ES2191058T3 - Celulas portadoras de receptores simulados de cd4, y moleculas y metodos relacionados. - Google Patents

Celulas portadoras de receptores simulados de cd4, y moleculas y metodos relacionados.

Info

Publication number
ES2191058T3
ES2191058T3 ES95928152T ES95928152T ES2191058T3 ES 2191058 T3 ES2191058 T3 ES 2191058T3 ES 95928152 T ES95928152 T ES 95928152T ES 95928152 T ES95928152 T ES 95928152T ES 2191058 T3 ES2191058 T3 ES 2191058T3
Authority
ES
Spain
Prior art keywords
receivers
simulated
methods
cells
related molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95928152T
Other languages
English (en)
Inventor
Brian Seed
Babak Banapour
Charles Romeo
Waldemar Kolanus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/284,391 external-priority patent/US5851828A/en
Priority claimed from US08/394,388 external-priority patent/US6753162B1/en
Application filed by General Hospital Corp filed Critical General Hospital Corp
Application granted granted Critical
Publication of ES2191058T3 publication Critical patent/ES2191058T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Feed For Specific Animals (AREA)

Abstract

SE PRESENTA UN METODO DE TRATAMIENTO DE HIV EN UN MAMIFERO QUE CONLLEVA LA ADMINISTRACION AL MAMIFERO DE UNA CANTIDAD EFECTIVA DE CELULAS TERAPEUTICAS QUE EXPRESAN UN RECEPTOR QUIMERICO PROTEINICO CON MEMBRANAS UNIDAS QUE COMPRENDE UNA PORCION EXTRACELULAR QUE INCLUYE UN FRAGMENTO DE CD4 QUE ES CAPAZ DE RECONOCER Y LIGAR ESPECIFICAMENTE LA CELULA INFECTADA POR HIV, PERO NO MEDIATIZA LA INFECCION DE HIV. ADEMAS, SE PRESENTAN LAS CELULAS QUE EXPRESAN ESTOS RECEPTORES CON CD4, EL DNA Y LOS VECTORES QUE CODIFICAN LOS RECEPTORES.
ES95928152T 1994-08-02 1995-07-26 Celulas portadoras de receptores simulados de cd4, y moleculas y metodos relacionados. Expired - Lifetime ES2191058T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/284,391 US5851828A (en) 1991-03-07 1994-08-02 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US08/394,388 US6753162B1 (en) 1991-03-07 1995-02-24 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells

Publications (1)

Publication Number Publication Date
ES2191058T3 true ES2191058T3 (es) 2003-09-01

Family

ID=26962581

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95928152T Expired - Lifetime ES2191058T3 (es) 1994-08-02 1995-07-26 Celulas portadoras de receptores simulados de cd4, y moleculas y metodos relacionados.

Country Status (21)

Country Link
EP (1) EP0781095B1 (es)
JP (1) JP3832856B2 (es)
KR (1) KR100384249B1 (es)
CN (1) CN1142941C (es)
AT (1) ATE234011T1 (es)
AU (1) AU697489B2 (es)
CA (1) CA2195653C (es)
CZ (1) CZ293943B6 (es)
DE (1) DE69529910T2 (es)
DK (1) DK0781095T3 (es)
ES (1) ES2191058T3 (es)
FI (1) FI119868B (es)
HU (1) HU221603B (es)
IL (1) IL114778A (es)
MX (1) MX9700800A (es)
NO (1) NO325081B1 (es)
NZ (1) NZ291017A (es)
PL (1) PL181085B1 (es)
PT (1) PT781095E (es)
UA (1) UA45349C2 (es)
WO (1) WO1996003883A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
DE69941126D1 (de) * 1998-09-23 2009-08-27 Zymogenetics Inc Cytokinerezeptor zalpha11
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
US11440946B2 (en) * 2015-03-13 2022-09-13 University Of Maryland, Baltimore Universal antibody-mediated biosensor
JP6751493B2 (ja) 2015-08-05 2020-09-09 セルレブメド インコーポレーテッド キメラ抗原受容体及びキメラ抗原受容体が発現されたｔ細胞
MX2018003463A (es) * 2015-09-22 2018-09-06 Univ Pennsylvania Método de redireccionamiento de células t para tratar la infección por virus de inmunodeficiencia humana (vih).
CN114728172A (zh) * 2019-09-24 2022-07-08 加利福尼亚大学董事会 具有最小接头的Notch受体
CN114728174A (zh) * 2019-09-24 2022-07-08 加利福尼亚大学董事会 具有异源跨膜结构域的受体
AU2020355031A1 (en) * 2019-09-24 2022-05-19 The Regents Of The University Of California Notch receptors with hinge domain
US20220348628A1 (en) * 2019-09-24 2022-11-03 The Regents Of The University Of California Novel receptors having a fibronectin repeat for ligand-dependent transcriptional regulation
CN112176037A (zh) * 2020-09-24 2021-01-05 深圳普瑞金生物药业有限公司 检测car-t细胞目的基因拷贝数的方法、引物对、探针及试剂盒
EP4112639A1 (en) * 2021-07-02 2023-01-04 Universitat de Barcelona Car t/nk-cells for use in the treatment of invasive fungal infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6463394A (en) * 1987-09-04 1989-03-09 Kyowa Hakko Kogyo Kk Novel chimera polypeptide
PT89484B (pt) * 1988-01-22 1994-03-31 Gen Hospital Corp Genes clonados codificadores de proteinas de fusao ig-cd4 e sua utilizacao
IE920716A1 (en) * 1991-03-07 1992-09-09 Gen Hospital Corp Redirection of cellular immunity by receptor chimeras
US5851828A (en) * 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells

Also Published As

Publication number Publication date
WO1996003883A1 (en) 1996-02-15
FI970428L (fi) 1997-03-26
NZ291017A (en) 1998-05-27
CZ293943B6 (cs) 2004-08-18
DE69529910T2 (de) 2003-12-18
CN1142941C (zh) 2004-03-24
UA45349C2 (uk) 2002-04-15
PL318443A1 (en) 1997-06-09
FI119868B (fi) 2009-04-30
FI970428A0 (fi) 1997-01-31
MX9700800A (es) 1997-11-29
KR100384249B1 (ko) 2003-08-30
JP3832856B2 (ja) 2006-10-11
IL114778A (en) 2008-08-07
IL114778A0 (en) 1995-11-27
CA2195653A1 (en) 1996-02-15
EP0781095A1 (en) 1997-07-02
PT781095E (pt) 2003-06-30
DK0781095T3 (da) 2003-06-23
CZ26497A3 (en) 1997-10-15
AU697489B2 (en) 1998-10-08
PL181085B1 (pl) 2001-05-31
NO970440D0 (no) 1997-01-31
HUT77253A (hu) 1998-03-02
NO325081B1 (no) 2008-01-28
JPH10503932A (ja) 1998-04-14
EP0781095B1 (en) 2003-03-12
NO970440L (no) 1997-03-26
EP0781095A4 (en) 1999-03-03
ATE234011T1 (de) 2003-03-15
AU3201495A (en) 1996-03-04
HU221603B (hu) 2002-11-28
HK1002545A1 (zh) 1998-09-04
CA2195653C (en) 2010-04-27
KR970704357A (ko) 1997-09-06
CN1158552A (zh) 1997-09-03
DE69529910D1 (de) 2003-04-17

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