ES2531053T3 - Ligandos de diacilhidrazina para modular la expresión de genes exógenos en sistemas de mamífero a través de un complejo de receptor de ecdisona - Google Patents

Ligandos de diacilhidrazina para modular la expresión de genes exógenos en sistemas de mamífero a través de un complejo de receptor de ecdisona Download PDF

Info

Publication number
ES2531053T3
ES2531053T3 ES12156069T ES12156069T ES2531053T3 ES 2531053 T3 ES2531053 T3 ES 2531053T3 ES 12156069 T ES12156069 T ES 12156069T ES 12156069 T ES12156069 T ES 12156069T ES 2531053 T3 ES2531053 T3 ES 2531053T3
Authority
ES
Spain
Prior art keywords
cyano
alkyl
alkenyl
halo
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES12156069T
Other languages
English (en)
Inventor
Robert Eugene Hormann
Colin M Tice
Orestes Chortyk
Howard Smith
Thomas Meteyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Precigen Inc
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Application granted granted Critical
Publication of ES2531053T3 publication Critical patent/ES2531053T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C07D213/87—Hydrazides; Thio or imino analogues thereof in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Compuesto de fórmula general:**Fórmula** en la que X y X' son independientemente O o S; Y es: (a) fenilo sustituido o no sustituido en el que los sustituyentes son independientemente 1-5 H, alquilo (C1-C4), alcoxilo (C1-C4), alquenilo (C2-C4), halo (F, Cl, Br, I), haloalquilo (C1-C4), hidroxilo, amino, ciano o nitro; o (b) 2-piridilo, 3-piridilo o 4-piridilo sustituidos o no sustituidos, en los que los sustituyentes son independientemente 1-4 H, alquilo (C1-C4), alcoxilo (C1-C4), alquenilo (C2-C4), halo (F, Cl, Br, I), haloalquilo (C1-C4), hidroxilo, amino, ciano o nitro; R1 y R2 son independientemente alquilo de cadena lineal o ramificada (C1-C7) sustituido con ciano o no sustituido o alquenilo de cadena lineal o ramificada (C2-C7) sustituido con ciano o no sustituido; alquenilalquilo de cadena lineal o ramificada (C3-C7) sustituido con ciano o no sustituido; R3 es H, metilo, etilo, n-propilo, isopropilo o ciano; R4, R7 y R8 son independientemente H, alquilo (C1-C4), alcoxilo (C1-C4), alquenilo (C2-C4), halo (F, Cl, Br, I), haloalquilo (C1-C4), hidroxilo, amino, ciano o nitro; y R5 y R6 son independientemente H, alquilo (C1-C4), alquenilo (C2-C4), alquenilalquilo (C3-C4), halo (F, Cl, Br, I), haloalquilo C1-C4, alcoxilo (C1-C4), hidroxilo, amino, ciano o nitro, siempre que el número de átomos de carbono, excluyendo los de la sustitución de ciano, para cualquiera o ambos de los grupos R1 o R2 sea mayor que 4, y el número de átomos de carbono, excluyendo los de la sustitución de ciano, para la suma de los grupos R1, R2 y R3 sea de 10,11 ó 12.
ES12156069T 2003-02-10 2004-02-10 Ligandos de diacilhidrazina para modular la expresión de genes exógenos en sistemas de mamífero a través de un complejo de receptor de ecdisona Expired - Lifetime ES2531053T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44623303P 2003-02-10 2003-02-10
US10/775,883 US7304161B2 (en) 2003-02-10 2004-02-09 Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex

Publications (1)

Publication Number Publication Date
ES2531053T3 true ES2531053T3 (es) 2015-03-10

Family

ID=32871979

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12156069T Expired - Lifetime ES2531053T3 (es) 2003-02-10 2004-02-10 Ligandos de diacilhidrazina para modular la expresión de genes exógenos en sistemas de mamífero a través de un complejo de receptor de ecdisona
ES04709841.3T Expired - Lifetime ES2478622T3 (es) 2003-02-10 2004-02-10 Ligandos de diacilhidrazina para modular la expresión de genes exógenos en sistemas de mamífero a través de un complejo de receptor de ecdisona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES04709841.3T Expired - Lifetime ES2478622T3 (es) 2003-02-10 2004-02-10 Ligandos de diacilhidrazina para modular la expresión de genes exógenos en sistemas de mamífero a través de un complejo de receptor de ecdisona

Country Status (8)

