IL122746A - Pharmaceutical formulations containing darifenacin - Google Patents

Pharmaceutical formulations containing darifenacin

Info

Publication number
IL122746A
IL122746A IL12274696A IL12274696A IL122746A IL 122746 A IL122746 A IL 122746A IL 12274696 A IL12274696 A IL 12274696A IL 12274696 A IL12274696 A IL 12274696A IL 122746 A IL122746 A IL 122746A
Authority
IL
Israel
Prior art keywords
pharmaceutical formulations
formulations containing
darifenacin
containing darifenacin
pharmaceutical
Prior art date
Application number
IL12274696A
Other languages
English (en)
Other versions
IL122746A0 (en
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10780813&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL122746(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of IL122746A0 publication Critical patent/IL122746A0/xx
Publication of IL122746A publication Critical patent/IL122746A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL12274696A 1995-09-15 1996-08-21 Pharmaceutical formulations containing darifenacin IL122746A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9518953.6A GB9518953D0 (en) 1995-09-15 1995-09-15 Pharmaceutical formulations
PCT/EP1996/003719 WO1997009980A1 (fr) 1995-09-15 1996-08-21 Formulations pharmaceutiques contenant de la darifenacine

Publications (2)

Publication Number Publication Date
IL122746A0 IL122746A0 (en) 1998-08-16
IL122746A true IL122746A (en) 2000-12-06

Family

ID=10780813

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12274696A IL122746A (en) 1995-09-15 1996-08-21 Pharmaceutical formulations containing darifenacin

Country Status (32)

Country Link
US (1) US6106864A (fr)
EP (2) EP0850059B1 (fr)
JP (1) JP3403203B2 (fr)
KR (1) KR100348585B1 (fr)
CN (1) CN1303998C (fr)
AR (1) AR005231A1 (fr)
AT (2) ATE233090T1 (fr)
BR (2) BR122012014331B8 (fr)
CA (1) CA2230314C (fr)
CO (1) CO4750822A1 (fr)
CY (3) CY2468B1 (fr)
CZ (1) CZ294024B6 (fr)
DE (4) DE69632753T2 (fr)
DK (2) DK1245231T3 (fr)
EG (1) EG23826A (fr)
ES (2) ES2224002T3 (fr)
FR (1) FR05C0019I2 (fr)
GB (1) GB9518953D0 (fr)
HU (2) HU227397B1 (fr)
IL (1) IL122746A (fr)
LU (1) LU91163I2 (fr)
MY (1) MY125662A (fr)
NL (1) NL300190I2 (fr)
NO (2) NO314783B1 (fr)
NZ (1) NZ316924A (fr)
PL (1) PL185604B1 (fr)
PT (1) PT1245231E (fr)
RU (1) RU2163803C2 (fr)
TR (1) TR199800461T1 (fr)
TW (1) TW442300B (fr)
WO (1) WO1997009980A1 (fr)
ZA (1) ZA967745B (fr)

Families Citing this family (316)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001502302A (ja) * 1996-09-19 2001-02-20 アメリカン・ホーム・プロダクツ・コーポレイション 尿失禁を治療する方法
US20100137358A1 (en) * 1996-11-05 2010-06-03 Dr. Reddy's Laboratories Ltd. Solifenacin compositions
IL141235A (en) * 2000-02-09 2012-04-30 Novartis Int Pharm Ltd Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the preparation of a drug for the treatment of non-malignant prostatic hyperplasia
US7858119B1 (en) * 2000-05-09 2010-12-28 Amina Odidi Extended release pharmaceuticals
US6653339B2 (en) 2001-08-15 2003-11-25 Pfizer Inc. Method of treating irritable bowel syndrome
DE10149674A1 (de) * 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
US7163696B2 (en) * 2001-10-11 2007-01-16 Pfizer Inc. Pharmaceutical formulations
US8329217B2 (en) 2001-11-06 2012-12-11 Osmotica Kereskedelmi Es Szolgaltato Kft Dual controlled release dosage form
US20030185882A1 (en) * 2001-11-06 2003-10-02 Vergez Juan A. Pharmaceutical compositions containing oxybutynin
GB0129962D0 (en) * 2001-12-14 2002-02-06 Pfizer Ltd Method of treatment
GB0207104D0 (en) * 2002-03-26 2002-05-08 Pfizer Ltd Stable hydrate of a muscarinic receptor antagonist
CA2451267A1 (fr) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Utilisations pharmaceutiques de ligands alpha2delta
WO2004054560A1 (fr) 2002-12-13 2004-07-01 Warner-Lambert Company Llc Ligand alpha-2-delta pour traiter des symptomes des voies urinaires inferieures
US20040235857A1 (en) * 2003-02-11 2004-11-25 Pfizer Inc Crystalline therapeutic agent
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040186046A1 (en) * 2003-03-17 2004-09-23 Pfizer Inc Treatment of type 1 diabetes with PDE5 inhibitors
EA008596B1 (ru) 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
US7268147B2 (en) * 2003-05-15 2007-09-11 Pfizer Inc Compounds useful for the treatment of diseases
WO2004112756A1 (fr) 2003-06-26 2004-12-29 Isa Odidi Capsules contenant un inhibiteur de la pompe a protons comprenant des unites secondaires differemment structurees permettant une liberation retardee de l'ingredient actif
US20050043300A1 (en) * 2003-08-14 2005-02-24 Pfizer Inc. Piperazine derivatives
KR100738784B1 (ko) * 2003-09-03 2007-07-12 화이자 인코포레이티드 5-ｈｔ4 수용체 효능 활성을 갖는 벤즈이미다졸론
NZ545494A (en) 2003-09-12 2009-10-30 Pfizer Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
EP1682545B1 (fr) * 2003-10-03 2007-12-12 Pfizer Limited Derives de tropane a substitution imidazopyridine en tant qu'antagonistes des recepteurs ccr5 pour le traitement du vih et de l'inflammation
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
US7572799B2 (en) * 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
GB0402491D0 (en) * 2004-02-04 2004-03-10 Pfizer Ltd Medicaments
US7629358B2 (en) * 2004-03-17 2009-12-08 Pfizer Inc Compounds useful for the treatment of diseases
EP1735284A1 (fr) * 2004-03-18 2006-12-27 Pfizer Limited Sulfamides n-(1-arylpyrazol-4l) et leur utilisation en tant qu'anti-parasitaires
US20050215542A1 (en) * 2004-03-23 2005-09-29 Pfizer Inc Compounds for the treatment of diseases
EP1730103B1 (fr) * 2004-03-23 2010-05-26 Pfizer Limited Derives du formamide utile comme adrenocepteur
US7538141B2 (en) * 2004-03-23 2009-05-26 Alan Daniel Brown Compounds for the treatment of diseases
DE602005011784D1 (de) * 2004-04-07 2009-01-29 Pfizer Pyrazoloä4,3-düpyrimidine
WO2005123718A2 (fr) * 2004-06-15 2005-12-29 Pfizer Japan Inc. Derives de benzimidazolone d'acide carboxylique
US7737163B2 (en) * 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
PL1778686T3 (pl) 2004-08-12 2009-04-30 Pfizer Pochodne triazolopirydynylosulfanylowe jako inhibitory kinazy MAP P38
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
BR122020017756B1 (pt) * 2004-08-26 2022-02-15 Pfizer Inc Uso de compostos de aminoeteroarila enantiomericamente puros na preparação de um medicamento para o tratamento de crescimento celular anormal em um mamífero
ME01309B (me) * 2004-08-26 2013-12-20 Pfizer Pirazolom supstituirani heteroarilni spojevi kao inhibitori proteinskih kinaza
MX2007005290A (es) * 2004-11-02 2007-07-09 Pfizer Derivados de sulfonilbencimidazol.
