ES2184786T3 - Nuevos derivados 2,2'-bi-1h-pirrol con actividad inmunosupresora. - Google Patents
Nuevos derivados 2,2'-bi-1h-pirrol con actividad inmunosupresora.Info
- Publication number
- ES2184786T3 ES2184786T3 ES95902113T ES95902113T ES2184786T3 ES 2184786 T3 ES2184786 T3 ES 2184786T3 ES 95902113 T ES95902113 T ES 95902113T ES 95902113 T ES95902113 T ES 95902113T ES 2184786 T3 ES2184786 T3 ES 2184786T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- alkilo
- replaced
- alcoxi
- alquenilo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- -1 POLYETHYLENE CHAIN Polymers 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE DESCRIBEN NUEVOS Y CONOCIDOS DERIVADOS 5-[[](()2H-PIRROLO-2ILIDENO())METILO[]]-2,2''-BI-1H-PIRROLO, QUE TIENEN ACTIVIDAD INMUNOMODULADORA Y, REPRESENTADOS POR LA FORMULA GENERAL (I), EN DONDE, SUJETO A UNA CONDICION, R{SUB, 1} REPRESENTA HIDROGENO, FENILO, ALKILO C{SUB, 1}-C{SUB, 20} O ALQUENILO C{SUB, 2}-C{SUB, 20}, EN DONDE LOS GRUPOS ALKILO Y ALQUENILO PUEDEN SER NO SUSTITUIDOS O SUSTITUIDOS POR 1 A 3 SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE DE HALOGENO, ALCOXI C{SUB, 1}-C{SUB, 6}, HIDROXI, ARILO Y ARILOXI; R{SUB, 2} REPRESENTA HIDROGENO, ALKILO C{SUB, 1}-C{SUB, 6}, CIANO, CARBOXI O (()ALCOXI C{SUB, 1}-C{SUB, 6}())CARBONILO; R{SUB, 3} REPRESENTA HALOGENO, HIDROXI O ALCOXI C{SUB, 1}-C{SUB, 11} NO SUSTITUIDO O SUSTITUIDO POR FENILO; R{SUB, 4} REPRESENTA HIDROGENO, ALKILO C{SUB, 1}-C{SUB, 6} O FENILO; CADA UNO DE R{SUB, 5} Y R{SUB, 6} REPRESENTA INDEPENDIENTEMENTE HIDROGENO, ALCANOILO C{SUB, 2}-C{SUB, 20}, ALQUENOILO C{SUB, 3}-C{SUB, 20}, FENILO, ALKILO C{SUB, 1}-C{SUB, 20}, O ALQUENILO C{SUB, 2}-C{SUB, 20}, EN DONDE EL ALCANOILO, ALQUENOILO, ALKILO Y LOS GRUPOS ALQUENILOS PUEDEN SER NO SUSTITUIDOS O SUSTITUIDOS POR DE 1 A 3 SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE DE HALOGENO, ALCOXI C{SUB, 1}C{SUB, 6}, HIDROXI, ARILO, ARILOXI, CIANO, CARBOXI, (()ALCOXI C{SUB, 1}-C{SUB, 6}())CARBONILO, (()ALQUENILO C{SUB, 3}-C{SUB, 4}())CARBAMOILO, ARALKILCARBAMOILO, ARILCARBAMOILO Y CONR{SUB,C}R{SUB,D} EN EL CUAL CADA UNO DE R{SUB,C} Y R{SUB, 4} ES INDEPENDIENTEMENTE HIDROGENO O ALKILO C{SUB, 1}-C{SUB, 6} O R{SUB, C} Y R{SUB, D} TOMADOS JUNTOS CON EL ATOMO DE NITROGENO AL QUE ESTAN ENLAZADOS, FORMAN UN ANILLO MORFOLINO O PIPERIDINO; O DOS DE R{SUB, 4}, R{SUB, 5} Y R{SUB, 6} TOMADOS JUNTOS FORMAN UNA CADENA DE POLIMETILENO C{SUB,4}-C{SUB,12}, QUE PUEDE SER NO SUSTITUIDA O SUSTITUIDA POR UN ALKILO C{SUB, 1}-C{SUB, 12}, POR UN ALQUENILO C{SUB, 2}-C{SUB, 12} O POR UN GRUPO DE ALKILIDENO C{SUB, 1}-C{SUB, 12}, EN DONDE LOS GRUPOS ALKILO, ALQUENILO Y ALKILIDENO PUEDE SER A SU VEZ NOSUSTITUIDOS O SUSTITUIDOS POR UN SUSTITUYENTE SELECCIONADO DE HALOGENO; ALCOXI C{SUB, 1}-C{SUB, 6}, HIDROXI, CIANO, CARBOXI, (()ALCOXI C{SUB, 1}-C{SUB, 6}())CARBONILO, ARILOXI Y ARILO; EL RESTO SIENDO HIDROGENO O ALKILO C{SUB, 1}-C{SUB, 12}; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939326284A GB9326284D0 (en) | 1993-12-23 | 1993-12-23 | Pyrrolydenemethyl-derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2184786T3 true ES2184786T3 (es) | 2003-04-16 |
Family