Country Link
US (5) US7304161B2 (es)
EP (2) EP1603860B1 (es)
JP (1) JP4598757B2 (es)
AU (1) AU2004210957B2 (es)
CA (2) CA2791225C (es)
DK (2) DK2455375T3 (es)
ES (2) ES2531053T3 (es)
WO (1) WO2004072254A2 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
EP1373470B1 (en) 2001-02-20 2013-04-24 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
CA2438133C (en) 2001-02-20 2015-01-27 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
WO2002066613A2 (en) 2001-02-20 2002-08-29 Rheogene Holdings, Inc Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system
ES2424812T3 (es) 2001-02-20 2013-10-08 Intrexon Corporation Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso
WO2003027289A1 (en) 2001-09-26 2003-04-03 Rheo Gene Holdings, Inc. Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
US7304161B2 (en) * 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7101798B2 (en) 2003-11-17 2006-09-05 Intel Corporation Method to modulate etch rate in SLAM
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
PE20090305A1 (es) * 2007-05-22 2009-03-15 Wyeth Corp Proceso mejorado para la elaboracion de hidrazidas
CN104761466A (zh) * 2007-05-29 2015-07-08 英特拉克森公司 通过蜕皮素受体复合物调节外源性基因表达的手性二酰基肼配体
AU2013204101B2 (en) * 2007-05-29 2015-07-02 Intrexon Corporation Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
WO2009025866A1 (en) 2007-08-23 2009-02-26 Intrexon Corporation Methods and compositions for diagnosing disease
KR101666228B1 (ko) 2007-09-28 2016-10-13 인트렉손 코포레이션 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도
HUE035406T2 (en) 2007-10-08 2018-05-02 Intrexon Corp Engineered dendritic cells and uses for the treatment of cancer
FR2924712B1 (fr) * 2007-12-06 2012-12-21 Univ Maine Derives du gossypol et de l'apogossypol, leurs preparations et leurs applications
EP2265116A4 (en) 2008-03-14 2013-02-06 Intrexon Corp STEROID LIGANDS AND THEIR USE IN GENE SWITCH MODULATION
CA2794196A1 (en) 2010-03-23 2011-09-29 Intrexon Corporation Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
SG10201600912SA (en) 2011-03-04 2016-03-30 Intrexon Corp Vectors conditionally expressing protein
CA3061802C (en) 2011-09-08 2022-04-05 Intrexon Corporation Crystalline diacylhydrazine and the use thereof
ES2683329T3 (es) 2013-03-15 2018-09-26 Intrexon Corporation Diacilhidrazinas que contienen boro
WO2016044390A1 (en) * 2014-09-17 2016-03-24 Intrexon Corporation Boron-containing diacylhydrazine compounds
US20160205433A1 (en) * 2015-01-08 2016-07-14 Wipro Limited Method and system for managing tuners of client devices
SG11201802912PA (en) 2015-10-10 2018-05-30 Intrexon Corp Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12
WO2017083750A1 (en) 2015-11-11 2017-05-18 Intrexon Corporation Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies
US11052111B2 (en) 2015-12-08 2021-07-06 Chimera Bioengineering, Inc. Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses
US11092599B2 (en) 2016-02-24 2021-08-17 Aromyx Corporation Biosensor for detecting smell, scent, and taste
EP3443001B1 (en) 2016-04-11 2025-04-30 Obsidian Therapeutics, Inc. REGULATED BIOCIRCUIT SYSTEMS
WO2017199227A1 (en) 2016-05-20 2017-11-23 S & I Ophthalmic, Llc. Process for preparation of 3,4-dihydroxy-2-methyl benzoic acid alkylester
UY37343A (es) 2016-07-25 2018-02-28 Intrexon Corp Control del fenotipo en plantas
EP4342978A3 (en) 2016-09-01 2024-07-03 Chimera Bioengineering Inc. Gold optimized car t-cells
CN110139933B (zh) 2016-11-09 2024-03-08 英特瑞克斯顿股份有限公司 共济蛋白表达构建体
KR20190102259A (ko) 2017-01-10 2019-09-03 인트렉손 코포레이션 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절
WO2019173465A1 (en) 2018-03-06 2019-09-12 Intrexon Corporation Human papillomavirus vaccines and uses of the same
IL277128B2 (en) 2018-03-06 2025-11-01 Precigen Inc Hepatitis b vaccines and uses of the same
WO2020206056A1 (en) 2019-04-04 2020-10-08 Greenvenus Llc Peptides and methods of plant protection

