PL357195A1 - Pochodne 8, 8a-dihydro-indeno [1,2-d] tiazolu, podstawione w pozycji 2 podstawnikiem sulfonamidowymalbo sulfonowym, sposób ich wytwarzania oraz ich zastosowanie jako leku - Google Patents

Pochodne 8, 8a-dihydro-indeno [1,2-d] tiazolu, podstawione w pozycji 2 podstawnikiem sulfonamidowymalbo sulfonowym, sposób ich wytwarzania oraz ich zastosowanie jako leku

Info

Publication number
PL357195A1
PL357195A1 PL01357195A PL35719501A PL357195A1 PL 357195 A1 PL357195 A1 PL 357195A1 PL 01357195 A PL01357195 A PL 01357195A PL 35719501 A PL35719501 A PL 35719501A PL 357195 A1 PL357195 A1 PL 357195A1
Authority
PL
Poland
Prior art keywords
substituent
sulphono
sulphonamido
indeno
dihydro
Prior art date
Application number
PL01357195A
Other languages
English (en)
Other versions
PL202763B1 (pl
Inventor
Gerhard Jaehne
Hans-Jochen Lang
Matthias Gossel
Martin Bickel
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of PL357195A1 publication Critical patent/PL357195A1/pl
Publication of PL202763B1 publication Critical patent/PL202763B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Indole Compounds (AREA)
PL357195A 2000-02-26 2001-02-13 Pochodne 8, 8a-dihydro-indeno [1,2-d] tiazolu oraz pochodne 8, 8a-dihydro-indeno [1,2-d] tiazolu do zastosowania jako lek PL202763B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10009311 2000-02-26
PCT/EP2001/001553 WO2001062747A1 (de) 2000-02-26 2001-02-13 8,8a-dihydro-indeno[1,2-d]thiazol-derivate, die in 2-stellung einen substituenten mit einer sulfonamidstruktur oder sulfonstruktur tragen; verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
PL357195A1 true PL357195A1 (pl) 2004-07-26
PL202763B1 PL202763B1 (pl) 2009-07-31

Family

ID=7632679

Family Applications (1)

Application Number Title Priority Date Filing Date
PL357195A PL202763B1 (pl) 2000-02-26 2001-02-13 Pochodne 8, 8a-dihydro-indeno [1,2-d] tiazolu oraz pochodne 8, 8a-dihydro-indeno [1,2-d] tiazolu do zastosowania jako lek

Country Status (29)

Country Link
US (2) US6352987B2 (pl)
EP (1) EP1261593B1 (pl)
JP (1) JP4950405B2 (pl)
KR (1) KR100763214B1 (pl)
CN (1) CN1173959C (pl)
AT (1) ATE248155T1 (pl)
AU (2) AU2001244136B2 (pl)
BR (1) BR0108631A (pl)
CA (1) CA2400704C (pl)
CZ (1) CZ301253B6 (pl)
DE (1) DE50100558D1 (pl)
DK (1) DK1261593T3 (pl)
EE (1) EE04963B1 (pl)
ES (1) ES2206412T3 (pl)
HK (1) HK1052515B (pl)
HR (1) HRP20020687B1 (pl)
HU (1) HU229137B1 (pl)
IL (1) IL151460A (pl)
MX (1) MXPA02007025A (pl)
NO (1) NO323400B1 (pl)
NZ (1) NZ520981A (pl)
PL (1) PL202763B1 (pl)
PT (1) PT1261593E (pl)
RS (1) RS49933B (pl)
RU (1) RU2263113C2 (pl)
SI (1) SI1261593T1 (pl)
SK (1) SK285571B6 (pl)
WO (1) WO2001062747A1 (pl)
ZA (1) ZA200206580B (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7261482B2 (en) * 2004-01-21 2007-08-28 Silverbrook Research Pty Ltd Photofinishing system with slitting mechanism
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP2013520502A (ja) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2826649C (en) 2011-02-25 2016-07-26 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
US20140045746A1 (en) 2012-08-02 2014-02-13 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
JP2016516004A (ja) 2013-02-22 2016-06-02 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗糖尿病二環式化合物
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2018106518A1 (en) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
DE2640358A1 (de) 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908533A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
CZ2001170A3 (cs) * 1999-07-03 2001-06-13 Aventis Pharma Gmbh Polycyklické thiazolidin-2-ylidenaminy, způsob jejich přípravy a léčivo, které je obsahuje
CZ20011111A3 (cs) * 1999-09-16 2001-07-11 Aventis Pharma Deutschland Gmbh Deriváty indeno-, nafto- a benzocyklohepťadihydrothiazolu, jejich příprava a použití jako anorektická léčiva

