DK324985A - Isoquinoliniumforbindelser, fremgangsmaade til deres fremstilling samt deres anvendelse - Google Patents

Isoquinoliniumforbindelser, fremgangsmaade til deres fremstilling samt deres anvendelse Download PDF

Info

Publication number: DK324985A
Authority: DK; Denmark
Prior art keywords: procedures; preparation; isoquinolinium compounds; image; isoquinolinium
Prior art date: 1984-07-18

Application number

DK324985A

Other languages

English (en)

Other versions

DK168093B1 (da

DK324985D0 (da

Inventor

Roy Archibald Swaringen Jr

Hassan Ali El-Sayad

David Arthur Yeowell

John Joseph Savarese

Original Assignee

Wellcome Found

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-18

Filing date

1985-07-17

Publication date

1986-01-19

1985-07-17 Application filed by Wellcome Found, Gen Hospital Corp filed Critical Wellcome Found

1985-07-17 Publication of DK324985D0 publication Critical patent/DK324985D0/da

1986-01-19 Publication of DK324985A publication Critical patent/DK324985A/da

1994-02-07 Application granted granted Critical

1994-02-07 Publication of DK168093B1 publication Critical patent/DK168093B1/da

Links

AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
150000001450 anions Chemical group 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
239000000842 neuromuscular blocking agent Substances 0.000 abstract 1
229940125706 skeletal muscle relaxant agent Drugs 0.000 abstract 1
238000001356 surgical procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Jib Cranes (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Meat, Egg Or Seafood Products (AREA)
Fats And Perfumes (AREA)
Cephalosporin Compounds (AREA)

DK324985A 1984-07-18 1985-07-17 Isoquinoliniumderivater, fremgangsmaade til deres fremstilling, farmaceutisk praeparat indeholdende disse samt deres anvendelse DK168093B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB848418303A GB8418303D0 (en)	1984-07-18	1984-07-18	Compounds
GB8418303		1984-07-18

Publications (3)

Publication Number	Publication Date
DK324985D0 DK324985D0 (da)	1985-07-17
DK324985A true DK324985A (da)	1986-01-19
DK168093B1 DK168093B1 (da)	1994-02-07

Family

ID=10564058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK324985A DK168093B1 (da)	1984-07-18	1985-07-17	Isoquinoliniumderivater, fremgangsmaade til deres fremstilling, farmaceutisk praeparat indeholdende disse samt deres anvendelse

Country Status (30)

