ES2038236T3 - Proceso perfeccionado de microencapsulacion de separacion de fases. - Google Patents

Proceso perfeccionado de microencapsulacion de separacion de fases.

Info

Publication number
ES2038236T3
ES2038236T3 ES198888106617T ES88106617T ES2038236T3 ES 2038236 T3 ES2038236 T3 ES 2038236T3 ES 198888106617 T ES198888106617 T ES 198888106617T ES 88106617 T ES88106617 T ES 88106617T ES 2038236 T3 ES2038236 T3 ES 2038236T3
Authority
ES
Spain
Prior art keywords
phase separation
hardening agent
separation microencapsulation
compositions
perfected process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888106617T
Other languages
English (en)
Inventor
James Ronald Lawter
Michael Gerard Lanzilotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2038236T3 publication Critical patent/ES2038236T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Polymerisation Methods In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Glass Compositions (AREA)
  • Packages (AREA)
  • Materials For Medical Uses (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

SE DESCUBRE UN PROCESO PARA LA PREPARACION DE COMPUESTOS, COMPRENDIENDO MICROCAPSULAS EN FASE DE SEPARACION EN MICROENCAPSULACION, EN EL QUE EL AGENTE ENDURECEDOR EMPLEADO ES UN FLUIDO DE SILICONA VOLATIL Y CON LOS COMPUESTOS PREPARADOS DE ESE MODO. EL USO DEL FLUIDO DE SILICONA VOLATIL COMO AGENTE ENDURECEDOR PERMITE LA PRODUCCION DE MICROCAPSULAS SUSTANCIALMENTE LIBRES DE CUALQUIER AGENTE ENDURECEDOR ALCANO, LA ELIMINACION POTENCIAL DE PROBLEMAS DE COMBUSTIBILIDAD EN LOS PROCESOS Y LOS PROBLEMAS DE TOXICIDAD EN LOS COMPUESTOS.
ES198888106617T 1987-05-26 1988-05-18 Proceso perfeccionado de microencapsulacion de separacion de fases. Expired - Lifetime ES2038236T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/054,372 US5000886A (en) 1987-05-26 1987-05-26 Silicone-hardened pharmaceutical microcapsules and process of making the same

Publications (1)

Publication Number Publication Date
ES2038236T3 true ES2038236T3 (es) 1993-07-16

Family

ID=21990585

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888106617T Expired - Lifetime ES2038236T3 (es) 1987-05-26 1988-05-18 Proceso perfeccionado de microencapsulacion de separacion de fases.

Country Status (19)

Country Link
US (1) US5000886A (es)
EP (1) EP0292710B1 (es)
JP (1) JP2712101B2 (es)
KR (1) KR970001209B1 (es)
AT (1) ATE70992T1 (es)
AU (1) AU618000B2 (es)
BR (1) BR1100810A (es)
CA (1) CA1330533C (es)
DE (1) DE3867313D1 (es)
DK (1) DK169119B1 (es)
ES (1) ES2038236T3 (es)
GR (1) GR3004186T3 (es)
HK (1) HK116493A (es)
IE (1) IE61338B1 (es)
IL (1) IL86274A (es)
NO (1) NO177984C (es)
NZ (1) NZ224722A (es)
PH (1) PH27019A (es)
ZA (1) ZA883737B (es)

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US5693343A (en) 1984-03-16 1997-12-02 The United States Of America As Represented By The Secretary Of The Army Microparticle carriers of maximal uptake capacity by both M cells and non-M cells
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US20030161889A1 (en) * 1984-03-16 2003-08-28 Reid Robert H. Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US6410056B1 (en) 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
USRE40786E1 (en) 1984-03-16 2009-06-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
US6024983A (en) * 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US5985354A (en) 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
US5143661A (en) * 1987-05-26 1992-09-01 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules
ES2059683T3 (es) * 1988-12-22 1994-11-16 American Cyanamid Co Composiciones farmaceuticas microencapsuladas con separacion de fases, perfeccionadas, utiles para aliviar enfermedades dentales.
EP0374531B1 (en) * 1988-12-22 1994-05-04 American Cyanamid Company Method for the treatment of periodontal disease by sustained delivery of a therapeutic agent to the periodontal pocket, composition of matter therefor and apparatus for the administration thereof
AU8303691A (en) 1991-04-24 1992-12-21 United States Of America, As Represented By The Secretary Of The Army, The Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
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DE4223169C1 (de) 1992-07-10 1993-11-25 Ferring Arzneimittel Gmbh Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
DE4239244A1 (de) * 1992-11-21 1994-05-26 Basf Ag Retard-Form für pharmazeutische Wirkstoffe
US6939546B2 (en) 1993-05-21 2005-09-06 The United States Of America As Represented By The Secretary Of The Army Model for testing immunogenicity of peptides
US5512278A (en) * 1994-01-11 1996-04-30 Phylomed Corporation Ointment base useful for pharmaceutical preparations
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US7033608B1 (en) 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
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Also Published As

Publication number Publication date
ATE70992T1 (de) 1992-01-15
DK169119B1 (da) 1994-08-22
BR1100810A (pt) 1999-10-13
PH27019A (en) 1993-02-01
US5000886A (en) 1991-03-19
IL86274A0 (en) 1988-11-15
AU618000B2 (en) 1991-12-12
KR880013553A (ko) 1988-12-21
KR970001209B1 (ko) 1997-02-04
JPS63307813A (ja) 1988-12-15
NO882277L (no) 1988-11-28
ZA883737B (en) 1989-02-22
GR3004186T3 (es) 1993-03-31
IE881565L (en) 1988-11-26
AU1659288A (en) 1988-12-01
CA1330533C (en) 1994-07-05
DK285088D0 (da) 1988-05-25
HK116493A (en) 1993-11-05
IE61338B1 (en) 1994-11-02
JP2712101B2 (ja) 1998-02-10
DE3867313D1 (de) 1992-02-13
EP0292710B1 (en) 1992-01-02
EP0292710A3 (en) 1989-03-22
DK285088A (da) 1988-11-27
NO177984B (no) 1995-09-25
NO177984C (no) 1996-01-03
EP0292710A2 (en) 1988-11-30
NZ224722A (en) 1990-04-26
NO882277D0 (no) 1988-05-25
IL86274A (en) 1992-03-29

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