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US626173A (en) * 1899-05-30 Apparatus for treating ores
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US5354762A (en) 1986-07-14 1994-10-11 Rohm And Haas Company Six-membered heterocyclic derivatives of N'-substituted N,N'-diacylhydrazines
US5117057A (en) 1985-10-21 1992-05-26 Rohm And Haas Company Insecticidal N' substituted-N-N'-disubstituted-hydrazines
US4985461A (en) * 1985-10-21 1991-01-15 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
DK483586A (da) 1985-10-21 1987-04-22 Rohm & Haas Insecticide n'-substituerede-n,n'-diacylhydraziner
US5424333A (en) * 1985-10-21 1995-06-13 Rohm And Haas Company Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines
US4814349A (en) * 1985-12-09 1989-03-21 American Cyanamid Company Insecticidal substituted and unsubstituted benzoic acid 1-alkyl, 2 alkyl and 2-cycloalkylhydrazides
ATE72231T1 (de) 1985-12-09 1992-02-15 American Cyanamid Co Insektentoetende diacylhydrazinverbindungen.
CA1338289C (en) 1986-01-22 1996-04-30 Raymond August Murphy Insecticidal n'-substituted-n-alkylcarbonyl- n'-acylhydrazines
CA1295618C (en) 1986-02-28 1992-02-11 Adam Chi-Tung Hsu Insecticidal n'-substituted-n-acyl -n'-alkylcarbonylhydrazines
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5225443A (en) 1986-05-01 1993-07-06 Rohm And Haas Company Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines
CA1281716C (en) 1986-05-01 1991-03-19 Raymond August Murphy Insecticidal n-substituted-n'-substituted-n,n'- diacylhydrazines
JPS62293150A (ja) 1986-06-13 1987-12-19 Amada Co Ltd 同期整流回路
DE3774347D1 (de) 1986-07-14 1991-12-12 Rohm & Haas Sechsgliedrige heterocyclische derivate von n'-substituierten n,n'-diacylhydrazinen.
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
ES2022342B3 (es) 1987-04-15 1991-12-01 Rohm & Haas Hidrazinas n-(opcinalmente sustituidas)-n'-sustituidas-n, n'-disustituidas, insecticidas.
US4813439A (en) 1987-06-09 1989-03-21 Susan Morgan Hair treatment solution applicator
US4906280A (en) * 1987-10-14 1990-03-06 Pennwalt Corporation Tertiary butylhydrazides as plant growth regulators
US5171671A (en) 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5429952A (en) * 1988-02-02 1995-07-04 Biocode, Inc. Marking of products to establish identity and source
US5110986A (en) 1988-04-26 1992-05-05 Rohm And Haas Company Synthesis of n-t-alkyl-1,2-diacylhydrazines
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
WO1989012690A1 (en) 1988-06-13 1989-12-28 American Biogentic Sciences, Inc. Method for the production of monoclonal antibodies utilizing a germfree animal
NZ229536A (en) 1988-06-15 1992-05-26 Rohm & Haas N'-substituted-n'-substituted carbonyl-n-substituted carbonyl-hydrazines and pesticidal compositions
AU637573B2 (en) 1988-06-16 1993-06-03 Dow Agrosciences Llc Hydrazine derivatives for pharmaceutical use
JPH02207066A (ja) 1989-02-07 1990-08-16 Ishihara Sangyo Kaisha Ltd ヒドラジン系化合物、それらの製造方法及びそれらを含有する有害動物防除剤
US5354844A (en) 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US4950666A (en) * 1989-03-30 1990-08-21 Fmc Corporation Difluoroalkane and difluoroalkenylalkane pesticides
US4954655A (en) * 1989-03-31 1990-09-04 Rohm And Haas Company Preparation of alkylhydrazines
EP0395581A1 (de) 1989-04-27 1990-10-31 Ciba-Geigy Ag N-Sulfenyl- und N-sulfinyl-N,N'-diacylhydrazide
NZ228936A (en) 1989-05-01 1992-04-28 Rohm & Haas Method for treating insect infestation in rice plants comprising applying diacylhydrazine derivatives
JPH03141245A (ja) 1989-10-24 1991-06-17 Ishihara Sangyo Kaisha Ltd ヒドラジン系化合物、それらの製造方法及びそれらを含有する有害動物防除剤
JPH03145447A (ja) 1989-10-31 1991-06-20 Nissan Chem Ind Ltd ジベンゾイルヒドラジン化合物および殺虫剤
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
CA2075182C (en) 1990-02-09 2003-03-25 David J. Mangelsdorf Retinoid receptor compositions and methods
