ES2239558T1 - Hemitartrato de zolpidem micronizado. - Google Patents

Hemitartrato de zolpidem micronizado.

Info

Publication number
ES2239558T1
ES2239558T1 ES04010651T ES04010651T ES2239558T1 ES 2239558 T1 ES2239558 T1 ES 2239558T1 ES 04010651 T ES04010651 T ES 04010651T ES 04010651 T ES04010651 T ES 04010651T ES 2239558 T1 ES2239558 T1 ES 2239558T1
Authority
ES
Spain
Prior art keywords
zolpidem
approximately
zolpidem hemitartrate
micronized
degrees
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES04010651T
Other languages
English (en)
Other versions
ES2239558T3 (es
Inventor
Judith Aronhime
David Leonov
Erzebet Meszaros-Sos
Szaboles Salyi
Shlomo Zavurov
Csaba Szabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27394001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2239558(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of ES2239558T1 publication Critical patent/ES2239558T1/es
Application granted granted Critical
Publication of ES2239558T3 publication Critical patent/ES2239558T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • Amplifiers (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Liquid Machine Or Engine Such As Wave Power Use (AREA)

Abstract

Forma A de hemitartato de zolpidem micronizado que presenta unas partículas con un tamaño de hasta aproximadamente 200 micras medido por difracción láser y una curva de difracción de rayos X que presenta un pico de dos theta de aproximadamente 8,6 ñ 0,2 grados.

Claims (4)

1. Forma A de hemitartato de zolpidem micronizado que presenta unas partículas con un tamaño de hasta aproximadamente 200 micras medido por difracción láser y una curva de difracción de rayos X que presenta un pico de dos theta de aproximadamente 8,6 \pm 0,2 grados.
2. Hemitartrato de zolpidem según la reivindicación 1, caracterizado porque presenta además una curva de difracción de rayos X con unos picos de dos theta de 6,7, 11, 2, 15,4 y 17,3 \pm 0,2 grados.
3. Hemitartrato de zolpidem según la reivindicación 1 ó 2, en el que las partículas de hemitartrato de zolpidem presentan un tamaño de hasta aproximadamente 50 micras medido por difracción láser.
4. Composición farmacéutica que comprende una cantidad terapéuticamente efectiva de hemitartrato de zolpidem según cualquiera de las reivindicaciones anteriores y un vehículo farmacéuticamente aceptable.
ES04010651T 2000-04-24 2001-04-24 Hemitartrato de zolpidem micronizado. Expired - Lifetime ES2239558T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19929800P 2000-04-24 2000-04-24
US199298P 2000-04-24
US20602500P 2000-05-22 2000-05-22
US206025P 2000-05-22
US22536400P 2000-08-14 2000-08-14
US225364P 2000-08-14

Publications (2)

Publication Number Publication Date
ES2239558T1 true ES2239558T1 (es) 2005-10-01
ES2239558T3 ES2239558T3 (es) 2007-04-01

Family

ID=27394001

Family Applications (4)

Application Number Title Priority Date Filing Date
ES04010651T Expired - Lifetime ES2239558T3 (es) 2000-04-24 2001-04-24 Hemitartrato de zolpidem micronizado.
ES05001922T Expired - Lifetime ES2277301T3 (es) 2000-04-24 2001-04-24 Solvato de hemitartrato de zolpidem.
ES01930705T Expired - Lifetime ES2248321T3 (es) 2000-04-24 2001-04-24 Hemitartrato de zolpidem.
ES04010435T Expired - Lifetime ES2238941T3 (es) 2000-04-24 2001-04-24 Solvato de hemitartrato de zolpidem.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES05001922T Expired - Lifetime ES2277301T3 (es) 2000-04-24 2001-04-24 Solvato de hemitartrato de zolpidem.
ES01930705T Expired - Lifetime ES2248321T3 (es) 2000-04-24 2001-04-24 Hemitartrato de zolpidem.
ES04010435T Expired - Lifetime ES2238941T3 (es) 2000-04-24 2001-04-24 Solvato de hemitartrato de zolpidem.

Country Status (21)

