FR25C1008I2 - Immunoconjugues contre du recepteur 1 du folate et leurs utilisations - Google Patents
Immunoconjugues contre du recepteur 1 du folate et leurs utilisationsInfo
- Publication number
- FR25C1008I2 FR25C1008I2 FR25C1008C FR25C1008C FR25C1008I2 FR 25C1008 I2 FR25C1008 I2 FR 25C1008I2 FR 25C1008 C FR25C1008 C FR 25C1008C FR 25C1008 C FR25C1008 C FR 25C1008C FR 25C1008 I2 FR25C1008 I2 FR 25C1008I2
- Authority
- FR
- France
- Prior art keywords
- folate receptor
- against folate
- immunoconjugates against
- immunoconjugates
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30779710P | 2010-02-24 | 2010-02-24 | |
| US34659510P | 2010-05-20 | 2010-05-20 | |
| US41317210P | 2010-11-12 | 2010-11-12 | |
| PCT/US2011/026079 WO2011106528A1 (fr) | 2010-02-24 | 2011-02-24 | Anticorps du récepteur 1 du folate et immunoconjugués et leurs utilisations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR25C1008I1 FR25C1008I1 (fr) | 2025-04-25 |
| FR25C1008I2 true FR25C1008I2 (fr) | 2026-01-16 |
Family
ID=44507210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR25C1008C Active FR25C1008I2 (fr) | 2010-02-24 | 2025-02-18 | Immunoconjugues contre du recepteur 1 du folate et leurs utilisations |
Country Status (34)
| Country | Link |
|---|---|
| US (11) | US8557966B2 (fr) |
| EP (3) | EP3196212B1 (fr) |
| JP (8) | JP5778700B2 (fr) |
| KR (11) | KR20230044026A (fr) |
| CN (2) | CN105777907B (fr) |
| AR (1) | AR080301A1 (fr) |
| AU (1) | AU2011220728B2 (fr) |
| BR (1) | BR112012021296B1 (fr) |
| CA (3) | CA3206109A1 (fr) |
| CY (2) | CY1118668T1 (fr) |
| DK (1) | DK2538976T3 (fr) |
| ES (2) | ES2813549T3 (fr) |
| FI (1) | FIC20250013I1 (fr) |
| FR (1) | FR25C1008I2 (fr) |
| HR (1) | HRP20170281T1 (fr) |
| HU (2) | HUE030854T2 (fr) |
| IL (7) | IL290617B2 (fr) |
| LT (2) | LT2538976T (fr) |
| MX (4) | MX340437B (fr) |
| MY (4) | MY205540A (fr) |
| NL (1) | NL301319I2 (fr) |
| NO (1) | NO2025021I1 (fr) |
| NZ (4) | NZ709390A (fr) |
| PL (1) | PL2538976T3 (fr) |
| PT (1) | PT2538976T (fr) |
| RS (1) | RS55738B1 (fr) |
| RU (2) | RU2740479C2 (fr) |
| SG (4) | SG10201801636QA (fr) |
| SI (1) | SI2538976T1 (fr) |
| SM (1) | SMT201700139T1 (fr) |
| TW (6) | TWI672318B (fr) |
| UA (1) | UA123257C2 (fr) |
| WO (1) | WO2011106528A1 (fr) |
| ZA (1) | ZA201508660B (fr) |
Families Citing this family (168)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| EP3539572A1 (fr) | 2005-08-24 | 2019-09-18 | ImmunoGen, Inc. | Procédé de préparation de conjugués d'anticorps de maytansinoïde |
| EP2281006B1 (fr) | 2008-04-30 | 2017-08-02 | Immunogen, Inc. | Agents de réticulation et leurs utilisations |
| CN102365021B (zh) | 2009-02-05 | 2015-07-15 | 伊缪诺金公司 | 新型苯并二氮杂*衍生物 |
| EP2437790B1 (fr) | 2009-06-03 | 2019-02-20 | Immunogen, Inc. | Procédés de conjugaison |
| AR080301A1 (es) | 2010-02-24 | 2012-03-28 | Immunogen Inc | Anticuerpos e inmunoconjugados del receptor 1 de folato y sus usos |
| US10273294B2 (en) * | 2010-10-11 | 2019-04-30 | University Of Southern California | Compositions and methods for treating HIF-1α over-expressing cancers |
| KR20140010076A (ko) | 2011-02-15 | 2014-01-23 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체 |
| WO2012135517A2 (fr) | 2011-03-29 | 2012-10-04 | Immunogen, Inc. | Préparation de conjugués de maytansinoïde anticorps par procédé en une étape |
| TR201902180T4 (tr) | 2011-03-29 | 2019-03-21 | Immunogen Inc | Tek adimli bi̇r i̇şlem i̇le maytansi̇noi̇d anti̇kor konjugatlarinin hazirlanmasi |
| PL2694106T3 (pl) * | 2011-04-01 | 2018-06-29 | Immunogen, Inc. | Sposoby zwiększania skuteczności terapii przeciwnowotworowej opartej na receptorze folr1 |
| MX350954B (es) | 2011-06-21 | 2017-09-26 | Immunogen Inc | Derivados de maitansinoides novedosos con enlazador de peptido y conjugados de estos. |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| HK1211208A1 (zh) | 2012-08-22 | 2016-05-20 | Immunogen, Inc. | 細胞毒性苯並二氮呯衍生物 |
| KR20150046316A (ko) | 2012-08-31 | 2015-04-29 | 이뮤노젠 아이엔씨 | 엽산 수용체 1의 검출을 위한 진단성 검정 및 키트 |
| RU2661083C2 (ru) | 2012-10-04 | 2018-07-11 | Иммуноджен, Инк. | Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент |
| WO2014055771A1 (fr) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Récepteur d'antigène chimérique de récepteur alpha du folate humain |
| WO2014089177A2 (fr) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Composés, conjugués et compositions d'épipolythiodicétopipérazines et de polythiodicétopipérazines |
| CA2893378A1 (fr) * | 2012-12-07 | 2014-06-12 | Kyowa Hakko Kirin Co., Ltd. | Anticorps anti-folr1 |
| KR20150119848A (ko) | 2012-12-21 | 2015-10-26 | 바이오얼라이언스 씨.브이. | 친수성 자기-희생 링커 및 그것의 포합체 |
| HK1219422A1 (zh) | 2013-02-28 | 2017-04-07 | Immunogen, Inc. | 包含细胞结合剂及细胞毒素剂的轭合物 |
| EP2961435B1 (fr) | 2013-02-28 | 2019-05-01 | ImmunoGen, Inc. | Conjugués comprenant des agents de liaison cellulaire (cba) et des agents cytotoxiques |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| CN119185571A (zh) * | 2013-05-14 | 2024-12-27 | 伊缪诺金公司 | 抗folr1免疫缀合物给药方案 |
| WO2014194030A2 (fr) | 2013-05-31 | 2014-12-04 | Immunogen, Inc. | Conjugués comprenant des agents de liaison cellulaire et des agents cytotoxiques |
| PT3038650T (pt) * | 2013-08-30 | 2021-08-25 | Immunogen Inc | Anticorpos e ensaios para a deteção do recetor de folato 1 |
| NZ757964A (en) | 2013-10-08 | 2022-07-01 | Immunogen Inc | Anti-folr1 immunoconjugate dosing regimens |
| KR102344170B1 (ko) * | 2013-12-27 | 2021-12-27 | 추가이 세이야쿠 가부시키가이샤 | 등전점이 낮은 항체의 정제방법 |
| EP3593812A3 (fr) | 2014-03-15 | 2020-05-27 | Novartis AG | Traitement du cancer à l'aide d'un récepteur d'antigène chimérique |
| WO2015149018A1 (fr) * | 2014-03-28 | 2015-10-01 | Immunogen, Inc. | Schémas posologiques d'immunoconjugués anti-folr1 |
| CN106661124A (zh) * | 2014-06-20 | 2017-05-10 | 荷商台医(有限合伙)公司 | 抗叶酸受体α(FRA)抗体‑药物缀合物及其使用方法 |