US20060111416A1 (en) * 2004-11-24 2006-05-25 Lane Charlotte A L Octahydropyrrolo[3,4-C]pyrrole derivatives
JP4521463B2 (ja) 2005-03-17 2010-08-11 ファイザー株式会社 疼痛の治療に有用なｎ−（ｎ−スルホニルアミノメチル）シクロプロパンカルボキサミド誘導体
WO2006103503A1 (fr) * 2005-03-28 2006-10-05 Pfizer Japan Inc. Composes substitues d’aryloxoethyl cyclopropanecarboxamide en tant qu’antagonistes du recepteur vr1
DE602006012042D1 (de) * 2005-06-15 2010-03-18 Pfizer Ltd Substituierte arylpyrazole zur verwendung gegen parasiten
US20070149464A1 (en) * 2005-06-15 2007-06-28 Pfizer Inc. Combination
US7645786B2 (en) * 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
US20080176865A1 (en) * 2005-06-15 2008-07-24 Pfizer Limited Substituted arylpyrazoles
US20080146643A1 (en) * 2005-06-15 2008-06-19 Pfizer Limited Combination
WO2007015162A1 (fr) * 2005-08-04 2007-02-08 Pfizer Limited Composes piperidinoyl-pyrrolidine et piperidinoyl-piperidine
EP1917257A1 (fr) * 2005-08-10 2008-05-07 Pfizer Limited Derives de triazole substitues en tant qu'antagonistes d'oxytocine
ES2365161T3 (es) 2005-09-02 2011-09-23 Theravida, Inc. Terapia para el tratamiento de la vejiga hiperactiva.
CA2547216A1 (fr) 2005-09-21 2007-03-21 Renuka D. Reddy Procede de recuit de l'atorvastatine amorphe
NL2000323C2 (nl) 2005-12-20 2007-11-20 Pfizer Ltd Pyrimidine-derivaten.
US20070141684A1 (en) 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US20090062326A1 (en) * 2006-03-17 2009-03-05 Spindel Eliot R M3 muscarinic receptor antagonists for treatment of m3 muscarinic receptor-expressing tumors
CA2648280C (fr) 2006-04-03 2014-03-11 Isa Odidi Dispositif d'administration a liberation commandee comprenant un enrobage organosol
EA200802058A1 (ru) 2006-05-09 2009-06-30 Пфайзер Продактс Инк. Производные циклоалкиламинокислот и их фармацевтические композиции
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US20100256357A1 (en) * 2006-08-09 2010-10-07 Agouron Pharmaceuticals, Inc. Heterocycles useful as inhibitors of carbonic anhydrase
WO2008031221A1 (fr) * 2006-09-12 2008-03-20 Cephalin Pharmaceuticals Inc. Traitement de la douleur par l'isovaline
ATE512969T1 (de) * 2006-09-21 2011-07-15 Raqualia Pharma Inc Benzimidazolderivate als selektive säurepumpenhemmer
EP2222631B1 (fr) 2006-10-23 2011-08-17 Pfizer Inc. Composés de phénylméthyl bicyclocarboxyamide substitués
RU2322998C1 (ru) * 2006-11-16 2008-04-27 Общество с ограниченной ответственностью "Березовый мир" Носитель лекарственных и диагностических средств
AU2008211613B2 (en) * 2007-02-02 2013-05-23 Pfizer Products Inc. Tricyclic compounds and their use as glucocorticoid receptor modulators
CA2687944A1 (fr) * 2007-05-24 2008-11-27 Pfizer Limited Derives spirocycliques
CN101084891A (zh) * 2007-06-29 2007-12-12 北京本草天源药物研究院 一种用于口服的达非那新或其药用盐的药物制剂
WO2009006413A1 (fr) * 2007-06-30 2009-01-08 Auspex Pharmaceuticals, Inc. Pyrrolidines substituées
US8323695B2 (en) 2007-08-13 2012-12-04 Mcneil-Ppc, Inc. Method for stabilizing phenylephrine
CZ300895B6 (cs) * 2008-01-28 2009-09-02 Zentiva, A. S. Zpusob prípravy Darifenacinu
WO2009105887A1 (fr) * 2008-02-26 2009-09-03 Ernest Puil Acides aminés cycliques pour le traitement de la douleur
WO2009140078A1 (fr) * 2008-05-16 2009-11-19 The Procter & Gamble Company Traitement d’un dysfonctionnement de l’appareil urinaire bas par des agonistes sélectifs du récepteur cb‑2
JP4746714B2 (ja) * 2008-05-16 2011-08-10 Ａｘｉｓ株式会社 線維筋痛症治療用医薬組成物
JP5553452B2 (ja) * 2008-05-30 2014-07-16 ユセベ ファルマ ソシエテ アノニム ブリバラセタムを含む医薬組成物
ES2378513T3 (es) * 2008-08-06 2012-04-13 Pfizer Inc. Compuestos 2-heterociclilamino piracinas sustituidas en posición 6 como inhibidores de CHK-1
EP2163253B1 (fr) 2008-09-15 2013-07-17 ULLRICH, Oliver Extraits de la plante Hornstedtia scyphifera et ses effets immunosuppresseurs
WO2010058858A1 (fr) 2008-11-21 2010-05-27 ラクオリア創薬株式会社 Nouveau dérivé de pyrazole-3-carboxamide doté d’une activité antagoniste du récepteur 5-ht2b
HUE025013T2 (hu) 2009-01-12 2016-04-28 Pfizer Ltd Szulfonamid-származékok
WO2010103070A2 (fr) 2009-03-12 2010-09-16 Charité - Universitätsmedizin Berlin Variants de la protéine morphogénétique osseuse 2 (bmp2) avec une sensibilité réduite aux antagonistes des bmp
