GR3015382T3 - Oxaspiro[2,5]octane derivative. - Google Patents

Oxaspiro[2,5]octane derivative.

Info

Publication number
GR3015382T3
GR3015382T3 GR950400533T GR950400533T GR3015382T3 GR 3015382 T3 GR3015382 T3 GR 3015382T3 GR 950400533 T GR950400533 T GR 950400533T GR 950400533 T GR950400533 T GR 950400533T GR 3015382 T3 GR3015382 T3 GR 3015382T3
Authority
GR
Greece
Prior art keywords
alkylcarbamoyl
alkyl
hydroxy
alkenoyl
alkoxy
Prior art date
Application number
GR950400533T
Other languages
English (en)
Inventor
Teruo Oku
Chiyoshi Kasahara
Takehiko Ohkawa
Masashi Hashimoto
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888819258A external-priority patent/GB8819258D0/en
Priority claimed from GB888819256A external-priority patent/GB8819256D0/en
Priority claimed from GB898908029A external-priority patent/GB8908029D0/en
Priority claimed from GB898909794A external-priority patent/GB8909794D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of GR3015382T3 publication Critical patent/GR3015382T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Dental Preparations (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Cereal-Derived Products (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR950400533T 1988-08-12 1995-03-13 Oxaspiro[2,5]octane derivative. GR3015382T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB888819258A GB8819258D0 (en) 1988-08-12 1988-08-12 Oxaspiro(2 5)octane compound
GB888819256A GB8819256D0 (en) 1988-08-12 1988-08-12 Oxaspiro(2 5)octane derivative
GB898908029A GB8908029D0 (en) 1989-04-10 1989-04-10 Oxaspriro(2,5)octane derivative
GB898909794A GB8909794D0 (en) 1989-04-28 1989-04-28 Cyclohexane derivative

Publications (1)

Publication Number Publication Date
GR3015382T3 true GR3015382T3 (en) 1995-06-30

Family

ID=27450157

Family Applications (1)

Application Number Title Priority Date Filing Date
GR950400533T GR3015382T3 (en) 1988-08-12 1995-03-13 Oxaspiro[2,5]octane derivative.

Country Status (18)

