DK0971901T3 - Phthalazinoner - Google Patents

Phthalazinoner

Info

Publication number
DK0971901T3
DK0971901T3 DK98901959T DK98901959T DK0971901T3 DK 0971901 T3 DK0971901 T3 DK 0971901T3 DK 98901959 T DK98901959 T DK 98901959T DK 98901959 T DK98901959 T DK 98901959T DK 0971901 T3 DK0971901 T3 DK 0971901T3
Authority
DK
Denmark
Prior art keywords
pct
date jul
sec
pub
phthalazinones
Prior art date
Application number
DK98901959T
Other languages
Danish (da)
English (en)
Inventor
Der Mey Margaretha Van
Hendrik Timmerman
Armin Hatzelmann
Dietrich Haefner
Rolf Beume
Hans-Peter Kley
Geert Jan Sterk
Der Laan Ivonne Johanna Van
Hildegard Boss
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of DK0971901T3 publication Critical patent/DK0971901T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DK98901959T 1997-01-15 1998-01-12 Phthalazinoner DK0971901T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97100488 1997-01-15
PCT/EP1998/000124 WO1998031674A1 (fr) 1997-01-15 1998-01-12 Phthalazinones

Publications (1)

Publication Number Publication Date
DK0971901T3 true DK0971901T3 (da) 2003-06-10

Family

ID=8226366

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98901959T DK0971901T3 (da) 1997-01-15 1998-01-12 Phthalazinoner

Country Status (26)

Country Link
US (1) US6103718A (fr)
EP (1) EP0971901B1 (fr)
JP (1) JP2001508078A (fr)
KR (1) KR20000070150A (fr)
CN (1) CN1127487C (fr)
AT (1) ATE233247T1 (fr)
AU (1) AU735934B2 (fr)
BR (1) BR9806752A (fr)
CA (1) CA2276455C (fr)
CY (1) CY2446B1 (fr)
CZ (1) CZ293815B6 (fr)
DE (1) DE69811645T2 (fr)
DK (1) DK0971901T3 (fr)
EA (1) EA002764B1 (fr)
EE (1) EE03968B1 (fr)
ES (1) ES2193508T3 (fr)
HU (1) HUP0001541A3 (fr)
IL (1) IL130659A (fr)
NO (1) NO313137B1 (fr)
NZ (1) NZ336573A (fr)
PL (1) PL189418B1 (fr)
PT (1) PT971901E (fr)
SI (1) SI0971901T1 (fr)
SK (1) SK283270B6 (fr)
TR (1) TR199901653T2 (fr)
WO (1) WO1998031674A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1070056T3 (da) * 1998-03-14 2004-11-08 Altana Pharma Ag Phthalazinon-PDE III/IV-inhibitorer
CA2715683A1 (fr) 1999-08-21 2001-03-01 Nycomed Gmbh Combinaison synergiste
WO2001019818A1 (fr) * 1999-09-14 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Derives de phthalazinone utilises comme inhibiteurs de pd3/4
EP1228046B1 (fr) 1999-10-25 2007-09-26 Nycomed GmbH Derives de phthalazinone, utilises comme inhibiteurs de pde4
HUP0203487A2 (hu) 1999-10-25 2003-02-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahidrotiopirán-ftalazinon-származékok, mint PDE4-inhibitorok és ezeket tartalmazó gyógyszerkészítmények
CZ20023997A3 (cs) 2000-06-05 2003-05-14 Altana Pharma Ag Pyridazinonové deriváty
US7868015B2 (en) * 2000-08-10 2011-01-11 Cold Spring Harbor Laboratory Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
US20040224316A1 (en) * 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
HRP20030636B1 (en) 2001-02-15 2012-05-31 Nycomed Gmbh Phthalayinone-piperidino-derivatives as pde4 inhibitors
EE200300514A (et) * 2001-04-25 2004-02-16 Altana Pharma Ag Ftalasinoonid, nende kasutamine hingamisteede haigusnähte leevendavate ravimite valmistamiseks ningneid sisaldavad ravimid
JP4021329B2 (ja) * 2001-04-25 2007-12-12 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング ピペラジノ誘導体およびｐｄｅ４阻害剤としてのその使用
US7402580B2 (en) 2002-02-19 2008-07-22 Ono Pharmaceutical Co., Ltd. Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient
WO2004018449A1 (fr) * 2002-08-10 2004-03-04 Altana Pharma Ag Derives de piperidine utilises comme inhibiteurs de la phospodiesterase-4 (pde4)
CA2494650A1 (fr) * 2002-08-10 2004-03-04 Altana Pharma Ag Derives de pyridazinone utilises comme inhibiteurs de pde4
HRP20050197A2 (en) * 2002-08-10 2006-06-30 Altana Pharma Ag Piperidine-n-oxide-derivatives
JP2005538140A (ja) * 2002-08-10 2005-12-15 アルタナ　ファルマ　アクチエンゲゼルシャフト Ｐｄｅ４インヒビターとしてのピペリジン−ピリダゾン及びフタラゾン
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
WO2004098633A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprenant un inhibiteur de la pde-4 et un antagoniste du tnf-alpha
JP4591349B2 (ja) * 2003-07-14 2010-12-01 宇部興産株式会社 ４−アミノテトラヒドロピラン化合物及びその酸塩の製法、その合成中間体およびその製法
AU2005210042B2 (en) * 2004-02-04 2011-04-21 Takeda Gmbh 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
CN101163681A (zh) * 2005-04-21 2008-04-16 日本新药株式会社 2,3-二氮杂萘酮衍生物及其医药品
EP2258359A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (fr) 2005-10-31 2007-05-10 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134136A2 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenèse par modulation de l'angiotensine
WO2007134077A2 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenèse induite par le récepteur 5ht
EP2068872A1 (fr) 2006-09-08 2009-06-17 Braincells, Inc. Combinaisons contenant un dérivé de 4-acylaminopyridine
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
SI2148876T1 (sl) 2007-05-16 2012-01-31 Nycomed Gmbh Pirazolonski derivati kot PDE4 inhibitorji
AR074318A1 (es) * 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
EP2721030B1 (fr) * 2011-06-17 2015-12-16 Takeda GmbH Nouveaux dérivés de phthalazinone-pyrrolopyrimidinecarboxamides
EP2804603A1 (fr) 2012-01-10 2014-11-26 President and Fellows of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
CN105307655B (zh) 2013-03-13 2019-05-03 弗拉特利发现实验室有限责任公司 哒嗪酮化合物及其用于制备治疗囊肿状纤维化的药物的应用
US20150050626A1 (en) * 2013-03-15 2015-02-19 Dart Neuroscience, Llc Systems, Methods, and Software for Improving Cognitive and Motor Abilities

