microparticles
CN1311868C (zh) *	2003-06-10	2007-04-25	上海兴康医药研究开发有限公司	一种胰岛素干粉吸入剂的制备方法
US8921311B2 (en)	2003-08-01	2014-12-30	Mannkind Corporation	Method for treating hyperglycemia
KR101152470B1 (ko) *	2003-08-13	2012-06-01	바이오콘 리미티드	치료제용 마이크로-입자 지방산 염 고형 투약 제형
SI1699434T1 (sl) *	2003-09-02	2011-06-30	Norton Healthcare Ltd	Postopek za pripravo zdravila
CA2538237A1 (en) *	2003-09-10	2005-03-24	Map Pharmaceuticals, Inc.	Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation
US7338171B2 (en) *	2003-10-27	2008-03-04	Jen-Chuen Hsieh	Method and apparatus for visual drive control
ES2584867T3 (es) *	2004-01-12	2016-09-29	Mannkind Corporation	Un método que reduce los niveles séricos de proinsulina en diabéticos de tipo 2
US20080090753A1 (en) *	2004-03-12	2008-04-17	Biodel, Inc.	Rapid Acting Injectable Insulin Compositions
DE602005014962D1 (de) *	2004-03-12	2009-07-30	Biodel Inc	Insulinzusammensetzungen mit verbesserter wirkstoffabsorption
US20080248999A1 (en) *	2007-04-04	2008-10-09	Biodel Inc.	Amylin formulations
US7625865B2 (en) *	2004-03-26	2009-12-01	Universita Degli Studi Di Parma	Insulin highly respirable microparticles
US8241670B2 (en) *	2004-04-15	2012-08-14	Chiasma Inc.	Compositions capable of facilitating penetration across a biological barrier
US20070219131A1 (en) *	2004-04-15	2007-09-20	Ben-Sasson Shmuel A	Compositions capable of facilitating penetration across a biological barrier
PL2708225T3 (pl)	2004-04-23	2019-07-31	Cydex Pharmaceuticals, Inc.	Formulacja DPI zawierająca eter sulfoalkilowy cyklodekstryny
BRPI0513508B1 (pt)	2004-07-19	2021-06-01	Biocon Limited	Conjugados de insulina-oligômero, formulações e usos desses
ATE486064T1 (de)	2004-08-20	2010-11-15	Mannkind Corp	Katalyse der diketopiperazinsynthese
KR20130066695A (ko)	2004-08-23	2013-06-20	맨카인드 코포레이션	약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
GB0425758D0 (en)	2004-11-23	2004-12-22	Vectura Ltd	Preparation of pharmaceutical compositions
MX373000B (es)	2005-09-14	2020-05-21	Mannkind Corp	Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
WO2007041481A1 (en) *	2005-09-29	2007-04-12	Biodel, Inc.	Rapid acting and prolonged acting insulin preparations
US8084420B2 (en) *	2005-09-29	2011-12-27	Biodel Inc.	Rapid acting and long acting insulin combination formulations
US7713929B2 (en)	2006-04-12	2010-05-11	Biodel Inc.	Rapid acting and long acting insulin combination formulations
BRPI0520622B8 (pt) *	2005-10-13	2021-05-25	Biocon Ltd	processo para o preparo de conjugados de insulina
US7629331B2 (en)	2005-10-26	2009-12-08	Cydex Pharmaceuticals, Inc.	Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
CN101309668A (zh) *	2005-11-30	2008-11-19	健乐克斯医药公司	经口吸收的药物制剂和用药方法
WO2007070851A2 (en) *	2005-12-15	2007-06-21	Acusphere, Inc.	Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
WO2007070843A2 (en) *	2005-12-15	2007-06-21	Acusphere, Inc.	Processes for making particle-based pharmaceutical formulations for oral administration
TWI299993B (en)	2005-12-15	2008-08-21	Dev Center Biotechnology	Aqueous inhalation pharmaceutical composition
EP1986679B1 (en)	2006-02-22	2017-10-25	MannKind Corporation	A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
CA2642229C (en)	2006-02-24	2015-05-12	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
