ES2112996T3 - Clonacion y secuenciacion de alergenos de dermatophagoides (acaros del polvo de la casa). - Google Patents

Clonacion y secuenciacion de alergenos de dermatophagoides (acaros del polvo de la casa).

Info

Publication number
ES2112996T3
ES2112996T3 ES93921462T ES93921462T ES2112996T3 ES 2112996 T3 ES2112996 T3 ES 2112996T3 ES 93921462 T ES93921462 T ES 93921462T ES 93921462 T ES93921462 T ES 93921462T ES 2112996 T3 ES2112996 T3 ES 2112996T3
Authority
ES
Spain
Prior art keywords
allergens
der
house dust
farinae
dna encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93921462T
Other languages
English (en)
Inventor
Wayne R Thomas
Kaw-Yan Chua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telethon Kids Institute TVW
Original Assignee
Telethon Kids Institute TVW
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telethon Kids Institute TVW filed Critical Telethon Kids Institute TVW
Application granted granted Critical
Publication of ES2112996T3 publication Critical patent/ES2112996T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EL PRESENTE INVENTO DESCRIBE ALERGENOS QUE CODIFICAN DNA AISLADOS DE DERMATOPHAGOIDES (ACAROS DE POLVO DE CASA) EN PARTICULAR DE LA ESPECIE DERMATOPHAGOIDES FARINAE Y DERMATOPHAGOIDES PTERONYSSINUS, QUE SON ALERGENOS DE PROTEINAS O PEPTIDOS QUE INCLUYEN AL MENOS UN EPITOPE DEL ALERGENO DE PROTEINA. EN PARTICULAR, EL INVENTO PROPORCIONA DNA QUE CODIFICA LOS PRINCIPALES ALERGENOS DE D. FARINAE, DER F I Y DER F II Y DNA CODIFICADOR DE LOS PRINCIPALES ALERGENOS DE D. PTERONYSSINUS, DER P I Y DER P II. EL PRESENTE INVENTO ADEMAS SE RELACIONA CON PROTEINAS Y PEPTIDOS CODIFICADOS POR LOS DNA AISLADOS DE D. FARINAE Y D. PTERONYSSINUS, INCLUYENDO PROTEINAS QUE CONTIENEN POLIMORFISMOS DE SECUENCIA. ADEMAS, SE DESCRIBEN PROTEINAS O PEPTIDOS CODIFICADOS POR EL DNA AISLADO, SU USO COMO REACTIVOS DE DIAGNOSTICO Y TERAPIA Y METODOS PARA DIAGNOSTICO Y TRATAMIENTO DE SENSIBILIDAD A LOS ALERGENOS DEL ACARO DE POLVO DE CASA.
ES93921462T 1992-09-10 1993-09-10 Clonacion y secuenciacion de alergenos de dermatophagoides (acaros del polvo de la casa). Expired - Lifetime ES2112996T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/945,288 US5433948A (en) 1990-02-13 1992-09-10 Cloning and sequencing of allergens of dermatophagoides (house dust mite)

Publications (1)

Publication Number Publication Date
ES2112996T3 true ES2112996T3 (es) 1998-04-16

Family

ID=25482920

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93921462T Expired - Lifetime ES2112996T3 (es) 1992-09-10 1993-09-10 Clonacion y secuenciacion de alergenos de dermatophagoides (acaros del polvo de la casa).

Country Status (12)

