DK390989D0 - Octanforbindelser - Google Patents

Octanforbindelser

Info

Publication number: DK390989D0
Authority: DK; Denmark
Prior art keywords: alkylcarbamoyl; alkyl; hydroxy; alkenoyl; alkoxy
Prior art date: 1988-08-12

Application number

DK390989A

Other languages

English (en)

Other versions

DK171987B1 (da

DK390989A (da

Inventor

Teruo Oku

Chiyoshi Kasahara

Takehiko Ohkawa

Masashi Hashimoto

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-12

Filing date

1989-08-09

Publication date

1989-08-09

1988-08-12 Priority claimed from GB888819258A external-priority patent/GB8819258D0/en

1988-08-12 Priority claimed from GB888819256A external-priority patent/GB8819256D0/en

1989-04-10 Priority claimed from GB898908029A external-priority patent/GB8908029D0/en

1989-04-28 Priority claimed from GB898909794A external-priority patent/GB8909794D0/en

1989-08-09 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1989-08-09 Publication of DK390989D0 publication Critical patent/DK390989D0/da

1990-02-13 Publication of DK390989A publication Critical patent/DK390989A/da

1997-09-08 Application granted granted Critical

1997-09-08 Publication of DK171987B1 publication Critical patent/DK171987B1/da

Links

TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical class CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title 1
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 12
125000000217 alkyl group Chemical group 0.000 abstract 12
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
VUEWYZJJYGPJDC-UHFFFAOYSA-N 1-oxaspiro[2.5]octane Chemical class C1OC11CCCCC1 VUEWYZJJYGPJDC-UHFFFAOYSA-N 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
230000033115 angiogenesis Effects 0.000 abstract 1
125000005116 aryl carbamoyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Dental Preparations (AREA)
Photoreceptors In Electrophotography (AREA)
Polyesters Or Polycarbonates (AREA)
Cereal-Derived Products (AREA)
Seasonings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK390989A 1988-08-12 1989-08-09 Oxaspiro(2,5)octanderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne DK171987B1 (da)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
GB8819256		1988-08-12
GB8819258		1988-08-12
GB888819258A GB8819258D0 (en)	1988-08-12	1988-08-12	Oxaspiro(2 5)octane compound
GB888819256A GB8819256D0 (en)	1988-08-12	1988-08-12	Oxaspiro(2 5)octane derivative
GB8908029		1989-04-10
GB898908029A GB8908029D0 (en)	1989-04-10	1989-04-10	Oxaspriro(2,5)octane derivative
GB8909794		1989-04-28
GB898909794A GB8909794D0 (en)	1989-04-28	1989-04-28	Cyclohexane derivative

Publications (3)

Publication Number	Publication Date
DK390989D0 true DK390989D0 (da)	1989-08-09
DK390989A DK390989A (da)	1990-02-13
DK171987B1 DK171987B1 (da)	1997-09-08

Family

ID=27450157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK390989A DK171987B1 (da)	1988-08-12	1989-08-09	Oxaspiro(2,5)octanderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne

Country Status (18)