EP2233502A1 (fr) 2009-03-27 2010-09-29 Deutsches Rheuma-Forschungszentrum Berlin Anticorps spécifiques à l'antigène syalilé pour le traitement ou prophylaxie des réactions immunitaires inflammatoires non désirables et leurs procédés de production
EP2236516A1 (fr) 2009-03-31 2010-10-06 Charité-Universitätsmedizin Berlin (Charité) Polypeptides et utilisation associée pour le traitement d'une lésion neuronale traumatique ou dégénérative
CN102448978A (zh) 2009-05-29 2012-05-09 辉瑞有限公司 新颖的糖皮质激素受体激动剂
EP2266563A1 (fr) 2009-06-11 2010-12-29 Charité-Universitätsmedizin Berlin (Charité) Utilisation d'antagonistes de récepteur opioïde pour le traitement aigu des états d'éveil paraphiliques
WO2011004276A1 (fr) 2009-07-06 2011-01-13 Pfizer Limited Inhibiteurs du virus de l’hépatite c
US8617763B2 (en) * 2009-08-12 2013-12-31 Bloom Energy Corporation Internal reforming anode for solid oxide fuel cells
EP2509978A1 (fr) 2009-12-11 2012-10-17 E.I. Du Pont De Nemours And Company Inhibiteurs azocycliques de l'hydrolase des amides d'acides gras
WO2011077313A1 (fr) 2009-12-22 2011-06-30 Pfizer Inc. Pipéridinecarboxamides en tant qu'inhibiteurs de mpges - 1
SG181857A1 (en) 2009-12-23 2012-07-30 Takeda Pharmaceutical Fused heteroaromatic pyrrolidinones as syk inhibitors
SG174658A1 (en) 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
EP2566858A2 (fr) 2010-05-04 2013-03-13 Pfizer Inc. Dérivés heterocycliques en tant qu'inhibiteurs d'alk
WO2011154871A1 (fr) 2010-06-10 2011-12-15 Pfizer Limited Inhibiteurs du virus de l'hépatite c
WO2011161504A1 (fr) * 2010-06-23 2011-12-29 Micro Labs Limited Formulations à libération prolongée contenant de la darifénacine ou des sels pharmaceutiquement acceptables de celle-ci
WO2012004743A1 (fr) 2010-07-09 2012-01-12 Pfizer Limited Benzènesulfonamides utiles en tant qu'inhibiteurs des canaux sodiques
WO2012004714A2 (fr) 2010-07-09 2012-01-12 Pfizer Limited Composés chimiques
JP5872552B2 (ja) 2010-07-09 2016-03-01 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 化学化合物
JP2013532185A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 化合物
ES2532357T3 (es) 2010-07-12 2015-03-26 Pfizer Limited Derivados de sulfonamida como inhibidores de Nav1.7 para el tratamiento del dolor
US9102621B2 (en) 2010-07-12 2015-08-11 Pfizer Limited Acyl sulfonamide compounds
JP2013532184A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 電位開口型ナトリウムチャネル阻害剤として有用なｎ−スルホニルベンズアミド誘導体
EP2593433B1 (fr) 2010-07-12 2014-11-26 Pfizer Limited N-sulfonylbenzamides comme inhibiteurs des canaux sodiques voltage-dépendan
WO2012042421A1 (fr) 2010-09-29 2012-04-05 Pfizer Inc. Procédé de traitement de la croissance cellulaire anormale
WO2012066442A1 (fr) 2010-11-15 2012-05-24 Pfizer Limited Inhibiteurs de la réplication du vih
EP2457900A1 (fr) 2010-11-25 2012-05-30 Almirall, S.A. Nouveaux dérivés de pyrazole présentant un comportement antagoniste CRTH2
EP2463289A1 (fr) 2010-11-26 2012-06-13 Almirall, S.A. Dérivés imidazo[1,2-b]pyridazine en tant qu'inhibiteur JAK
CN102048706B (zh) * 2011-01-12 2012-02-22 山东创新药物研发有限公司 一种氢溴酸达非那新缓释片及制备方法
WO2012095781A1 (fr) 2011-01-13 2012-07-19 Pfizer Limited Dérivés d'indazole comme inhibiteurs des canaux sodiques
EP2489663A1 (fr) 2011-02-16 2012-08-22 Almirall, S.A. Composés en tant qu'inhibiteurs de la syk kinase
CA2827770A1 (fr) 2011-02-25 2012-11-01 Takeda Pharmaceutical Company Limited Oxazinopteridines et oxazonopteridinones n-substituees
WO2012120398A1 (fr) 2011-03-04 2012-09-13 Pfizer Limited Dérivés de carboxamide substitués par aryle en tant que modulateurs de trpm8
ES2581848T3 (es) 2011-04-05 2016-09-07 Pfizer Limited Derivados de pirrolo[2,3-d]pirimidina como inhibidores de quinasas relacionadas con tropomiosina
EP2518071A1 (fr) 2011-04-29 2012-10-31 Almirall, S.A. Dérivés d'imidazopyridine en tant qu'inhibiteurs PI3K
EP2518070A1 (fr) 2011-04-29 2012-10-31 Almirall, S.A. Dérivés de pyrrolotriazinon en tant qu'inhibiteurs PI3K
US20120289562A1 (en) 2011-05-10 2012-11-15 Theravida, Inc. Combinations of darifenacin and salivary stimulants for the treatment of overactive bladder
RU2671575C2 (ru) 2011-05-10 2018-11-02 Теравида, Инк. Применение солифенацина и стимуляторов слюноотделения в лечении гиперактивного мочевого пузыря