DE69133064T2 (de) * 1990-02-26 2003-03-06 The Board Of Trustees Of The Leland Stanford Junior University, Stanford Identifizierung und expression von insekten-steroidrezeptor-dns-sequenzen
AU655417B2 (en) 1990-03-22 1994-12-22 Salk Institute For Biological Studies, The Insect retinoid receptor compositions and methods
US7119077B1 (en) 1990-03-22 2006-10-10 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
US5688691A (en) 1990-03-22 1997-11-18 The Salk Institute For Biological Studies Insect retinoid-like receptor compositions and methods
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
CA2043775A1 (en) 1990-06-14 1991-12-15 Dat P. Le Dibenzoylakylcyanohydrazines
US5139749A (en) 1990-06-22 1992-08-18 Tas, Inc. Fluidized calcining process
JP3068846B2 (ja) 1990-08-01 2000-07-24 日本化薬株式会社 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物
JPH0539252A (ja) 1990-08-01 1993-02-19 Nippon Kayaku Co Ltd Ｎ，Ｎ’−ジベンゾイル−ｔｅｒｔ−ブチルヒドラジン誘導体およびそれを有効成分とする殺虫組成物
JP2885902B2 (ja) 1990-08-01 1999-04-26 日本化薬株式会社 Ｎ’―ｔｅｒｔ―ブチル―Ｎ―ハロゲノメチルスルフェニル―Ｎ，Ｎ’―ジベンゾイルヒドラジン誘導体およびそれを有効成分とする殺虫組成物
US5075471A (en) * 1990-10-09 1991-12-24 Rohm And Haas Company Insecticidal ferrocenoyl acylhydrazines
JP3087854B2 (ja) 1991-01-09 2000-09-11 日本化薬株式会社 新規ヒドラジン誘導体及びそれを有効成分とする殺虫組成物
IL100643A (en) 1991-01-25 1996-10-31 Nippon Kayaku Kk History of hydrazine and pesticides containing these histories as an active ingredient
US5229562A (en) * 1991-04-05 1993-07-20 The Boeing Company Process for consolidation of composite materials
US5668175A (en) 1991-08-23 1997-09-16 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like retinoids
WO1993003713A1 (en) 1991-08-23 1993-03-04 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones
WO1993006215A1 (en) 1991-09-17 1993-04-01 The Salk Institute For Biological Studies Receptor of the thyroid/steroid hormone receptor superfamily
JPH07503609A (ja) 1991-12-06 1995-04-20 ザ　ソールク　インスチチュート　フォア　バイオロジカル　スタディズ リセプターのステロイド／甲状腺スーパーファミリーのメンバーの多量体型
US5530028A (en) 1992-11-23 1996-06-25 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US5344958A (en) * 1992-11-23 1994-09-06 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US6013836A (en) * 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
JPH06172342A (ja) 1992-12-07 1994-06-21 Nippon Kayaku Co Ltd 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物
JP3298954B2 (ja) 1992-12-16 2002-07-08 三共株式会社 新規ｎ，ｎ’−ジベンゾイルヒドラジン誘導体及び殺虫組成物
JP3394777B2 (ja) 1993-05-27 2003-04-07 セレクタイド コーポレーション 位相学的に分離された、コードされた固相ライブラリー
US5358966A (en) * 1993-06-08 1994-10-25 Rohm And Haas Company Turfgrass insecticides
DE69406227T2 (de) 1993-08-19 1998-04-30 Rohm & Haas Die Herstellung von 1,2-Diacyl-2-(t-alkyl)-Hydrazinen
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
US5482962A (en) * 1994-07-22 1996-01-09 Rohm And Haas Company Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines
FR2727679B1 (fr) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
CA2210248A1 (en) 1995-01-13 1996-07-18 Ronald M. Evans Allosteric control of nuclear hormone receptors
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
JP3600298B2 (ja) 1995-02-27 2004-12-15 日本化薬株式会社 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物
JPH08231529A (ja) 1995-02-27 1996-09-10 Nippon Kayaku Co Ltd ヒドラジン誘導体およびそれを有効成分とする殺虫組成物
ATE293699T1 (de) 1995-03-03 2005-05-15 Syngenta Participations Ag Kontrolle der pflanzengenexpression durch rezeptor-vermittelte transaktivation in gegenwart von einem chemischen ligand
CA2219121A1 (en) 1995-05-26 1996-11-28 Zeneca Limited A gene switch comprising an ecdysone receptor
JPH09100262A (ja) 1995-06-06 1997-04-15 Rohm & Haas Co Ｎ，Ｎ’−ジアシル−Ｎ’−ｔ−アルキルヒドラジン化合物の製造方法
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