Country	Link
US (2)	US5789405A (da)
EP (1)	EP0354787B1 (da)
JP (2)	JP2773275B2 (da)
KR (1)	KR0130765B1 (da)
CN (1)	CN1051703C (da)
AT (1)	ATE118490T1 (da)
AU (1)	AU632056B2 (da)
CA (1)	CA1340291C (da)
DE (1)	DE68921114T2 (da)
DK (1)	DK171987B1 (da)
ES (1)	ES2067546T3 (da)
FI (1)	FI97805C (da)
GR (1)	GR3015382T3 (da)
HU (1)	HU211569A9 (da)
IE (1)	IE66923B1 (da)
IL (1)	IL91250A (da)
NO (1)	NO173236C (da)
PH (1)	PH26256A (da)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH26256A (en) *	1988-08-12	1992-04-01	Fujisawa Pharmaceutical Co	Oxaspiro [2,5] octane derivative
JPH0660095B2 (ja) *	1988-09-01	1994-08-10	武田薬品工業株式会社	血管新生阻害剤
JPH0660168B2 (ja) *	1988-09-01	1994-08-10	武田薬品工業株式会社	０―置換フマギロール誘導体
ES2099064T3 (es) *	1988-09-01	1997-05-16	Takeda Chemical Industries Ltd	Derivados de fumagillol.
ATE87623T1 (de) *	1989-03-06	1993-04-15	Takeda Chemical Industries Ltd	6-epifumagillole, ihre herstellung und ihre verwendung.
US5290807A (en) *	1989-08-10	1994-03-01	Children's Medical Center Corporation	Method for regressing angiogenesis using o-substituted fumagillol derivatives
US6017954A (en) *	1989-08-10	2000-01-25	Children's Medical Center Corp.	Method of treating tumors using O-substituted fumagillol derivatives
EP0415294A3 (en) *	1989-08-31	1991-06-12	Takeda Chemical Industries, Ltd.	Cyclohexanol derivatives, production and use thereof
TW282399B (da) *	1990-05-25	1996-08-01	Takeda Pharm Industry Co Ltd
EP1004318A3 (en) *	1991-06-21	2002-08-07	Takeda Chemical Industries, Ltd.	Cyclodextrin composition
WO1993005777A1 (fr) *	1991-09-18	1993-04-01	Fujisawa Pharmaceutical Co., Ltd.	Preparation transoculaire
DE69311278T2 (de) *	1992-12-16	1997-10-30	Takeda Chemical Industries Ltd	Stabile pharmazeutische Zubereitung mit Fumagillolderivaten
US5710148A (en) *	1995-03-06	1998-01-20	Senju Pharmaceuticals Co., Ltd.	Corneal opacification inhibitory composition
FR2733499B1 (fr) *	1995-04-27	1997-05-30	Adir	Nouvelles tetrahydropyrano(3,2-d)oxazolones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2733498B1 (fr) *	1995-04-27	1997-05-30	Adir	Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5719167A (en) *	1995-08-07	1998-02-17	Alcon Laboratories, Inc.	Angiostatic compounds
US5798356A (en) *	1995-08-07	1998-08-25	Alcon Laboratories, Inc.	Angiostatic compounds
EP0867180A4 (en) *	1995-10-11	1999-09-15	Fujisawa Pharmaceutical Co	VASCULAR PERMEATION INHIBITOR
US6207704B1 (en)	1997-06-09	2001-03-27	Massachusetts Institute Of Technology	Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof
WO1999061432A1 (en) *	1998-05-12	1999-12-02	Biochem Pharma Inc.	Fumagillin analogs and their use as angiogenesis inhibitors
KR100357541B1 (ko) *	1998-05-15	2002-10-18	주식회사종근당	5-데메톡시 푸마질롤 유도체 및 그 제조방법
KR100357542B1 (ko) *	1998-05-15	2002-10-18	주식회사종근당	푸마질롤 유도체 및 그 제조방법
US7105482B2 (en) *	2000-11-01	2006-09-12	Praecis Pharmaceuticals, Inc.	Methionine aminopeptidase-2 inhibitors and methods of use thereof
US6548477B1 (en)	2000-11-01	2003-04-15	Praecis Pharmaceuticals Inc.	Therapeutic agents and methods of use thereof for the modulation of angiogenesis
PL366216A1 (en) *	2000-11-01	2005-01-24	Praecis Pharmaceuticals Inc.	Therapeutic agents and methods of use thereof for the modulation of angiogenesis
US6919307B2 (en) *	2000-11-01	2005-07-19	Praecis Pharmaceuticals, Inc.	Therapeutic agents and methods of use thereof for the modulation of angiogenesis
EP1699812A2 (en) *	2003-12-29	2006-09-13	Praecis Pharmaceuticals Inc.	Inhibitors of methionine aminopeptidase-2 and uses thereof
US7931261B2 (en) *	2006-01-24	2011-04-26	Goss International Americas, Inc.	Signature hopper with lap straightening device
CN101990441A (zh)	2007-11-28	2011-03-23	默萨那治疗学股份有限公司	生物相容的生物可降解的烟曲霉素类似物轭合物
US8865746B2 (en) *	2008-07-18	2014-10-21	Zafgen, Inc.	Methods of treating an overweight or obese subject
WO2010065883A2 (en)	2008-12-04	2010-06-10	Zafgen Corporation	Method of treating an overweight or obese subject
WO2010065877A2 (en)	2008-12-04	2010-06-10	Zafgen Corporation	Methods of treating an overweight or obese subject
CN102448469A (zh)	2009-05-28	2012-05-09	摩萨纳医疗有限公司	包括具有可变的释放速率的连接物的聚缩醛(酮)-药物共轭物
EP2486004B1 (en)	2009-10-09	2017-05-03	Zafgen, Inc.	Sulphone compounds for use in the treatment of obesity
US8815309B2 (en)	2010-01-08	2014-08-26	Zafgen, Inc.	Methods of treating a subject with benign prostate hyperplasia