| WO2016014530A1 (fr) | 2014-07-21 | 2016-01-28 | Novartis Ag | Combinaisons de faibles doses renforçant l'immunité d'inhibiteurs de mtor et car |
| AU2015311951B2 (en) | 2014-09-02 | 2021-04-08 | Immunogen, Inc. | Methods for formulating antibody drug conjugate compositions |
| PT3189056T (pt) | 2014-09-03 | 2020-09-04 | Immunogen Inc | Derivados citotóxicos de benzodiazepina |
| TW201613930A (en) | 2014-09-03 | 2016-04-16 | Immunogen Inc | Cytotoxic benzodiazepine derivatives |
| TW201609152A (zh) | 2014-09-03 | 2016-03-16 | 免疫原公司 | 包含細胞結合劑及細胞毒性劑之偶聯物 |
| US10413615B2 (en) | 2014-11-19 | 2019-09-17 | Immunogen, Inc. | Process for preparing cell-binding agent-cytotoxic agent conjugates |
| EP3221356B1 (fr) | 2014-11-20 | 2020-09-02 | F.Hoffmann-La Roche Ag | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t ciblant folr1 et cd3 |
| BR112017010513A2 (pt) | 2014-11-20 | 2018-04-03 | F. Hoffmann-La Roche Ag | ?cadeias leves comuns e métodos de uso? |
| FI4141032T3 (fi) | 2014-11-20 | 2024-07-31 | Hoffmann La Roche | T-solua aktivoivien bispesifisten antigeeniä sitovien molekyylien ja pd-1-akselia sitovien antagonistien yhdistelmähoito |
| US20180334490A1 (en) | 2014-12-03 | 2018-11-22 | Qilong H. Wu | Methods for b cell preconditioning in car therapy |
| JP7264592B2 (ja) * | 2015-01-26 | 2023-04-25 | ザ ユニバーシティー オブ シカゴ | IL13Rα2結合剤及び癌治療におけるその使用 |
| EP3250611B1 (fr) | 2015-01-26 | 2021-04-21 | The University of Chicago | Lymphocytes t à récepteur d'antigène chimérique (car) reconnaissant le récepteur il 13r-alpha2 spécifique au cancer |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| EP3286211A1 (fr) | 2015-04-23 | 2018-02-28 | Novartis AG | Traitement du cancer à l'aide de protéine récepteur antigénique chimérique et un inhibiteur de protéine kinase |
| CN106267225B (zh) * | 2015-05-29 | 2020-03-06 | 上海新理念生物医药科技有限公司 | 三马来酰亚胺型连接子及其应用 |
| SMT202100092T1 (it) | 2015-06-29 | 2021-03-15 | Immunogen Inc | Anticorpi anti-cd123 e loro coniugati e derivati |
| MD3313845T2 (ro) * | 2015-06-29 | 2021-02-28 | Immunogen Inc | Conjugați cu anticorpi având cisteină modificată prin inginerie genetică |
| SMT202000004T1 (it) | 2015-07-21 | 2020-03-13 | Immunogen Inc | Metodi di preparazione dei derivati citotossici di benzodiazepina |
| US11667691B2 (en) | 2015-08-07 | 2023-06-06 | Novartis Ag | Treatment of cancer using chimeric CD3 receptor proteins |
| JP6880006B2 (ja) * | 2015-09-17 | 2021-06-02 | イミュノジェン, インコーポレイテッド | 抗folr1免疫複合体を含む治療組み合わせ |
| ES2987957T3 (es) | 2015-11-23 | 2024-11-18 | Novartis Ag | Vectores de transferencia lentivirales optimizados y usos de los mismos |
| US20170189548A1 (en) | 2015-11-25 | 2017-07-06 | Immunogen, Inc. | Pharmaceutical formulations and methods of use thereof |
| BR112018013074A2 (en) | 2015-12-30 | 2018-12-11 | Novartis Ag | immune effector cell therapies with enhanced efficacy |
| JP7078536B2 (ja) | 2016-01-08 | 2022-05-31 | アルトゥルバイオ, インコーポレイテッド | 四価抗psgl-1抗体とその使用 |
| CN105542004B (zh) * | 2016-01-12 | 2019-02-19 | 中国人民解放军军事医学科学院生物工程研究所 | 一种抗破伤风毒素的中和性单克隆抗体及其应用 |
| JP2019510741A (ja) | 2016-02-05 | 2019-04-18 | イミュノジェン・インコーポレーテッド | 細胞結合剤・細胞毒性剤コンジュゲートを調製するための効率的なプロセス |
| CA3016287A1 (fr) | 2016-03-04 | 2017-09-08 | Novartis Ag | Cellules exprimant de multiples molecules de recepteur d'antigene chimere (car) et leurs utilisations |
| US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
| EP3443096B1 (fr) | 2016-04-15 | 2023-03-01 | Novartis AG | Compositions et méthodes pour l'expression sélective des récepteurs antigéniques chimériques |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| EP3490590A2 (fr) | 2016-08-01 | 2019-06-05 | Novartis AG | Traitement du cancer au moyen d'un récepteur d'antigène chimérique en combinaison avec un inhibiteur d'une molécule de macrophage pro-m2 |
| EA201990473A1 (ru) | 2016-08-12 | 2019-07-31 | Эл.И.Эй.Эф. ХОЛДИНГС ГРУП ЭлЭлСи | Полиглутамированные антифолаты и их применение |
| WO2018031967A1 (fr) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Antifolates de polyglutamates et leurs utilisations. |
| WO2018031980A1 (fr) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Antifolates de polyglutamates et leurs utilisations. |
| TWI755450B (zh) | 2016-11-23 | 2022-02-21 | 美商伊繆諾金公司 | 苯二氮平衍生物之選擇性磺化 |
| JP7350313B2 (ja) | 2016-12-16 | 2023-09-26 | ブルーフィン バイオメディシン, インコーポレイテッド | 抗cubドメイン含有タンパク質1(cdcp1)抗体、抗体薬物コンジュゲート、およびその使用方法 |
| WO2018111340A1 (fr) | 2016-12-16 | 2018-06-21 | Novartis Ag | Procédés de détermination de la puissance et de la fonction proliférative de lymphocytes t à récepteur antigénique chimérique (car) |
| US11787858B2 (en) | 2016-12-22 | 2023-10-17 | Icahn School Of Medicine At Mount Sinai | Anti-LILRB3 antibodies and methods of use thereof |
| EP3574005B1 (fr) | 2017-01-26 | 2021-12-15 | Novartis AG | Compositions de cd28 et procédés pour une thérapie à base de récepteur antigénique chimérique |
| JP2020506700A (ja) | 2017-01-31 | 2020-03-05 | ノバルティス アーゲー | 多重特異性を有するキメラt細胞受容体タンパク質を用いた癌の治療 |
| US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
| CN116785450A (zh) | 2017-02-28 | 2023-09-22 | 伊缪诺金公司 | 具有自分解肽接头的类美登素衍生物和其缀合物 |
| US20200048359A1 (en) | 2017-02-28 | 2020-02-13 | Novartis Ag | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
| JP2020517256A (ja) | 2017-04-19 | 2020-06-18 | エルスター セラピューティクス, インコーポレイテッド | 多重特異性分子およびその使用 |
| TW201839001A (zh) | 2017-04-20 | 2018-11-01 | 美商伊繆諾金公司 | 細胞毒性苯并二氮平衍生物及其綴合物 |
| US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| MX2019013753A (es) * | 2017-05-16 | 2020-07-20 | Immunogen Inc | Combinaciones de inmunoconjugados anti-folr1 y anticuerpo anti-pd-1. |
| WO2018229715A1 (fr) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprenant des anticorps anti-cd32b et procédés d'utilisation correspondants |
| US10688247B2 (en) | 2017-07-13 | 2020-06-23 | Haselmeier Ag | Injection device with flexible dose selection |
| KR102643780B1 (ko) * | 2017-09-05 | 2024-03-05 | 이뮤노젠 아이엔씨 | 환자 샘플에서 엽산 수용체 1의 검출 방법 |