AU734051B2 (en) 1996-04-05 2001-05-31 Salk Institute For Biological Studies, The Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6723531B2 (en) 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6025483A (en) * 1996-06-05 2000-02-15 The Regents Of The University Of California Maize and cauliflower apetalai gene products and nucleic acid molecules encoding same
US5919667A (en) 1996-06-20 1999-07-06 The Salk Institute For Biological Studies Modular assembly retroviral vectors and uses thereof
US5948406A (en) * 1996-08-12 1999-09-07 Rohm And Haas Company Immunogens, antibodies formed therefrom, and coating antigens useful in a diacylhydrazine immunoassay method
AU738494B2 (en) 1997-07-10 2001-09-20 Salk Institute For Biological Studies, The Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression
US6300488B1 (en) 1997-07-10 2001-10-09 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
DE19837620A1 (de) 1997-08-22 1999-02-25 Novartis Ag Organische Verbindungen
US6117680A (en) 1997-08-26 2000-09-12 Ariad Gene Therapeutics, Inc. Compositions and methods for regulation of transcription
US6756491B2 (en) 1998-01-09 2004-06-29 The Salk Institute For Biological Studies Steroid-activated nuclear receptors and uses therefor
AUPP135698A0 (en) 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US6333318B1 (en) 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6258603B1 (en) * 1998-06-17 2001-07-10 Rohm And Haas Company Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
JP2000026423A (ja) 1998-07-09 2000-01-25 Otsuka Chem Co Ltd イソニコチノイルヒドラジン誘導体及び該誘導体を有効成分として含有する害虫防除剤
DE19831710A1 (de) * 1998-07-15 2000-01-20 Merck Patent Gmbh Diacylhydrazinderivate
EP0984009A1 (en) 1998-08-25 2000-03-08 Rohm And Haas Company Benzodioxincarboxylic acid hydrazides as insecticides
US6117639A (en) 1998-08-31 2000-09-12 Vertex Pharmaceuticals Incorporated Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
US5989863A (en) 1998-10-14 1999-11-23 Incyte Pharmaceuticals, Inc. Human ankyrin family protein
CN1177813C (zh) 1999-09-06 2004-12-01 华东理工大学 1,2-烷(芳)酰基芳酰基肼类昆虫生长调节剂及制备和应用
US7057015B1 (en) 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
AU2001241682A1 (en) 2000-02-24 2001-09-03 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
JP5031967B2 (ja) 2000-03-22 2012-09-26 イントレキソン コーポレーション 新規エクジソン受容体ベースの誘導性遺伝子発現系
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
ES2424812T3 (es) 2001-02-20 2013-10-08 Intrexon Corporation Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso
CA2438133C (en) 2001-02-20 2015-01-27 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
WO2002066613A2 (en) * 2001-02-20 2002-08-29 Rheogene Holdings, Inc Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system
EP1373470B1 (en) 2001-02-20 2013-04-24 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
CN1161325C (zh) 2001-03-26 2004-08-11 江苏省农药研究所 作为杀虫剂的二酰基肼类化合物及制备此种化合物的中间体以及它们的制备方法
CA2459807C (en) 2001-09-26 2013-09-03 Jianzhong Zhang Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
WO2003027289A1 (en) 2001-09-26 2003-04-03 Rheo Gene Holdings, Inc. Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
US20050228016A1 (en) 2002-06-13 2005-10-13 Enrique Michelotti Tetrahydroquinolines for modulating the expression of exogenous genes via an ecdysone receptor complex
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
JP4178380B2 (ja) 2002-10-04 2008-11-12 栗田工業株式会社 メンテナンス管理システム
US7304161B2 (en) * 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7304162B2 (en) 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US9034650B2 (en) 2005-02-02 2015-05-19 Intrexon Corporation Site-specific serine recombinases and methods of their use
US9331524B1 (en) 2010-07-03 2016-05-03 Best Energy Reduction Technologies, Llc Method, system and apparatus for monitoring and measuring power usage
US9814215B2 (en) 2014-03-11 2017-11-14 Little Big Cat, Inc. Pet toy with telescoping wand with metallic wire