AU2011204267B2 (en)	2010-01-08	2015-12-03	Zafgen Corporation	Fumagillol type compounds and methods of making and using same
WO2011127304A2 (en)	2010-04-07	2011-10-13	Zafgen Corporation	Methods of treating an overweight subject
CN103249735B (zh)	2010-07-22	2016-04-06	扎夫根股份有限公司	三环化合物及其制备和使用方法
PH12013500934A1 (en)	2010-11-09	2022-10-24	Zafgen Inc	Crystalline solids of a metap-2 inhibitor and methods of making and using same
WO2012075020A1 (en)	2010-11-29	2012-06-07	Zafgen Corporation	Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
KR20140006888A (ko)	2011-01-26	2014-01-16	자프겐 인크.	테트라졸화합물, 그리고, 이를 제조하는 방법 및 이를 이용하는 방법
CN103534244B (zh)	2011-03-08	2016-10-12	扎夫根股份有限公司	氧杂螺[2.5]辛烷衍生物及类似物
AU2012253759B2 (en)	2011-05-06	2016-01-21	Zafgen Inc.	Tricyclic sulfonamide compounds and methods of making and using same
CA2835261C (en)	2011-05-06	2019-06-04	Zafgen, Inc.	Partially saturated tricyclic compounds and methods of making and using same
BR112013028666A2 (pt)	2011-05-06	2017-08-08	Zafgen Inc	compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
CA2837840C (en)	2011-06-10	2020-08-04	Mersana Therapeutics, Inc.	Protein-polymer-drug conjugates
EP2763671A2 (en)	2011-10-03	2014-08-13	Zafgen, Inc.	Methods of treating age related disorders
MX2014008706A (es)	2012-01-18	2015-03-05	Zafgen Inc	Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
JP2015509102A (ja)	2012-01-18	2015-03-26	ザフゲン，インコーポレイテッド	三環式スルホン化合物並びにその作製および使用方法
US9260419B2 (en)	2012-05-07	2016-02-16	Zafgen, Inc.	Polymorphic salt of a metap-2 inhibitor and methods of making and using same
AU2013259617A1 (en)	2012-05-08	2014-11-27	Zafgen, Inc.	Treating hypothalamic obesity with MetAP2 inhibitors
MX356755B (es) *	2012-05-09	2018-06-11	Zafgen Inc	Compuestos de tipo fumagilol y metodos para su elaboración y uso.
JP2015536981A (ja)	2012-11-05	2015-12-24	ザフゲン，インコーポレイテッド	三環式化合物ならびにその製造および使用方法
NZ707773A (en)	2012-11-05	2019-05-31	Zafgen Inc	Methods of treating liver diseases
BR112015010223A2 (pt)	2012-11-05	2017-07-11	Zafgen Inc	compostos tricíclicos para o uso no tratamento e/ou controle de obesidade
CA2892863C (en)	2012-12-10	2022-03-15	Mersana Therapeutics, Inc.	Polymeric scaffold based on phf for targeted drug delivery
EP2931316B1 (en)	2012-12-12	2019-02-20	Mersana Therapeutics, Inc.	Hydroxyl-polymer-drug-protein conjugates
CN105228610A (zh)	2013-03-14	2016-01-06	扎夫根股份有限公司	治疗肾疾病和其它病症的方法
KR102087850B1 (ko)	2013-10-11	2020-03-12	메르사나 테라퓨틱스, 인코포레이티드	단백질-고분자-약물 접합체
KR102572149B1 (ko)	2013-10-11	2023-08-30	아사나 바이오사이언시스 엘엘씨	단백질-폴리머-약물 접합체
TW201636342A (zh)	2014-12-19	2016-10-16	武田藥品工業有限公司	煙黴醇衍生物
AR105671A1 (es) *	2015-08-11	2017-10-25	Zafgen Inc	Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106432255A (zh)	2015-08-11	2017-02-22	扎夫根公司	烟曲霉素醇螺环化合物和制备和使用其的方法
US11135307B2 (en)	2016-11-23	2021-10-05	Mersana Therapeutics, Inc.	Peptide-containing linkers for antibody-drug conjugates
US10772971B2 (en)	2017-06-22	2020-09-15	Mersana Therpeutics, Inc.	Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
CN108530375B (zh) *	2018-05-29	2020-04-21	南京药石科技股份有限公司	4-氧杂-7-氮杂螺[2.5]辛烷或其盐的中间体及制备方法
MX2021004906A (es)	2018-10-29	2021-09-10	Mersana Therapeutics Inc	Conjugados de anticuerpo modificado con cisteína-fármaco con enlazadores que contienen péptidos.
US20250129033A1 (en) *	2022-02-16	2025-04-24	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.	Metap2 inhibitors and uses thereof
CN119836306A (zh)	2022-07-15	2025-04-15	费恩治疗有限公司	与cdcp1结合的抗体药物缀合物和其用途
WO2024040009A2 (en) *	2022-08-17	2024-02-22	Primetime Life Sciences, Llc	Inhibitors of methionine aminopeptidase-2 and methods of preparation and uses thereof
WO2025149667A1 (en)	2024-01-12	2025-07-17	Pheon Therapeutics Ltd	Antibody drug conjugates and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0629278B2 (ja) *	1985-06-26	1994-04-20	藤沢薬品工業株式会社	オキサスピロオクタン化合物
PH26256A (en) *	1988-08-12	1992-04-01	Fujisawa Pharmaceutical Co	Oxaspiro [2,5] octane derivative
JPH0660168B2 (ja) *	1988-09-01	1994-08-10	武田薬品工業株式会社	０―置換フマギロール誘導体
ES2099064T3 (es) *	1988-09-01	1997-05-16	Takeda Chemical Industries Ltd	Derivados de fumagillol.
KR0141692B1 (ko) *	1988-09-01	1998-06-01	우메모또 요시마사	맥관 형성 억제제
ATE87623T1 (de) *	1989-03-06	1993-04-15	Takeda Chemical Industries Ltd	6-epifumagillole, ihre herstellung und ihre verwendung.