| CA3075896A1 (fr) * | 2017-09-22 | 2019-03-28 | Immunogen, Inc. | Procedes de prevention de l'oxydation de la methionine dans des immunoconjugues |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| KR20200086278A (ko) | 2017-10-18 | 2020-07-16 | 노파르티스 아게 | 선택적 단백질 분해를 위한 조성물 및 방법 |
| WO2019084288A1 (fr) | 2017-10-25 | 2019-05-02 | Novartis Ag | Procédés de conception de cellules d'expression de récepteur antigénique chimérique |
| WO2019081983A1 (fr) | 2017-10-25 | 2019-05-02 | Novartis Ag | Anticorps ciblant cd32b et leurs procédés d'utilisation |
| WO2019089798A1 (fr) | 2017-10-31 | 2019-05-09 | Novartis Ag | Compositions anti-car et procédés |
| ES3062820T3 (en) | 2017-11-08 | 2026-04-14 | L E A F Holdings Group Llc | Platinum complexes and uses thereof |
| CN111727075B (zh) | 2017-11-27 | 2024-04-05 | 普渡制药公司 | 靶向人组织因子的人源化抗体 |
| EP3732178A1 (fr) | 2017-12-28 | 2020-11-04 | ImmunoGen, Inc. | Dérivés de benzodiazépine |
| CA3087993A1 (fr) | 2018-01-12 | 2019-07-18 | Immunogen, Inc. | Procedes de production, purification et formulation de conjugues anticorps-medicaments |
| US12076402B2 (en) | 2018-02-07 | 2024-09-03 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| EP3749312A4 (fr) | 2018-02-07 | 2022-02-23 | L.E.A.F Holdings Group LLC | Lométrexol alpha-polyglutamaté et utilisations associées |
| WO2019157123A1 (fr) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Aminoptérine alpha-polyglutamatée et utilisations associées |
| US11779584B2 (en) | 2018-02-07 | 2023-10-10 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pemetrexed and uses thereof |
| EP3749316A4 (fr) | 2018-02-07 | 2021-10-27 | L.E.A.F Holdings Group LLC | Pralatrexate alpha-polyglutamaté et utilisations associées |
| CA3090506A1 (fr) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Tetrahydrofolates alpha polyglutames et leurs utilisations |
| EP3749311A4 (fr) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | Compositions de pémétrexed polyglutamaté gamma et leurs utilisations |
| CA3090389A1 (fr) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Raltitrexed alpha-polyglutamate et utilisations associees |
| CN111954529A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化氨甲蝶呤及其用途 |
| EP3749318A4 (fr) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | Raltitrexed gamma-polyglutamaté et utilisations associées |
| US12048766B2 (en) | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated tetrahydrofolates and uses thereof |
| CN111936145A (zh) | 2018-02-14 | 2020-11-13 | L.E.A.F.控股集团公司 | γ聚谷氨酸化氨甲蝶呤及其用途 |
| CA3090943A1 (fr) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Aminopterine gamma polyglutamique et ses utilisations |
| US11771700B2 (en) | 2018-02-14 | 2023-10-03 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| EP3752156A4 (fr) | 2018-02-14 | 2021-10-27 | L.E.A.F Holdings Group LLC | Pralatrexate gamma-polyglutamaté et utilisations associées |
| JP2021518748A (ja) * | 2018-02-23 | 2021-08-05 | アールイーエムディー バイオセラピューティクス,インコーポレイテッドREMD Biotherapeutics,Inc | カルシトニン遺伝子関連ペプチド(cgrp)アンタゴニスト抗体 |
| CN115925952A (zh) * | 2018-03-13 | 2023-04-07 | 东莞凡恩世生物医药有限公司 | 抗叶酸受体1抗体及其用途 |
| KR102275930B1 (ko) | 2018-03-14 | 2021-07-12 | (주)알테오젠 | Folr1에 특이적으로 결합하는 항체 및 그의 용도 |
| WO2019178601A1 (fr) | 2018-03-16 | 2019-09-19 | Zoetis Services Llc | Vaccins peptidiques contre l'interleukine-31 |
| KR20250026872A (ko) | 2018-03-16 | 2025-02-25 | 조에티스 서비시즈 엘엘씨 | 수의학적 용도를 위한 인터류킨-31 단클론성 항체 |
| EP3784351A1 (fr) | 2018-04-27 | 2021-03-03 | Novartis AG | Thérapies reposant sur des cellules car-t présentant une efficacité améliorée |
| EP3788369A1 (fr) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarqueurs pour évaluer des cellules car-t pour prédire un résultat clinique |
| WO2019227003A1 (fr) | 2018-05-25 | 2019-11-28 | Novartis Ag | Polythérapie comprenant des thérapies par récepteur antigénique chimérique (car) |
| US20210123075A1 (en) | 2018-06-08 | 2021-04-29 | Novartis Ag | Compositions and methods for immunooncology |
| JP7623939B2 (ja) * | 2018-07-09 | 2025-01-29 | マルチチュード インコーポレーテッド | 葉酸受容体アルファに特異的な抗体 |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| WO2020128972A1 (fr) | 2018-12-20 | 2020-06-25 | Novartis Ag | Schéma posologique et combinaison pharmaceutique comprenant des dérivés de 3-(1-oxoisoindoline-2-yl) pipéridine-2,6-dione |
| BR112021015672A2 (pt) | 2019-02-15 | 2021-10-05 | Novartis Ag | Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona substituída e usos dos mesmos |
| ES3032659T3 (en) | 2019-02-15 | 2025-07-23 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| AU2020240310A1 (en) | 2019-03-21 | 2021-10-07 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| EP3947395A1 (fr) | 2019-03-29 | 2022-02-09 | ImmunoGen, Inc. | Dérivés de bis-benzodiazépine cytotoxiques et leurs conjugués avec des agents de liaison à une cellule pour inhiber la croissance cellulaire anormale ou pour traiter des maladies prolifératives |
| EP3959320A1 (fr) | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions et procédés de dégradation sélective de protéines |
| HUE065484T2 (hu) | 2019-04-26 | 2024-05-28 | Immunogen Inc | Camptothecin-származékok |
| CN114222756A (zh) * | 2019-04-29 | 2022-03-22 | 伊缪诺金公司 | 双互补位FR-α抗体和免疫缀合物 |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| CN114786732A (zh) * | 2019-06-06 | 2022-07-22 | 神话治疗股份有限公司 | 抗原结合蛋白构建体及其用途 |
| CN114555127A (zh) | 2019-08-06 | 2022-05-27 | L.E.A.F.控股集团公司 | 制备聚谷氨酸化抗叶酸剂的方法以及它们的组合物的用途 |
| KR20220116257A (ko) | 2019-12-20 | 2022-08-22 | 노파르티스 아게 | 골수섬유증 및 골수이형성 증후군을 치료하기 위한, 데시타빈 또는 항 pd-1 항체 스파르탈리주맙을 포함하거나 또는 포함하지 않는, 항 tim-3 항체 mbg453 및 항 tgf-베타 항체 nis793의 조합물 |
| US11890828B2 (en) | 2019-12-30 | 2024-02-06 | Idaho Forest Group, LLC | Moisture extraction press and moisture removal from wood materials |
| CN116096862A (zh) | 2020-06-11 | 2023-05-09 | 诺华股份有限公司 | Zbtb32抑制剂及其用途 |
| CN115916199A (zh) | 2020-06-23 | 2023-04-04 | 诺华股份有限公司 | 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案 |
