ES2120605T3 - Procedimiento asimetrico para preparar florfenicol, tianfenicol, cloranfenicol e intermedios de oxazolina. - Google Patents

Procedimiento asimetrico para preparar florfenicol, tianfenicol, cloranfenicol e intermedios de oxazolina.

Info

Publication number
ES2120605T3
ES2120605T3 ES94903599T ES94903599T ES2120605T3 ES 2120605 T3 ES2120605 T3 ES 2120605T3 ES 94903599 T ES94903599 T ES 94903599T ES 94903599 T ES94903599 T ES 94903599T ES 2120605 T3 ES2120605 T3 ES 2120605T3
Authority
ES
Spain
Prior art keywords
florphenicol
thyanphenicol
chloranphenicol
preparing
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94903599T
Other languages
English (en)
Inventor
Guang-Zhong Wu
Wanda I Tormos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2120605T3 publication Critical patent/ES2120605T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA LA SINTESIS DE ASIMETRICO DE FLORFENICOL, TIANFENICOL O CLORANFENICO. EN UNA REALIZACION ALTERNATIVA, LA PRESENTE INVENCION COMPRENDE UN PROCESO PARA ISOMERIZAR EL S,S-ISOMERO DEL FLORFENICOL AL R,RISOMERO (I) TRATANDO SECUENCIALMENTE CON : (I) UN CLORURO ALKILSULFONILO INFERIOR Y UNA BASE DE AMINA TERCIARIA, (II) ACIDO SULFURICO Y AGUA, (III) UN HIDROXIDO DE METAL ALCALINO. LA PRESENTE INVENCION SE REFIERE ADEMAS A UN PROCESO PARA ABRIR REGIOSELECTIVAMENTE UN EPOXIDO PARA FORMAR UN TREOOXAZOLINA.
ES94903599T 1992-12-18 1993-12-15 Procedimiento asimetrico para preparar florfenicol, tianfenicol, cloranfenicol e intermedios de oxazolina. Expired - Lifetime ES2120605T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/993,932 US5352832A (en) 1992-12-18 1992-12-18 Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates

Publications (1)

Publication Number Publication Date
ES2120605T3 true ES2120605T3 (es) 1998-11-01

Family

ID=25540089

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94903599T Expired - Lifetime ES2120605T3 (es) 1992-12-18 1993-12-15 Procedimiento asimetrico para preparar florfenicol, tianfenicol, cloranfenicol e intermedios de oxazolina.

Country Status (20)

Country Link
US (1) US5352832A (es)
EP (1) EP0674618B1 (es)
JP (1) JP3428016B2 (es)
KR (1) KR100284216B1 (es)
AT (1) ATE170835T1 (es)
AU (1) AU676003B2 (es)
CA (1) CA2152089C (es)
CZ (1) CZ287461B6 (es)
DE (1) DE69320986T2 (es)
DK (1) DK0674618T3 (es)
ES (1) ES2120605T3 (es)
FI (1) FI109295B (es)
HU (1) HU225110B1 (es)
NO (1) NO303575B1 (es)
NZ (1) NZ259239A (es)
PL (1) PL177891B1 (es)
RU (1) RU2126383C1 (es)
SK (1) SK281701B6 (es)
UA (1) UA43331C2 (es)
WO (1) WO1994014764A1 (es)