1989
- 1989-08-01 PH PH39029A patent/PH26256A/en unknown
- 1989-08-02 IE IE250589A patent/IE66923B1/en not_active IP Right Cessation
- 1989-08-07 JP JP1204257A patent/JP2773275B2/ja not_active Expired - Lifetime
- 1989-08-08 IL IL9125089A patent/IL91250A/en not_active IP Right Cessation
- 1989-08-09 DE DE68921114T patent/DE68921114T2/de not_active Expired - Fee Related
- 1989-08-09 EP EP89308113A patent/EP0354787B1/en not_active Expired - Lifetime
- 1989-08-09 ES ES89308113T patent/ES2067546T3/es not_active Expired - Lifetime
- 1989-08-09 DK DK390989A patent/DK171987B1/da not_active IP Right Cessation
- 1989-08-09 AT AT89308113T patent/ATE118490T1/de not_active IP Right Cessation
- 1989-08-09 AU AU39453/89A patent/AU632056B2/en not_active Ceased
- 1989-08-10 CA CA000607998A patent/CA1340291C/en not_active Expired - Fee Related
- 1989-08-11 NO NO893235A patent/NO173236C/no unknown
- 1989-08-11 KR KR1019890011591A patent/KR0130765B1/ko not_active Expired - Fee Related
- 1989-08-11 CN CN93104924A patent/CN1051703C/zh not_active Expired - Fee Related
- 1989-08-11 FI FI893794A patent/FI97805C/fi not_active IP Right Cessation
1991
- 1991-06-05 US US07/711,420 patent/US5789405A/en not_active Expired - Fee Related
1994
- 1994-08-05 US US08/287,589 patent/US5767293A/en not_active Expired - Fee Related
1995
- 1995-03-13 GR GR950400533T patent/GR3015382T3/el unknown
- 1995-06-22 HU HU95P/P00365P patent/HU211569A9/hu unknown
1996
- 1996-03-25 JP JP8067849A patent/JP2970524B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2773275B2 (ja)	1998-07-09
AU632056B2 (en)	1992-12-17
CA1340291C (en)	1998-12-29
DK171987B1 (da)	1997-09-08
NO173236C (no)	1993-11-17
NO893235L (no)	1990-02-13
NO173236B (no)	1993-08-09
HU211569A9 (en)	1995-12-28
IL91250A (en)	1994-10-21
PH26256A (en)	1992-04-01
GR3015382T3 (en)	1995-06-30
IE66923B1 (en)	1996-02-07
KR900003164A (ko)	1990-03-23
JP2970524B2 (ja)	1999-11-02
IL91250A0 (en)	1990-03-19
IE892505L (en)	1990-02-12
EP0354787B1 (en)	1995-02-15
NO893235D0 (no)	1989-08-11
AU3945389A (en)	1990-02-15
DK390989A (da)	1990-02-13
JPH0285272A (ja)	1990-03-26
CN1079898A (zh)	1993-12-29
CN1051703C (zh)	2000-04-26
EP0354787A1 (en)	1990-02-14
US5767293A (en)	1998-06-16
FI893794A0 (fi)	1989-08-11
KR0130765B1 (ko)	1998-04-09
ATE118490T1 (de)	1995-03-15
FI97805B (fi)	1996-11-15
FI893794L (fi)	1990-02-13
JPH08319281A (ja)	1996-12-03
ES2067546T3 (es)	1995-04-01
DE68921114T2 (de)	1995-06-08
US5789405A (en)	1998-08-04
FI97805C (fi)	1997-02-25
DE68921114D1 (de)	1995-03-23