EP2710002B1 (fr) 2011-05-18 2017-03-01 RaQualia Pharma Inc Forme polymorphe de l'acide 4-{[4-({[4-(2,2,2-trifluoroéthoxy)- 1,2-benzisoxazol-3-yl]oxy}méthyl)pipéridin-1-yl]méthyl}-tétrahydro-2h-pyran-4-carboxylique
EP2526945A1 (fr) 2011-05-25 2012-11-28 Almirall, S.A. Nouveaux antagonistes de CRTH2
EP2527344A1 (fr) 2011-05-25 2012-11-28 Almirall, S.A. Dérivés de pyridin-2(1h)-one utiles comme médicaments pour le traitement de maladies myeloproliferatives, de rejets de greffe, de maladies a médiation immune et de maladies inflammatoires
JP6026525B2 (ja) 2011-06-22 2016-11-16 武田薬品工業株式会社 置換６−アザ−イソインドリン−１−オン誘導体
EP2548876A1 (fr) 2011-07-18 2013-01-23 Almirall, S.A. Nouveaux antagonistes de CRTH2
EP2548863A1 (fr) 2011-07-18 2013-01-23 Almirall, S.A. Nouveaux antagonistes de CRTH2
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
EP2554544A1 (fr) 2011-08-01 2013-02-06 Almirall, S.A. Dérivés de pyridin-2(1h)-one en tant qu'inhibiteurs de JAK
AU2012291744A1 (en) 2011-08-02 2014-02-20 Pfizer Inc. Crizotinib for use in the treatment of cancer
WO2013054185A1 (fr) 2011-10-13 2013-04-18 Pfizer, Inc. Dérivés de pyrimidine et de pyridine utiles en thérapie
CA2851412A1 (fr) 2011-10-19 2013-04-25 Zoetis Llc Utilisation de derives d'aminoacetonitrile contre des endoparasites
JP5363636B2 (ja) 2011-10-21 2013-12-11 ファイザー・リミテッド 新規な塩および医学的使用
EA023375B1 (ru) 2011-10-26 2016-05-31 Пфайзер Лимитед Производные (4-фенилимидазол-2-ил)этиламина в качестве модуляторов натриевых каналов
ES2748656T3 (es) 2011-10-28 2020-03-17 Inhibitaxin Ltd Derivados de piridazina útiles en terapia
CA2857603C (fr) 2011-12-15 2016-08-02 Pfizer Limited Derives de sulfonamide
WO2013093688A1 (fr) 2011-12-19 2013-06-27 Pfizer Limited Dérivés sulfonamides et leur utilisation en tant qu'inhibiteurs de vgsc
CN102579379B (zh) * 2011-12-29 2016-08-10 北京科信必成医药科技发展有限公司 一种药物缓释制剂及其制备方法
CN102600096B (zh) * 2011-12-29 2016-08-10 北京科信必成医药科技发展有限公司 一种达非那新缓释制剂及其制备方法
US20150291514A1 (en) 2012-01-04 2015-10-15 Pfizer Limted N-Aminosulfonyl Benzamides
WO2013114250A1 (fr) 2012-02-03 2013-08-08 Pfizer Inc. Dérivés d'imidazopyridine et de benziimidazole en tant que modulateurs du canal sodium
HUE034118T2 (en) 2012-03-06 2018-01-29 Pfizer Macrocyclic derivatives for the treatment of proliferative diseases
US9365566B2 (en) 2012-03-27 2016-06-14 Takeda Pharmaceutical Company Limited Cinnoline derivatives
EP2833886B1 (fr) 2012-04-04 2020-08-12 HangzhouDeRenYuCheng Biotechnology Ltd. Quinoléines substituées en tant qu'inhibiteurs de tyrosine kinase de bruton
TW201414734A (zh) 2012-07-10 2014-04-16 Takeda Pharmaceutical 氮雜吲哚衍生物
US9475816B2 (en) 2012-09-07 2016-10-25 Takeda Pharmaceutical Company Limited Substituted-1,4-dihydropyrazolo[4,3-b]indoles
EP2897950A1 (fr) 2012-09-18 2015-07-29 Ziarco Pharma Ltd 2-(2-aminocyclohexyl)aminopyrimidino-5-carboxamides utilisés comme inhibiteurs de la spleen tyrosine kinase (syk)
JP6254169B2 (ja) 2012-09-28 2017-12-27 ファイザー・インク ベンズアミドおよびヘテロベンズアミド化合物
EP2912036A1 (fr) 2012-10-04 2015-09-02 Pfizer Limited Inhibiteurs de kinase associée à la tropomyosine pyrrolo[3,2-c]pyridine
US20150250785A1 (en) 2012-10-04 2015-09-10 Pfizer Limited Tropomyosin-Related Kinase Inhibitors
EP2903989A1 (fr) 2012-10-04 2015-08-12 Pfizer Limited Inhibiteurs de kinase associée à la tropomyosine pyrrolo[2,3-d]pyrimidine
WO2014060431A1 (fr) 2012-10-16 2014-04-24 Almirall, S.A. Dérivés de pyrrolotriazinone en tant qu'inhibiteurs des pi3k
BR112015010620A2 (pt) 2012-11-08 2017-07-11 Pfizer compostos heteroaromáticos e seus usos como ligantes de dopamina d1
MD20150037A2 (ro) 2012-11-08 2015-11-30 Pfizer Inc. Compuşi heteroaromatici şi utilizarea lor ca liganzi de dopamină D1
EP2922849B1 (fr) 2012-11-21 2017-07-12 RaQualia Pharma Inc. Polymorphes du 4-{[4-({[4-(2,2,2-trifluoroéthoxy)-1,2-benzisoxazol-3-yl]oxy}méthyl)pipéridin-1-yl]méthyl}-tetrahydro-2h-pyran-4-acide carboxilique en tant qu'agonistes du recepteur 5-hydroxytryptamine-4 (5-ht4) pour le traitement de maladies gastrointestinales
MX368898B (es) 2012-12-03 2019-10-21 Pfizer Moduladores selectivos del receptor de androgenos novedosos.
