ES545319A0 - Un procedimiento para preparar derivados de trimetoxibencil-isoquinolinio - Google Patents

Un procedimiento para preparar derivados de trimetoxibencil-isoquinolinio

Info

Publication number
ES545319A0
ES545319A0 ES545319A ES545319A ES545319A0 ES 545319 A0 ES545319 A0 ES 545319A0 ES 545319 A ES545319 A ES 545319A ES 545319 A ES545319 A ES 545319A ES 545319 A0 ES545319 A0 ES 545319A0
Authority
ES
Spain
Prior art keywords
trimetoxibencil
isoquinolinio
derivatives
preparing
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES545319A
Other languages
English (en)
Other versions
ES8609260A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
General Hospital Corp
Original Assignee
Wellcome Foundation Ltd
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd, General Hospital Corp filed Critical Wellcome Foundation Ltd
Publication of ES545319A0 publication Critical patent/ES545319A0/es
Publication of ES8609260A1 publication Critical patent/ES8609260A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Jib Cranes (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Fats And Perfumes (AREA)
  • Cephalosporin Compounds (AREA)
ES545319A 1984-07-18 1985-07-17 Un procedimiento para preparar derivados de trimetoxibencil-isoquinolinio Expired ES8609260A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds

Publications (2)

Publication Number Publication Date
ES545319A0 true ES545319A0 (es) 1986-09-01
ES8609260A1 ES8609260A1 (es) 1986-09-01

Family

ID=10564058

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545319A Expired ES8609260A1 (es) 1984-07-18 1985-07-17 Un procedimiento para preparar derivados de trimetoxibencil-isoquinolinio

Country Status (30)

Country Link
US (1) US4761418A (es)
EP (1) EP0181055B1 (es)
JP (1) JPH0662568B2 (es)
AT (1) ATE60759T1 (es)
AU (1) AU574481B2 (es)
BG (1) BG60411B2 (es)
CA (1) CA1273341A (es)
CY (1) CY1687A (es)
DD (1) DD235638A5 (es)
DE (2) DE19675039I2 (es)
DK (1) DK168093B1 (es)
ES (1) ES8609260A1 (es)
FI (1) FI85019C (es)
GB (1) GB8418303D0 (es)
GE (1) GEP19960468B (es)
HK (1) HK47593A (es)
HU (1) HU193996B (es)
IE (1) IE58138B1 (es)
IL (1) IL75833A (es)
LT (1) LT2078B (es)
LU (1) LU88801I2 (es)
LV (1) LV5483A3 (es)
MC (1) MC1690A1 (es)
MX (1) MX9203667A (es)
NL (1) NL940023I2 (es)
NZ (1) NZ212766A (es)
PL (1) PL146066B1 (es)
SG (1) SG3493G (es)
SU (1) SU1468414A3 (es)
ZA (1) ZA855407B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
CN1203061C (zh) * 1997-03-25 2005-05-25 艾弗拉药品公司 取代异喹啉类，其制备方法，药物组合物及其制药用途
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
WO2005041960A2 (en) * 2003-10-28 2005-05-12 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
AU2007328210B2 (en) * 2006-12-06 2012-11-22 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
EP2125743A1 (en) * 2007-03-26 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
US8293912B2 (en) * 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2685488A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0812625A2 (pt) * 2007-07-09 2019-02-19 Chemagis Ltd processo para preparar um sal de cis-atracúrio
CA2702535A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
ITMI20080319A1 (it) 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
CA2722651A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
JP6236077B2 (ja) * 2012-06-29 2017-11-22 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ 持続時間が超短期、短期、または中期の非対称性逆転可能神経筋遮断物質
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法
CN116410078B (zh) * 2021-12-29 2026-04-03 苏州特瑞药业股份有限公司 一种制备(e)-辛-4-烯-1,8-二酸的方法
WO2025140288A1 (zh) * 2023-12-25 2025-07-03 上海森辉医药有限公司 一种四氢异喹啉及其药物用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
NL7808067A (nl) 1977-08-01 1979-02-05 Massachusetts Gen Hospital Werkwijze voor het bereiden van een middel dat zenuw- spieren blokkeert.
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
CA1153380A (en) 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
EP0054309B1 (en) * 1980-12-17 1984-08-22 The Wellcome Foundation Limited Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
FI852807A0 (fi) 1985-07-17
IE851791L (en) 1986-01-18
FI85019B (fi) 1991-11-15
IE58138B1 (en) 1993-07-14
AU4510885A (en) 1986-01-23
GEP19960468B (en) 1996-08-29
EP0181055A1 (en) 1986-05-14
DK168093B1 (da) 1994-02-07
MC1690A1 (fr) 1986-07-18
HUT40626A (en) 1987-01-28
PL146066B1 (en) 1988-12-31
JPH0662568B2 (ja) 1994-08-17
MX9203667A (es) 1992-07-31
HK47593A (en) 1993-05-21
US4761418A (en) 1988-08-02
DK324985D0 (da) 1985-07-17
LT2078B (lt) 1993-06-15
CY1687A (en) 1993-10-10
DD235638A5 (de) 1986-05-14
NZ212766A (en) 1988-03-30
EP0181055B1 (en) 1991-02-06
CA1273341A (en) 1990-08-28
PL254571A1 (en) 1986-07-15
GB8418303D0 (en) 1984-08-22
NL940023I1 (nl) 1995-01-02
DE19675039I2 (de) 2003-01-09
IL75833A0 (en) 1985-11-29
DK324985A (da) 1986-01-19
AU574481B2 (en) 1988-07-07
ZA855407B (en) 1986-04-30
ATE60759T1 (de) 1991-02-15
DE3581699D1 (de) 1991-03-14
SU1468414A3 (ru) 1989-03-23
SG3493G (en) 1993-03-12
LV5483A3 (lv) 1994-03-10
FI852807L (fi) 1986-01-19
IL75833A (en) 1988-11-30
ES8609260A1 (es) 1986-09-01
HU193996B (en) 1987-12-28
BG60411B2 (bg) 1995-02-28
JPS6187666A (ja) 1986-05-06
FI85019C (fi) 1992-02-25
LU88801I2 (fr) 1996-11-05
NL940023I2 (nl) 1998-06-02