Country Link
US (2) US5789405A (el)
EP (1) EP0354787B1 (el)
JP (2) JP2773275B2 (el)
KR (1) KR0130765B1 (el)
CN (1) CN1051703C (el)
AT (1) ATE118490T1 (el)
AU (1) AU632056B2 (el)
CA (1) CA1340291C (el)
DE (1) DE68921114T2 (el)
DK (1) DK171987B1 (el)
ES (1) ES2067546T3 (el)
FI (1) FI97805C (el)
GR (1) GR3015382T3 (el)
HU (1) HU211569A9 (el)
IE (1) IE66923B1 (el)
IL (1) IL91250A (el)
NO (1) NO173236C (el)
PH (1) PH26256A (el)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
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PH26256A (en) * 1988-08-12 1992-04-01 Fujisawa Pharmaceutical Co Oxaspiro [2,5] octane derivative
JPH0660095B2 (ja) * 1988-09-01 1994-08-10 武田薬品工業株式会社 血管新生阻害剤
JPH0660168B2 (ja) * 1988-09-01 1994-08-10 武田薬品工業株式会社 ０―置換フマギロール誘導体
ES2099064T3 (es) * 1988-09-01 1997-05-16 Takeda Chemical Industries Ltd Derivados de fumagillol.
ATE87623T1 (de) * 1989-03-06 1993-04-15 Takeda Chemical Industries Ltd 6-epifumagillole, ihre herstellung und ihre verwendung.
US5290807A (en) * 1989-08-10 1994-03-01 Children's Medical Center Corporation Method for regressing angiogenesis using o-substituted fumagillol derivatives
US6017954A (en) * 1989-08-10 2000-01-25 Children's Medical Center Corp. Method of treating tumors using O-substituted fumagillol derivatives
EP0415294A3 (en) * 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
TW282399B (el) * 1990-05-25 1996-08-01 Takeda Pharm Industry Co Ltd
EP1004318A3 (en) * 1991-06-21 2002-08-07 Takeda Chemical Industries, Ltd. Cyclodextrin composition
WO1993005777A1 (fr) * 1991-09-18 1993-04-01 Fujisawa Pharmaceutical Co., Ltd. Preparation transoculaire
DE69311278T2 (de) * 1992-12-16 1997-10-30 Takeda Chemical Industries Ltd Stabile pharmazeutische Zubereitung mit Fumagillolderivaten
US5710148A (en) * 1995-03-06 1998-01-20 Senju Pharmaceuticals Co., Ltd. Corneal opacification inhibitory composition
FR2733499B1 (fr) * 1995-04-27 1997-05-30 Adir Nouvelles tetrahydropyrano(3,2-d)oxazolones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2733498B1 (fr) * 1995-04-27 1997-05-30 Adir Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5719167A (en) * 1995-08-07 1998-02-17 Alcon Laboratories, Inc. Angiostatic compounds
US5798356A (en) * 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
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US6207704B1 (en) 1997-06-09 2001-03-27 Massachusetts Institute Of Technology Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof
WO1999061432A1 (en) * 1998-05-12 1999-12-02 Biochem Pharma Inc. Fumagillin analogs and their use as angiogenesis inhibitors
KR100357541B1 (ko) * 1998-05-15 2002-10-18 주식회사종근당 5-데메톡시 푸마질롤 유도체 및 그 제조방법
KR100357542B1 (ko) * 1998-05-15 2002-10-18 주식회사종근당 푸마질롤 유도체 및 그 제조방법
US7105482B2 (en) * 2000-11-01 2006-09-12 Praecis Pharmaceuticals, Inc. Methionine aminopeptidase-2 inhibitors and methods of use thereof
US6548477B1 (en) 2000-11-01 2003-04-15 Praecis Pharmaceuticals Inc. Therapeutic agents and methods of use thereof for the modulation of angiogenesis
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US6919307B2 (en) * 2000-11-01 2005-07-19 Praecis Pharmaceuticals, Inc. Therapeutic agents and methods of use thereof for the modulation of angiogenesis
EP1699812A2 (en) * 2003-12-29 2006-09-13 Praecis Pharmaceuticals Inc. Inhibitors of methionine aminopeptidase-2 and uses thereof
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CN103249735B (zh) 2010-07-22 2016-04-06 扎夫根股份有限公司 三环化合物及其制备和使用方法
PH12013500934A1 (en) 2010-11-09 2022-10-24 Zafgen Inc Crystalline solids of a metap-2 inhibitor and methods of making and using same
WO2012075020A1 (en) 2010-11-29 2012-06-07 Zafgen Corporation Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
KR20140006888A (ko) 2011-01-26 2014-01-16 자프겐 인크. 테트라졸화합물, 그리고, 이를 제조하는 방법 및 이를 이용하는 방법
CN103534244B (zh) 2011-03-08 2016-10-12 扎夫根股份有限公司 氧杂螺[2.5]辛烷衍生物及类似物
AU2012253759B2 (en) 2011-05-06 2016-01-21 Zafgen Inc. Tricyclic sulfonamide compounds and methods of making and using same
CA2835261C (en) 2011-05-06 2019-06-04 Zafgen, Inc. Partially saturated tricyclic compounds and methods of making and using same
BR112013028666A2 (pt) 2011-05-06 2017-08-08 Zafgen Inc compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
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MX2014008706A (es) 2012-01-18 2015-03-05 Zafgen Inc Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
JP2015509102A (ja) 2012-01-18 2015-03-26 ザフゲン，インコーポレイテッド 三環式スルホン化合物並びにその作製および使用方法
US9260419B2 (en) 2012-05-07 2016-02-16 Zafgen, Inc. Polymorphic salt of a metap-2 inhibitor and methods of making and using same
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BR112015010223A2 (pt) 2012-11-05 2017-07-11 Zafgen Inc compostos tricíclicos para o uso no tratamento e/ou controle de obesidade
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Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0629278B2 (ja) * 1985-06-26 1994-04-20 藤沢薬品工業株式会社 オキサスピロオクタン化合物
PH26256A (en) * 1988-08-12 1992-04-01 Fujisawa Pharmaceutical Co Oxaspiro [2,5] octane derivative
JPH0660168B2 (ja) * 1988-09-01 1994-08-10 武田薬品工業株式会社 ０―置換フマギロール誘導体
ES2099064T3 (es) * 1988-09-01 1997-05-16 Takeda Chemical Industries Ltd Derivados de fumagillol.
KR0141692B1 (ko) * 1988-09-01 1998-06-01 우메모또 요시마사 맥관 형성 억제제
ATE87623T1 (de) * 1989-03-06 1993-04-15 Takeda Chemical Industries Ltd 6-epifumagillole, ihre herstellung und ihre verwendung.

Also Published As

Publication number Publication date
JP2773275B2 (ja) 1998-07-09
AU632056B2 (en) 1992-12-17
CA1340291C (en) 1998-12-29
DK171987B1 (da) 1997-09-08
NO173236C (no) 1993-11-17
NO893235L (no) 1990-02-13
NO173236B (no) 1993-08-09
HU211569A9 (en) 1995-12-28
IL91250A (en) 1994-10-21
PH26256A (en) 1992-04-01
DK390989D0 (da) 1989-08-09
IE66923B1 (en) 1996-02-07
KR900003164A (ko) 1990-03-23
JP2970524B2 (ja) 1999-11-02
IL91250A0 (en) 1990-03-19
IE892505L (en) 1990-02-12
EP0354787B1 (en) 1995-02-15
NO893235D0 (no) 1989-08-11
AU3945389A (en) 1990-02-15
DK390989A (da) 1990-02-13
JPH0285272A (ja) 1990-03-26
CN1079898A (zh) 1993-12-29
CN1051703C (zh) 2000-04-26
EP0354787A1 (en) 1990-02-14
US5767293A (en) 1998-06-16
FI893794A0 (fi) 1989-08-11
KR0130765B1 (ko) 1998-04-09
ATE118490T1 (de) 1995-03-15
FI97805B (fi) 1996-11-15
FI893794L (fi) 1990-02-13
JPH08319281A (ja) 1996-12-03
ES2067546T3 (es) 1995-04-01
DE68921114T2 (de) 1995-06-08
US5789405A (en) 1998-08-04
FI97805C (fi) 1997-02-25
DE68921114D1 (de) 1995-03-23

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