KR101191322B1 (ko)	2006-04-07	2012-10-16	메리온 리서치 Ⅲ 리미티드	증진제를 함유하는 고형 경구용 투여 제형
WO2007121256A2 (en) *	2006-04-12	2007-10-25	Biodel, Inc.	Rapid acting and long acting insulin combination formulations
DK2425820T3 (en)	2007-02-11	2015-07-13	Map Pharmaceuticals Inc	A method for the therapeutic administration of DHE in order to enable quick relief of migraine, while minimizing the adverse event profile
KR100785656B1 (ko)	2007-05-14	2007-12-17	재단법인서울대학교산학협력재단	소염제로 사용되는 소디움글리코콜레이트 또는 그 유도체
JP5868594B2 (ja) *	2007-10-16	2016-02-24	バイオコン・リミテッドＢｉｏｃｏｎＬｉｍｉｔｅｄ	経口投与可能な固形医薬組成物及びそのプロセス
EP2211842B1 (en)	2007-10-24	2015-08-12	MannKind Corporation	An inhalable dry powder formulation comprising glp-1 for use in the treatment of hyperglycemia and diabetes by pulmonary administration
US8785396B2 (en)	2007-10-24	2014-07-22	Mannkind Corporation	Method and composition for treating migraines
JP5570996B2 (ja)	2007-12-14	2014-08-13	エアロデザインズインコーポレイテッド	エアロゾル化可能な食料品の送達
US20090271021A1 (en) *	2008-04-28	2009-10-29	Popp Shane M	Execution system for the monitoring and execution of insulin manufacture
CN107096012A (zh)	2008-05-07	2017-08-29	诺和诺德股份有限公司	肽的组合物及其制备方法
CN101827626B (zh)	2008-06-13	2015-03-18	曼金德公司	干粉吸入器和用于药物输送的系统
US8485180B2 (en)	2008-06-13	2013-07-16	Mannkind Corporation	Dry powder drug delivery system
ES2421385T3 (es)	2008-06-20	2013-09-02	Mannkind Corp	Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
TWI532497B (zh)	2008-08-11	2016-05-11	曼凱公司	超快起作用胰島素之用途
CN102176900B (zh)	2008-09-17	2017-09-26	克艾思马有限公司	药物组合物和相关的给药方法
US8314106B2 (en)	2008-12-29	2012-11-20	Mannkind Corporation	Substituted diketopiperazine analogs for use as drug delivery agents
DK2379100T3 (en)	2009-01-08	2014-12-01	Mannkind Corp	Treatment of hyperglycemia with GLP-1
PL2565193T3 (pl)	2009-01-23	2014-07-31	Rigel Pharmaceuticals Inc	Kompozycje i sposoby hamowania szlaku JAK
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
DK2405963T3 (da)	2009-03-11	2013-12-16	Mannkind Corp	Apparat, system og fremgangsmåde til at måle modstand i en inhalator
EP2421396A2 (en)	2009-04-24	2012-02-29	Veronica Haupt	A heel for a shoe
US20100310660A1 (en) *	2009-06-08	2010-12-09	Taipei Medical University	Dry powder microparticles for pulmonary delivery
KR102584844B1 (ko)	2009-06-12	2023-10-04	맨카인드 코포레이션	한정된 비표면적을 갖는 디케토피페라진 마이크로입자
CA2778698A1 (en)	2009-11-03	2011-05-12	Mannkind Corporation	An apparatus and method for simulating inhalation efforts
JP2013518097A (ja)	2010-01-26	2013-05-20	イッサムリサーチディヴェロップメントカンパニーオブザヘブリューユニバーシティーオブエルサレムエルティーディー	肺高血圧を予防および治療するための組成物および方法
WO2011120033A1 (en)	2010-03-26	2011-09-29	Merrion Research Iii Limited	Pharmaceutical compositions of selective factor xa inhibitors for oral administration
CN102985125A (zh)	2010-06-21	2013-03-20	曼金德公司	干粉药物输送系统和方法
EP2661273A4 (en)	2011-01-07	2014-06-04	Merrion Res Iii Ltd	IRON PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION
SG194034A1 (en)	2011-04-01	2013-11-29	Mannkind Corp	Blister package for pharmaceutical cartridges
WO2012174472A1 (en)	2011-06-17	2012-12-20	Mannkind Corporation	High capacity diketopiperazine microparticles
MX2014004983A (es)	2011-10-24	2014-09-22	Mannkid Corp	Metodos y composiciones para tratar dolor.