| CN111690061B (zh) * | 2020-06-28 | 2022-08-23 | 中国人民解放军东部战区疾病预防控制中心 | 人源化抗鼠疫耶尔森菌抗原f1的抗体及应用 |
| US20230271940A1 (en) | 2020-08-03 | 2023-08-31 | Novartis Ag | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| EP4274619A4 (fr) * | 2021-01-08 | 2025-09-24 | Lycia Therapeutics Inc | Composés bifonctionnels de liaison au récepteur des folates |
| US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| EP4319820A1 (fr) * | 2021-04-10 | 2024-02-14 | Profoundbio Us Co. | Agents de liaison à folr1, conjugués de ceux-ci et leurs procédés d'utilisation |
| CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
| BR112023021873A2 (pt) | 2021-04-23 | 2023-12-19 | King S College London | Composição compreendendo um anticorpo ige |
| TW202309294A (zh) | 2021-04-27 | 2023-03-01 | 瑞士商諾華公司 | 病毒載體生產系統 |
| CN117396220A (zh) * | 2021-05-04 | 2024-01-12 | 免疫里森公司 | 抗nkg2d抗体及其用途 |
| TW202320857A (zh) * | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| JP2024524614A (ja) | 2021-07-14 | 2024-07-05 | ライシア セラピューティクス, インコーポレイテッド | Asgpr細胞表面受容体結合化合物及びコンジュゲート |
| EP4741423A2 (fr) | 2022-03-11 | 2026-05-13 | Mablink Bioscience | Conjugués anticorps-médicament et leurs utilisations |
| JP2025513721A (ja) * | 2022-03-25 | 2025-04-30 | ザイムワークス ビーシー インコーポレイテッド | 抗葉酸受容体アルファ抗体及び使用方法 |
| WO2023214325A1 (fr) | 2022-05-05 | 2023-11-09 | Novartis Ag | Dérivés de pyrazolopyrimidine et leurs utilisations en tant qu'inhibiteurs de tet2 |
| JP2025523630A (ja) * | 2022-07-04 | 2025-07-23 | ブイアイビー ブイゼットダブリュ | 血液-脳脊髄液関門通過抗体 |
| KR102763885B1 (ko) | 2022-08-29 | 2025-02-05 | 전남대학교산학협력단 | Dlc 적층에 의한 금속 박막의 강화방법 |
| EP4342488A1 (fr) | 2022-09-26 | 2024-03-27 | Miltenyi Biotec B.V. & Co. KG | Récepteur antigénique chimérique spécifique du récepteur 1 du folate |
| AU2023369684A1 (en) | 2022-10-26 | 2025-04-17 | Novartis Ag | Lentiviral formulations |
| EP4720059A1 (fr) | 2023-05-24 | 2026-04-08 | Kumquat Biosciences Inc. | Composés hétérocycliques et leurs utilisations |
| US12624097B2 (en) | 2023-07-03 | 2026-05-12 | Medicovestor, Inc. | Nucleic acids, vectors, and cells that encode anti-Sp17 antibodies and other Sp17 binding proteins |
| US12319747B2 (en) | 2023-07-03 | 2025-06-03 | Medicovestor, Inc. | Methods of using anti-SP17 immunotherapeutics |
| US12364777B2 (en) | 2023-10-20 | 2025-07-22 | Medicovestor, Inc. | Homodimeric antibodies for use in treating cancers and methods of use |
| WO2025094146A1 (fr) | 2023-11-02 | 2025-05-08 | Immunogen Switzerland Gmbh | Vasoconstricteurs pour réduire la toxicité oculaire de conjugués anticorps-maytansinoïde |
| US12600795B2 (en) | 2023-12-26 | 2026-04-14 | Medicovestor, Inc. | Oligomeric IgG for immunotherapeutics and diagnostics |
| US12121587B1 (en) | 2023-12-26 | 2024-10-22 | Medicovestor, Inc. | Dimeric antibodies |
| US12116410B1 (en) | 2023-12-26 | 2024-10-15 | Medicovestor, Inc. | Methods of manufacturing dimeric antibodies |
| WO2025161939A1 (fr) * | 2024-01-31 | 2025-08-07 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anticorps et leurs utilisations |
| US12240900B1 (en) | 2024-02-02 | 2025-03-04 | Medicovestor, Inc. | Nucleic acids, vectors, and cells that encode antibodies and other proteins that bind folate receptor alpha |
| US12258396B1 (en) | 2024-02-02 | 2025-03-25 | Medicovestor, Inc. | Methods of using immunotherapeutics that bind folate receptor alpha |
| US12378314B1 (en) | 2024-02-02 | 2025-08-05 | Medicovestor, Inc. | Proteins that bind folate receptor alpha including fully-human antibodies |
| CN118549647B (zh) * | 2024-04-02 | 2025-03-18 | 智泽童康(广州)生物科技有限公司 | 一种mmp7检测试剂盒、制备方法及其检测方法 |
| WO2026082125A1 (fr) * | 2024-10-16 | 2026-04-23 | 上海医药集团股份有限公司 | Anticorps se liant à folr1, médicament le contenant et utilisation associée |
| CN120842412B (zh) * | 2025-09-23 | 2025-12-05 | 合肥综合性国家科学中心大健康研究院 | 一种靶向人的叶酸受体α的单克隆抗体及其应用 |
Family Cites Families (182)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720760A (en) | 1968-09-06 | 1973-03-13 | Pharmacia Ab | Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples |
| US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| EP0028683A1 (fr) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotique C-15003 PHO et sa préparation |
| JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
| WO1982001188A1 (fr) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | Composes 4,5-deoxymaytansinoide et leur procede de preparation |
| US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
| US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
| US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
| US4563304A (en) | 1981-02-27 | 1986-01-07 | Pharmacia Fine Chemicals Ab | Pyridine compounds modifying proteins, polypeptides or polysaccharides |
| JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| US4588585A (en) | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| DE3546807C2 (fr) | 1985-03-30 | 1991-03-28 | Marc Genf/Geneve Ch Ballivet | |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| DE3600905A1 (de) | 1986-01-15 | 1987-07-16 | Ant Nachrichtentech | Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen |
| US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| WO1989006692A1 (fr) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Procede de traitement de cellules tumorales par inhibition de la fonction receptrice du facteur de croissance |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| GB8826530D0 (en) | 1988-11-12 | 1988-12-14 | Ped Capacitors Ltd | Electrical capacitors |
| US20030229208A1 (en) * | 1988-12-28 | 2003-12-11 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| CA2016841C (fr) | 1989-05-16 | 1999-09-21 | William D. Huse | Methode de production de polymeres ayant une activite choisie |
| EP0478627A4 (en) | 1989-05-16 | 1992-08-19 | William D. Huse | Co-expression of heteromeric receptors |
