EE03968B1 - Ftalasinoonid - Google Patents

Ftalasinoonid

Info

Publication number
EE03968B1
EE03968B1 EEP199900274A EEP9900274A EE03968B1 EE 03968 B1 EE03968 B1 EE 03968B1 EE P199900274 A EEP199900274 A EE P199900274A EE P9900274 A EEP9900274 A EE P9900274A EE 03968 B1 EE03968 B1 EE 03968B1
Authority
EE
Estonia
Prior art keywords
pct
date jul
sec
pub
phthalazinones
Prior art date
Application number
EEP199900274A
Other languages
English (en)
Estonian (et)
Inventor
Johanna Van Der Laan Ivonne
Van Der Mey Margaretha
Timmerman Hendrik
Hatzelmann Armin
Boss Hildegard
H�fner Dietrich
Beume Rolf
Kley Hans-Peter
Jan Sterk Geert
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of EE9900274A publication Critical patent/EE9900274A/xx
Publication of EE03968B1 publication Critical patent/EE03968B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
EEP199900274A 1997-01-15 1998-01-12 Ftalasinoonid EE03968B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97100488 1997-01-15
PCT/EP1998/000124 WO1998031674A1 (fr) 1997-01-15 1998-01-12 Phthalazinones

Publications (2)

Publication Number Publication Date
EE9900274A EE9900274A (et) 2000-02-15
EE03968B1 true EE03968B1 (et) 2003-02-17

Family

ID=8226366

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900274A EE03968B1 (et) 1997-01-15 1998-01-12 Ftalasinoonid

Country Status (26)

Country Link
US (1) US6103718A (fr)
EP (1) EP0971901B1 (fr)
JP (1) JP2001508078A (fr)
KR (1) KR20000070150A (fr)
CN (1) CN1127487C (fr)
AT (1) ATE233247T1 (fr)
AU (1) AU735934B2 (fr)
BR (1) BR9806752A (fr)
CA (1) CA2276455C (fr)
CY (1) CY2446B1 (fr)
CZ (1) CZ293815B6 (fr)
DE (1) DE69811645T2 (fr)
DK (1) DK0971901T3 (fr)
EA (1) EA002764B1 (fr)
EE (1) EE03968B1 (fr)
ES (1) ES2193508T3 (fr)
HU (1) HUP0001541A3 (fr)
IL (1) IL130659A (fr)
NO (1) NO313137B1 (fr)
NZ (1) NZ336573A (fr)
PL (1) PL189418B1 (fr)
PT (1) PT971901E (fr)
SI (1) SI0971901T1 (fr)
SK (1) SK283270B6 (fr)
TR (1) TR199901653T2 (fr)
WO (1) WO1998031674A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1070056T1 (en) * 1998-03-14 2004-12-31 Altana Pharma Ag Phthalazinone pde iii/iv inhibitors
CA2715683A1 (fr) 1999-08-21 2001-03-01 Nycomed Gmbh Combinaison synergiste
AU7654200A (en) * 1999-09-14 2001-04-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pd3/4 inhibitors
HUP0203487A2 (hu) 1999-10-25 2003-02-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahidrotiopirán-ftalazinon-származékok, mint PDE4-inhibitorok és ezeket tartalmazó gyógyszerkészítmények
WO2001030766A1 (fr) * 1999-10-25 2001-05-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Derives de phthalazinone, utilises comme inhibiteurs de pde4
NZ522882A (en) 2000-06-05 2004-07-30 Altana Pharma Bv Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors
US7868015B2 (en) * 2000-08-10 2011-01-11 Cold Spring Harbor Laboratory Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
US20040224316A1 (en) * 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
CZ20032491A3 (cs) * 2001-02-15 2004-01-14 Altana Pharma Ag Ftalazinonpiperidinové deriváty
EP1385848A2 (fr) * 2001-04-25 2004-02-04 ALTANA Pharma AG Phtalazinones
BR0209076A (pt) * 2001-04-25 2004-08-10 Altana Pharma Ag Derivados de piperazino e seu uso como inibidor de pde4
AU2003211381B9 (en) 2002-02-19 2009-07-30 Ono Pharmaceutical Co., Ltd. Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient
WO2004018449A1 (fr) * 2002-08-10 2004-03-04 Altana Pharma Ag Derives de piperidine utilises comme inhibiteurs de la phospodiesterase-4 (pde4)
EP1556369A1 (fr) * 2002-08-10 2005-07-27 ALTANA Pharma AG Derives de pyridazinone utilises comme inhibiteurs de pde4
BR0313330A (pt) 2002-08-10 2005-06-14 Altana Pharma Ag Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4
US20060166995A1 (en) * 2002-08-10 2006-07-27 Altana Pharma Ag Piperidine-n-oxide-derivatives
US7153824B2 (en) 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
WO2004098633A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprenant un inhibiteur de la pde-4 et un antagoniste du tnf-alpha
EP1661894A4 (fr) 2003-07-14 2007-02-28 Ube Industries Procede de production de 4-aminotetrahydropyranes et de sels de ces derniers presentant des acides, intermediaires pour ledit procede et procede de production de ces derniers
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
DE602005005638T2 (de) * 2004-02-04 2009-05-14 Nycomed Gmbh 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-on-derivate als pde4-inhibitoren
BRPI0607533A2 (pt) * 2005-04-21 2009-09-15 Nippon Shinyaku Co Ltd derivado de ftalazinona, composição farmacêutica, inibidor de fosfodiesterase do tipo 4,supressor da produção de tnf-alfa, agente preventivo ou terapêutico, preparado externo, bem como uso do referido derivado
EP2275095A3 (fr) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenese par modulation des recepteurs muscariniques
EP2258358A3 (fr) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenèse avec un inhibiteur de l'acetylcholinestérase
EP1940389A2 (fr) 2005-10-21 2008-07-09 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
EP2382975A3 (fr) 2006-05-09 2012-02-29 Braincells, Inc. Neurogénèse par modulation d'angiotensine
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
ES2427442T3 (es) * 2007-05-16 2013-10-30 Takeda Gmbh Derivados de pirazolona como inhibidores de PDE4
AR074318A1 (es) 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
US20140112945A1 (en) * 2011-06-17 2014-04-24 Takeda Gmbh Novel phthalazinone-pyrrolopyrimidinecarboxamide derivatives
WO2013106547A1 (fr) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
EP2968323A4 (fr) 2013-03-13 2016-12-14 Flatley Discovery Lab Composés de pyridazinone et procédés pour le traitement de fibrose kystique
US20150050626A1 (en) * 2013-03-15 2015-02-19 Dart Neuroscience, Llc Systems, Methods, and Software for Improving Cognitive and Motor Abilities

