ES2155137T3 - Tratamiento por terapia genetica de tumores con una sustancia activa especifica de celulas endoteliales y dependiente del ciclo celular. - Google Patents

Tratamiento por terapia genetica de tumores con una sustancia activa especifica de celulas endoteliales y dependiente del ciclo celular.

Info

Publication number
ES2155137T3
ES2155137T3 ES95931204T ES95931204T ES2155137T3 ES 2155137 T3 ES2155137 T3 ES 2155137T3 ES 95931204 T ES95931204 T ES 95931204T ES 95931204 T ES95931204 T ES 95931204T ES 2155137 T3 ES2155137 T3 ES 2155137T3
Authority
ES
Spain
Prior art keywords
endotelial
cells
cell cycle
tumor therapy
dependent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95931204T
Other languages
English (en)
Inventor
Hans-Harald Sedlacek
Klaus Bosslet
Rolf Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26305524&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2155137(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9417366A external-priority patent/GB9417366D0/en
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Application granted granted Critical
Publication of ES2155137T3 publication Critical patent/ES2155137T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE DESCRIBE UNA SECUENCIA DE ADN PARA LA TERAPIA GENICA DE TUMORES. LA SECUENCIA DE ADN CONSTA ESENCIALMENTE DE UNA SECUENCIA ACTIVADORA, UN MODULO PROMOTOR Y UN GEN PARA EL PRINCIPIO ACTIVO. LA SECUENCIA ACTIVADORA SE ACTIVA ESPECIFICAMENTE EN LAS CELULAS ENDOTELIALES EN PROLIFERACION O CELULAS CONTIGUAS A ESTAS CELULAS ENDOTELIALES. ESTA ACTIVACION ES REGULADA DE FORMA ESPECIFICA SEGUN EL CICLO CELULAR MEDIANTE EL MODULO PROMOTOR. EL PRINCIPIO ACTIVO ES UN INHIBIDOR DE LA ANGIOGENESIS O UNA MOLECULA CITOSTATICA O CITOTOXICA. LA SECUENCIA DE ADN SE INTRODUCE EN UN VECTOR VIRAL O NO VIRAL, COMPLETADO POR UN LIGANDO CON AFINIDAD POR LA CELULA ENDOTELIAL ACTIVADA.
ES95931204T 1994-08-26 1995-08-25 Tratamiento por terapia genetica de tumores con una sustancia activa especifica de celulas endoteliales y dependiente del ciclo celular. Expired - Lifetime ES2155137T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9417366A GB9417366D0 (en) 1994-08-26 1994-08-26 Cell cycle regulated repressor and DNA element
GBGB9506466.3A GB9506466D0 (en) 1994-08-26 1995-03-29 Cell cycle regulated repressor and dna element

Publications (1)

Publication Number Publication Date
ES2155137T3 true ES2155137T3 (es) 2001-05-01

Family

ID=26305524

Family Applications (4)

Application Number Title Priority Date Filing Date
ES95929181T Expired - Lifetime ES2190787T3 (es) 1994-08-26 1995-08-23 Represor regulado por el ciclo celular y elemento de adn.
ES95931204T Expired - Lifetime ES2155137T3 (es) 1994-08-26 1995-08-25 Tratamiento por terapia genetica de tumores con una sustancia activa especifica de celulas endoteliales y dependiente del ciclo celular.
ES95931933T Expired - Lifetime ES2146775T3 (es) 1994-08-26 1995-08-25 Tratamiento de terapia genica de enfermedades del sistema nervioso central (snc) mediante un principio activo especifico de las celulas e independiente del ciclo celular.
ES95930524T Expired - Lifetime ES2146770T3 (es) 1994-08-26 1995-08-25 Tratamiento de terapia genica de enfermedades vasculares mediante una sustancia activa citoespecifica y dependiente del ciclo celular.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES95929181T Expired - Lifetime ES2190787T3 (es) 1994-08-26 1995-08-23 Represor regulado por el ciclo celular y elemento de adn.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES95931933T Expired - Lifetime ES2146775T3 (es) 1994-08-26 1995-08-25 Tratamiento de terapia genica de enfermedades del sistema nervioso central (snc) mediante un principio activo especifico de las celulas e independiente del ciclo celular.
ES95930524T Expired - Lifetime ES2146770T3 (es) 1994-08-26 1995-08-25 Tratamiento de terapia genica de enfermedades vasculares mediante una sustancia activa citoespecifica y dependiente del ciclo celular.

