FI108463B - Geenikoetinbioanturimenetelmõ - Google Patents

Geenikoetinbioanturimenetelmõ Download PDF

Info

Publication number: FI108463B
Authority: FI; Finland
Prior art keywords: oligonucleotide; fluorescence; waveguide; rna; dna
Prior art date: 1991-09-16

Application number

FI941220A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI941220A0 (fi

FI941220L (fi

Inventor

David James Squirrell

Original Assignee

Secr Defence Brit

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-16

Filing date

1994-03-15

Publication date

2002-01-31

1994-03-15 Application filed by Secr Defence Brit filed Critical Secr Defence Brit

1994-03-15 Publication of FI941220A0 publication Critical patent/FI941220A0/fi

1994-03-15 Publication of FI941220L publication Critical patent/FI941220L/fi

2002-01-31 Application granted granted Critical

2002-01-31 Publication of FI108463B publication Critical patent/FI108463B/fi

Links

238000000034 method Methods 0.000 title claims description 54
239000000523 sample Substances 0.000 title description 29
230000002068 genetic effect Effects 0.000 title description 2
108091034117 Oligonucleotide Proteins 0.000 claims abstract description 89
238000009396 hybridization Methods 0.000 claims abstract description 35
230000000295 complement effect Effects 0.000 claims abstract description 33
239000000463 material Substances 0.000 claims abstract description 26
241001465754 Metazoa Species 0.000 claims abstract description 6
244000005700 microbiome Species 0.000 claims abstract description 6
239000003795 chemical substances by application Substances 0.000 claims abstract description 4
108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 23
108020004414 DNA Proteins 0.000 claims description 23
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 20
230000003321 amplification Effects 0.000 claims description 15
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims description 15
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238000007834 ligase chain reaction Methods 0.000 claims description 5
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239000003054 catalyst Substances 0.000 claims description 4
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108020004707 nucleic acids Proteins 0.000 claims description 4
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239000002773 nucleotide Substances 0.000 claims description 4
125000003729 nucleotide group Chemical group 0.000 claims description 4
108091008146 restriction endonucleases Proteins 0.000 claims description 3
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CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
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230000008878 coupling Effects 0.000 description 4
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108091033319 polynucleotide Proteins 0.000 description 4
102000040430 polynucleotide Human genes 0.000 description 4
239000002157 polynucleotide Substances 0.000 description 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
230000035945 sensitivity Effects 0.000 description 4
210000001519 tissue Anatomy 0.000 description 4
WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 3
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 3
108091028043 Nucleic acid sequence Proteins 0.000 description 3
108010090804 Streptavidin Proteins 0.000 description 3
231100000673 dose–response relationship Toxicity 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
230000001900 immune effect Effects 0.000 description 3
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
229920000936 Agarose Polymers 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
229920001213 Polysorbate 20 Polymers 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
239000000427 antigen Substances 0.000 description 2
230000000890 antigenic effect Effects 0.000 description 2
230000008901 benefit Effects 0.000 description 2
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239000000356 contaminant Substances 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
229910021641 deionized water Inorganic materials 0.000 description 2
238000010494 dissociation reaction Methods 0.000 description 2
230000005593 dissociations Effects 0.000 description 2
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230000002255 enzymatic effect Effects 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
238000007899 nucleic acid hybridization Methods 0.000 description 2
238000005457 optimization Methods 0.000 description 2
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
239000010453 quartz Substances 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 2
UGDMYHVETQRVGB-UHFFFAOYSA-N 1,3-benzothiazole-6-sulfonic acid Chemical compound OS(=O)(=O)C1=CC=C2N=CSC2=C1 UGDMYHVETQRVGB-UHFFFAOYSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
244000105975 Antidesma platyphyllum Species 0.000 description 1
241000193830 Bacillus <bacterium> Species 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
108010009685 Cholinergic Receptors Proteins 0.000 description 1
102000053602 DNA Human genes 0.000 description 1
230000004544 DNA amplification Effects 0.000 description 1
239000003298 DNA probe Substances 0.000 description 1
230000007018 DNA scission Effects 0.000 description 1
229920001917 Ficoll Polymers 0.000 description 1
108010001336 Horseradish Peroxidase Proteins 0.000 description 1
230000007022 RNA scission Effects 0.000 description 1
108010006785 Taq Polymerase Proteins 0.000 description 1
OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
229960004373 acetylcholine Drugs 0.000 description 1
102000034337 acetylcholine receptors Human genes 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
239000012491 analyte Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
238000013459 approach Methods 0.000 description 1
OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
239000011324 bead Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
238000004166 bioassay Methods 0.000 description 1
239000012620 biological material Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229960002685 biotin Drugs 0.000 description 1
235000020958 biotin Nutrition 0.000 description 1
239000011616 biotin Substances 0.000 description 1
229940098773 bovine serum albumin Drugs 0.000 description 1
238000006555 catalytic reaction Methods 0.000 description 1
230000006037 cell lysis Effects 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
230000008859 change Effects 0.000 description 1
239000000544 cholinesterase inhibitor Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000003795 desorption Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
230000029087 digestion Effects 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
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235000013355 food flavoring agent Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
235000009424 haa Nutrition 0.000 description 1
238000010324 immunological assay Methods 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000011005 laboratory method Methods 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
239000000203 mixture Substances 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
238000012856 packing Methods 0.000 description 1
230000002572 peristaltic effect Effects 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
238000003239 susceptibility assay Methods 0.000 description 1
239000013077 target material Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
125000003396 thiol group Chemical class [H]S* 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
229940038773 trisodium citrate Drugs 0.000 description 1
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
239000010937 tungsten Substances 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pathology (AREA)
Wood Science & Technology (AREA)
General Physics & Mathematics (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Plasma & Fusion (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