CA2865504A1 (en)	2012-03-23	2013-09-26	Oxigene, Inc.	Compositions and methods for inhibition of cathepsins
KR102264177B1 (ko)	2012-07-12	2021-06-11	맨카인드 코포레이션	건조 분말 약물 전달 시스템 및 방법
WO2014066856A1 (en)	2012-10-26	2014-05-01	Mannkind Corporation	Inhalable influenza vaccine compositions and methods
US9757395B2 (en)	2012-12-20	2017-09-12	Otitopic Inc.	Dry powder inhaler and methods of use
US9757529B2 (en)	2012-12-20	2017-09-12	Otitopic Inc.	Dry powder inhaler and methods of use
EP3587404B1 (en)	2013-03-15	2022-07-13	MannKind Corporation	Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
GB201305825D0 (en)	2013-03-28	2013-05-15	Vectura Ltd	New use
HK1218720A1 (zh)	2013-04-30	2017-03-10	欧缇托匹克公司	干粉制剂及使用方法
MX375448B (es)	2013-07-18	2025-03-06	Mannkind Corp	Composiciones farmacéuticas en polvo seco estables al calor y métodos.
EP3030294B1 (en)	2013-08-05	2020-10-07	MannKind Corporation	Insufflation apparatus
ES2922206T3 (es)	2014-02-20	2022-09-09	Otitopic Inc	Formulaciones de polvo seco para la inhalación
US10307464B2 (en)	2014-03-28	2019-06-04	Mannkind Corporation	Use of ultrarapid acting insulin
US10561806B2 (en)	2014-10-02	2020-02-18	Mannkind Corporation	Mouthpiece cover for an inhaler
US10265384B2 (en)	2015-01-29	2019-04-23	Novo Nordisk A/S	Tablets comprising GLP-1 agonist and enteric coating
HUE071943T2 (hu)	2015-02-03	2025-10-28	Amryt Endo Inc	Akromegália kezelése oktreotid orális alkalmazásával
WO2017193110A1 (en) *	2016-05-06	2017-11-09	Stites Adam	Cannabinoid compositions for sublingual spray nebulizer
HUE059420T2 (hu) *	2018-04-16	2022-11-28	Ioulia Tseti	Egy tiroid hormont tartalmazó gyógyászati száraz por készítmény inhalálásra
US20220000880A1 (en)	2018-11-01	2022-01-06	Rigel Pharmaceuticals, Inc.	Method and composition embodiments for treating acute myeloid leukemia
US20200377518A1 (en)	2019-05-29	2020-12-03	Rigel Pharmaceuticals, Inc.	Method of preventing and treating thrombosis
BR112022001418A2 (pt)	2019-08-08	2022-06-07	Rigel Pharmaceuticals Inc	Compostos e método para tratar a síndrome de liberação de citocinas
ES2970382T3 (es)	2019-08-14	2024-05-28	Rigel Pharmaceuticals Inc	Método para bloquear o mejorar el síndrome de liberación de citocinas
US11141457B1 (en)	2020-12-28	2021-10-12	Amryt Endo, Inc.	Oral octreotide therapy and contraceptive methods
JP2025513716A (ja)	2022-03-23	2025-04-30	ライジェル・ファーマシューティカルズ・インコーポレイテッド	Ｉｒａｋ阻害剤としてのピリミド－２－イル－ピラゾール化合物

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE556587A (et)	1957-01-31	1957-04-11
GB1527605A (en) *	1975-08-20	1978-10-04	Takeda Chemical Industries Ltd	Insulin preparation for intranasal administration
JPS6034925B2 (ja)	1979-07-31	1985-08-12	帝人株式会社	持続性鼻腔用製剤およびその製造法
JPS5795920A (en)	1980-12-04	1982-06-15	Teijin Ltd	Remedy for respiratory disease
US4900730A (en) *	1981-01-14	1990-02-13	Toyo Jozo Co., Ltd.	Preparation which promotes the absorption of peptides
SE438261B (sv) *	1981-07-08	1985-04-15	Draco Ab	Anvendning i dosinhalator av ett perforerat membran
DE3274065D1 (de) *	1981-07-08	1986-12-11	Draco Ab	Powder inhalator
