ES2138346T3 - Derivados de 5-(hidroximetil)oxazolidin-2-ona. - Google Patents
Derivados de 5-(hidroximetil)oxazolidin-2-ona.Info
- Publication number
- ES2138346T3 ES2138346T3 ES96918719T ES96918719T ES2138346T3 ES 2138346 T3 ES2138346 T3 ES 2138346T3 ES 96918719 T ES96918719 T ES 96918719T ES 96918719 T ES96918719 T ES 96918719T ES 2138346 T3 ES2138346 T3 ES 2138346T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- group
- hydrogen atom
- atom
- oxazolidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 4
- -1 METHYL GROUP Chemical group 0.000 abstract 4
- KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical compound C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 abstract 1
- YMBWJIKPLFYHOD-UHFFFAOYSA-N 1,3-oxazolidin-5-ylmethanol Chemical class OCC1CNCO1 YMBWJIKPLFYHOD-UHFFFAOYSA-N 0.000 abstract 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION TIENE POR OBJETO EN PARTICULAR LOS DERIVADOS DE LA 5 - (HIDROXIMETIL)OXAZOLIDIN - 2 - ONA SUSTITUIDOS EN 3 - POR UN NUCLEO INDAZOL, BENZISOXAZOL O BENZISOTIAZOL QUE RESPONDEN A LA FORMULA GENERAL (I) EN LA CUAL: X REPRESENTA UN ATOMO DE OXIGENO, UN ATOMO DE AZUFRE O UN GRUPO NR, SIENDO R UN ATOMO DE HIDROGENO O UNA CADENA ALQUIL EN C SUB,1} - C SUB,4} LINEAL O RAMIFICADA; R SUB,1} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO METILO; Y R SUB,2} REPRESENTA: (I) UN GRUPO R SUB,3}O EN EL CUAL R SUB,3} REPRESENTA, O BIEN UN ATOMO DE HIDROGENO O UN GRUPO BENZILO EVENTUALMENTE SUSTITUIDO POR UN ATOMO DE HALOGENO O POR UN GRUPO NITRO O METILENDIOXI, O BIEN UN GRUPO METOXIETILO, BUTILO, 4,4,4 - TRIFLUOROBUTILO, 4,4,4 - TRIFLUORO - 3 - HIDROXIBUTILO O 4,4,4 - TRIFLUOROBUT - 2 ENILO; O (II) UN GRUPO - CH = CH - R O - CH SUB,2} - CH SUB,2} R SUB,4} Y EN EL CUAL R SUB,4} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO FENILO, 3,3,3 - TRIFLUOROPROPILO O 3,3,3 - TRIFLUORO 2 HIDROXIPROPILO; SU METODO DE PREPARACION Y SU APLICACION TERAPEUTICA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9506564A FR2734821B1 (fr) | 1995-06-02 | 1995-06-02 | Derives de 5-methoxymethyl-3-(1,2-benzisoxazol-3-yl) oxazolidin-2-one, leur preparation et leur application en therapeutique |
| FR9506563A FR2734820B1 (fr) | 1995-06-02 | 1995-06-02 | Derives de 3-(1,2-benzisoxazol-3-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2138346T3 true ES2138346T3 (es) | 2000-01-01 |
Family
ID=26232004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96918719T Expired - Lifetime ES2138346T3 (es) | 1995-06-02 | 1996-05-28 | Derivados de 5-(hidroximetil)oxazolidin-2-ona. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5843975A (es) |
| EP (1) | EP0835254B1 (es) |
| JP (1) | JP3856829B2 (es) |
| KR (1) | KR100457502B1 (es) |
| CN (1) | CN1075072C (es) |
| AR (1) | AR006301A1 (es) |
| AT (1) | ATE184005T1 (es) |
| AU (1) | AU699367B2 (es) |
| BR (1) | BR9608896A (es) |
| CA (1) | CA2223011C (es) |
| CO (1) | CO4700462A1 (es) |
| CZ (1) | CZ378497A3 (es) |
| DE (1) | DE69604071T2 (es) |
| DK (1) | DK0835254T3 (es) |
| ES (1) | ES2138346T3 (es) |
| GR (1) | GR3031710T3 (es) |
| HU (1) | HU224879B1 (es) |
| MX (1) | MX9709410A (es) |
| NO (1) | NO309091B1 (es) |
| NZ (1) | NZ310487A (es) |
| PL (1) | PL183919B1 (es) |
| RU (1) | RU2164226C2 (es) |
| SK (1) | SK281934B6 (es) |
| TW (1) | TW360654B (es) |
| WO (1) | WO1996038444A1 (es) |
| ZA (1) | ZA964563B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1078632A1 (en) * | 1999-08-16 | 2001-02-28 | Sanofi-Synthelabo | Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity |
| BR0206844A (pt) * | 2001-01-31 | 2005-07-12 | Synaptic Pharma Corp | Uso de antagonistas do receptor gal3 para o tratamento de depressão e/ou ansiedade e compostos usados em tais métodos |
| TWI248438B (en) * | 2001-04-10 | 2006-02-01 | Sod Conseils Rech Applic | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| WO2003028720A1 (en) * | 2001-09-26 | 2003-04-10 | Pharmacia Italia S.P.A. | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
| DE10334309A1 (de) * | 2003-07-28 | 2005-03-03 | Aventis Pharma Deutschland Gmbh | Substituierte Thiazol-Benzoisothiazoldioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| JP2009525318A (ja) * | 2006-02-01 | 2009-07-09 | ファイザー・プロダクツ・インク | 抗菌剤としてのベンズイソオキサゾールオキサゾリジノン |
| US7998992B2 (en) * | 2007-03-30 | 2011-08-16 | Institute Of Medicinal Molecular Design, Inc. | Oxazolidinone derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 |
| EP2123159A1 (de) * | 2008-05-21 | 2009-11-25 | Bayer CropScience AG | (1,2-Benzisothiazol-3-yl)(thio)carbamate und (1,2-Benzisothiazol-3-yl)(thio)oxamate und deren Oxidationsformen als Pestizide |
| JP2013514385A (ja) * | 2009-12-18 | 2013-04-25 | ヤンセン ファーマシューティカ エヌ．ベー． | エストロゲン関連受容体αモジュレーターとしての置換アミノチアゾロンインダゾール |
| EP2536716B1 (en) * | 2010-02-17 | 2014-05-21 | Janssen Pharmaceutica, N.V. | Aminothiazolones as estrogen related receptor-alpha modulators |
| WO2016097355A1 (en) * | 2014-12-19 | 2016-06-23 | Ge Healthcare Limited | Labelled oxazolidinone derivatives |
| DE102015012050A1 (de) * | 2015-09-15 | 2017-03-16 | Merck Patent Gmbh | Verbindungen als ASIC-Inhibitoren und deren Verwendungen |
| RU2637643C1 (ru) * | 2016-09-05 | 2017-12-05 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фундаментальной и клинической иммунологии" (НИИФКИ) | Иммунодепрессант |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2076253T3 (es) * | 1989-05-19 | 1995-11-01 | Hoechst Roussel Pharma | N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos. |
| US5235063A (en) * | 1989-10-17 | 1993-08-10 | Delalande S.A. | Process of preparing by condensation certain |
| US5196543A (en) * | 1989-10-17 | 1993-03-23 | Delalande S.A. | 3-aryloxazolidinone derivatives, process for their preparation and their use in therapy |
| FR2653017B1 (fr) * | 1989-10-17 | 1995-05-05 | Delalande Sa | Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique. |
| US5182296A (en) * | 1989-10-26 | 1993-01-26 | Tanabe Seiyaky Co., Ltd. | Naphthyloxazolidone derivatives |
| FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
| WO1992014418A1 (en) * | 1991-02-20 | 1992-09-03 | Yusaku Koda | Articulator |
-
1996
- 1996-05-28 AU AU61288/96A patent/AU699367B2/en not_active Expired
- 1996-05-28 BR BR9608896A patent/BR9608896A/pt active IP Right Grant
- 1996-05-28 CN CN96195713A patent/CN1075072C/zh not_active Expired - Lifetime
- 1996-05-28 WO PCT/FR1996/000792 patent/WO1996038444A1/fr not_active Ceased
- 1996-05-28 RU RU98100257/04A patent/RU2164226C2/ru active
- 1996-05-28 KR KR1019970708666A patent/KR100457502B1/ko not_active Expired - Lifetime
- 1996-05-28 CZ CZ973784A patent/CZ378497A3/cs unknown
- 1996-05-28 AT AT96918719T patent/ATE184005T1/de active
- 1996-05-28 HU HU9901349A patent/HU224879B1/hu unknown
- 1996-05-28 JP JP53624596A patent/JP3856829B2/ja not_active Expired - Lifetime
- 1996-05-28 ES ES96918719T patent/ES2138346T3/es not_active Expired - Lifetime
- 1996-05-28 SK SK1614-97A patent/SK281934B6/sk not_active IP Right Cessation