Also Published As

Publication number Publication date
DK1603860T3 (da) 2014-07-14
EP2455375B1 (en) 2014-11-19
EP2455375A3 (en) 2012-08-22
WO2004072254A3 (en) 2005-05-19
EP1603860A4 (en) 2008-05-14
US20080194521A1 (en) 2008-08-14
EP2455375A2 (en) 2012-05-23
US20080214627A1 (en) 2008-09-04
CA2791225C (en) 2014-10-21
WO2004072254A2 (en) 2004-08-26
AU2004210957A1 (en) 2004-08-26
US20050209283A1 (en) 2005-09-22
US7851220B2 (en) 2010-12-14
CA2791225A1 (en) 2004-08-26
CA2513807A1 (en) 2004-08-26
DK2455375T3 (en) 2015-02-23
AU2004210957B2 (en) 2011-03-03
CA2513807C (en) 2012-12-11
JP2006517964A (ja) 2006-08-03
EP1603860B1 (en) 2014-04-09
JP4598757B2 (ja) 2010-12-15
US8748125B2 (en) 2014-06-10
US20080103113A1 (en) 2008-05-01
EP1603860A2 (en) 2005-12-14
US20150005256A1 (en) 2015-01-01
US9272986B2 (en) 2016-03-01
ES2478622T3 (es) 2014-07-22
US7304161B2 (en) 2007-12-04

Similar Documents

Publication Publication Date Title
ES2531053T3 (es) Ligandos de diacilhidrazina para modular la expresión de genes exógenos en sistemas de mamífero a través de un complejo de receptor de ecdisona
AR035548A1 (es) Compuestos organicos
AR117916A1 (es) Compuesto heterocíclico y su uso
CO5611128A2 (es) Compuestos derivados de n-aril-2-oxazolidinona-5-carboxamida como agentes antibacteriales
ECSP034611A (es) Aminotiazoles y su uso como antagonistas del receptor de adenosina
ES2193590T3 (es) Derivados de imidazol que tienen actividad inhibitoria frente a la farnesil transferasa y procedimiento para la preparacion de los mismos.
CY1110651T1 (el) Παραγωγα της ν-'(1,5-διφαινυλ-1η- πυραζολ-3-υλ)μεθυλ σουλφοναμιδης με μια συγγενεια για τους υποδοχεις cb1
CO6260062A2 (es) (carboxilalquilenfenil)feniloxamidas metodo para su produccion y uso de las mismas como medicamentos
AR060749A1 (es) Uso de bifenilamidas de acido arilcarboxilico para el tratamiento de semillas
TN2009000081A1 (en) 2-ARYL-6-PHENYLIMIDAZO[1,2- α ] PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
AR031597A1 (es) Compuestos piperidinos,un proceso para su preparacion, composiciones farmaceuticas,y el uso de dichos compuestos para la fabricacion de un medicamento para uso como inhibidores ccr-3
ES2161382T3 (es) Derivados de pirazol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
HRP20070203T3 (hr) Derivati n-[fenil(alkilpiperidin-2-il)metil]benzamida, njihovo dobivanje i njihova primjena u terapiji
ES2191484T3 (es) Compuestos heterociclicos como inhibidores de enzimas de rotamasa.
CO5380019A1 (es) Azalidas de 13 miembros utiles como agentes antibioticos
DK0613366T3 (da) 5,6-dihydroxyindoliner som additiver til hårfarvende præparater
AR001061A1 (es) Composición fungicida sinergica procedimiento par a combatir hongos nocivos uso de los compuestos que integran dicha composición como componentes sinergicos de la misma
ES2121183T3 (es) Ligandos selectivos de los receptores 5ht1d-5ht1b derivados de indol-piperacina utiles como medicamentos.
BRPI0506927A (pt) compostos orgánicos
YU45805B (sh) Postupak za dobijanje dihidroimidazopirolopiridina hinolina, tieno-i furo/2,3-b/ piridina, dihidrotieno i furo/2,3-b/piridina, tieno- i furo/3,2-b/piridina i dihidrotieno i furo/3,2-b/piridina
CR7249A (es) Derivados de diamina, proceso para producir los derivados de diamina, y funguicidas que contienen los derivados de diamina como ingrediente activo
PY0435702A (es) Mezclas fungicidas a base de derivados de carbamato e insecticidas
AR016416A1 (es) Fenil-alquil-imidazoles, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de un medicamento
DE69817810D1 (de) Cyanoguanidine als zellproliferation inhibitoren
CO5170535A1 (es) Derivados de n-[2-(4-aminofenil)etil]2,3-dihidro-1,4- benzodioxin-2-metanamina, su preparacion y su aplciacion en terapeutica