US5260306A (en)	1981-07-24	1993-11-09	Fisons Plc	Inhalation pharmaceuticals
JPS59163313A (ja) *	1983-03-09	1984-09-14	Teijin Ltd	経鼻投与用ペプチドホルモン類組成物
US4959358A (en) *	1983-06-06	1990-09-25	Beth Israel Hospital Assn.	Drug administration
US4548922A (en) *	1983-06-06	1985-10-22	Beth Israel Hospital	Drug administration
US4746508A (en) *	1983-06-06	1988-05-24	Beth Israel Hospital Assn.	Drug administration
US4963367A (en)	1984-04-27	1990-10-16	Medaphore, Inc.	Drug delivery compositions and methods
US5288498A (en)	1985-05-01	1994-02-22	University Of Utah Research Foundation	Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
JPS61267528A (ja) *	1984-11-26	1986-11-27	Yamanouchi Pharmaceut Co Ltd	吸収促進剤を含有するカルシトニン経鼻剤
SE448277B (sv) *	1985-04-12	1987-02-09	Draco Ab	Indikeringsanordning vid en doseringsanordning for lekemedel
EP0200383A3 (en)	1985-04-15	1987-09-02	Eli Lilly And Company	An improved method for administering insulin
US5122127A (en)	1985-05-01	1992-06-16	University Of Utah	Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues
DE3686025T2 (de)	1985-05-22	1993-01-07	Liposome Technology Inc	Verfahren und system zum einatmen von liposomen.
US4847298A (en)	1985-08-16	1989-07-11	Merck & Co., Inc.	Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments
IL77186A0 (en) *	1985-11-29	1986-04-29	Touitou Elka	Pharmaceutical insulin composition
SE453566B (sv) *	1986-03-07	1988-02-15	Draco Ab	Anordning vid pulverinhalatorer
JPS632932A (ja)	1986-06-23	1988-01-07	Teijin Ltd	経鼻投与用粉末状組成物
EP0257915B1 (en)	1986-08-11	1993-03-10	Innovata Biomed Limited	Pharmaceutical formulations comprising microcapsules
US5179079A (en) *	1986-12-16	1993-01-12	Novo Nordisk A/S	Nasal formulation and intranasal administration therewith
NZ222907A (en) *	1986-12-16	1990-08-28	Novo Industri As	Preparation for intranasal administration containing a phospholipid absorption enhancing system
GB8712176D0 (en) *	1987-05-22	1987-06-24	Cosmas Damian Ltd	Drug delivery system
JPH01117825A (ja)	1987-10-28	1989-05-10	Sanwa Kagaku Kenkyusho Co Ltd	鼻くう、副鼻くう投与用製剤及びその使用方法並びにその形状及び使用器具
EP0360340A1 (en) *	1988-09-19	1990-03-28	Akzo N.V.	Composition for nasal administration containing a peptide
US5997856A (en) *	1988-10-05	1999-12-07	Chiron Corporation	Method and compositions for solubilization and stabilization of polypeptides, especially proteins
SE8803935L (sv) *	1988-10-31	1990-05-01	Kabivitrum Ab	Laekemedelskomposition
US5006343A (en)	1988-12-29	1991-04-09	Benson Bradley J	Pulmonary administration of pharmaceutically active substances
GB8900267D0 (en)	1989-01-06	1989-03-08	Riker Laboratories Inc	Narcotic analgesic formulations and apparatus containing same
US4994439A (en)	1989-01-19	1991-02-19	California Biotechnology Inc.	Transmembrane formulations for drug administration
US5011678A (en)	1989-02-01	1991-04-30	California Biotechnology Inc.	Composition and method for administration of pharmaceutically active substances
KR0157428B1 (ko)	1989-02-17	1998-11-16	알렌 불룸	비 전달용 지질부형제와 그 사용법
IT8920486A0 (it)	1989-05-12	1989-05-12	Isf Spa	Composizioni farmaceutiche.