Country Link
US (8) US20020077332A1 (es)
EP (1) EP1292304B1 (es)
JP (3) JP2003531173A (es)
KR (1) KR20030069796A (es)
AT (4) ATE348613T1 (es)
AU (2) AU2001257213B2 (es)
CA (1) CA2406982A1 (es)
CZ (1) CZ20023775A3 (es)
DE (7) DE20122435U1 (es)
DK (1) DK1292304T3 (es)
ES (4) ES2239558T3 (es)
HR (1) HRP20020909A2 (es)
HU (1) HUP0300701A2 (es)
IL (1) IL152411A0 (es)
NZ (1) NZ522015A (es)
PL (1) PL358548A1 (es)
PT (3) PT1473036E (es)
SE (1) SE5292304T3 (es)
SK (1) SK16372002A3 (es)
WO (1) WO2001080857A1 (es)
YU (1) YU79402A (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001284322A1 (en) 2000-08-29 2002-03-13 Ranbaxy Laboratories Limited Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem
US6869970B2 (en) 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
ES2320758T3 (es) 2002-12-18 2009-05-28 Mallinckrodt Inc. Sintesis de heteroaril acetamidas.
WO2004087703A1 (en) * 2003-03-12 2004-10-14 Sun Pharmaceutical Industries Limited Process for the preparation of n,n,6-trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide
EP1660496A1 (en) * 2003-07-31 2006-05-31 Ranbaxy Laboratories Limited Process for the synthesis of zolpidem
KR20130116378A (ko) * 2004-02-17 2013-10-23 트랜스셉트 파마슈티칼스, 인코포레이티드 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
WO2006008636A2 (en) * 2004-07-16 2006-01-26 Ranbaxy Laboratories Limited Processes for the preparation of zolpidem and its hemitartrate
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20060276501A1 (en) * 2005-05-25 2006-12-07 Transoral Pharmaceuticals, Inc. Solid compositions for treating middle-of-the-night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
RU2008110477A (ru) * 2005-08-19 2009-09-27 Авентис Фармасьютикалз Инк. (Us) Комбинация снотворного и r (+)-а-(2, 3-диметоксифенил)-1-[2-(4-фторфенил)этил]-4-пиперидинметанола и его терапевтическое применение
KR20080038416A (ko) * 2005-08-19 2008-05-06 아벤티스 파마슈티칼스 인크. 수면제와 치환된 비스 아릴 및 헤테로아릴 화합물의 배합물및 이의 치료요법적 용도
WO2007040995A1 (en) * 2005-10-03 2007-04-12 Mallinckrodt Inc. Process for preparing zolpidem hemitartrate and tartrate polymorphs
CA2626242A1 (en) * 2005-10-17 2007-04-26 Mallinckrodt Inc. Polymorph transformation of zolpidem in tablet matrix
US20070098788A1 (en) * 2005-10-28 2007-05-03 Gore Subhash P Non-benzodiazepine hypnotic compositions
WO2007117399A2 (en) 2006-03-31 2007-10-18 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
US20080132535A1 (en) * 2006-11-30 2008-06-05 Transcept Pharmaceuticals, Inc. Stabilized Zolpidem Pharmaceutical Compositions
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
MY157197A (en) * 2008-06-30 2016-05-13 Janssen Pharmaceutica Nv Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
SG10201407881WA (en) 2009-11-27 2015-01-29 Genzyme Corp An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
RS59909B1 (sr) * 2013-03-06 2020-03-31 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidinski modulatori histaminskog h4 receptora
CN116283958B (zh) * 2021-12-03 2026-02-24 山东新时代药业有限公司 唑吡坦共晶体及其制备方法
CN116283957A (zh) * 2021-12-03 2023-06-23 山东新时代药业有限公司 唑吡坦水合物及其制备方法
CN117907368A (zh) * 2024-01-27 2024-04-19 鲁南贝特制药有限公司 一种酒石酸唑吡坦药用晶型d中晶型a、e的定量测定方法
CN118750459B (zh) * 2024-07-22 2025-04-01 常州市武进中医医院 一种酒石酸唑吡坦片及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
FR2408345A1 (fr) * 1976-11-30 1979-06-08 Besins Jean Louis Nouvelle composition a action anti-conceptionnelle
US4302446A (en) * 1979-10-02 1981-11-24 Bristol-Myers Company Pharmaceutical compositions
IT1130924B (it) * 1980-03-06 1986-06-18 Secifarma Spa Procedimento per la preparazione di spironolattone micronizzato
DE3018940A1 (de) * 1980-05-17 1981-11-26 Hoechst Ag, 6000 Frankfurt Verwendung eines vinylchlorid-pfropf-copolymerisates in der plastisolverarbeitung
FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
FR2525601A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Derives d'imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4675323A (en) * 1985-08-06 1987-06-23 Synthelabo Imidazo(1,2-a)quinoline derivatives useful as anxiolytic agents
SE457326B (sv) * 1986-02-14 1988-12-19 Lejus Medical Ab Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
FR2600650B1 (fr) * 1986-06-27 1988-09-09 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires
FR2606410B1 (fr) * 1986-11-07 1989-02-24 Synthelabo Imidazopyridines, leur preparation et leur application en therapeutique
DE3865073D1 (de) * 1987-03-27 1991-10-31 Synthelabo Imidazopyridinderivate, ihre herstellung und therapeutische verwendung.
US5271944A (en) * 1991-04-05 1993-12-21 Biofor, Ltd. Pharmacologically enhanced formulations
IT1276522B1 (it) * 1995-04-07 1997-10-31 Elena Benincasa Uso dello zolpidem per il trattamento terapeudico di sindromi neuropsichiatriche associate a disfunsione e di circuiti neurali dei
DE60020814T2 (de) * 1999-03-25 2006-05-04 Synthon B.V. Zolpidem salze
EP1038875B1 (en) * 1999-03-25 2003-06-04 Synthon B.V. Imidazopyridine derivatives and process for making them
WO2001042239A1 (en) * 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound

Also Published As

Publication number Publication date
US20020077332A1 (en) 2002-06-20
CZ20023775A3 (cs) 2003-10-15
WO2001080857A1 (en) 2001-11-01
DE60114617D1 (de) 2005-12-08
PT1473036E (pt) 2006-10-31
JP2006137778A (ja) 2006-06-01
EP1292304A4 (en) 2003-07-23
DE04010651T1 (de) 2005-09-01
PT1541146E (pt) 2007-01-31
EP1292304B1 (en) 2005-11-02
DK1292304T3 (da) 2005-12-19
WO2001080857A9 (en) 2002-06-27
JP2003531173A (ja) 2003-10-21
DE04010435T1 (de) 2005-09-01
DE60114617T2 (de) 2006-07-27
DE60122944D1 (de) 2006-10-19
KR20030069796A (ko) 2003-08-27
DE60125429D1 (de) 2007-02-01
US20040220211A1 (en) 2004-11-04
YU79402A (sh) 2006-03-03
PT1475093E (pt) 2006-11-30
DE60122944T2 (de) 2007-04-12
EP1292304A1 (en) 2003-03-19
JP2006249105A (ja) 2006-09-21
ATE308324T1 (de) 2005-11-15
ES2239558T3 (es) 2007-04-01
PL358548A1 (en) 2004-08-09
CA2406982A1 (en) 2001-11-01
US20040220212A1 (en) 2004-11-04
US20040220210A1 (en) 2004-11-04
ES2238941T1 (es) 2005-09-16
DE60122216D1 (de) 2006-09-21
HUP0300701A2 (hu) 2003-07-28
ES2248321T3 (es) 2006-03-16
SK16372002A3 (sk) 2003-04-01
US20040214858A1 (en) 2004-10-28
DE20122435U1 (de) 2005-10-06
ES2277301T3 (es) 2007-07-01
ES2238941T3 (es) 2007-04-01
SE5292304T3 (es) 2005-11-02
DE60125429T2 (de) 2007-09-27
ATE338550T1 (de) 2006-09-15
US20070037843A1 (en) 2007-02-15
AU2001257213B2 (en) 2005-09-29
AU5721301A (en) 2001-11-07
US20040220213A1 (en) 2004-11-04
NZ522015A (en) 2004-08-27
US20040214859A1 (en) 2004-10-28
DE60122216T2 (de) 2007-08-30
HRP20020909A2 (en) 2004-08-31
IL152411A0 (en) 2003-05-29
ATE335481T1 (de) 2006-09-15
ATE348613T1 (de) 2007-01-15

Similar Documents

Publication Publication Date Title
JP2004504381A5 (es)
IT9022155A0 (it) Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione
ES2238941T1 (es) Solvato de hemitartrato de zolpidem.
ATE486840T1 (de) Modifizierte formen pharmazeutisch aktiver agenzien und verwendungen dafür
EE200100235A (et) cGMP PDE-5 inhibiitorit sisaldavad kontrollitud vabanemisega farmatseutilised formulatsioonid
PL361341A1 (pl) Nowa kompozycja farmaceutyczna
HUP0102039A3 (en) Use of paclitaxel stabilized with albumin for the preparation of pharmaceutical compositions treating solid tumors and the pharmaceutical compositions obtained thereby
IL150225A0 (en) Lipopeptides, pharmaceutical compositions containing the same and methods for the production thereof
BR0207961A (pt) Combinação de análogos da epotilona e agentes quimioterápicos para o tratamento de doenças proliferativas
IL150223A0 (en) Lipopeptides and pharmaceutical compositions containing the same
ATE101517T1 (de) Pharmazeutische zusammensetzung, enthaltend loratadin, ibuprofen und pseudoephedrin.
TR199801861T2 (xx) Farmas�tik olarak yararl� bile�imler.
ITMI950568A0 (it) Formulazioni farmaceutiche in forma di gel tissotropico
IL177018A0 (en) Cyclopropyl-fused pyrrolidine derivatives and pharmaceutical compositions containing the same
DE60142197D1 (de) Pharmazeutische Zusammensetzung
DK1467724T3 (da) Farmaceutisk sammensætning med agomelatin til dispergering i mundhulen
IL158671A0 (en) Benzyloxy derivatives and pharmaceutical compositions containing the same
ATE302746T1 (de) Amorphe salpetersäureester und deren pharmazeutische zusammensetzungen
WO2005032470A3 (en) Compositions and methods for treating burns
IT1302682B1 (it) Composizioni farmaceutiche orali contenenti buprenorfina
MX9100080A (es) Composiciones farmaceuticas y metodos para aliviar sintomas gastrointestinales inducidos por drogas antiinflamatorias no esteroidales
BRPI0415123A (pt) uso de l-butilftalida e respectiva composição farmacêutica
ATE366128T1 (de) Pharmazeutische zusammensetzung
RU2003105901A (ru) Противовоспалительное лекарственное средство
FR2804024B1 (fr) Nouvelles compositions pharmaceutiques a action anti- inflammatoire et leur procede de preparation