| CA2016842A1 (fr) | 1989-05-16 | 1990-11-16 | Richard A. Lerner | Methode pour puiser dans le repertoire immunologique |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5705337A (en) | 1990-06-11 | 1998-01-06 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-SELEX |
| US6344321B1 (en) | 1990-06-11 | 2002-02-05 | Gilead Sciences, Inc. | Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US6916605B1 (en) * | 1990-07-10 | 2005-07-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
| US5840867A (en) | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| EP0605522B1 (fr) | 1991-09-23 | 1999-06-23 | Medical Research Council | Méthodes de production d'anticorps humanisés |
| PT1696031E (pt) | 1991-12-02 | 2010-06-25 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| JP4157160B2 (ja) | 1991-12-13 | 2008-09-24 | ゾーマ テクノロジー リミテッド | 改変抗体可変領域の調製のための方法 |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| WO1993017715A1 (fr) | 1992-03-05 | 1993-09-16 | Board Of Regents, The University Of Texas System | Agents diagnostiques et/ou therapeutiques cibles sur des cellules endotheliales neovasculaires |
| US20030148406A1 (en) * | 1992-03-17 | 2003-08-07 | David John King | Multivalent antigen-binding proteins |
| CA2076465C (fr) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Conjugues agents de liaison cellulaire d'analogues et de derives de cc-1065 |
| US5756291A (en) | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| JPH08511420A (ja) * | 1993-06-16 | 1996-12-03 | セルテック・セラピューテイクス・リミテッド | 抗 体 |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6696248B1 (en) | 1995-08-18 | 2004-02-24 | Morphosys Ag | Protein/(poly)peptide libraries |
| ATE219517T1 (de) | 1995-08-18 | 2002-07-15 | Morphosys Ag | Protein-/(poly)peptidbibliotheken |
| WO1997011971A1 (fr) | 1995-09-28 | 1997-04-03 | Alexion Pharmaceuticals, Inc. | Proteines d'interaction de cellules porcines |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| US6596850B1 (en) * | 1998-01-30 | 2003-07-22 | Ixsys, Incorporated | Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same |
| US20060057573A1 (en) | 2002-02-15 | 2006-03-16 | Somalogic, Inc | Methods and reagents for detecting target binding by nucleic acid ligands |
| CA2354862A1 (fr) | 1998-10-19 | 2000-04-27 | Yeda Research And Development Co. Ltd. | Traitement du lupus erythemateux systemique par regulation negative de la reponse auto-immune a des autoantigenes |
| US20030054360A1 (en) | 1999-01-19 | 2003-03-20 | Larry Gold | Method and apparatus for the automated generation of nucleic acid ligands |
| US20040031072A1 (en) | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
| ATE482275T1 (de) | 1999-07-02 | 2010-10-15 | Morphosys Ag | Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden |
| US20020068066A1 (en) | 1999-08-20 | 2002-06-06 | Wenyuan Shi | Method for the treatment and prevention of dental caries |
| IT1307309B1 (it) * | 1999-12-30 | 2001-10-30 | Enea Ente Nuove Tec | Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono. |
| NZ521898A (en) | 2000-03-31 | 2004-11-26 | Purdue Research Foundation | Use of a ligand-immunogen conjugate such as folate-FITC for enhancing an endogenous immune response |
| RU2280650C2 (ru) * | 2000-04-17 | 2006-07-27 | Шанхай Фармко Рисерч, Инк. | Комплекс фолиевой кислоты или производного фолиевой кислоты, фармацевтическая композиция и применение комплекса |
| DE10037759A1 (de) * | 2000-08-03 | 2002-07-04 | Gruenenthal Gmbh | Screeningverfahren |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| EP2351855A1 (fr) | 2000-09-26 | 2011-08-03 | Duke University | Aptamères d'ARN et leurs procédés d'identification |
| AU2002256624B2 (en) | 2001-02-19 | 2007-12-06 | Merck Patent Gmbh | Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity |
| AU2002258518A1 (en) | 2001-03-14 | 2002-09-24 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
| PL367102A1 (en) | 2001-05-02 | 2005-02-21 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
| GB0202319D0 (en) | 2002-02-01 | 2002-03-20 | Calex Electronics Ltd | Apparatus |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| EP1486566A4 (fr) | 2002-03-01 | 2005-10-12 | Japan Enviro Chemicals Ltd | Proteines capables de se lier aux hormones sexuelles feminines et procede de preparation |
| WO2003089475A2 (fr) | 2002-04-22 | 2003-10-30 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Resistance des plantes aux moisissures exercee par des anticorps, des anticorps recombines, des fragments et des fusions d'anticorps recombines |
| KR100480244B1 (ko) | 2002-06-03 | 2005-04-06 | 삼성전자주식회사 | 레이저 모듈 |
| US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| HUE026914T2 (en) | 2002-11-07 | 2016-08-29 | Immunogen Inc | Anti-CD33 antibodies and a method of treating acute myeloid leukemia |
| AU2003295411A1 (en) * | 2002-11-07 | 2004-06-03 | Celltech R & D | Human monoclonal antibodies to heparanase |
| US20050124565A1 (en) | 2002-11-21 | 2005-06-09 | Diener John L. | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| EP1481993A1 (fr) | 2003-05-28 | 2004-12-01 | Xerion Pharmaceuticals AG | Modulation de la fonction du récepteur du poliovirus |
| US20050255114A1 (en) | 2003-04-07 | 2005-11-17 | Nuvelo, Inc. | Methods and diagnosis for the treatment of preeclampsia |
| US20050025763A1 (en) * | 2003-05-08 | 2005-02-03 | Protein Design Laboratories, Inc. | Therapeutic use of anti-CS1 antibodies |
| KR101351122B1 (ko) | 2003-05-09 | 2014-01-14 | 듀크 유니버시티 | Cd20-특이적 항체 및 이를 이용한 방법 |
| US7374762B2 (en) * | 2003-05-14 | 2008-05-20 | Immunogen, Inc. | Drug conjugate composition |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| EP1639000A2 (fr) | 2003-07-02 | 2006-03-29 | Genentech, Inc. | Compositions et methodes de diagnostic et de traitement de tumeur |
| WO2005024042A2 (fr) | 2003-09-04 | 2005-03-17 | The Regents Of The University Of California | Aptameres et procedes pour leur selection in vitro, et utilisations correspondantes |
