EE04963B1 - 8,8a-dihdroindeno[1,2-d]tiasooli derivaadid, mille 2-asendis on sulfoonamido- v?i sulfonorhma sisaldav asendaja, nende valmistamismeetod ja kasutamine ravimitena - Google Patents

8,8a-dihdroindeno[1,2-d]tiasooli derivaadid, mille 2-asendis on sulfoonamido- v?i sulfonorhma sisaldav asendaja, nende valmistamismeetod ja kasutamine ravimitena

Info

Publication number
EE04963B1
EE04963B1 EEP200200467A EEP200200467A EE04963B1 EE 04963 B1 EE04963 B1 EE 04963B1 EE P200200467 A EEP200200467 A EE P200200467A EE P200200467 A EEP200200467 A EE P200200467A EE 04963 B1 EE04963 B1 EE 04963B1
Authority
EE
Estonia
Prior art keywords
preparation
substituent
sulphonorma
droindeno
sulphonamido
Prior art date
Application number
EEP200200467A
Other languages
English (en)
Estonian (et)
Inventor
Jaehne Gerhard
Lang Hans-Jochen
Gossel Matthias
Bickel Martin
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of EE200200467A publication Critical patent/EE200200467A/xx
Publication of EE04963B1 publication Critical patent/EE04963B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Indole Compounds (AREA)
EEP200200467A 2000-02-26 2001-02-13 8,8a-dihdroindeno[1,2-d]tiasooli derivaadid, mille 2-asendis on sulfoonamido- v?i sulfonorhma sisaldav asendaja, nende valmistamismeetod ja kasutamine ravimitena EE04963B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10009311 2000-02-26
PCT/EP2001/001553 WO2001062747A1 (de) 2000-02-26 2001-02-13 8,8a-dihydro-indeno[1,2-d]thiazol-derivate, die in 2-stellung einen substituenten mit einer sulfonamidstruktur oder sulfonstruktur tragen; verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
EE200200467A EE200200467A (et) 2003-12-15
EE04963B1 true EE04963B1 (et) 2008-02-15

Family

ID=7632679

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200467A EE04963B1 (et) 2000-02-26 2001-02-13 8,8a-dihdroindeno[1,2-d]tiasooli derivaadid, mille 2-asendis on sulfoonamido- v?i sulfonorhma sisaldav asendaja, nende valmistamismeetod ja kasutamine ravimitena

Country Status (29)

Country Link
US (2) US6352987B2 (pl)
EP (1) EP1261593B1 (pl)
JP (1) JP4950405B2 (pl)
KR (1) KR100763214B1 (pl)
CN (1) CN1173959C (pl)
AT (1) ATE248155T1 (pl)
AU (2) AU2001244136B2 (pl)
BR (1) BR0108631A (pl)
CA (1) CA2400704C (pl)
CZ (1) CZ301253B6 (pl)
DE (1) DE50100558D1 (pl)
DK (1) DK1261593T3 (pl)
EE (1) EE04963B1 (pl)
ES (1) ES2206412T3 (pl)
HK (1) HK1052515B (pl)
HR (1) HRP20020687B1 (pl)
HU (1) HU229137B1 (pl)
IL (1) IL151460A (pl)
MX (1) MXPA02007025A (pl)
NO (1) NO323400B1 (pl)
NZ (1) NZ520981A (pl)
PL (1) PL202763B1 (pl)
PT (1) PT1261593E (pl)
RS (1) RS49933B (pl)
RU (1) RU2263113C2 (pl)
SI (1) SI1261593T1 (pl)
SK (1) SK285571B6 (pl)
WO (1) WO2001062747A1 (pl)
ZA (1) ZA200206580B (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7261482B2 (en) * 2004-01-21 2007-08-28 Silverbrook Research Pty Ltd Photofinishing system with slitting mechanism
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP2013520502A (ja) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2826649C (en) 2011-02-25 2016-07-26 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
US20140045746A1 (en) 2012-08-02 2014-02-13 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
JP2016516004A (ja) 2013-02-22 2016-06-02 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗糖尿病二環式化合物
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2018106518A1 (en) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
DE2640358A1 (de) 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908533A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
CZ2001170A3 (cs) * 1999-07-03 2001-06-13 Aventis Pharma Gmbh Polycyklické thiazolidin-2-ylidenaminy, způsob jejich přípravy a léčivo, které je obsahuje
CZ20011111A3 (cs) * 1999-09-16 2001-07-11 Aventis Pharma Deutschland Gmbh Deriváty indeno-, nafto- a benzocyklohepťadihydrothiazolu, jejich příprava a použití jako anorektická léčiva

Also Published As

Publication number Publication date
HRP20020687A2 (en) 2004-12-31
ES2206412T3 (es) 2004-05-16
RU2263113C2 (ru) 2005-10-27
DE50100558D1 (de) 2003-10-02
MXPA02007025A (es) 2003-03-27
CA2400704A1 (en) 2001-08-30
BR0108631A (pt) 2002-12-03
PL202763B1 (pl) 2009-07-31
NO20023977D0 (no) 2002-08-21
CZ20022861A3 (cs) 2002-11-13
HK1052515A1 (en) 2003-09-19
RS49933B (sr) 2008-09-29
US6352987B2 (en) 2002-03-05
WO2001062747A1 (de) 2001-08-30
SK285571B6 (sk) 2007-04-05
AU2001244136B2 (en) 2005-04-14
PT1261593E (pt) 2004-01-30
HK1052515B (zh) 2005-04-22
AU4413601A (en) 2001-09-03
SK12252002A3 (sk) 2003-03-04
ATE248155T1 (de) 2003-09-15
SI1261593T1 (en) 2004-02-29
US20010039278A1 (en) 2001-11-08
CA2400704C (en) 2008-11-04
CN1173959C (zh) 2004-11-03
HUP0300304A3 (en) 2004-10-28
JP2003531117A (ja) 2003-10-21
KR20020079897A (ko) 2002-10-19
HU229137B1 (en) 2013-08-28
NO323400B1 (no) 2007-04-23
CZ301253B6 (cs) 2009-12-23
NZ520981A (en) 2004-08-27
CN1406234A (zh) 2003-03-26
ZA200206580B (en) 2003-05-15
YU56402A (sh) 2005-11-28
US6444669B1 (en) 2002-09-03
US20020103231A1 (en) 2002-08-01
RU2002125673A (ru) 2004-01-10
JP4950405B2 (ja) 2012-06-13
EP1261593B1 (de) 2003-08-27
KR100763214B1 (ko) 2007-10-08
HUP0300304A2 (hu) 2003-06-28
EE200200467A (et) 2003-12-15
NO20023977L (no) 2002-10-18
DK1261593T3 (da) 2003-12-01
EP1261593A1 (de) 2002-12-04
HRP20020687B1 (hr) 2011-01-31
IL151460A (en) 2008-08-07
PL357195A1 (pl) 2004-07-26

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20150213