US5176132A (en)	1989-05-31	1993-01-05	Fisons Plc	Medicament inhalation device and formulation
JP2642486B2 (ja) *	1989-08-04	1997-08-20	田辺製薬株式会社	難溶性薬物の超微粒子化法
US5258185A (en) *	1989-08-23	1993-11-02	Bauer Kurt H	Highly active, rapidly absorbable formulations of glibenclamide, processes for the production thereof and their use
GB8921222D0 (en)	1989-09-20	1989-11-08	Riker Laboratories Inc	Medicinal aerosol formulations
US5707644A (en)	1989-11-04	1998-01-13	Danbiosyst Uk Limited	Small particle compositions for intranasal drug delivery
GB9001635D0 (en)	1990-01-24	1990-03-21	Ganderton David	Aerosol carriers
US5376386A (en)	1990-01-24	1994-12-27	British Technology Group Limited	Aerosol carriers
US5118494A (en)	1990-03-23	1992-06-02	Minnesota Mining And Manufacturing Company	Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
JPH05963A (ja) *	1990-04-13	1993-01-08	Toray Ind Inc	ポリペプチド類組成物
US5192548A (en) *	1990-04-30	1993-03-09	Riker Laboratoires, Inc.	Device
JPH05507090A (ja)	1990-05-08	1993-10-14	リポサーム　テクノロジー　インコーポレイテッド	直接噴霧乾燥された薬剤／脂質粉末組成物
ES2117642T3 (es)	1990-05-10	1998-08-16	Bechgaard Int Res	Preparado farmaceutico que contiene n-glicofuroles y n-etilen glicoles.
JPH0441421A (ja)	1990-06-07	1992-02-12	Taisho Pharmaceut Co Ltd	肺吸収組成物
JPH04149126A (ja)	1990-10-09	1992-05-22	Mitsubishi Kasei Corp	経粘膜投与用医薬組成物
IL99699A (en)	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
GB9024365D0 (en)	1990-11-09	1991-01-02	Glaxo Group Ltd	Medicaments
AU643141B2 (en)	1991-03-15	1993-11-04	Amgen, Inc.	Pulmonary administration of granulocyte colony stimulating factor
US5320094A (en)	1992-01-10	1994-06-14	The Johns Hopkins University	Method of administering insulin
EP0621774B1 (en) *	1992-01-21	1996-12-18	Sri International	Improved process for preparing micronized polypeptide drugs
US5482706A (en) *	1992-04-17	1996-01-09	Takeda Chemical Industries, Ltd.	Transmucosal therapeutic composition
ES2177544T3 (es)	1992-06-12	2002-12-16	Teijin Ltd	Polvo ultrafinno para inhalar y metodo para su preparacion.
US5376359A (en) *	1992-07-07	1994-12-27	Glaxo, Inc.	Method of stabilizing aerosol formulations
ES2179831T3 (es) *	1992-09-29	2003-02-01	Inhale Therapeutic Syst	Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana.
US5364838A (en)	1993-01-29	1994-11-15	Miris Medical Corporation	Method of administration of insulin
DE69426415T2 (de) *	1993-01-29	2001-07-26	Aradigm Corp., Hayward	Intrapulmonares hormonabgabesystem
BE1006873A6 (nl)	1993-03-26	1995-01-10	Merkus Franciscus W H M	Toedieningsformulering voor nasale insuline toediening.