| US7622112B2 (en) * | 2003-12-05 | 2009-11-24 | Jody Berry | Anti-SARS monoclonal antibodies |
| EP1716179A2 (fr) | 2004-02-12 | 2006-11-02 | Morphotek, Inc. | Anticorps monoclonaux liant specifiquement le recepteur alpha de l'acide folique |
| WO2005075514A2 (fr) | 2004-03-10 | 2005-08-18 | Lonza Ltd. | Procede de production d'anticorps |
| FR2867784B1 (fr) | 2004-03-17 | 2006-06-09 | Commissariat Energie Atomique | Aptameres selectionnes a partir de cellules vivantes tumorales et leurs applications |
| US20050239134A1 (en) | 2004-04-21 | 2005-10-27 | Board Of Regents, The University Of Texas System | Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein |
| CA2562833A1 (fr) | 2004-04-27 | 2005-11-03 | Galapagos N.V. | Procedes, agents, et analyses de criblage de composes permettant d'induire une differenciation de cellules mammaliennes non differenciees en osteoblastes |
| AU2005279347A1 (en) | 2004-08-30 | 2006-03-09 | Lonza Biologics Plc. | Affinity- plus ion exchange- chromatography for purifying antibodies |
| AU2005306997B2 (en) * | 2004-10-25 | 2012-07-05 | Merck Sharp & Dohme Corp. | Anti-ADDL antibodies and uses thereof |
| AU2005337132B2 (en) * | 2004-12-21 | 2011-01-20 | Monsanto Technology, Llc | Transgenic plants with enhanced agronomic traits |
| EA200701211A1 (ru) * | 2004-12-31 | 2007-12-28 | Дженентек, Инк. | Полипептиды, которые связываются с br3, и их применение |
| EP2153848A3 (fr) * | 2005-01-27 | 2010-07-21 | The Regents of the University of California | Anticorps monoclonaux thérapeutiques neutralisant les neurotoxines botuliques |
| US7608413B1 (en) | 2005-03-25 | 2009-10-27 | Celera Corporation | Kidney disease targets and uses thereof |
| AU2006230099B2 (en) * | 2005-03-25 | 2012-04-19 | Gitr, Inc. | GITR binding molecules and uses therefor |
| WO2006105141A1 (fr) | 2005-03-30 | 2006-10-05 | Purdue Research Foundation | Methode destinee a pronostiquer un cancer par quantification des recepteurs des folates cellulaires |
| WO2006112585A1 (fr) | 2005-04-18 | 2006-10-26 | Lg Electronics Inc. | Procede de fonctionnement d'un dispositif de composition de musique |
| JP2009521206A (ja) | 2005-04-22 | 2009-06-04 | モルフォテック、インク. | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
| EP1888639A1 (fr) * | 2005-05-12 | 2008-02-20 | Oncotherapy Science, Inc. | Procedes pour endommager des cellules en utilisant une fonction effectrice d un anticorps anti-dsc2 |
| EP1915394B1 (fr) | 2005-05-20 | 2021-01-27 | Lonza Biologics plc. | Expression de niveau eleve d'un anticorps recombinant d'une cellule hote de mammifere |
| KR20080039844A (ko) * | 2005-05-24 | 2008-05-07 | 아베스타 겐그레인 테크놀로지스 피브이티 리미티드 | B―세포 림프종 치료를 위한 cd20에 대한 모노클로날항체의 제조 방법 |
| JP5175723B2 (ja) | 2005-07-05 | 2013-04-03 | パーデュー・リサーチ・ファウンデーション | 単球介在性疾患を治療するための組成物の調製 |
| US7521195B1 (en) | 2005-07-21 | 2009-04-21 | Celera Corporation | Lung disease targets and uses thereof |
| CA2619725C (fr) * | 2005-08-18 | 2016-06-07 | Ramot At Tel Aviv University Ltd. | Anticorps monocatenaires diriges contre le peptide beta-amyloide |
| US7906116B2 (en) | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
| EP1937815B1 (fr) | 2005-09-13 | 2015-05-13 | National Research Council of Canada | Méthodes et compositions permettant de moduler l'activité des cellules tumorales |
| US20070099251A1 (en) | 2005-10-17 | 2007-05-03 | Institute For Systems Biology | Tissue-and serum-derived glycoproteins and methods of their use |
| EP1790664A1 (fr) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Anticorps monoclonaux contre claudin-18 pour le traitement du cancer |
| HUE039865T2 (hu) * | 2005-12-20 | 2019-02-28 | Sbi Biotech Co Ltd | Anti-ILT7 antitest |
| US8486412B2 (en) | 2006-06-01 | 2013-07-16 | Mayo Foundation For Medical Education And Research | Immunity to folate receptors |
| JP5564249B2 (ja) | 2006-06-23 | 2014-07-30 | アレシア・バイオセラピューティクス・インコーポレーテッド | 癌に関与するポリヌクレオチド配列およびポリペプチド配列 |
| US7910702B2 (en) * | 2006-07-28 | 2011-03-22 | The Governors Of The University Of Alberta | Recombinant antibodies to sclerotinia antigens |
| JP5244103B2 (ja) | 2006-08-09 | 2013-07-24 | ホームステッド クリニカル コーポレイション | 器官特異的蛋白質およびその使用方法 |
| JP4711910B2 (ja) * | 2006-08-24 | 2011-06-29 | パナソニック株式会社 | 紙製包装箱 |
| EP1900752A1 (fr) * | 2006-09-15 | 2008-03-19 | DOMPE' pha.r.ma s.p.a. | Anticorps monoclonaux humains et ses fragments liant spécifiquement le récepteur alpha de l'acide folique pour l'immunothérapie du cancer de l'ovaire |
| NZ601022A (en) | 2006-10-12 | 2014-09-26 | Chugai Pharmaceutical Co Ltd | Diagnosis and treatment of cancer using anti-ereg antibody |
| CA2672581A1 (fr) | 2006-12-14 | 2008-06-19 | Forerunner Pharma Research Co., Ltd. | Anticorps monoclonal anti-claudine 3, et traitement et diagnostic du cancer au moyen d'un tel anticorps |
| CA2673725C (fr) | 2006-12-20 | 2016-01-12 | Mmr Information Systems, Inc. | Anticorps et procedes de fabrication et d'utilisation de ceux-ci |
| US20080227704A1 (en) * | 2006-12-21 | 2008-09-18 | Kamens Joanne S | CXCL13 binding proteins |
| US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| EP2604283A1 (fr) | 2007-02-16 | 2013-06-19 | KTB Tumorforschungsgesellschaft mbH | Récepteur et promédicament ciblé antigène |
| NZ580132A (en) * | 2007-03-14 | 2012-11-30 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins to vitamins |
| WO2008145136A1 (fr) | 2007-05-30 | 2008-12-04 | Aarhus Universitet | Inactivation des stat3 par inhibition de la voie du récepteur des folates |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| CN101139613B (zh) | 2007-08-01 | 2011-06-08 | 姜荣锡 | 抗肿瘤二元多肽及其应用与制备方法 |
| ES2546086T3 (es) | 2007-12-21 | 2015-09-18 | Novartis Ag | Sistema de selección en un cultivo de células eucariotas basado en un gen receptor de folato unido a la membrana |
| DE202008000527U1 (de) | 2008-01-11 | 2009-03-05 | Bucyrus Dbt Europe Gmbh | Firstmeißelträgerverstellung und Sicherungselement hierfür |