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845456A1 (de) * 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
BR9307570A (pt) * 1992-12-02 1999-05-25 Pfizer Diéteres de catecol como inibidores seletivos de pdeiv
EP0634404A1 (fr) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Dérivés de phtalazine et leur utilisation comme pesticides
CA2173493C (fr) * 1994-08-09 2008-03-25 Nobuhisa Watanabe Compose de pyridazine condense

Also Published As

Publication number Publication date
CA2276455C (fr) 2006-10-31
WO1998031674A1 (fr) 1998-07-23
NZ336573A (en) 2000-10-27
PT971901E (pt) 2003-07-31
EP0971901A1 (fr) 2000-01-19
JP2001508078A (ja) 2001-06-19
CN1127487C (zh) 2003-11-12
HUP0001541A2 (hu) 2001-05-28
ATE233247T1 (de) 2003-03-15
HUP0001541A3 (en) 2001-11-28
CN1249749A (zh) 2000-04-05
IL130659A (en) 2002-07-25
NO993301L (no) 1999-09-10
EP0971901B1 (fr) 2003-02-26
NO313137B1 (no) 2002-08-19
KR20000070150A (ko) 2000-11-25
AU735934B2 (en) 2001-07-19
AU5862998A (en) 1998-08-07
SK283270B6 (sk) 2003-04-01
EE03968B1 (et) 2003-02-17
CA2276455A1 (fr) 1998-07-23
CY2446B1 (en) 2004-11-12
SK95199A3 (en) 1999-12-10
US6103718A (en) 2000-08-15
EE9900274A (et) 2000-02-15
EA199900620A1 (ru) 2000-04-24
ES2193508T3 (es) 2003-11-01
PL334561A1 (en) 2000-03-13
CZ253399A3 (cs) 2000-05-17
IL130659A0 (en) 2000-06-01
EA002764B1 (ru) 2002-08-29
SI0971901T1 (en) 2003-10-31
PL189418B1 (pl) 2005-08-31
NO993301D0 (no) 1999-07-02
TR199901653T2 (xx) 1999-10-21
DE69811645T2 (de) 2003-12-04
CZ293815B6 (cs) 2004-08-18
HK1024692A1 (en) 2000-10-20
DE69811645D1 (de) 2003-04-03
BR9806752A (pt) 2000-03-14

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