FI941220A 1991-09-16 1994-03-15 Geenikoetinbioanturimenetelmõ FI108463B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB919119735A GB9119735D0 (en)	1991-09-16	1991-09-16	Gene probe biosensor method
GB9119735		1991-09-16
GB9201698		1992-09-16
PCT/GB1992/001698 WO1993006241A1 (fr)	1991-09-16	1992-09-16	Procede de capteur biologique de sonde genique

Publications (3)

Publication Number	Publication Date
FI941220A0 FI941220A0 (fi)	1994-03-15
FI941220L FI941220L (fi)	1994-03-15
FI108463B true FI108463B (fi)	2002-01-31

Family

ID=10701461

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI941220A FI108463B (fi)	1991-09-16	1994-03-15	Geenikoetinbioanturimenetelmõ

Country Status (20)

Country	Link
US (1)	US5750337A (fr)
EP (1)	EP0604506B1 (fr)
JP (1)	JP3324607B2 (fr)
KR (1)	KR100249288B1 (fr)
AT (1)	ATE174968T1 (fr)
AU (1)	AU665369B2 (fr)
BG (1)	BG62337B1 (fr)
CA (1)	CA2116239C (fr)
CZ (1)	CZ286927B6 (fr)
DE (1)	DE69227997T2 (fr)
DK (1)	DK0604506T3 (fr)
ES (1)	ES2125272T3 (fr)
FI (1)	FI108463B (fr)
GB (2)	GB9119735D0 (fr)
GR (1)	GR3029722T3 (fr)
HU (1)	HU218596B (fr)
NO (1)	NO315380B1 (fr)
RU (1)	RU2116349C1 (fr)
SK (1)	SK280713B6 (fr)
WO (1)	WO1993006241A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2133643A1 (fr) *	1992-04-06	1993-10-14	Stanley R. Bouma	Methode et dispositif pour la detection d'acide nucleique ou d'une substance a analyser, utilisant la reflectance interne totale
WO1995026416A1 (fr) *	1994-03-25	1995-10-05	Research Corporation Technologies, Inc.	Procede de diagnostic par biocapteurs d'acide nucleique
US5599668A (en) *	1994-09-22	1997-02-04	Abbott Laboratories	Light scattering optical waveguide method for detecting specific binding events
WO1996019587A2 (fr) *	1994-12-22	1996-06-27	Abbott Laboratories	Procedes d'immobilisation d'oligonucleotides sur des materiaux de support et procedes d'utilisation des oligonucleotides fixes auxdits supports
US5690894A (en) *	1995-05-23	1997-11-25	The Regents Of The University Of California	High density array fabrication and readout method for a fiber optic biosensor
SE9502608D0 (sv) *	1995-07-14	1995-07-14	Pharmacia Biosensor Ab	Method for nucleic acid senquencing
DE69733650T2 (de) *	1996-03-01	2006-04-20	Beckman Coulter, Inc., Fullerton	System zum simultanen Durchführen einer Vielzahl von Ligandenbindungs-Untersuchungen
US5832165A (en) *	1996-08-28	1998-11-03	University Of Utah Research Foundation	Composite waveguide for solid phase binding assays
NZ502303A (en)	1997-06-18	2002-02-01	Ulrich J Krull	Nucleic acid biosensor system & diagnostic use
DE19730359A1 (de) *	1997-07-15	1999-01-21	Boehringer Mannheim Gmbh	Integriertes Verfahren und System zur Amplifizierung und zum Nachweis von Nukleinsäuren
JP2001511358A (ja) *	1997-07-28	2001-08-14	メディカル・バイオシステムズ・リミテッド	核酸配列の解析
