ES2196459T3 - Procedimiento para la preparacion de 1-(9`h-carbazol-4`-iloxil)-3-(2""-(2"""-metoxi [-fenoxi)-etil)-amino)-2-propano(carvedilol) y productos intermedios. - Google Patents

Procedimiento para la preparacion de 1-(9`h-carbazol-4`-iloxil)-3-(2""-(2"""-metoxi [-fenoxi)-etil)-amino)-2-propano(carvedilol) y productos intermedios.

Info

Publication number
ES2196459T3
ES2196459T3 ES98122114T ES98122114T ES2196459T3 ES 2196459 T3 ES2196459 T3 ES 2196459T3 ES 98122114 T ES98122114 T ES 98122114T ES 98122114 T ES98122114 T ES 98122114T ES 2196459 T3 ES2196459 T3 ES 2196459T3
Authority
ES
Spain
Prior art keywords
metoxi
etil
carbazol
amino
fenoxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98122114T
Other languages
English (en)
Other versions
ES2196459T5 (es
Inventor
Zoltan Ratkai
Jozsef Dr Barkoczy
Gyula Dr Simig
Tamas Dr Gregor
Gyorgyi Donath Vereczkey
Norbert Nemeth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9702209A external-priority patent/HU9702209D0/hu
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2196459T3 publication Critical patent/ES2196459T3/es
Application granted granted Critical
Publication of ES2196459T5 publication Critical patent/ES2196459T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA PREPARAR 1 - [9''H - CARBAZOL - 4'' - ILOXI] - 3 - [ 2'''' - (2'''''' - <METOXI> - FENOXI) - ETIL - AMINO] - PROPAN - 2 - OL ASI COMO EL ENANTIOMERO R O S DE DICHO COMPUESTO Y MEZCLAS DE DICHOS ENANTIOMEROS Y SALES DE ADICION ACIDAS DE DICHOS COMPUESTOS, EN LOS QUE: A) SE HACE REACCIONAR AL 4 - (OXIRANILMETOXI) - 9H - CARBAZOL O AL ENANTIOMERO R O S DEL MISMO CON LA N - [2 (2'' - <METOXI> - FENOXI) - ETIL] - BENCILAMINA EN UN DISOLVENTE ORGANICO PROTICO, EL 1 - [N - BENCIL - 2'' - ( 2'''' - <METOXI> - FENOXI) - ETIL - AMINO] - 3 - [9''''''H - CARBAZOL - 4'''''' ILOXI] - PROPAN - 2 - OL [BENCIL - CARVEDILOL] ASI FORMADO SE SOMETE A DESBENCILACION MEDIANTE HIDROGENACION CATALITICA O B) SE HACE REACCIONAR LA N - [2 - (2'' - <METOXI> - FENOXI) - ETIL] - BENCILAMINA CON LA EPICLORHIDRINA, EL 1 - [N - BENCIL - 2'' - ( 2'''' <METOXI> - FENOXI) - ETIL - AMINO] - 3 - [CLORO] - PROPAN - 2 - OL ASI FORMADO SE HACE REACCIONAR CON EL 4 - (HIDROXI) - 9H - CARBAZOL PARA PRODUCIR 1 - [N - BENCIL - 2'' -( 2'''' - <METOXI> - FENOXI) - ETIL - AMINO] - 3 [9''''''H - CARBAZOL - 4'''''' ILOXI] - PROPAN - 2 - OL, EL CUAL ES SOMETIDO A DESBENCILACION MEDIANTE HIDROGENACION CATALITICA.
ES98122114T 1997-11-24 1998-11-24 Procedimiento para la preparacion de 1-(9'h-carbazol-4'-iloxi)-3-(2''-(2'''-metoxi-fenoxi)-etil)-amino)-2-propanol (carvedilol) y productos intermedios. Expired - Lifetime ES2196459T5 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU9702209 1997-11-24
HU9702209A HU9702209D0 (en) 1997-11-24 1997-11-24 Process for producing pharmaceutical product
HU9802180 1998-10-01
HU9802180A HU227441B1 (en) 1997-11-24 1998-10-01 Process for producing carvedilol, enantiomers and salts thereof

Publications (2)

Publication Number Publication Date
ES2196459T3 true ES2196459T3 (es) 2003-12-16
ES2196459T5 ES2196459T5 (es) 2006-12-01

Family

ID=89997149

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01111213T Expired - Lifetime ES2221875T3 (es) 1997-11-24 1998-11-24 Procedimiento para la preparacion de 1-(9'h-carbazol-4'-iloxi)-3-((2''-(2'''-metoxi-fenoxi)etil)-amino)-propan-2-ol(carvedilol).
ES98122114T Expired - Lifetime ES2196459T5 (es) 1997-11-24 1998-11-24 Procedimiento para la preparacion de 1-(9'h-carbazol-4'-iloxi)-3-(2''-(2'''-metoxi-fenoxi)-etil)-amino)-2-propanol (carvedilol) y productos intermedios.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES01111213T Expired - Lifetime ES2221875T3 (es) 1997-11-24 1998-11-24 Procedimiento para la preparacion de 1-(9'h-carbazol-4'-iloxi)-3-((2''-(2'''-metoxi-fenoxi)etil)-amino)-propan-2-ol(carvedilol).