UA112028C2 (uk) 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
UA111305C2 (uk) 2012-12-21 2016-04-11 Пфайзер Інк. Конденсовані лактами арилу та гетероарилу
TW201446767A (zh) 2013-02-15 2014-12-16 Almirall Sa 作為磷脂肌醇3-激酶抑製劑之吡咯並三嗪衍生物
SI2958916T1 (sl) 2013-02-21 2018-11-30 Pfizer Inc. Trdne oblike selektivnih zaviralcev CDK4/6
JO3377B1 (ar) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co مشتقات بيريدينيل وبيريدينيل مندمج
EP2968167A1 (fr) * 2013-03-13 2016-01-20 ratiopharm GmbH Forme dosifiée comprenant du crizotinib
EP2784083A1 (fr) 2013-03-28 2014-10-01 Charité - Universitätsmedizin Berlin Variantes de protéine morphogénétique osseuse (BMP) avec sensibilité antagoniste fortement réduite et meilleure activité biologique spécifique
EP2792360A1 (fr) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide pour utilisation dans le traitement de HCV
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
TW201443025A (zh) 2013-04-19 2014-11-16 Pfizer Ltd 化學化合物
WO2014181213A1 (fr) 2013-05-10 2014-11-13 Pfizer Inc. Forme cristalline de (sa)-(-)-3-(3-bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1 (2h)-yl)-n,4-dimethylbenzamide
EP2997084A4 (fr) 2013-05-17 2016-10-12 Acupac Packaging Inc Composition d'hydrogel anhydre
SG11201509186TA (en) 2013-06-27 2016-01-28 Pfizer Heteroaromatic compounds and their use as dopamine d1 ligands
CN104513253A (zh) 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 用于治疗增殖性疾病的大环化合物
US20170305857A1 (en) 2013-12-20 2017-10-26 Pfizer Limited N-acylpiperidine ether tropomyosin-related kinase inhibitors
WO2015092614A1 (fr) 2013-12-20 2015-06-25 Pfizer Inc. Altérations d'activation de notch dans le cancer du sein
AR099052A1 (es) 2014-01-09 2016-06-29 Takeda Pharmaceuticals Co Derivados de azaindol
WO2015106014A1 (fr) 2014-01-09 2015-07-16 Takeda Pharmaceutical Company Limited Dérivés d'azaindole
US20170197939A1 (en) 2014-04-15 2017-07-13 Pfizer Inc. Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety
SG11201608468TA (en) 2014-04-25 2016-11-29 Pfizer Heteroaromatic compounds and their use as dopamine d1 ligands
EA201691831A1 (ru) 2014-04-25 2017-02-28 Пфайзер Инк. Гетероароматические соединения и их применение в качестве допаминовых d1 лигандов
EP3134405B1 (fr) 2014-04-25 2019-08-28 Pfizer Inc Composes hetero-aromatiques et leur utilisation comme ligands d1 de la dopamine
US9856263B2 (en) 2014-04-28 2018-01-02 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
EP3137469B1 (fr) 2014-04-28 2019-10-09 Pfizer Inc Composés hétérocycliques et leur utilisation comme ligands des récepteurs d1 de la dopamine
WO2015170218A1 (fr) 2014-05-07 2015-11-12 Pfizer Inc. Inhibiteurs de kinases apparentées à la tropomyosine
CR20160525A (es) 2014-05-14 2016-12-20 Pfizer Pirazolopiridinas y pirazolopirimidinas
AU2015260906B2 (en) 2014-05-15 2017-08-31 Pfizer Inc. Crystalline form of 6-((4R)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl)isoquinoline-1-carbonitrile
RU2679619C2 (ru) 2014-05-20 2019-02-12 Раквалиа Фарма Инк. Солевое производное бензизоксазола
SG11201609050UA (en) 2014-05-30 2016-12-29 Pfizer Carbonitrile derivatives as selective androgen receptor modulators
CA2950393A1 (fr) 2014-05-30 2015-12-03 Pfizer Inc. Benzenesulfonamides utiles en tant qu'inhibiteurs des canaux sodiques
EP3154979B1 (fr) 2014-06-12 2018-03-07 Pfizer Limited Dérivés d'imidazopyridazine utilisés comme modulateurs de l'activité des récepteurs gabaa.
WO2015193768A1 (fr) 2014-06-17 2015-12-23 Pfizer Inc. Lactames à fusion aryle à utiliser en tant que modulateurs ezh2
EP3157915B1 (fr) 2014-06-17 2019-02-27 Pfizer Inc Composés dihydroisoquinolinone substitués
WO2016009296A1 (fr) 2014-07-16 2016-01-21 Pfizer Inc. Inhibiteurs de kinase liés à la n-acylpipéridine éther tropomyosine
WO2016009303A1 (fr) 2014-07-17 2016-01-21 Pfizer Inc. Associations de produits pharmaceutiques comprenant de la gabapentine ou de la prégabaline avec des inhibiteurs de nav1.7
WO2016009297A1 (fr) 2014-07-18 2016-01-21 Pfizer Inc. Dérivés de la pyridine en tant que modulateurs allostériques positifs du récepteur m1 muscarinique
WO2016020784A1 (fr) 2014-08-05 2016-02-11 Pfizer Inc. Inhibiteurs de kinases apparentées à la n-acylpyrrolidine éther tropomyosine
WO2016034971A1 (fr) 2014-09-04 2016-03-10 Pfizer Limited Dérivés sulfonamides utilisés en tant qu'inhibiteurs d'urat1
WO2016044433A2 (fr) 2014-09-16 2016-03-24 Biopharma Works Dérivés de la metformine
GB201417165D0 (en) 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Treatments for Autoimmune Disease
GB201417163D0 (en) 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Substituted pyrimidine derivatives useful in the treatment of autoimmune diseases
WO2016067143A1 (fr) 2014-10-28 2016-05-06 Pfizer Inc. Composés n- (2-alkylèneimino-3-phénylpropyl)acétamide et leur utilisation contre la douleur et le prurit par inhibition des canaux trpa1
ES2746839T3 (es) 2014-12-18 2020-03-09 Pfizer Derivados de pirimidina y triazina y su uso como inhibidores de AXL
TW201636342A (zh) 2014-12-19 2016-10-16 武田藥品工業有限公司 煙黴醇衍生物
US9765000B2 (en) 2015-01-22 2017-09-19 Phytoplant Research S.L. Methods of purifying cannabinoids, compositions and kits thereof
JP6584521B2 (ja) 2015-02-24 2019-10-02 ファイザー・インク 抗がん剤として有用な置換ヌクレオシド誘導体
JP6676650B2 (ja) 2015-03-13 2020-04-08 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 疾患を処置するためのコンジュゲート
MA41938A (fr) 2015-04-21 2018-02-28 Almirall Sa Dérivés hétérocycliques amino-substitués utilisés comme inhibiteurs des canaux sodiques
MX376083B (es) 2015-06-04 2025-03-07 Pfizer Formas de dosificacion solidas de palbociclib.