US5437271A (en)	1993-04-06	1995-08-01	Minnesota Mining And Manufacturing Company	Deagglomerators for dry powder inhalers
IS1796B (is) *	1993-06-24	2001-12-31	Ab Astra	Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5830853A (en) *	1994-06-23	1998-11-03	Astra Aktiebolag	Systemic administration of a therapeutic preparation
US5747445A (en)	1993-06-24	1998-05-05	Astra Aktiebolag	Therapeutic preparation for inhalation
TW402506B (en) *	1993-06-24	2000-08-21	Astra Ab	Therapeutic preparation for inhalation
US5506203C1 (en) *	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation
US5661130A (en)	1993-06-24	1997-08-26	The Uab Research Foundation	Absorption enhancers for drug administration
GB9314614D0 (en)	1993-07-14	1993-08-25	Minnesota Mining & Mfg	Dry powder inhalers
US5514670A (en)	1993-08-13	1996-05-07	Pharmos Corporation	Submicron emulsions for delivery of peptides
US6051256A (en)	1994-03-07	2000-04-18	Inhale Therapeutic Systems	Dispersible macromolecule compositions and methods for their preparation and use
NZ281112A (en) *	1994-03-07	1998-04-27	Inhale Therapeutic Syst	Powdered insulin delivered as an aerosol
US5451569A (en)	1994-04-19	1995-09-19	Hong Kong University Of Science And Technology R & D Corporation Limited	Pulmonary drug delivery system
SE9404468D0 (sv) *	1994-12-22	1994-12-22	Astra Ab	Powder formulations

1994
- 1994-06-20 TW TW083105540A patent/TW402506B/zh not_active IP Right Cessation
- 1994-06-21 IS IS4178A patent/IS1768B/is unknown
- 1994-06-22 IL IL11008494A patent/IL110084A/xx not_active IP Right Cessation
- 1994-06-22 EG EG36694A patent/EG20599A/xx active
- 1994-06-23 UA UA95125417A patent/UA49794C2/uk unknown
- 1994-06-23 KR KR1019950705904A patent/KR100372673B1/ko not_active Expired - Fee Related
- 1994-06-23 NZ NZ268137A patent/NZ268137A/en not_active IP Right Cessation
- 1994-06-23 DK DK94919960T patent/DK0706382T3/da active
- 1994-06-23 EP EP94919960A patent/EP0706382B1/en not_active Expired - Lifetime
- 1994-06-23 DE DE69420412T patent/DE69420412T2/de not_active Expired - Lifetime
- 1994-06-23 CN CN94193190A patent/CN1110301C/zh not_active Expired - Fee Related
- 1994-06-23 US US08265372 patent/US5518998C1/en not_active Expired - Lifetime
- 1994-06-23 MY MYPI94001630A patent/MY112098A/en unknown
- 1994-06-23 WO PCT/SE1994/000633 patent/WO1995000127A1/en not_active Ceased
- 1994-06-23 CZ CZ19953428A patent/CZ287314B6/cs not_active IP Right Cessation
- 1994-06-23 BR BR9406907A patent/BR9406907A/pt not_active Application Discontinuation
- 1994-06-23 ES ES94919960T patent/ES2138087T3/es not_active Expired - Lifetime
- 1994-06-23 RU RU96103636A patent/RU2148398C1/ru not_active IP Right Cessation
- 1994-06-23 PL PL94312205A patent/PL178403B1/pl not_active IP Right Cessation
- 1994-06-23 JP JP50273695A patent/JP3874789B2/ja not_active Expired - Fee Related
- 1994-06-23 CA CA002166108A patent/CA2166108C/en not_active Expired - Fee Related
- 1994-06-23 HU HU9503659A patent/HU228129B1/hu not_active IP Right Cessation
- 1994-06-23 SK SK1601-95A patent/SK283145B6/sk not_active IP Right Cessation
- 1994-06-23 AT AT94919960T patent/ATE183920T1/de active
- 1994-06-23 AU AU70901/94A patent/AU692780B2/en not_active Ceased
- 1994-06-23 MX MX9404761A patent/MX9404761A/es unknown
- 1994-06-27 SA SA94150030A patent/SA94150030B1/ar unknown
- 1994-11-23 EE EE9400429A patent/EE03221B1/et not_active IP Right Cessation