Country	Link
US (1)	US4761418A (da)
EP (1)	EP0181055B1 (da)
JP (1)	JPH0662568B2 (da)
AT (1)	ATE60759T1 (da)
AU (1)	AU574481B2 (da)
BG (1)	BG60411B2 (da)
CA (1)	CA1273341A (da)
CY (1)	CY1687A (da)
DD (1)	DD235638A5 (da)
DE (2)	DE19675039I2 (da)
DK (1)	DK168093B1 (da)
ES (1)	ES8609260A1 (da)
FI (1)	FI85019C (da)
GB (1)	GB8418303D0 (da)
GE (1)	GEP19960468B (da)
HK (1)	HK47593A (da)
HU (1)	HU193996B (da)
IE (1)	IE58138B1 (da)
IL (1)	IL75833A (da)
LT (1)	LT2078B (da)
LU (1)	LU88801I2 (da)
LV (1)	LV5483A3 (da)
MC (1)	MC1690A1 (da)
MX (1)	MX9203667A (da)
NL (1)	NL940023I2 (da)
NZ (1)	NZ212766A (da)
PL (1)	PL146066B1 (da)
SG (1)	SG3493G (da)
SU (1)	SU1468414A3 (da)
ZA (1)	ZA855407B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5453510A (en) *	1990-07-13	1995-09-26	Burroughs Wellcome Co.	Neuromuscular blocking agents
US5240939A (en) *	1991-10-31	1993-08-31	Anaquest, Inc.	Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) *	1994-09-06	1996-04-23	Bencherif; Merouane	Depolarizing skeletal muscle relaxants
CN1203061C (zh) *	1997-03-25	2005-05-25	艾弗拉药品公司	取代异喹啉类，其制备方法，药物组合物及其制药用途
GB0204087D0 (en) *	2002-02-21	2002-04-10	Legislator 1563 Ltd	Di-ester derivatives as short acting neuromuscular blockers
WO2005041960A2 (en) *	2003-10-28	2005-05-12	Cornell Research Foundation, Inc.	Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) *	2006-06-20	2011-01-18	Farmabios S.P.A.	Process for the preparation of mivacurium chloride
AU2007328210B2 (en) *	2006-12-06	2012-11-22	Cornell Research Foundation, Inc.	Intermediate duration neuromuscular blocking agents and antagonists thereof
AU2008222298A1 (en) *	2007-03-08	2008-09-12	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
EP2125743A1 (en) *	2007-03-26	2009-12-02	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
US8293912B2 (en) *	2007-05-01	2012-10-23	Chemagis Ltd.	Process for producing cisatracurium compounds and associated intermediates
CA2685488A1 (en) *	2007-05-01	2008-11-06	Chemagis Ltd.	Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
CA2687157A1 (en) *	2007-06-18	2008-12-24	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
BRPI0812625A2 (pt) *	2007-07-09	2019-02-19	Chemagis Ltd	processo para preparar um sal de cis-atracúrio
CA2702535A1 (en) *	2007-10-29	2009-05-07	Chemagis Ltd.	Novel r,r'-atracurium salts
ITMI20080319A1 (it)	2008-02-28	2009-08-29	Recordati Chem Pharm	Processo per la risoluzione di derivati isochinolinici
CA2722651A1 (en) *	2008-05-01	2009-11-05	Chemagis Ltd.	Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en)	2009-03-17	2013-11-26	Cornell University	Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en)	2009-08-19	2015-12-29	Cornell University	Cysteine for physiological injection
WO2013021398A2 (en) *	2011-08-05	2013-02-14	Sequent Scientific Limited	A process for preparation of mivacurium chloride
JP6236077B2 (ja) *	2012-06-29	2017-11-22	コーネル・ユニバーシティーＣｏｒｎｅｌｌＵｎｉｖｅｒｓｉｔｙ	持続時間が超短期、短期、または中期の非対称性逆転可能神経筋遮断物質
CN103373959A (zh) *	2013-06-14	2013-10-30	安徽省先锋制药有限公司	顺式苄基异喹啉类化合物的制备方法及其用途
CN107782821B (zh) *	2016-08-26	2021-11-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂的分析方法
CN107778237A (zh) *	2016-08-26	2018-03-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN108938573B (zh) *	2017-05-26	2021-08-10	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) *	2017-09-30	2018-09-07	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) *	2019-07-29	2022-04-29	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) *	2019-11-11	2021-03-09	武汉大安制药有限公司	一种5’-甲氧基劳丹素的拆分方法
CN116410078B (zh) *	2021-12-29	2026-04-03	苏州特瑞药业股份有限公司	一种制备(e)-辛-4-烯-1,8-二酸的方法
WO2025140288A1 (zh) *	2023-12-25	2025-07-03	上海森辉医药有限公司	一种四氢异喹啉及其药物用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3004031A (en) *	1958-07-03	1961-10-10	Allen & Hauburys Ltd	Diquaternary salts of papaverino esters
GB863717A (en) *	1958-07-03	1961-03-22	Allen & Hanburys Ltd	Tetrahydropapaverine derivatives and their preparation
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
NL7808067A (nl)	1977-08-01	1979-02-05	Massachusetts Gen Hospital	Werkwijze voor het bereiden van een middel dat zenuw- spieren blokkeert.
US4192877A (en) *	1977-08-01	1980-03-11	Massachusetts General Hospital	Neuromuscular blocking agents
CA1125287A (en) *	1978-07-21	1982-06-08	John J. Savarese	Bis isoquinolinium compositions and methods of use
US4235906A (en) *	1978-07-21	1980-11-25	Massachusetts General Hospital	Bis-isoquinolinium compounds, compositions and methods of use
CA1153380A (en)	1979-10-19	1983-09-06	Hassan A. El-Sayad	Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) *	1979-10-19	1985-01-01	Burroughs Wellcome Co.	Method of preparing isomers of bis isoquinolinium compounds
EP0054309B1 (en) *	1980-12-17	1984-08-22	The Wellcome Foundation Limited	Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) *	1981-11-23	1983-06-13	ザ・ウエルカム・フアウンデ−シヨン・リミテツド	イソキノリン誘導体