TN2017000544A1 (en) 2015-07-31 2019-04-12 Pfizer 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors
WO2017060488A1 (fr) 2015-10-09 2017-04-13 Almirall, S.A. Nouveaux antagonistes de trpa1
WO2017064068A1 (fr) 2015-10-14 2017-04-20 Almirall, S.A. Nouveaux antagonistes de trpa1
EP3386983A1 (fr) 2015-12-10 2018-10-17 Pfizer Limited Dérivés 4-(biphényl-3-yl)-1h-pyrazolo[3,4-c]pyridazine de formule (i) utilisés comme modulateurs de récepteur gaba pour le traitement de l'épilepsie et de la douleur
CN108473467B (zh) 2015-12-24 2021-08-13 武田药品工业株式会社 共结晶、其制造方法及含有共结晶的药物
EP3399968B8 (fr) 2016-01-07 2021-12-01 Xuanzhu Biopharmaceutical Co., Ltd. Inhibiteurs sélectifs de mutants cliniquement importants de la tyrosine kinase de l'egfr
WO2017119732A1 (fr) 2016-01-08 2017-07-13 Samsung Electronics Co., Ltd. Dispositif électronique, et son procédé de fonctionnement
EP3402796B1 (fr) 2016-01-15 2020-11-18 Pfizer Inc Ligands 6,7,8,9-tétrahydro-5h-pyrido[2,3-d]azépine du récepteur d3 de la dopamine
WO2017127073A1 (fr) 2016-01-20 2017-07-27 Theravida, Inc. Méthodes et compositions pour le traitement de l'hyperhidrose
CN108884445A (zh) 2016-03-09 2018-11-23 北京智康博药肿瘤医学研究有限公司 肿瘤细胞悬浮培养物和相关方法
CA3019134C (fr) 2016-03-31 2024-04-23 Takeda Pharmaceutical Company Limited Complexes isoquinoleinyle-triazolone
CA2969295A1 (fr) 2016-06-06 2017-12-06 Pfizer Inc. Derives de carbonucleosides substitues et leur utilisation comme inhibiteur de prmt5
WO2018031987A1 (fr) 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Régulateurs de protéine kinases
CN109803968A (zh) 2016-08-15 2019-05-24 辉瑞公司 吡啶并嘧啶酮cdk2/4/6抑制剂
US10316021B2 (en) 2016-11-28 2019-06-11 Pfizer Inc. Heteroarylphenoxy benzamide kappa opioid ligands
CA3047730A1 (fr) 2016-12-20 2018-06-28 Oligomerix, Inc. Quinazolinones inhibant la formation d'oligomeres tau et methode d'utilisation
CA3047729A1 (fr) 2016-12-20 2018-06-28 Oligomerix, Inc. Nouveaux analogues de benzofuranes, de benzothiophenes et d'indoles qui inhibent la formation d'oligomeres tau et leur procede d'utilisation
RU2720203C1 (ru) 2017-01-20 2020-04-27 Пфайзер Инк. 1,1,1-трифтор-3-гидроксипропан-2-илкарбаматные производные как ингибиторы magl
CN110198944A (zh) 2017-01-23 2019-09-03 辉瑞大药厂 作为单酰基甘油脂肪酶抑制剂的杂环螺环化合物
MX2019008773A (es) 2017-01-24 2019-09-18 Pfizer Derivados de caliqueamicina y conjugados anticuerpo-farmaco de los mismos.
MX390512B (es) 2017-03-26 2025-03-20 Takeda Pharmaceuticals Co Carboxamidas heteroaromáticas sustituidas con piperidinilo y piperazinilo como moduladores de gpr6.
JOP20180057A1 (ar) 2017-06-15 2019-01-30 Takeda Pharmaceuticals Co مركبات رابع هيدروبيريدو بيرازين والتي تعمل كمعدلات gpr6
PE20200696A1 (es) 2017-06-22 2020-06-16 Curadev Pharma Ltd Moduladores de moleculas pequenas de sting humana
WO2019043634A2 (fr) 2017-08-30 2019-03-07 Beijing Xuanyi Pharmasciences Co., Ltd. Di-nucléotides cycliques en tant que stimulateurs de modulateurs de gènes d'interféron
WO2019051469A1 (fr) 2017-09-11 2019-03-14 Krouzon Pharmaceuticals, Inc. Inhibiteurs allostériques octahydrocyclopenta[c]pyrrole de shp2
TW201920108A (zh) 2017-09-25 2019-06-01 日商武田藥品工業有限公司 N-(氰基取代之苄基或吡啶基甲基)-3-羥基吡啶醯胺衍生物
KR20200088386A (ko) 2017-11-14 2020-07-22 화이자 인코포레이티드 Ezh2 억제제 병용 요법
AU2019211188A1 (en) 2018-01-29 2020-07-30 Phytoplant Research S.L. Methods of purifying cannabinoids using liquid:liquid chromatography
TW201942115A (zh) 2018-02-01 2019-11-01 美商輝瑞股份有限公司 作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物
TW201942116A (zh) 2018-02-09 2019-11-01 美商輝瑞股份有限公司 作為抗癌劑之四氫喹唑啉衍生物
EP3758753A1 (fr) 2018-02-27 2021-01-06 Pfizer Inc Association d'un inhibiteur de kinases dépendantes des cyclines et d'un inhibiteur de bromodomaines bet
TWI834637B (zh) 2018-03-01 2024-03-11 日商武田藥品工業有限公司 六氫吡啶基-3-(芳氧基)丙醯胺及丙酸酯
MD3784664T2 (ro) 2018-04-26 2025-06-30 Pfizer Derivați de 2-amino-piridină sau de 2-amino-pirimidină utilizați ca inhibitori de kinaze dependente de cicline
WO2019243823A1 (fr) 2018-06-21 2019-12-26 Curadev Pharma Limited Modulateurs azahétérocycliques à petites molécules de sting humain
MX2021000549A (es) 2018-07-19 2021-03-25 Pfizer Compuestos espiro heterociclicos como inhibidores de magl.
