IES20180113A2 - Drug intermediates p-benzoylbenzoic acid synthesis method - Google Patents
Drug intermediates p-benzoylbenzoic acid synthesis methodInfo
- Publication number
- IES20180113A2 IES20180113A2 IES20180113A IES20180113A2 IE S20180113 A2 IES20180113 A2 IE S20180113A2 IE S20180113 A IES20180113 A IE S20180113A IE S20180113 A2 IES20180113 A2 IE S20180113A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- added
- benzoylbenzoic acid
- synthesis method
- acid synthesis
- Prior art date
Links
- IFQUPKAISSPFTE-UHFFFAOYSA-N 4-benzoylbenzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C(=O)C1=CC=CC=C1 IFQUPKAISSPFTE-UHFFFAOYSA-N 0.000 title abstract 3
- 238000001308 synthesis method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical group CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 abstract 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 abstract 2
- QPRQEDXDYOZYLA-UHFFFAOYSA-N 2-methylbutan-1-ol Chemical compound CCC(C)CO QPRQEDXDYOZYLA-UHFFFAOYSA-N 0.000 abstract 1
- ZROPUQRWEPCSPQ-UHFFFAOYSA-N [3-amino-4-(hydroxymethyl)phenyl]-phenylmethanone Chemical compound NC=1C=C(C(=O)C2=CC=CC=C2)C=CC=1CO ZROPUQRWEPCSPQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- VHHHONWQHHHLTI-UHFFFAOYSA-N hexachloroethane Chemical compound ClC(Cl)(Cl)C(Cl)(Cl)Cl VHHHONWQHHHLTI-UHFFFAOYSA-N 0.000 abstract 1
- 229940078552 o-xylene Drugs 0.000 abstract 1
- 235000010333 potassium nitrate Nutrition 0.000 abstract 1
- 239000004323 potassium nitrate Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 229910003451 terbium oxide Inorganic materials 0.000 abstract 1
- SCRZPWWVSXWCMC-UHFFFAOYSA-N terbium(iii) oxide Chemical compound [O-2].[O-2].[O-2].[Tb+3].[Tb+3] SCRZPWWVSXWCMC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention discloses p-benzoylbenzoic acid synthesis method, comprises the following steps: 3-amino-4-hydroxymethylbenzophenone and potassium nitrate solution were added to the reaction vessel, controlled the stirring speed, raised the temperature of the solution, added 2-methyl-l-butanol solution, added terbium oxide powder in batches; maintain reflux, added potassium bromide solution, precipitateed the crystals, filter, washed with o-xylene solution for several times, washed with hexachloroethane solution for several times, recrystallized in thionyl chloro solution, dehydrated with dehydration, got the finished product of p-benzoylbenzoic acid. <Figure 1>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710457417.4A CN108238901A (en) | 2017-06-16 | 2017-06-16 | Pharmaceutical intermediate is to the synthetic method of benzoyl benzoic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IES20180113A2 true IES20180113A2 (en) | 2019-11-13 |
Family
ID=59523434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180113 IES20180113A2 (en) | 2017-06-16 | 2018-04-04 | Drug intermediates p-benzoylbenzoic acid synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108238901A (en) |
| AU (1) | AU2018100526A4 (en) |
| GB (1) | GB201709978D0 (en) |
| IE (1) | IES20180113A2 (en) |
-
2017
- 2017-06-16 CN CN201710457417.4A patent/CN108238901A/en active Pending
- 2017-06-22 GB GBGB1709978.9A patent/GB201709978D0/en not_active Ceased
-
2018
- 2018-04-04 IE IES20180113 patent/IES20180113A2/en not_active Application Discontinuation
- 2018-04-24 AU AU2018100526A patent/AU2018100526A4/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN108238901A (en) | 2018-07-03 |
| GB201709978D0 (en) | 2017-08-09 |
| AU2018100526A4 (en) | 2018-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FJ9A | Application deemed to be withdrawn section 31(3) |