| US9274119B2 (en) | 2008-01-11 | 2016-03-01 | The University Of Tokyo | Anti-CLDN6 antibody |
| US8093364B2 (en) | 2008-01-18 | 2012-01-10 | Bio-Rad Laboratories, Inc. | Enhanced purification of antibodies and antibody fragments by apatite chromatography |
| JP5470817B2 (ja) | 2008-03-10 | 2014-04-16 | 日産自動車株式会社 | 電池用電極およびこれを用いた電池、並びにその製造方法 |
| WO2009132081A2 (fr) | 2008-04-24 | 2009-10-29 | The Research Foundation Of State University Of New York | Ciblage à base d’anticorps monoclonaux des récepteurs de folate |
| RU2487877C2 (ru) | 2008-04-30 | 2013-07-20 | Иммьюноджен, Инк. | Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры) |
| EP2281006B1 (fr) | 2008-04-30 | 2017-08-02 | Immunogen, Inc. | Agents de réticulation et leurs utilisations |
| US8383351B2 (en) * | 2008-06-11 | 2013-02-26 | Oxford Brookes University | Antibody to inhibin/ activin β-B subunit |
| US8546425B2 (en) | 2008-09-17 | 2013-10-01 | Purdue Research Foundation | Folate receptor binding conjugates of antifolates |
| US20100092470A1 (en) | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
| CN101440130B (zh) | 2008-11-21 | 2011-07-27 | 中国人民解放军第四军医大学 | 一种抗人IL-13Rα2单克隆抗体的重链和轻链的可变区 |
| CN102365021B (zh) | 2009-02-05 | 2015-07-15 | 伊缪诺金公司 | 新型苯并二氮杂*衍生物 |
| CA2756493C (fr) | 2009-03-24 | 2019-07-02 | Biocept, Inc. | Dispositifs et procedes de capture et d'analyse de cellules |
| US20110011931A1 (en) | 2009-07-14 | 2011-01-20 | Fidelisoft Inc. | One-Card Transaction Management System |
| DK2462161T3 (en) | 2009-08-06 | 2017-06-06 | Immunas Pharma Inc | Antibodies specifically binding to A-beta oligomers and their use |
| AR080155A1 (es) | 2010-02-10 | 2012-03-14 | Immunogen Inc | Anticuerpos anti-cd20 y su utilizacion |
| AR080301A1 (es) | 2010-02-24 | 2012-03-28 | Immunogen Inc | Anticuerpos e inmunoconjugados del receptor 1 de folato y sus usos |
| US20120207771A1 (en) | 2010-11-05 | 2012-08-16 | Morphotek Inc. | Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers |
| CN103619357A (zh) | 2011-03-29 | 2014-03-05 | 伊缪诺金公司 | 用于制造具有改善的同质性的缀合物的方法 |
| TR201902180T4 (tr) | 2011-03-29 | 2019-03-21 | Immunogen Inc | Tek adimli bi̇r i̇şlem i̇le maytansi̇noi̇d anti̇kor konjugatlarinin hazirlanmasi |
| PL2694106T3 (pl) | 2011-04-01 | 2018-06-29 | Immunogen, Inc. | Sposoby zwiększania skuteczności terapii przeciwnowotworowej opartej na receptorze folr1 |
| US20120282282A1 (en) | 2011-04-04 | 2012-11-08 | Immunogen, Inc. | Methods for Decreasing Ocular Toxicity of Antibody Drug Conjugates |
| AU2012284321C1 (en) | 2011-07-15 | 2017-07-13 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
| KR20150046316A (ko) | 2012-08-31 | 2015-04-29 | 이뮤노젠 아이엔씨 | 엽산 수용체 1의 검출을 위한 진단성 검정 및 키트 |
| WO2014055842A1 (fr) | 2012-10-04 | 2014-04-10 | Immunogen, Inc. | Procédé de préparation de conjugués maytansinoïdes anticorps stables |
| JP6136279B2 (ja) | 2013-01-15 | 2017-05-31 | 株式会社ジェイテクト | 転がり軸受装置 |
| TWI503850B (zh) | 2013-03-22 | 2015-10-11 | Polytronics Technology Corp | 過電流保護元件 |
| CN119185571A (zh) | 2013-05-14 | 2024-12-27 | 伊缪诺金公司 | 抗folr1免疫缀合物给药方案 |
| PT3038650T (pt) | 2013-08-30 | 2021-08-25 | Immunogen Inc | Anticorpos e ensaios para a deteção do recetor de folato 1 |
| TWI510996B (zh) | 2013-10-03 | 2015-12-01 | Acer Inc | 控制觸控面板的方法以及使用該方法的可攜式電腦 |
| NZ757964A (en) | 2013-10-08 | 2022-07-01 | Immunogen Inc | Anti-folr1 immunoconjugate dosing regimens |
| WO2015149018A1 (fr) | 2014-03-28 | 2015-10-01 | Immunogen, Inc. | Schémas posologiques d'immunoconjugués anti-folr1 |
| JP6880006B2 (ja) | 2015-09-17 | 2021-06-02 | イミュノジェン, インコーポレイテッド | 抗folr1免疫複合体を含む治療組み合わせ |
| US9816280B1 (en) | 2016-11-02 | 2017-11-14 | Matthew Reitnauer | Portable floor |
-
2011
- 2011-02-24 AR ARP110100569 patent/AR080301A1/es active IP Right Grant
- 2011-02-24 JP JP2012555146A patent/JP5778700B2/ja active Active
- 2011-02-24 KR KR1020237009605A patent/KR20230044026A/ko not_active Ceased
- 2011-02-24 RU RU2017102988A patent/RU2740479C2/ru active
- 2011-02-24 NZ NZ709390A patent/NZ709390A/en unknown
- 2011-02-24 KR KR1020187023173A patent/KR102028531B1/ko active Active
- 2011-02-24 HR HRP20170281TT patent/HRP20170281T1/hr unknown
- 2011-02-24 KR KR1020177019242A patent/KR20170085143A/ko not_active Ceased
- 2011-02-24 CA CA3206109A patent/CA3206109A1/fr active Pending
- 2011-02-24 CA CA3014767A patent/CA3014767C/fr active Active
- 2011-02-24 PL PL11748067T patent/PL2538976T3/pl unknown
- 2011-02-24 AU AU2011220728A patent/AU2011220728B2/en active Active
- 2011-02-24 KR KR1020167017526A patent/KR101759057B1/ko active Active
- 2011-02-24 ES ES16002534T patent/ES2813549T3/es active Active
- 2011-02-24 TW TW107102975A patent/TWI672318B/zh active
- 2011-02-24 MY MYPI2022000429A patent/MY205540A/en unknown
- 2011-02-24 TW TW100106217A patent/TWI504408B/zh active
- 2011-02-24 TW TW112106609A patent/TW202348631A/zh unknown
- 2011-02-24 NZ NZ621938A patent/NZ621938A/en unknown
- 2011-02-24 NZ NZ724971A patent/NZ724971A/en unknown
- 2011-02-24 NZ NZ601617A patent/NZ601617A/en unknown
- 2011-02-24 MX MX2012009754A patent/MX340437B/es active IP Right Grant
- 2011-02-24 MY MYPI2018000278A patent/MY197016A/en unknown
- 2011-02-24 MX MX2015008785A patent/MX367345B/es unknown
- 2011-02-24 TW TW108122949A patent/TWI781327B/zh active
- 2011-02-24 PT PT117480673T patent/PT2538976T/pt unknown
- 2011-02-24 WO PCT/US2011/026079 patent/WO2011106528A1/fr not_active Ceased
- 2011-02-24 CN CN201610089034.1A patent/CN105777907B/zh active Active
- 2011-02-24 MY MYPI2014002245A patent/MY171234A/en unknown
- 2011-02-24 US US13/033,723 patent/US8557966B2/en active Active
- 2011-02-24 MY MYPI2012003708A patent/MY165151A/en unknown
- 2011-02-24 RU RU2012135395A patent/RU2610663C2/ru active
- 2011-02-24 KR KR1020127024475A patent/KR101580713B1/ko active Active
- 2011-02-24 SM SM20170139T patent/SMT201700139T1/it unknown