Country Link
US (4) US5433948A (es)
EP (1) EP0662129B1 (es)
JP (1) JP3487852B2 (es)
AT (1) ATE163674T1 (es)
AU (1) AU680202B2 (es)
CA (1) CA2144055C (es)
DE (1) DE69317292T2 (es)
DK (1) DK0662129T3 (es)
ES (1) ES2112996T3 (es)
GR (1) GR3026711T3 (es)
NZ (1) NZ256255A (es)
WO (1) WO1994005790A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5433948A (en) * 1990-02-13 1995-07-18 Thomas; Wayne R. Cloning and sequencing of allergens of dermatophagoides (house dust mite)
JP2596466B2 (ja) * 1990-03-03 1997-04-02 アサヒビール株式会社 ダニの主要アレルゲンの還伝情報を有するｄｎａおよび該アレルゲンの製造方法
US7288256B1 (en) * 1991-10-16 2007-10-30 Merck Patent Gmbh T cell epitopes of the major allergens from dermatophagoides (house dust mite)
US6254869B1 (en) * 1996-03-27 2001-07-03 The Regents Of The University Of California Cryptopain vaccines, antibodies, proteins, peptides, DNA and RNA for prophylaxis, treatment and diagnosis and for detection of cryptosporidium species
JP3520089B2 (ja) * 1993-12-22 2004-04-19 アサヒビール株式会社 新規な組換えＤｅｒｌアレルゲン物質、そのプロ体及びこれらの産生方法
EP0815451B1 (de) * 1995-03-24 2001-10-24 VORWERK & CO. INTERHOLDING GmbH Verfahren zur untersuchung von hausstaub
ES2229263T3 (es) * 1995-03-28 2005-04-16 Asahi Breweries, Ltd. Sustancia alergena para acaridos obtenida mediante ingenieria genetica y proceso para la produccion de la misma.
DE69733343D1 (de) 1996-03-21 2005-06-30 Circassia Ltd Kryptische peptide und verfahren zu ihrer identifizierung
EP1027435A2 (en) * 1997-10-02 2000-08-16 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. Nucleic acid molecule encoding a (poly)peptide co-segregating in mutated form with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (apeced)
GB9724531D0 (en) * 1997-11-19 1998-01-21 Smithkline Biolog Novel compounds
US7128921B1 (en) * 1998-04-17 2006-10-31 Heska Corporation Dermatophagoides proteins and fragments thereof
US6455686B1 (en) * 1998-04-17 2002-09-24 Heska Corporation Dermatophagoides nucleic acid molecules, proteins and uses thereof
WO2001029078A2 (en) * 1999-10-15 2001-04-26 Heska Corporation Method for production and use of mite group 1 proteins
AU2001252246A1 (en) * 2000-04-05 2001-10-23 Syngenta Participations Ag Therapeutically active proteins in plants
GB0014288D0 (en) * 2000-06-10 2000-08-02 Smithkline Beecham Biolog Vaccine
CA2429372A1 (en) * 2001-01-03 2002-08-29 Heska Corporation Detection of allergen-specific ige
FR2822709B1 (fr) * 2001-03-30 2007-01-19 Antialis Composition pharmaceutique anti-allergique comprenant au moins un allergene et au moins un compose antihistaminique
US7927600B2 (en) * 2001-03-30 2011-04-19 Emile Loria Anti-allergic pharmaceutical composition containing at least one allergen and at least one antihistamine compound
GB0120150D0 (en) * 2001-08-17 2001-10-10 Glaxosmithkline Biolog Sa Novel compounds
AU2003246586A1 (en) * 2002-07-10 2004-02-02 Merck Patent Gmbh Variants of the house dust mite allergen der f2
WO2004019978A1 (en) * 2002-08-29 2004-03-11 National University Of Singapore Recombinant nucleic acid useful for inducing protective immune response against allergens
EP1756275A1 (en) * 2004-04-23 2007-02-28 Novozymes A/S Method for obtaining mature protease by enzymatic digestion
AT501101B1 (de) * 2004-12-02 2008-01-15 Biomay Ag Protein-allergen-derivat
US7334521B2 (en) * 2005-02-25 2008-02-26 Cosco Industries, Inc. Hand held two-ended ink stamper
EP2037916A4 (en) * 2006-04-07 2011-09-14 Mike Nicolaou PURE TRITOQUALINE ISOMERS
ES2709176T3 (es) 2006-08-11 2019-04-15 Life Sciences Res Partners Vzw Péptidos inmunogénicos y su uso en trastornos inmunitarios
EP2170317A4 (en) * 2007-02-12 2011-03-23 Mike Nicolaou TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD), GASTRO-OESOPHAGEAL REFLUX DISEASE (GERD), FOOD ALLERGIES, AND OTHER DISEASES AND GASTROINTESTIN DISORDERS AFFECTED BY APPROPRIATE MANAGEMENT OF HISTAMINE USING A COMBINATION OF INHIBITORS HISTIDINE DECARBOXYLASE, MEDICAMEN
EA023303B1 (ru) * 2007-08-15 2016-05-31 Сиркейшиа Лимитед Пептидная композиция для формирования толерантности к клещам домашней пыли и ее применение
EP2719396B1 (en) 2008-02-14 2017-06-21 Life Sciences Research Partners VZW Immunotherapy targeting intracellular pathogens
EP2247306B1 (en) 2008-02-14 2018-04-18 Life Sciences Research Partners VZW Immunogenic control of tumours and tumour cells
EP2436691B1 (en) * 2008-03-25 2017-08-02 Bial Industrial Farmaceutica, S.A. Hypoallergenic hybrid proteins of major group 1 and 2 mite allergens for use in the treatment of allergies
ES2869155T3 (es) 2010-11-25 2021-10-25 Imnate Sarl Péptidos inmunogénicos para su uso en la prevención y/o tratamiento de enfermedades infecciosas, enfermedades autoinmunitarias, respuestas inmunitarias a alofactores, enfermedades alérgicas, tumores, rechazo de injerto y respuestas inmunitarias contra vectores virales usados para terapia génica o vacunación génica
GB201201511D0 (en) * 2012-01-30 2012-03-14 Univ Leuven Kath Modified epitopes for boosting CD4+ T-cell responses
GB201309469D0 (en) 2013-05-28 2013-07-10 Imcyse Sa Detection of CD4+ T lymphocytes
GB201418433D0 (en) 2014-10-17 2014-12-03 Imcyse Sa Novel immunogenic peptides
US10729791B2 (en) 2015-05-18 2020-08-04 Imcyse Sa Animal models for evaluating pharmaceutical compounds
EP3352782B1 (en) 2015-09-25 2021-03-31 ImCyse SA Improved methods and compounds for eliminating immune responses to therapeutic agents
KR20220132023A (ko) 2016-04-19 2022-09-29 임시스 에스에이 신규 면역원성 CD1d 결합 펩티드