1984
- 1984-07-18 GB GB848418303A patent/GB8418303D0/en active Pending
1985
- 1985-07-11 PL PL1985254571A patent/PL146066B1/pl unknown
- 1985-07-17 AU AU45108/85A patent/AU574481B2/en not_active Expired
- 1985-07-17 IE IE179185A patent/IE58138B1/en not_active IP Right Cessation
- 1985-07-17 DE DE1996175039 patent/DE19675039I2/de active Active
- 1985-07-17 JP JP60157963A patent/JPH0662568B2/ja not_active Expired - Lifetime
- 1985-07-17 DE DE8585305097T patent/DE3581699D1/de not_active Expired - Lifetime
- 1985-07-17 FI FI852807A patent/FI85019C/fi not_active IP Right Cessation
- 1985-07-17 SU SU853926201A patent/SU1468414A3/ru active
- 1985-07-17 DK DK324985A patent/DK168093B1/da not_active IP Right Cessation
- 1985-07-17 MC MC851781A patent/MC1690A1/fr unknown
- 1985-07-17 DD DD85278691A patent/DD235638A5/de unknown
- 1985-07-17 IL IL75833A patent/IL75833A/xx not_active IP Right Cessation
- 1985-07-17 ES ES545319A patent/ES8609260A1/es not_active Expired
- 1985-07-17 CA CA000486916A patent/CA1273341A/en not_active Expired - Lifetime
- 1985-07-17 EP EP85305097A patent/EP0181055B1/en not_active Expired - Lifetime
- 1985-07-17 US US06/756,025 patent/US4761418A/en not_active Expired - Lifetime
- 1985-07-17 LU LU88801C patent/LU88801I2/fr unknown
- 1985-07-17 ZA ZA855407A patent/ZA855407B/xx unknown
- 1985-07-17 NZ NZ212766A patent/NZ212766A/en unknown
- 1985-07-17 HU HU852745A patent/HU193996B/hu unknown
- 1985-07-17 AT AT85305097T patent/ATE60759T1/de active
1992
- 1992-06-26 MX MX9203667A patent/MX9203667A/es unknown
1993
- 1993-01-08 SG SG34/93A patent/SG3493G/en unknown
- 1993-03-10 LV LV930178A patent/LV5483A3/xx unknown
- 1993-04-07 LT LTRP478A patent/LT2078B/xx not_active IP Right Cessation
- 1993-05-13 HK HK475/93A patent/HK47593A/en not_active IP Right Cessation
- 1993-09-14 BG BG098109A patent/BG60411B2/bg unknown
- 1993-10-10 CY CY1687A patent/CY1687A/xx unknown
- 1993-12-06 GE GEAP19931677A patent/GEP19960468B/en unknown
1994
- 1994-11-18 NL NL940023C patent/NL940023I2/nl unknown