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US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
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WO2005066119A2 (en) * 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof
PL1776109T3 (pl) 2004-08-13 2009-06-30 Schering Plough Ltd Farmaceutyczna formulacja zawierająca antybiotyk, triazol i kortykosteroid
MX2007003378A (es) 2004-09-23 2007-05-10 Schering Plough Ltd Control de parasitos en animales mediante el uso de nuevos derivados de trifluorometansulfonanilida oxima eter.
EP1811841B1 (en) * 2004-11-19 2009-10-28 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
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MX2007015729A (es) * 2005-06-09 2008-02-21 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida.
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
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US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
EP2091909A1 (en) * 2006-12-13 2009-08-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
CN101600686A (zh) * 2006-12-13 2009-12-09 先灵-普劳有限公司 氯霉素、甲砜霉素及其类似物的水溶性前药
US20090062397A1 (en) * 2007-04-27 2009-03-05 Schering-Plough Animal Health Corporation Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
HUE037127T2 (hu) 2007-06-27 2018-08-28 Du Pont Állati károkozó irtására szolgáló eljárás
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
NZ585219A (en) 2007-11-09 2012-11-30 Intervet Int Bv Fast release solid formulation, preparation and use thereof
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
JP2011529895A (ja) 2008-07-30 2011-12-15 インターベツト・インターナシヨナル・ベー・ベー フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
CN101337916B (zh) * 2008-08-12 2011-02-16 张家港市恒盛药用化学有限公司 氟苯尼考磺酸酯及其盐以及它们的制备方法
KR20120047996A (ko) 2009-08-05 2012-05-14 이 아이 듀폰 디 네모아 앤드 캄파니 메소이온성 살충제
MX2012001651A (es) 2009-08-05 2012-03-16 Du Pont Pesticidas mesoionicos.
UA107804C2 (xx) 2009-08-05 2015-02-25 Du Pont Суміші мезоіонних пестицидів
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
MA34247B1 (fr) 2010-05-27 2013-05-02 Du Pont Forme cristalline du 4-[5-[3-chloro-5-(trifluorométhyl) phényl] -4,5-dihydro-5-(trifluorométhyl)-3-isoxazolyl]-n-[2-oxo-2-[(2, 2,2-trifluoroéthyl) amino] éthyl]-1-naphtalènecarboxamide
CN101921214B (zh) * 2010-08-03 2013-04-10 复旦大学 反式对甲砜基肉桂醇的合成方法
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN103415511B (zh) * 2011-01-31 2016-01-20 国立大学法人长崎大学 光学活性化合物或其盐的制造方法
CN102417472B (zh) * 2011-12-12 2013-11-13 齐鲁动物保健品有限公司 一种氟苯尼考的制备方法
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102827042B (zh) * 2012-09-17 2013-11-06 湖北美天生物科技有限公司 氟苯尼考的手性合成方法
CN102863361B (zh) * 2012-10-17 2014-03-12 湖北美天生物科技有限公司 甲砜霉素的手性催化合成方法
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103336072A (zh) * 2013-06-19 2013-10-02 湖北龙翔药业有限公司 一种测定氟苯尼考中手性活性成分含量的方法
CN103880719A (zh) * 2014-03-27 2014-06-25 张家港威胜生物医药有限公司 一种制备氟苯尼考琥珀酸酯的方法
WO2015157927A1 (zh) * 2014-04-16 2015-10-22 湖北美天生物科技有限公司 氟苯尼考的合成方法
CN103980167B (zh) * 2014-04-17 2016-06-08 天津大学 一种无定形氟苯尼考及其制备方法
CN106349130B (zh) * 2016-08-25 2018-01-23 潍坊大有生物化工有限公司 一种新的氟苯尼考的合成方法
CN111153838B (zh) * 2020-01-19 2021-08-24 浙江大学宁波理工学院 一种氟苯尼考的合成方法
CN113185473B (zh) * 2021-06-30 2021-10-08 山东国邦药业有限公司 一种氟苯尼考中间体氟甲砜噁唑的制备方法

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Also Published As

Publication number Publication date
DE69320986T2 (de) 1999-03-04
NZ259239A (en) 1996-04-26
CZ287461B6 (en) 2000-11-15
FI952872A0 (fi) 1995-06-12
RU2126383C1 (ru) 1999-02-20
EP0674618A1 (en) 1995-10-04
HU9501776D0 (en) 1995-08-28
EP0674618B1 (en) 1998-09-09
SK281701B6 (sk) 2001-07-10
JPH08504819A (ja) 1996-05-28
CA2152089A1 (en) 1994-07-07
NO952425L (no) 1995-06-16
KR100284216B1 (ko) 2001-04-02
NO952425D0 (no) 1995-06-16
WO1994014764A1 (en) 1994-07-07
UA43331C2 (uk) 2001-12-17
JP3428016B2 (ja) 2003-07-22
US5352832A (en) 1994-10-04
CZ159895A3 (en) 1996-01-17
DE69320986D1 (de) 1998-10-15
ATE170835T1 (de) 1998-09-15
AU5748494A (en) 1994-07-19
NO303575B1 (no) 1998-08-03
FI109295B (fi) 2002-06-28
AU676003B2 (en) 1997-02-27
CA2152089C (en) 2006-10-24
PL309393A1 (en) 1995-10-02
PL177891B1 (pl) 2000-01-31
HU225110B1 (en) 2006-06-28
KR950704244A (ko) 1995-11-17
DK0674618T3 (da) 1999-02-22
FI952872L (fi) 1995-06-12
SK77795A3 (en) 1995-12-06
HUT72669A (en) 1996-05-28

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