Legal Events

Date	Code	Title	Description
2007-03-26	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DE68921114D1 (de)	1995-03-23	Oxaspiro[2,5]octan-Derivate.
DE69530389D1 (de)	2003-05-22	Dexanabinol-derivate und ihre verwendung als neuroprotektive pharmazeutische zusammensetzungen
AU1025795A (en)	1995-08-03	Prolineamide derivatives
AU692090B2 (en)	1998-05-28	Novel 4,6-diarylpyrimidine derivatives and salts thereof
HU9300309D0 (en)	1993-04-28	Pyrazole derivatives, their production and medical preparatives containing them
AU6199494A (en)	1994-11-24	New polypeptide compound and a process for preparation thereof
AU4723097A (en)	1998-05-22	1-phenylpyrazole compounds and pharmaceutical use thereof
MX9702382A (es)	1998-02-28	Nuevos derivados de pirimidona con actividad antifungica.
DE68906609D1 (de)	1993-06-24	Dopamin-vorlaeufer.
HUT60507A (en)	1992-09-28	Process for producing trifluoromethyl ketone derivatives and pharmaceutical compositions comprising same as active ingredient
ATE46335T1 (de)	1989-09-15	Piperazinverbindungen als paf-antagonisten.
EA199800721A1 (ru)	1999-02-25	Ингибитор реваскуляризации
FI101227B1 (fi)	1998-05-15	Menetelmä farmaseuttisesti aktiivisten 4-desoksi-4-epipodofyllotoksiinijohdannaisten valmistamiseksi
TNSN97039A1 (fr)	2005-03-15	Derives d'oxadiazole et de thiadiazole antagonistes des recepteurs muscariniques.
CA2139731A1 (en)	1994-02-17	2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
PT91203A (pt)	1990-02-08	Processo para a preparacao de novos derivados de antibioticos bu-3608 e de composicoes farmaceuticas que os contem
AU1643592A (en)	1992-11-17	Novel compound and use of the same as medicine
RU94040865A (ru)	1996-08-10	Производные пептида и их терапевтически приемлемые соли, способ их получения, фармацевтическая и косметическая композиция с антивирусной активностью
AU7424394A (en)	1995-04-13	3- or 4-glycosyloxybenzopyran derivatives and antiallergic agents containing the derivatives as active ingredients
RU95106652A (ru)	1996-12-10	Оптически активные производные карбоксамида, аналгезирующее средство
RU94045839A (ru)	1996-09-27	Производные 3-(фенилалкиламиноалкилокси)-5-фенилпиразола, а также способ и промежуточные вещества для их получения, лекарственное средство, содержащее эти соединения
EP0420086A3 (en)	1991-11-06	Pyrimidoindole derivatives and processes for preparation thereof
AU7506591A (en)	1991-10-24	A therapeutic agent for dysuria comprising alpha-phenyl-alpha-pyridylalkanoic acid derivatives
FR2757509B1 (fr)	1999-03-26	Nouveaux derives de sulfonamides et sulfonylurees, leurs preparations et medicaments les contenant
EP0980867A4 (en)	2000-02-23	KETON DERIVATIVES AND THEIR USE IN MEDICINE