Also Published As

Publication number	Publication date
FI852807A0 (fi)	1985-07-17
IE851791L (en)	1986-01-18
FI85019B (fi)	1991-11-15
IE58138B1 (en)	1993-07-14
AU4510885A (en)	1986-01-23
GEP19960468B (en)	1996-08-29
EP0181055A1 (en)	1986-05-14
DK168093B1 (da)	1994-02-07
MC1690A1 (fr)	1986-07-18
HUT40626A (en)	1987-01-28
PL146066B1 (en)	1988-12-31
JPH0662568B2 (ja)	1994-08-17
MX9203667A (es)	1992-07-31
HK47593A (en)	1993-05-21
US4761418A (en)	1988-08-02
DK324985D0 (da)	1985-07-17
LT2078B (lt)	1993-06-15
CY1687A (en)	1993-10-10
DD235638A5 (de)	1986-05-14
NZ212766A (en)	1988-03-30
EP0181055B1 (en)	1991-02-06
CA1273341A (en)	1990-08-28
PL254571A1 (en)	1986-07-15
GB8418303D0 (en)	1984-08-22
NL940023I1 (nl)	1995-01-02
DE19675039I2 (de)	2003-01-09
IL75833A0 (en)	1985-11-29
AU574481B2 (en)	1988-07-07
ZA855407B (en)	1986-04-30
ATE60759T1 (de)	1991-02-15
DE3581699D1 (de)	1991-03-14
SU1468414A3 (ru)	1989-03-23
SG3493G (en)	1993-03-12
LV5483A3 (lv)	1994-03-10
FI852807L (fi)	1986-01-19
ES545319A0 (es)	1986-09-01
IL75833A (en)	1988-11-30
ES8609260A1 (es)	1986-09-01
HU193996B (en)	1987-12-28
BG60411B2 (bg)	1995-02-28
JPS6187666A (ja)	1986-05-06
FI85019C (fi)	1992-02-25
LU88801I2 (fr)	1996-11-05
NL940023I2 (nl)	1998-06-02

Legal Events

Date	Code	Title	Description
1994-02-07	B1	Patent granted (law 1993)
1995-01-30	CTFF	Application for supplementary protection certificate (spc) filed	Free format text: CA 1994 00013, 941215
1995-09-11	CTFG	Supplementary protection certificate (spc) issued	Free format text: CA 1994 00013, 941215, EXPIRES: 20071208
2005-08-01	PUP	Patent expired

Publication	Publication Date	Title
DK324985D0 (da)	1985-07-17	Isoquinoliniumforbindelser, fremgangsmaade til deres fremstilling samt deres anvendelse
NZ208831A (en)	1988-09-29	Imidazolium derivatives and pharmaceutical compositions
GR3023825T3 (en)	1997-09-30	Benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds
DE3173954D1 (en)	1986-04-10	Use of adenosin derivatives for the manufacture of psychopharmacons
ES493269A0 (es)	1981-06-16	Procedimiento para la preparacion de nuevos derivados halo- genados de n-(3-trifluorometil-4-haloenalcoxi-fenil)n'-ben- zoilureas
ES554305A0 (es)	1987-11-16	Procedimiento para la fabricacion de derivados quinolilglicinamidas
NZ217418A (en)	1988-11-29	Tricyclic heterocyclic compounds and pharmaceutical compositions
NO162557C (no)	1990-01-17	Analogifremgangsmaate ved fremstilling av terapeutisk aktive (pyrrol-1-yl)-fenyldihydropyridazinoner.
AR222075A1 (es)	1981-04-15	Procedimiento de preparacion de 2',6'-dialquil-n-alcoximetil-2-cloro-acetanilida
ZA796789B (en)	1980-12-31	Novel 3,4-diaza-bicyclo (4.1.0) hept-2-en-5-ones, their preparation, and therapeutic agents containing these compounds
DE3467161D1 (de)	1987-12-10	Unsaturated arylalkyl ammonium salts
ES2096559T3 (es)	1997-03-16	Interferon gamma humano, procedimiento para la preparacion de dicho interferon gamma humano, y su uso.
EP0194164A3 (en)	1987-06-16	N-carboxyalcoyl-2-oxo-3-diaryl-5,6-triazines useful as therapeutic agents
NO903585L (no)	1991-02-18	Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksaziner.
IT1129278B (it)	1986-06-04	Procedimento per la preparazione di 2 osso diidrobenzo (d)(1,3) ossazione
ES553984A0 (es)	1986-12-01	Procedimiento para preparar derivados de n-(1(s)-propilo sustituido)-(s)-alanil-(s)-prolina
JPS53119846A (en)	1978-10-19	Sulfoxide compounds and their preparation