WO2020076728A1 (fr) 2018-10-08 2020-04-16 Takeda Pharmaceutical Company Limited Oxazinoptéridinones substituées en tant qu'inhibiteurs de mtor
US11142525B2 (en) 2018-11-15 2021-10-12 Pfizer Inc. Azalactam compounds as HPK1 inhibitors
BR112021013019A2 (pt) 2019-01-23 2021-09-14 Pfizer Inc. Forma polimórfica de um sal de hidrato de monofosfato de um derivado de tetra-hidroisoquinolina conhecido
CN113330000B (zh) 2019-01-31 2024-12-24 辉瑞公司 具有对cdk2的抑制活性的3-羰基氨基-5-环戊基-1fi-吡咯化合物
US20220125777A1 (en) 2019-02-01 2022-04-28 Pfizer Inc. Combination of a cdk inhibitor and a pim inhibitor
AU2020228047B2 (en) 2019-02-27 2025-11-20 Madera Therapeutics, LLC Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents
TW202102498A (zh) 2019-03-22 2021-01-16 日商武田藥品工業股份有限公司 作為ripk2 抑制劑之吡啶稠合咪唑及吡咯衍生物
GB201905371D0 (en) 2019-04-16 2019-05-29 Mission Therapeutics Ltd Novel compounds
GB201905375D0 (en) 2019-04-16 2019-05-29 Mission Therapeutics Ltd Novel compounds
AU2020266529B2 (en) 2019-04-29 2026-01-29 Solent Therapeutics, Llc 3-amino-4H-benzo[E][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of MRGX2
US11339159B2 (en) 2019-07-17 2022-05-24 Pfizer Inc. Toll-like receptor agonists
TWI904095B (zh) 2019-07-25 2025-11-11 印度商裘拉德製藥私人有限公司 乙醯輔酶a合成酶短鏈2(acss2)之小分子抑制劑
GB201912674D0 (en) 2019-09-04 2019-10-16 Mission Therapeutics Ltd Novel compounds
AU2020348675B2 (en) 2019-09-16 2025-11-20 Takeda Pharmaceutical Company Limited Azole-fused pyridazin-3(2H)-one derivatives
WO2021161230A1 (fr) 2020-02-12 2021-08-19 Curadev Pharma Pvt. Ltd. Antagonistes de sting à petites molécules
TW202146017A (zh) 2020-03-05 2021-12-16 美商輝瑞股份有限公司 間變性淋巴瘤激酶抑制劑及周期蛋白依賴型激酶抑制劑之組合
AR121682A1 (es) 2020-03-31 2022-06-29 Takeda Pharmaceuticals Co Derivados de n-(heterociclil y heterociclilalquil)-3-bencilpiridin-2-amina como agonistas de sstr4
AR121683A1 (es) 2020-03-31 2022-06-29 Takeda Pharmaceuticals Co Derivados de n-heteroarilalquil-2-(heterociclil y heterociclilmetil)acetamida como agonistas de sstr4
JP2021167301A (ja) 2020-04-08 2021-10-21 ファイザー・インク Ｃｄｋ２阻害剤に対する腫瘍適応を抑制するためのｃｄｋ４／６およびｃｄｋ２阻害剤による同時処置
WO2021204856A1 (fr) 2020-04-08 2021-10-14 Mission Therapeutics Limited N-cyanopyrrolidines ayant une activité en tant qu'inhibiteurs de l'usp30
CN115698004A (zh) 2020-05-01 2023-02-03 辉瑞公司 作为hpk1抑制剂的氮杂内酰胺化合物
IL297456A (en) 2020-05-04 2022-12-01 Takeda Pharmaceuticals Co n-(piperidin-4-yl)benzamide derivatives are active in Nahor
WO2021224818A1 (fr) 2020-05-08 2021-11-11 Pfizer Inc. Composés d'isoindolone en tant qu'inhibiteurs de hpk1
IL298526A (en) 2020-05-28 2023-01-01 Mission Therapeutics Ltd N-(1-cyano-pyrrolidin-3-yl)-5-(3-(trifluoromethyl)phenyl)oxazole-2-carboxamide derivatives and the corresponding oxadiazole derivatives as usp30 inhibitors for the treatment of mitochondrial dysfunction
BR112022019722A2 (pt) 2020-06-04 2022-12-20 Mission Therapeutics Ltd N-cianopirrolidinas com atividade como inibidores de usp30
DK4161929T3 (da) 2020-06-08 2025-08-18 Mission Therapeutics Ltd 1-(5-(2-cyanopyridin-4-yl)oxazol-2-carbonyl)-4-methylhexahydropyrrolo[3,4-b]pyrrol-5(1h)-carbonitril som usp30-hæmmer til anvendelse i behandling af mitokondriedysfunktion, cancer og fibrose
TW202214641A (zh) 2020-06-30 2022-04-16 美商艾瑞生藥股份有限公司 Ｈｅｒ２突變抑制劑
WO2022013691A1 (fr) 2020-07-15 2022-01-20 Pfizer Inc. Polymorphe de (1s,2s,3s,5r)-3-((6-(difluorométhyl)-5-flu­oro-1,2,3,4-tétrahydroisoquinolin-8-yl)oxy)-5-(4-méthyl-7h-pyrrolo[2,3-d]­pyrimidin-7-yl)cyclopentane-1,2-diol
WO2022013692A1 (fr) 2020-07-15 2022-01-20 Pfizer Inc. Polymorphes de (1s,2s,3s,5r)-3-((6-(difluorométhyl)-3-((6-(difluorométhyl)-5-fluoro-1,2,3,4-tétrahydroisoquinolin-8-yl)oxy)-5-(4-méthyl-7h-pyrrolo[2,3-d]pyrimidin-7-yl) cyclopentane-1,2-diol monochlorhydrate
EP4181919A1 (fr) 2020-07-20 2023-05-24 Pfizer Inc. Polythérapie
WO2022018667A1 (fr) 2020-07-24 2022-01-27 Pfizer Inc. Polythérapies utilisant des inhibiteurs de cdk2 et de cdc25a