1995
- 1995-06-06 US US08/471,488 patent/US5658878A/en not_active Expired - Lifetime
- 1995-12-21 NO NO19955226A patent/NO313657B1/no not_active IP Right Cessation
- 1995-12-22 FI FI956227A patent/FI111688B/fi not_active IP Right Cessation
1997
- 1997-08-06 US US08/906,825 patent/US6306440B1/en not_active Expired - Fee Related
1999
- 1999-11-29 GR GR990403067T patent/GR3031974T3/el unknown
2005
- 2005-11-09 JP JP2005325056A patent/JP4294635B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ342895A3 (en)	1996-05-15
CN1129904A (zh)	1996-08-28
IS1768B (is)	2001-05-02
US5518998A (en)	1996-05-21
JP3874789B2 (ja)	2007-01-31
US6306440B1 (en)	2001-10-23
GR3031974T3 (en)	2000-03-31
SA94150030B1 (ar)	2006-04-04
JP4294635B2 (ja)	2009-07-15
HK1009584A1 (en)	1999-06-04
IL110084A (en)	1999-07-14
AU7090194A (en)	1995-01-17
EP0706382B1 (en)	1999-09-01
MX9404761A (es)	1995-01-31
EG20599A (en)	1999-09-30
NO955226D0 (no)	1995-12-21
SK283145B6 (sk)	2003-03-04
IS4178A (is)	1994-12-25
CA2166108C (en)	2008-10-21
CN1110301C (zh)	2003-06-04
HU228129B1 (en)	2012-12-28
KR100372673B1 (ko)	2003-05-12
CA2166108A1 (en)	1995-01-05
CZ287314B6 (en)	2000-10-11
HUT75065A (en)	1997-03-28
ES2138087T3 (es)	2000-01-01
IL110084A0 (en)	1994-10-07
PL312205A1 (en)	1996-04-01
NO313657B1 (no)	2002-11-11
EP0706382A1 (en)	1996-04-17
DE69420412T2 (de)	2000-04-13
TW402506B (en)	2000-08-21
HU9503659D0 (en)	1996-02-28
US5658878A (en)	1997-08-19
MY112098A (en)	2001-04-30
NZ268137A (en)	1997-10-24
SK160195A3 (en)	1997-02-05
UA49794C2 (uk)	2002-10-15
DK0706382T3 (da)	2000-03-13
ATE183920T1 (de)	1999-09-15
NO955226L (no)	1996-02-15
JP2006089496A (ja)	2006-04-06
FI956227L (fi)	1995-12-22
FI111688B (fi)	2003-09-15
US5518998C1 (en)	2001-02-13
FI956227A0 (fi)	1995-12-22
BR9406907A (pt)	1996-04-02
JPH08512027A (ja)	1996-12-17
DE69420412D1 (de)	1999-10-07
PL178403B1 (pl)	2000-04-28
AU692780B2 (en)	1998-06-18
RU2148398C1 (ru)	2000-05-10
WO1995000127A1 (en)	1995-01-05

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-12-15	HC1A	Change of owner name
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2013-08-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20121123

Publication	Publication Date	Title
EE03221B1 (et)	1999-10-15	Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks
ES2162927T3 (es)	2002-01-16	Formulacion para la aplicacion por inhalacion.
CA2146954A1 (en)	1996-10-13	Breath activated nicotine inhalers
PH27594A (en)	1993-08-31	Medicaments for the treatment of asthma and other respiratory disorders
AR002261A1 (es)	1998-03-11	Composicion en polvo para la administracion por inhalacion de polipeptidos utiles en medicina, metodos para la manufactura de dicha composicion, y uso de la composicion para la manufactura de un medicamento para el tratamietno de enfermedades a traves del tracto respiratorio
FI101858B1 (fi)	1998-09-15	Kertakäyttöinen lääkkeen sisäänhengityslaite
ATE271852T1 (de)	2004-08-15	Verbesserte inhalationspräparate
DK0533896T3 (et)	1997-02-17
IT9030691U1 (it)	1992-01-28	Inalatore per aerosolterapia basato sul sistema "usa e getta" dei due componenti "mascheria per inalazione " e "contenitore portafarmaco"
IT9041667A0 (it)	1990-07-27	Inalatore per aerosolterapia basato sul sistema "usa e getta" dei due componenti "mascherina per inalazione" e "contenitore portafarmaco".
MY111155A (en)	1999-09-30	Medicaments