- 1996-05-28 NZ NZ310487A patent/NZ310487A/xx not_active IP Right Cessation
- 1996-05-28 DE DE69604071T patent/DE69604071T2/de not_active Expired - Lifetime
- 1996-05-28 EP EP96918719A patent/EP0835254B1/fr not_active Expired - Lifetime
- 1996-05-28 DK DK96918719T patent/DK0835254T3/da active
- 1996-05-28 PL PL96323673A patent/PL183919B1/pl unknown
- 1996-05-28 CA CA002223011A patent/CA2223011C/en not_active Expired - Lifetime
- 1996-05-28 US US08/973,246 patent/US5843975A/en not_active Expired - Lifetime
- 1996-05-31 CO CO96028173A patent/CO4700462A1/es unknown
- 1996-06-01 TW TW085106564A patent/TW360654B/zh not_active IP Right Cessation
- 1996-06-03 AR ARP960102870A patent/AR006301A1/es active IP Right Grant
- 1996-06-03 ZA ZA964563A patent/ZA964563B/xx unknown
-
1997
- 1997-12-01 NO NO975530A patent/NO309091B1/no not_active IP Right Cessation
- 1997-12-02 MX MX9709410A patent/MX9709410A/es unknown
-
1999
- 1999-11-03 GR GR990402802T patent/GR3031710T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2138346T3 (es) | Derivados de 5-(hidroximetil)oxazolidin-2-ona. | |
| PT1305286E (pt) | Ciclopentanoindoles composicoes que contem os referidos compostos e metodos de tratamento | |
| CY1105915T1 (el) | Παραγωγα θειαζολιου για τη θepαπεια των παθησεων που σχετιζονται με τους ppar | |
| EA200000358A1 (ru) | Способ получения диарилпиридинов, полезных в качестве ингибиторов cox-2 | |
| ATE229515T1 (de) | (methylsulfonyl)phenyl-2-(5h)-furanone als cox-2 inhibitoren | |
| DK1040108T3 (da) | Orthoanthranilamidderivater som antikoagulanter | |
| EA200400971A1 (ru) | Фторзамещенные циклоалканоиндолы, композиции, содержащие такие соединения, и способы лечения | |
| CY1105836T1 (el) | 12, 13-τροποποιημενα παραγωγα εποθιλονης | |
| DE69516866D1 (de) | Stereochemische wortmanninderivate | |
| EA199900837A1 (ru) | Способ применения ингибиторов циклооксигеназы-2 для предупреждения сердечно-сосудистых расстройств | |
| PE20050012A1 (es) | Compuestos de benzopirano como inhibidores de la ciclooxigenasa-2 | |
| FI840463A0 (fi) | Vissa bensazokinon- och bensazoninonderivat | |
| ES2163665T3 (es) | Fenilimidazolidinas y su utilizacion como agente anti-androgeno. | |
| ES2171723T3 (es) | 3,4-diaril-2-hidroxi-2,5-dihidrofuranos como profarmacos de inhibidores de cox-2. | |
| PT887344E (pt) | Quinolinas e quinazolinas uteis em terapia | |
| DE69327796D1 (de) | Antiproliferative substituierte 5-thiapyrimidinon- und 5-selenopyrimidinonverbindungen | |
| EA199900079A1 (ru) | Способ получения фенильных гетероциклов, пригодных в качестве ингибиторов цог-2 | |
| DE3750685D1 (de) | Dopamin-beta-hydroxylasehemmer. | |
| CY1107473T1 (el) | Ενα παραγωγο pyridine-n-oxide, και διαδικασια για τη μετατροπη του σε αποτελεσματικες φαρμακευτικες συνθεσεις | |
| DK0804410T3 (da) | Fremgangsmåde til fremstilling af retrovirale proteaseinhibitor-mellemprodukter | |
| PE20001067A1 (es) | Derivados de 2-fenilpiran-4-ona | |
| ATE223376T1 (de) | Bisarylcyclobutenderivate als cyclooxygenasehemmer | |
| ATE244232T1 (de) | (methylsulfonyl)phenyl-2-(5h)-furanone mit sauerstoff-bindung als cox-2-hemmer | |
| DK0835251T3 (da) | Fremgangsmåde til fremstilling af liponsyre | |
| AR017097A1 (es) | Compuestos de 2-(3h)-oxazolona, utiles como inhibidores selectivos de cox-2; procedimiento para preparar dichos compuestos y composiciones farmaceuticasformuladas con dichos compuestos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 835254 Country of ref document: ES |