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845456A1 (de) * 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
NZ257955A (en) * 1992-12-02 1996-05-28 Pfizer Catechol diethers pharmaceutical compositions
EP0634404A1 (fr) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Dérivés de phtalazine et leur utilisation comme pesticides
DE69533057T2 (de) * 1994-08-09 2005-06-16 Eisai Co., Ltd. Kondensierte pyridazinverbindungen

Also Published As

Publication number Publication date
NO313137B1 (no) 2002-08-19
EA199900620A1 (ru) 2000-04-24
IL130659A (en) 2002-07-25
NO993301D0 (no) 1999-07-02
EP0971901A1 (fr) 2000-01-19
DE69811645T2 (de) 2003-12-04
US6103718A (en) 2000-08-15
JP2001508078A (ja) 2001-06-19
AU5862998A (en) 1998-08-07
EA002764B1 (ru) 2002-08-29
PL334561A1 (en) 2000-03-13
CN1249749A (zh) 2000-04-05
EE9900274A (et) 2000-02-15
NZ336573A (en) 2000-10-27
SI0971901T1 (en) 2003-10-31
SK95199A3 (en) 1999-12-10
PT971901E (pt) 2003-07-31
PL189418B1 (pl) 2005-08-31
BR9806752A (pt) 2000-03-14
SK283270B6 (sk) 2003-04-01
CN1127487C (zh) 2003-11-12
CY2446B1 (en) 2004-11-12
EP0971901B1 (fr) 2003-02-26
HUP0001541A2 (hu) 2001-05-28
HUP0001541A3 (en) 2001-11-28
CA2276455C (fr) 2006-10-31
ES2193508T3 (es) 2003-11-01
CZ293815B6 (cs) 2004-08-18
WO1998031674A1 (fr) 1998-07-23
TR199901653T2 (xx) 1999-10-21
IL130659A0 (en) 2000-06-01
CA2276455A1 (fr) 1998-07-23
NO993301L (no) 1999-09-10
HK1024692A1 (en) 2000-10-20
DE69811645D1 (de) 2003-04-03
DK0971901T3 (da) 2003-06-10
AU735934B2 (en) 2001-07-19
KR20000070150A (ko) 2000-11-25
CZ253399A3 (cs) 2000-05-17
ATE233247T1 (de) 2003-03-15

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090112