Also Published As

Publication number Publication date
HRP20020687A2 (en) 2004-12-31
EE04963B1 (et) 2008-02-15
ES2206412T3 (es) 2004-05-16
RU2263113C2 (ru) 2005-10-27
DE50100558D1 (de) 2003-10-02
MXPA02007025A (es) 2003-03-27
CA2400704A1 (en) 2001-08-30
BR0108631A (pt) 2002-12-03
PL202763B1 (pl) 2009-07-31
NO20023977D0 (no) 2002-08-21
CZ20022861A3 (cs) 2002-11-13
HK1052515A1 (en) 2003-09-19
RS49933B (sr) 2008-09-29
US6352987B2 (en) 2002-03-05
WO2001062747A1 (de) 2001-08-30
SK285571B6 (sk) 2007-04-05
AU2001244136B2 (en) 2005-04-14
PT1261593E (pt) 2004-01-30
HK1052515B (zh) 2005-04-22
AU4413601A (en) 2001-09-03
SK12252002A3 (sk) 2003-03-04
ATE248155T1 (de) 2003-09-15
SI1261593T1 (en) 2004-02-29
US20010039278A1 (en) 2001-11-08
CA2400704C (en) 2008-11-04
CN1173959C (zh) 2004-11-03
HUP0300304A3 (en) 2004-10-28
JP2003531117A (ja) 2003-10-21
KR20020079897A (ko) 2002-10-19
HU229137B1 (en) 2013-08-28
NO323400B1 (no) 2007-04-23
CZ301253B6 (cs) 2009-12-23
NZ520981A (en) 2004-08-27
CN1406234A (zh) 2003-03-26
ZA200206580B (en) 2003-05-15
YU56402A (sh) 2005-11-28
US6444669B1 (en) 2002-09-03
US20020103231A1 (en) 2002-08-01
RU2002125673A (ru) 2004-01-10
JP4950405B2 (ja) 2012-06-13
EP1261593B1 (de) 2003-08-27
KR100763214B1 (ko) 2007-10-08
HUP0300304A2 (hu) 2003-06-28
EE200200467A (et) 2003-12-15
NO20023977L (no) 2002-10-18
DK1261593T3 (da) 2003-12-01
EP1261593A1 (de) 2002-12-04
HRP20020687B1 (hr) 2011-01-31
IL151460A (en) 2008-08-07

Similar Documents

Publication Publication Date Title
SI1261593T1 (en) 8,8a-dihydro-indeno 1,2-d)thiazole derivatives with a sulphonamido or sulphono substituent in the 2 position, a method for production thereof and use thereof as a medicament
NO20023978L (no) 8,8A-dihydro-indeno(1,2-D)tiazolderivater, substituert i posisjon 8A, en fremgangsmåte for deres fremstilling og deresanvendelse som legemidler, for eksempel anoreksimidler
JO2353B1 (en) New derivatives of mixed-ring fluoroglycosides and drugs containing these compounds and their use
SG151271A1 (en) Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof
NO20035210D0 (no) 2-anilino-pyrimidinderivater som cyklinavhengige kinaseinhibitorer
IL145647A0 (en) 1,4-benzothiazepine -1,1-dioxide derivatives substituted by sugar radicals, methods for the production thereof, medicaments containing these compounds and the use thereof
MXPA02012034A (es) Derivados de tiofeno utiles como agentes anticancerosos.
ES2128137T3 (es) Derivados de propiofenona y procedimientos para su preparacion.
BR0310057A (pt) melhoria do desenvolvimento de catarata e outras doenças oftálmicas
PL1682528T3 (pl) Pochodne benzo[b][1,4]dioksepiny
AU2001244136A1 (en) 8,8a-dihydro-indeno[1,2-d]thiazole derivatives with a sulphonamido or sulphono substituent in the 2 position, method for production thereof and use thereof as medicament
NO20071616L (no) Benzoksazin- og kinoksalinderivater og anvendelser
WO2000051579A3 (de) Verwendung von polycyclischen thiazol-systemen zur herstellung von medikamenten zur prophylaxe oder behandlung von obesitas
PT1183247E (pt) Sistemas tiazole policiclicos e sua utilizacao como anorecticos
MXPA04001855A (es) Derivados de sistemas de indan-1-ol c2-sustituidos, metodos para la produccion de los mismos y su uso como medicamentos.
TW200505892A (en) Substituted 3-(benzoylureido)thiophene derivatives, processes for preparing them and their use
IL151326A0 (en) Substituted 8, 8a-dihydro-3ah-indeno[1,2-d] thiazoles, a method for their production and their use as medicaments
MXPA04001856A (es) Indan-1-oles c2-sustituidos y sus derivados, metodo para su produccion y su uso como medicamentos.
ATE252598T1 (de) Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen
MXPA03003466A (es) Derivados de piranosido.
ECSP034778A (es) Derivados de 2-amino-propanol