- 2011-02-24 KR KR1020157004684A patent/KR101637138B1/ko active Active
- 2011-02-24 SG SG10201801636QA patent/SG10201801636QA/en unknown
- 2011-02-24 SG SG10201606573SA patent/SG10201606573SA/en unknown
- 2011-02-24 IL IL290617A patent/IL290617B2/en unknown
- 2011-02-24 HU HUE11748067A patent/HUE030854T2/en unknown
- 2011-02-24 IL IL303569A patent/IL303569A/en unknown
- 2011-02-24 DK DK11748067.3T patent/DK2538976T3/en active
- 2011-02-24 UA UAA201507804A patent/UA123257C2/uk unknown
- 2011-02-24 SG SG2012057410A patent/SG183144A1/en unknown
- 2011-02-24 CA CA2790412A patent/CA2790412C/fr active Active
- 2011-02-24 LT LTEP11748067.3T patent/LT2538976T/lt unknown
- 2011-02-24 ES ES11748067.3T patent/ES2617283T3/es active Active
- 2011-02-24 TW TW111104514A patent/TWI796132B/zh active
- 2011-02-24 KR KR1020197028473A patent/KR20190114019A/ko not_active Ceased
- 2011-02-24 SI SI201131111A patent/SI2538976T1/sl unknown
- 2011-02-24 RS RS20170197A patent/RS55738B1/sr unknown
- 2011-02-24 KR KR1020247012350A patent/KR20240052894A/ko not_active Ceased
- 2011-02-24 CN CN201180019687.8A patent/CN103037900B/zh active Active
- 2011-02-24 KR KR1020217042946A patent/KR20220017432A/ko not_active Ceased
- 2011-02-24 BR BR112012021296-6A patent/BR112012021296B1/pt active IP Right Grant
- 2011-02-24 SG SG10201501342UA patent/SG10201501342UA/en unknown
- 2011-02-24 TW TW104124093A patent/TWI622402B/zh active
- 2011-02-24 EP EP16002534.2A patent/EP3196212B1/fr active Active
- 2011-02-24 EP EP11748067.3A patent/EP2538976B8/fr active Active
- 2011-02-24 KR KR1020207025672A patent/KR102287474B1/ko active Active
- 2011-02-24 KR KR1020217024497A patent/KR102346223B1/ko active Active
- 2011-02-24 EP EP20177867.7A patent/EP3760643A1/fr not_active Withdrawn
-
2012
- 2012-08-01 IL IL221241A patent/IL221241A/en active IP Right Grant
- 2012-08-22 MX MX2019009654A patent/MX2019009654A/es unknown
- 2012-08-22 MX MX2022001086A patent/MX2022001086A/es unknown
-
2013
- 2013-03-13 US US13/800,835 patent/US9133275B2/en active Active
-
2015
- 2015-06-15 JP JP2015120269A patent/JP6039751B2/ja active Active
- 2015-08-05 US US14/819,209 patent/US9657100B2/en active Active
- 2015-11-19 US US14/946,423 patent/US9670278B2/en active Active
- 2015-11-25 US US14/952,659 patent/US9670279B2/en active Active
- 2015-11-25 ZA ZA2015/08660A patent/ZA201508660B/en unknown
- 2015-12-15 US US14/970,436 patent/US9670280B2/en active Active
- 2015-12-15 US US14/970,433 patent/US9598490B2/en active Active
-
2016
- 2016-03-16 JP JP2016052044A patent/JP2016153412A/ja not_active Withdrawn
- 2016-09-04 IL IL247615A patent/IL247615B/en active IP Right Grant
-
2017
- 2017-02-24 CY CY20171100254T patent/CY1118668T1/el unknown
- 2017-05-01 US US15/583,281 patent/US10301385B2/en active Active
- 2017-09-21 JP JP2017181137A patent/JP2018021069A/ja not_active Withdrawn
- 2017-10-15 IL IL25501317A patent/IL255013B/en active IP Right Grant
-
2019
- 2019-04-15 US US16/384,031 patent/US10752683B2/en active Active
- 2019-06-12 JP JP2019109555A patent/JP6860614B2/ja active Active
- 2019-09-23 IL IL269530A patent/IL269530B/en active IP Right Grant
-
2020
- 2020-07-21 US US16/934,143 patent/US20210032327A1/en not_active Abandoned
- 2020-11-11 IL IL278658A patent/IL278658B/en unknown
-
2021
- 2021-03-26 JP JP2021053225A patent/JP7167228B2/ja active Active
-
2022
- 2022-10-26 JP JP2022171587A patent/JP7515228B2/ja active Active
-
2023
- 2023-09-08 US US18/464,020 patent/US20240132585A1/en active Pending
-
2024
- 2024-06-27 JP JP2024103680A patent/JP2024138308A/ja active Pending
-
2025
- 2025-02-18 FR FR25C1008C patent/FR25C1008I2/fr active Active
- 2025-02-18 NL NL301319C patent/NL301319I2/nl unknown
- 2025-03-03 FI FIC20250013C patent/FIC20250013I1/fi unknown
- 2025-03-18 HU HUS2500015C patent/HUS2500015I1/hu unknown
- 2025-04-10 LT LTPA2025515C patent/LTPA2025515I1/lt unknown
- 2025-05-05 CY CY2025014C patent/CY2025014I2/el unknown
- 2025-05-07 NO NO2025021C patent/NO2025021I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR25C1008I1 (fr) | Immunoconjugues contre du recepteur 1 du folate et leurs utilisations | |
| FR24C1027I2 (fr) | Agents antifongiques et leurs utilisations | |
| EP2475647A4 (fr) | Antagonistes du récepteur des androgènes et leurs utilisations | |
| EP2504439A4 (fr) | Endonucléases optimisées et leurs utilisations | |
| EP2844637A4 (fr) | Inhibiteurs de ssao 3-halogénoallylamines substituées et leurs utilisations | |
| EP2885318A4 (fr) | Conjugués peptides-dendrimères et leurs utilisations | |
| EP2646446A4 (fr) | Inhibiteurs de bromodomaines et leurs utilisations | |
| DK2528625T3 (da) | Pyrrolobenzodiazepiner og konjugater deraf | |
| DK2839860T3 (da) | Pyrrolobenzodiazepiner og konjugater deraf | |
| DK3470086T3 (da) | Pyrrolobenzodiazepiner og konjugater deraf | |
| EP2771020A4 (fr) | Dérivés n-acyldipeptides et leurs utilisations | |
| EP2605789A4 (fr) | Polypeptides de relaxine modifiés et leurs utilisations | |
| EP2861622A4 (fr) | Anticorps anti-idiotypiques anti-cd22 et leurs utilisations | |
| EP2766723A4 (fr) | Billes d'inhibiteur de kinase multiplexées et leurs utilisations | |
| DK2900805T3 (da) | Probiotiske og præbiotiske sammensætninger | |
| EP2608785A4 (fr) | Lipomacrocycles et leurs utilisations | |
| EP2616468A4 (fr) | Hétéroaryles condensés et leurs utilisations | |
| FR2963889B1 (fr) | Formulations a base de nalbuphine et leurs utilisations | |
| EP2391217A4 (fr) | Conjugués synthétiques et leurs utilisations | |
| BR112013009579A2 (pt) | método e comprimido | |
| EP2627324A4 (fr) | Benzamides substitués et leurs utilisations | |
| EP2775831A4 (fr) | Compositions pharmaceutiques et leurs utilisations | |
| EP3581563C0 (fr) | Inhibiteurs ship et leurs utilisations | |
| EP2768797A4 (fr) | Nouvelles curcumines modifiées et leurs utilisations | |
| EP2864345A4 (fr) | Conjugués particule-acide nucléique et utilisations thérapeutiques associées |