Country Status (9)

Country Link
EP (3) EP0918055B2 (es)
CZ (2) CZ296521B6 (es)
DE (2) DE69823394T2 (es)
ES (2) ES2221875T3 (es)
HR (1) HRP980590B1 (es)
HU (1) HU227441B1 (es)
PL (1) PL205193B1 (es)
SK (1) SK284109B6 (es)
UA (1) UA57737C2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
DK174645B1 (da) * 2000-05-18 2003-08-04 Gea Farmaceutisk Fabrik As Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf
US6699997B2 (en) * 2000-06-28 2004-03-02 Teva Pharmaceutical Industries Ltd. Carvedilol
ES2291503T3 (es) * 2001-09-28 2008-03-01 F. Hoffmann-La Roche Ag Formas pseudopolimorficas de carvedilol.
PL371409A1 (en) * 2002-01-15 2005-06-13 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
SK285547B6 (sk) 2002-11-08 2007-03-01 Zentiva, A. S. Spôsob prípravy Carvedilolu
WO2004094378A1 (en) 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of carvedilol form-ii
WO2004113296A1 (en) * 2003-06-20 2004-12-29 Sun Pharmaceutical Industries Limited A process for preparation of 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propan-2-ol
GB0411273D0 (en) * 2004-05-20 2004-06-23 Cipla Ltd Process and product
WO2006135757A1 (en) * 2005-06-09 2006-12-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of carvedilol and processes for their preparation
KR100746455B1 (ko) * 2006-02-23 2007-08-03 안국약품 주식회사 고광학순도의 키랄 카베딜롤의 제조방법
EP1991527A2 (en) 2006-06-28 2008-11-19 Teva Pharmaceutical Industries Ltd Polymorphous forms of carvedilol phosphate
CZ302357B6 (cs) * 2007-01-26 2011-03-30 Zentiva, A. S. Zpusob cištení Carvedilolu
WO2009116069A2 (en) * 2008-02-04 2009-09-24 Ipca Laboratories Limited Process for preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(2- methoxyphenoxy) ethyl] amino]-2-propanol
WO2009115906A2 (en) * 2008-03-19 2009-09-24 Cadila Pharmaceuticals Ltd. An improved process for preparation of carvedilol involving halohydrin derivative
WO2009115902A1 (en) * 2008-03-19 2009-09-24 Cadila Pharmaceuticals Ltd. Process for the preparation of carvedilol via silyl protection of substituted amine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) † 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
DE3540149A1 (de) † 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Verwendung von 1-(benztriazol-4-yloxy)3-(2-(2-methoxyphenoxy) -ethylamino)-2-propanol als antiglaukommittel, optisch aktive r und s isomere dieser substanz, verfahren zur herstellung derselben sowie arzneimittel, die diese substanzen enthalten
ES2070151T3 (es) † 1988-08-10 1995-06-01 Otsuka Pharma Co Ltd Agentes cardiotonicos.

Also Published As

Publication number Publication date
DE69823394T2 (de) 2005-05-04
UA57737C2 (uk) 2003-07-15
EP1142874A2 (en) 2001-10-10
DE69813729T2 (de) 2004-02-05
EP1142873B1 (en) 2004-04-21
HU227441B1 (en) 2011-06-28
PL205193B1 (pl) 2010-03-31
CZ356198A3 (cs) 1999-06-16
DE69823394D1 (de) 2004-05-27
EP1142873A2 (en) 2001-10-10
PL329828A1 (en) 1999-06-07
EP0918055B1 (en) 2003-04-23
EP0918055B2 (en) 2006-04-26
CZ296521B6 (cs) 2006-04-12
ES2221875T3 (es) 2005-01-16
EP1142873A3 (en) 2003-09-10
ES2196459T5 (es) 2006-12-01
DE69813729D1 (de) 2003-05-28
HUP9802180A1 (hu) 2000-12-28
SK156098A3 (en) 1999-06-11
CZ297445B6 (cs) 2006-12-13
SK284109B6 (sk) 2004-09-08
HRP980590B1 (en) 2003-12-31
EP1142874A3 (en) 2003-10-22
HRP980590A2 (en) 1999-10-31
EP0918055A1 (en) 1999-05-26
DE69813729T3 (de) 2006-11-30
HU9802180D0 (en) 1998-11-30

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