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1991
- 1991-09-16 GB GB919119735A patent/GB9119735D0/en active Pending
1992
- 1992-09-16 ES ES92919549T patent/ES2125272T3/es not_active Expired - Lifetime
- 1992-09-16 US US08/196,185 patent/US5750337A/en not_active Expired - Lifetime
- 1992-09-16 DE DE69227997T patent/DE69227997T2/de not_active Expired - Lifetime
- 1992-09-16 AU AU25641/92A patent/AU665369B2/en not_active Ceased
- 1992-09-16 JP JP50589793A patent/JP3324607B2/ja not_active Expired - Fee Related
- 1992-09-16 RU RU94019336A patent/RU2116349C1/ru not_active IP Right Cessation
- 1992-09-16 HU HU9400770A patent/HU218596B/hu not_active IP Right Cessation
- 1992-09-16 KR KR1019940700843A patent/KR100249288B1/ko not_active Expired - Fee Related
- 1992-09-16 GB GB9402823A patent/GB2274710B/en not_active Revoked
- 1992-09-16 EP EP92919549A patent/EP0604506B1/fr not_active Expired - Lifetime
- 1992-09-16 WO PCT/GB1992/001698 patent/WO1993006241A1/fr not_active Ceased
- 1992-09-16 CZ CZ1994521A patent/CZ286927B6/cs not_active IP Right Cessation
- 1992-09-16 DK DK92919549T patent/DK0604506T3/da active
- 1992-09-16 SK SK306-94A patent/SK280713B6/sk not_active IP Right Cessation
- 1992-09-16 CA CA002116239A patent/CA2116239C/fr not_active Expired - Fee Related
- 1992-09-16 AT AT92919549T patent/ATE174968T1/de not_active IP Right Cessation
1994
- 1994-03-14 NO NO19940901A patent/NO315380B1/no not_active IP Right Cessation
- 1994-03-15 BG BG98660A patent/BG62337B1/bg unknown
- 1994-03-15 FI FI941220A patent/FI108463B/fi active
1999
- 1999-03-18 GR GR990400807T patent/GR3029722T3/el unknown

Also Published As

Publication number	Publication date
GB2274710A (en)	1994-08-03
CA2116239A1 (fr)	1993-04-01
JP3324607B2 (ja)	2002-09-17
DE69227997D1 (de)	1999-02-04
FI941220A0 (fi)	1994-03-15
BG62337B1 (bg)	1999-08-31
NO940901D0 (no)	1994-03-14
US5750337A (en)	1998-05-12
AU665369B2 (en)	1996-01-04
CA2116239C (fr)	2008-11-18
WO1993006241A1 (fr)	1993-04-01
NO940901L (no)	1994-05-16
HU9400770D0 (en)	1994-06-28
AU2564192A (en)	1993-04-27
BG98660A (bg)	1995-03-31
EP0604506A1 (fr)	1994-07-06
RU94019336A (ru)	1996-09-27
HUT68771A (en)	1995-07-28
NO315380B1 (no)	2003-08-25
KR100249288B1 (ko)	2000-04-01
EP0604506B1 (fr)	1998-12-23
SK280713B6 (sk)	2000-06-12
SK30694A3 (en)	1994-07-06
RU2116349C1 (ru)	1998-07-27
ATE174968T1 (de)	1999-01-15
DE69227997T2 (de)	1999-05-12
GR3029722T3 (en)	1999-06-30
CZ52194A3 (en)	1994-07-13
DK0604506T3 (da)	1999-08-23
ES2125272T3 (es)	1999-03-01
GB9119735D0 (en)	1991-10-30
HU218596B (hu)	2000-10-28
JPH06510670A (ja)	1994-12-01
CZ286927B6 (cs)	2000-08-16
FI941220L (fi)	1994-03-15
GB2274710B (en)	1995-09-06
GB9402823D0 (en)	1994-04-27

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