Country Status (18)

Country Link
US (3) US6214614B1 (es)
EP (4) EP0802985B1 (es)
JP (4) JPH10508188A (es)
KR (1) KR970705638A (es)
CN (1) CN1158144A (es)
AT (4) ATE229569T1 (es)
AU (4) AU711012B2 (es)
CA (4) CA2198080A1 (es)
DE (4) DE69529174T2 (es)
DK (4) DK0802985T3 (es)
ES (4) ES2190787T3 (es)
FI (2) FI970768A0 (es)
GB (1) GB9506466D0 (es)
GR (3) GR3033535T3 (es)
IL (1) IL115051A0 (es)
NZ (1) NZ291495A (es)
PT (4) PT802985E (es)
WO (3) WO1996006943A1 (es)

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JPH10505234A (ja) 1998-05-26
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DE69529174T2 (de) 2003-10-23
CA2198473A1 (en) 1996-03-07
EP0804601B1 (de) 2001-03-14
DE59508144D1 (de) 2000-05-11
DK0804601T3 (da) 2001-07-09
AU3518595A (en) 1996-03-22
DE69529174D1 (de) 2003-01-23
PT777740E (pt) 2000-07-31
EP0777739B1 (de) 2000-04-05
AU695458B2 (en) 1998-08-13
NZ291495A (en) 2004-12-24
EP0802985A1 (en) 1997-10-29
FI970674A0 (fi) 1997-02-18
PT777739E (pt) 2000-07-31
EP0777740B1 (de) 2000-04-05
IL115051A0 (en) 1995-12-08
AU3387495A (en) 1996-03-22
ATE199741T1 (de) 2001-03-15
CA2198472A1 (en) 1996-03-07
PT804601E (pt) 2001-06-29
WO1996006943A1 (en) 1996-03-07
ES2146775T3 (es) 2000-08-16
AU690733B2 (en) 1998-04-30
GR3033535T3 (en) 2000-09-29
DK0777740T3 (da) 2000-08-14
US5830880A (en) 1998-11-03
PT802985E (pt) 2003-04-30
ATE229569T1 (de) 2002-12-15
DK0777739T3 (da) 2000-07-31
FI970768A7 (fi) 1997-02-24
DK0802985T3 (da) 2003-03-17
FI970674L (fi) 1997-04-21
WO1996006940A1 (de) 1996-03-07
EP0777739A1 (de) 1997-06-11
US6214614B1 (en) 2001-04-10
ES2190787T3 (es) 2003-08-16
GB9506466D0 (en) 1995-05-17
WO1996006939A1 (de) 1996-03-07
KR970705638A (ko) 1997-10-09
AU3263995A (en) 1996-03-22
GR3033534T3 (en) 2000-09-29
ATE191506T1 (de) 2000-04-15
EP0777740A1 (de) 1997-06-11
AU711012B2 (en) 1999-10-07
JPH10506526A (ja) 1998-06-30
AU696593B2 (en) 1998-09-17
FI970768L (fi) 1997-02-24
JPH10507626A (ja) 1998-07-28
GR3035994T3 (en) 2001-09-28
FI970768A0 (fi) 1997-02-24
EP0804601A1 (de) 1997-11-05
CA2198080A1 (en) 1996-03-07
US6358732B1 (en) 2002-03-19
ES2146770T3 (es) 2000-08-16
DE59508145D1 (de) 2000-05-11
EP0802985B1 (en) 2002-12-11
DE59509100D1 (de) 2001-04-19
JPH10508188A (ja) 1998-08-18
CA2198474A1 (en) 1996-03-07
CN1158144A (zh) 1997-08-27
ATE191507T1 (de) 2000-04-15
AU3473295A (en) 1996-03-22

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