ID=10747089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95902113T Expired - Lifetime ES2184786T3 (es) | 1993-12-23 | 1994-12-02 | Nuevos derivados 2,2'-bi-1h-pirrol con actividad inmunosupresora. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5691334A (es) |
| EP (2) | EP0686147B1 (es) |
| JP (1) | JP3594311B2 (es) |
| KR (1) | KR100365057B1 (es) |
| CN (1) | CN1120153C (es) |
| AT (1) | ATE224874T1 (es) |
| AU (1) | AU689169B2 (es) |
| CA (1) | CA2155096A1 (es) |
| DE (1) | DE69431429T2 (es) |
| DK (1) | DK0686147T3 (es) |
| ES (1) | ES2184786T3 (es) |
| FI (1) | FI109688B (es) |
| GB (1) | GB9326284D0 (es) |
| HU (1) | HUT73663A (es) |
| IL (1) | IL112022A (es) |
| MY (1) | MY113304A (es) |
| NO (1) | NO305796B1 (es) |
| NZ (1) | NZ276716A (es) |
| PL (1) | PL183112B1 (es) |
| PT (1) | PT686147E (es) |
| RU (1) | RU2145957C1 (es) |
| TW (1) | TW285670B (es) |
| UA (1) | UA57697C2 (es) |
| WO (1) | WO1995017381A1 (es) |
| ZA (1) | ZA9410203B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2736550B1 (fr) | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
| GB9603212D0 (en) * | 1996-02-15 | 1996-04-17 | Pharmacia Spa | Process for the preparation of 2,2'-bipyrrolyl-pyrromethane derivatives |
| GB9619706D0 (en) * | 1996-09-20 | 1996-11-06 | Pharmacia Spa | Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole comp und |
| GB9705035D0 (en) * | 1997-03-11 | 1997-04-30 | Pharmacia & Upjohn Spa | Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation |
| US5989591A (en) * | 1997-03-14 | 1999-11-23 | American Home Products Corporation | Rapamycin formulations for oral administration |
| KR100252197B1 (ko) * | 1997-09-20 | 2000-04-15 | 박호군 | 세라시아 마르세센스 균주의 배양액으로 부터 분리한 면역억제제용 프로디지오신 |
| GB9802745D0 (en) * | 1998-02-09 | 1998-04-08 | Pharmacia & Upjohn Spa | Benzyloxy prodigiosine compounds |
| US6407244B1 (en) | 2000-01-26 | 2002-06-18 | Gemin X Biotechnologies Inc. | Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases |
| US20040014987A1 (en) * | 2000-01-26 | 2004-01-22 | Gemin X Biotechnologies Inc. | Pyrrole-Type compounds, compositions, and methods for treating cancer or viral diseases |
| KR20010081515A (ko) * | 2000-02-15 | 2001-08-29 | 복성해 | 프로디지오신의 당뇨병 예방 및 치료용 조성물 |
| KR100392225B1 (ko) * | 2001-04-19 | 2003-07-22 | 한국생명공학연구원 | 류머티스 관절염 치료용 프로디지오신 조성물 |
| ES2304135T3 (es) | 2001-07-18 | 2008-09-16 | Gemin X Biotechnologies Inc. | Compuestos tipo pirrol, composiciones y metodos para tratar el cancer, tratar enfermedades virales y causar inmunosupresion. |
| ES2382377T3 (es) | 2003-05-30 | 2012-06-07 | Gemin X Pharmaceuticals Canada Inc. | Compuestos triheterocíclicos, composiciones, y métodos para tratar cáncer |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| WO2006089397A1 (en) * | 2005-02-22 | 2006-08-31 | Gemin X Biotechnologies Inc. | Methods for treating arthritis using triheterocyclic compounds |
| KR100674222B1 (ko) * | 2005-07-11 | 2007-01-24 | 한국생명공학연구원 | 세라시아 마르세센스 ｂ-1231 ｋｃｔｃ 0386ｂｐ로부터분리한 프로디지오신을 유효성분으로 포함한 급성이식편대숙주병의 예방 및 치료용 조성물 |
| NZ569608A (en) | 2006-01-06 | 2011-09-30 | Sepracor Inc | Tetralone-based monoamine reuptake inhibitors |
