HRP20161027T1 - Derivat purinona kao inhibitor btk kinaze - Google Patents

Derivat purinona kao inhibitor btk kinaze Download PDF

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Publication number
HRP20161027T1
HRP20161027T1 HRP20161027TT HRP20161027T HRP20161027T1 HR P20161027 T1 HRP20161027 T1 HR P20161027T1 HR P20161027T T HRP20161027T T HR P20161027TT HR P20161027 T HRP20161027 T HR P20161027T HR P20161027 T1 HRP20161027 T1 HR P20161027T1
Authority
HR
Croatia
Prior art keywords
kinase inhibitor
btk kinase
purinone derivative
purinone
derivative
Prior art date
Application number
HRP20161027TT
Other languages
English (en)
Inventor
Shingo Yamamoto
Toshio Yoshizawa
Original Assignee
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co., Ltd. filed Critical Ono Pharmaceutical Co., Ltd.
Publication of HRP20161027T1 publication Critical patent/HRP20161027T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (2)

1. 6-amino-9-[(3R)-1-(2-butinoil)-3-pirolidinil]-7-(4-fenoksifenil)-7,9-dihidro-8H-purin-8-on, ili njegova sol.
2. Spoj prema patentnom zahtjevu 1 koje je 6-amino-9-[(3R)-1-(2-butinoil)-3-pirolidinil]-7-(4-fenoksifenil)-7,9-dihidro-8H-purin-8-on.
HRP20161027TT 2010-05-31 2011-05-30 Derivat purinona kao inhibitor btk kinaze HRP20161027T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010123727 2010-05-31
EP11789754.6A EP2578585B1 (en) 2010-05-31 2011-05-30 Purinone derivative as btk kinase inhibitor
PCT/JP2011/062377 WO2011152351A1 (ja) 2010-05-31 2011-05-30 プリノン誘導体

Publications (1)

Publication Number Publication Date
HRP20161027T1 true HRP20161027T1 (hr) 2016-11-04

Family

ID=45066718

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20161027TT HRP20161027T1 (hr) 2010-05-31 2011-05-30 Derivat purinona kao inhibitor btk kinaze

Country Status (28)

Country Link
US (10) US8940725B2 (hr)
EP (3) EP2578585B1 (hr)
JP (3) JP5648686B2 (hr)
KR (1) KR101537148B1 (hr)
CN (1) CN102918040B (hr)
AU (1) AU2011260961B9 (hr)
BR (2) BR112012030711B1 (hr)
CA (1) CA2800523C (hr)
CY (1) CY1118088T1 (hr)
DK (1) DK2578585T3 (hr)
ES (3) ES2782873T3 (hr)
HR (1) HRP20161027T1 (hr)
HU (1) HUE030720T2 (hr)
IL (1) IL223361A (hr)
LT (1) LT2578585T (hr)
MX (1) MX2012013622A (hr)
MY (2) MY169745A (hr)
NZ (1) NZ603643A (hr)
PH (1) PH12012502369A1 (hr)
PL (1) PL2578585T3 (hr)
PT (1) PT2578585T (hr)
RS (1) RS55184B1 (hr)
SG (2) SG10201503991SA (hr)
SI (1) SI2578585T1 (hr)
SM (1) SMT201600360B (hr)
TW (2) TWI500617B (hr)
WO (1) WO2011152351A1 (hr)
ZA (1) ZA201208900B (hr)

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