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026545A (en) * 1984-09-17 1991-06-25 Baxter International, Inc. Treatment of allergy and composition therefor
WO1988010297A1 (en) * 1987-06-17 1988-12-29 Princess Margaret Children's Medical Research Foun Cloning of mite allergens
JP2787162B2 (ja) * 1989-08-24 1998-08-13 フマキラー株式会社 精製ダニアレルゲン
US5433948A (en) * 1990-02-13 1995-07-18 Thomas; Wayne R. Cloning and sequencing of allergens of dermatophagoides (house dust mite)
JP2596466B2 (ja) * 1990-03-03 1997-04-02 アサヒビール株式会社 ダニの主要アレルゲンの還伝情報を有するｄｎａおよび該アレルゲンの製造方法
JP3139777B2 (ja) * 1990-08-27 2001-03-05 フマキラー株式会社 組換えダニアレルゲン
EP0548200B1 (en) * 1990-09-11 1999-04-14 Institute For Child Health Research Cloning and sequencing of allergens of dermatophagoides (house dust mite)
JPH07502890A (ja) * 1991-10-16 1995-03-30 イミユロジク・フアーマシユーチカル・コーポレーシヨン ダーマトファゴイデス（Ｄｅｒｍａｔｏｐｈａｇｏｉｄｅｓ）（家ほこりダニ）からの主要なアレルゲンのＴ細胞エピトープ

Also Published As

Publication number Publication date
EP0662129B1 (en) 1998-03-04
GR3026711T3 (en) 1998-07-31
US5770202A (en) 1998-06-23
EP0662129A1 (en) 1995-07-12
US5773002A (en) 1998-06-30
JPH08504179A (ja) 1996-05-07
DE69317292D1 (de) 1998-04-09
WO1994005790A1 (en) 1994-03-17
DE69317292T2 (de) 1998-06-18
AU4854893A (en) 1994-03-29
US5552142A (en) 1996-09-03
AU680202B2 (en) 1997-07-24
CA2144055A1 (en) 1994-03-17
NZ256255A (en) 1999-03-29
DK0662129T3 (da) 1998-03-30
JP3487852B2 (ja) 2004-01-19
US5433948A (en) 1995-07-18
CA2144055C (en) 1999-11-02
ATE163674T1 (de) 1998-03-15

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