| BRPI0706365A2 (pt) | 2006-01-06 | 2011-03-22 | Sepracor Inc | Cicloalquilaminas como inibidores da recaptação de monoamina |
| DK2816024T3 (en) | 2006-03-31 | 2017-10-30 | Sunovion Pharmaceuticals Inc | CHIRALE AMINER |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| US20080051400A1 (en) * | 2006-07-06 | 2008-02-28 | Gemin X Biotechnologies Inc. | Methods for treating or preventing anemia or thrombocytopenia using a triheterocyclic compound |
| US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| AU2008259841B2 (en) | 2007-05-31 | 2015-02-05 | Sunovion Pharmaceuticals Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
| CN103387529B (zh) * | 2013-07-30 | 2016-03-30 | 中国农业科学院烟草研究所 | 抗tmv的三吡咯环类化合物及其制备方法和用途 |
| ES2615077B1 (es) * | 2015-12-02 | 2018-03-14 | Universidad De Burgos | Una nueva familia de compuestos, procedimiento de obtención de los mismos y sus usos en el tratamiento y/o profilaxis de enfermedades |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61280429A (ja) * | 1985-06-06 | 1986-12-11 | Chugai Pharmaceut Co Ltd | 免疫抑制剤 |
| SU1409276A1 (ru) * | 1985-11-10 | 1988-07-15 | Донецкий медицинский институт им.М.Горького | Способ лечени острых кишечных инфекций |
| JPH02250828A (ja) * | 1989-03-23 | 1990-10-08 | Nippon Kayaku Co Ltd | 新規免疫抑制剤 |
-
1993
- 1993-12-23 GB GB939326284A patent/GB9326284D0/en active Pending
-
1994
- 1994-02-12 UA UA95094273A patent/UA57697C2/uk unknown
- 1994-12-02 PT PT95902113T patent/PT686147E/pt unknown
- 1994-12-02 HU HU9502782A patent/HUT73663A/hu unknown
- 1994-12-02 US US08/505,292 patent/US5691334A/en not_active Expired - Fee Related
- 1994-12-02 JP JP51712595A patent/JP3594311B2/ja not_active Expired - Fee Related
- 1994-12-02 CA CA002155096A patent/CA2155096A1/en not_active Abandoned
- 1994-12-02 AU AU11090/95A patent/AU689169B2/en not_active Ceased
- 1994-12-02 AT AT95902113T patent/ATE224874T1/de not_active IP Right Cessation
- 1994-12-02 CN CN94191273A patent/CN1120153C/zh not_active Expired - Fee Related
- 1994-12-02 DE DE69431429T patent/DE69431429T2/de not_active Expired - Fee Related
- 1994-12-02 DK DK95902113T patent/DK0686147T3/da active
- 1994-12-02 PL PL94310387A patent/PL183112B1/pl not_active IP Right Cessation
- 1994-12-02 EP EP95902113A patent/EP0686147B1/en not_active Expired - Lifetime
- 1994-12-02 RU RU95120169A patent/RU2145957C1/ru not_active IP Right Cessation
- 1994-12-02 WO PCT/EP1994/004006 patent/WO1995017381A1/en not_active Ceased
- 1994-12-02 EP EP02077192A patent/EP1241162A1/en not_active Withdrawn
- 1994-12-02 ES ES95902113T patent/ES2184786T3/es not_active Expired - Lifetime
- 1994-12-02 KR KR1019950703548A patent/KR100365057B1/ko not_active Expired - Fee Related
- 1994-12-02 NZ NZ276716A patent/NZ276716A/en unknown
- 1994-12-19 IL IL11202294A patent/IL112022A/en not_active IP Right Cessation
- 1994-12-19 TW TW083111857A patent/TW285670B/zh active
- 1994-12-21 ZA ZA9410203A patent/ZA9410203B/xx unknown
- 1994-12-22 MY MYPI94003486A patent/MY113304A/en unknown
-
1995
- 1995-08-21 FI FI953919A patent/FI109688B/fi not_active IP Right Cessation
- 1995-08-21 NO NO953280A patent/NO305796B1/no unknown
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