Similar Documents

Publication Publication Date Title
AU574481B2 (en) Bis-isoquinolium derivatives
GR3023825T3 (en) Benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds
ES538757A0 (es) Procedimiento para la preparacion de 11b-aril-estradienos
MY102986A (en) Benzo (5,6) cycloheptapyridines, compositions and methods of use
IL72354A0 (en) Imidazolium salts,processes for the preparation thereof and pharmaceutical compositions containing the same
EA199900756A1 (ru) Замещенные изохинолины в качестве нервно-мышечных блокаторов ультракраткосрочного действия
DE3173954D1 (en) Use of adenosin derivatives for the manufacture of psychopharmacons
ES493269A0 (es) Procedimiento para la preparacion de nuevos derivados halo- genados de n-(3-trifluorometil-4-haloenalcoxi-fenil)n'-ben- zoilureas
ES554305A0 (es) Procedimiento para la fabricacion de derivados quinolilglicinamidas
ES525441A0 (es) Procedimiento para preparar derivados de acidos isoquinolein-4-carboxilicos
ZA904524B (en) Dibenzo(1,5)dioxocin-5-one derivatives,their use in medicaments and processes for their preparation
DE2966809D1 (en) 3,4-diaza-bicyclo(4.1.0)hepten-2-ones-5, process for their preparation and therapeutical compositions containing them
ATE30582T1 (de) Ungesaettigte arylalkylammoniumsalze.
NO903585L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksaziner.
GB8600666D0 (en) Apparatus for surgical & medical uses
ES553984A0 (es) Procedimiento para preparar derivados de n-(1(s)-propilo sustituido)-(s)-alanil-(s)-prolina

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060530