GB202011812D0 (en) 2020-07-29 2020-09-09 Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid Compounds
GB202011811D0 (en) 2020-07-29 2020-09-09 Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid Compounds
CA3188821A1 (fr) 2020-08-13 2022-02-17 Lars ANDERS Polytherapie
SI4214202T1 (sl) 2020-09-15 2025-05-30 Pfizer Inc. Trdne oblike inhibitorja cdk4
TW202229239A (zh) 2020-09-23 2022-08-01 日商武田藥品工業股份有限公司 作為ｒｉｐｋ２抑制劑之３－（６－胺基吡啶－３－基）苯甲醯胺衍生物
CN116710090A (zh) 2020-10-09 2023-09-05 Napa医疗有限公司 Cd38的杂芳基酰胺抑制剂
GB202016800D0 (en) 2020-10-22 2020-12-09 Mission Therapeutics Ltd Novel compounds
JP2023554521A (ja) 2020-12-22 2023-12-27 ファイザー・インク Ｅｉｆ４ｅ阻害剤の固体形態
CA3206153A1 (fr) 2020-12-24 2022-06-30 Pfizer Inc. Formes solides d'un inhibiteur de cdk2
US11964978B2 (en) 2021-03-18 2024-04-23 Pfizer Inc. Modulators of STING (stimulator of interferon genes)
BR112023018906A2 (pt) 2021-03-24 2023-10-10 Astellas Pharma Inc Combinação de talazoparib e um antiandrógeno para o tratamento de câncer de próstata metastático sensível à castração com mutação no gene ddr
EP4313151A1 (fr) 2021-03-31 2024-02-07 Sevenless Therapeutics Limited Inhibiteurs de sos1 et inhibiteurs de ras destinés à être utilisés dans le traitement de la douleur
GB202104609D0 (en) 2021-03-31 2021-05-12 Sevenless Therapeutics Ltd New Treatments for Pain
CN117545751A (zh) 2021-04-07 2024-02-09 生命爱科 作为ulk1/2抑制剂的2,4-二氨基嘧啶衍生物及其用途
WO2022229846A1 (fr) 2021-04-29 2022-11-03 Pfizer Inc. Traitement du cancer à l'aide d'un inhibiteur du récepteur du facteur de croissance transformant bêta de type 1
PE20250118A1 (es) 2021-06-26 2025-01-16 Array Biopharma Inc Inhibidores de mutacion de her2
WO2023002362A1 (fr) 2021-07-22 2023-01-26 Pfizer Inc. Traitement d'une malignité hématologique
AU2022325543A1 (en) 2021-08-11 2024-02-15 Curadev Pharma Pvt. Ltd. Small molecule sting antagonists
CA3228653A1 (fr) 2021-08-11 2023-02-16 Monali BANERJEE Derives d'uree a petites molecules en tant qu'antagonistes de sting
WO2023084459A1 (fr) 2021-11-15 2023-05-19 Pfizer Inc. Méthodes de traitement du sars-cov-2
US20250034122A1 (en) 2021-12-01 2025-01-30 Mission Therapeutics Limited Substituted n-cyanopyrrolidines with activity as usp30 inhibitors
KR20240110971A (ko) 2021-12-01 2024-07-16 푼다시온 델 섹토르 푸블리코 에스타탈 센트로 나시오날 데 인베스티가시오네스 온콜로지카스 카를로스 3 (에프.에스.피 씨엔아이오) 화합물
WO2023100134A1 (fr) 2021-12-02 2023-06-08 Pfizer Inc. Méthodes et schémas posologiques comprenant un inhibiteur de cdk2 et un inhibiteur de cdk4 pour le traitement du cancer
IL315998A (en) 2022-03-30 2024-11-01 Takeda Pharmaceuticals Co N-(pyrrolidin-3-yl or piperidin-4-yl)acetamide derivatives
AR129012A1 (es) 2022-04-07 2024-07-03 Takeda Pharmaceuticals Co Derivados de piridazina fusionados
US20240024313A1 (en) 2022-07-15 2024-01-25 Jazz Pharmaceuticals Ireland Limited Biaryl ether urea compounds
AU2023316863A1 (en) 2022-07-29 2025-02-13 Pfizer Inc. Novel acc inhibitors
AR130151A1 (es) 2022-08-10 2024-11-06 Takeda Pharmaceuticals Co Compuesto heterocíclico
JP2025526784A (ja) 2022-08-11 2025-08-15 イヴクスタ・バイオ 癌を処置するための化合物
WO2024074827A1 (fr) 2022-10-05 2024-04-11 Sevenless Therapeutics Limited Nouveaux traitements de la douleur
AU2023380028A1 (en) 2022-11-15 2025-05-22 Curadev Pharma Ltd Pyridone and pyrimidinone inhibitors of hematopoietic progenitor kinase 1
TW202444347A (zh) 2023-01-13 2024-11-16 以色列商琉璃藥品（１９９１）有限公司 使用吡美拉汀(piromelatine)治療與rem睡眠鬆弛喪失相關之異睡症之方法
EP4655303A1 (fr) 2023-01-26 2025-12-03 Takeda Pharmaceutical Company Limited Dérivés de 1-amino-4-phénylphtalazine utiles pour le traitement de maladies neurodégénératives
EP4694980A1 (fr) 2023-04-14 2026-02-18 Takeda Pharmaceutical Company Limited Dérivés de pyrazolopyrimidine utilisés en tant qu'inhibiteurs de nlrp3
EP4724109A1 (fr) 2023-06-09 2026-04-15 Institut Gustave-Roussy Conjugué de médicament ciblant ctla4, produits le comprenant et leurs utilisations thérapeutiques
KR20260022394A (ko) 2023-06-12 2026-02-19 아비나스 오퍼레이션스, 인코포레이티드 에스트로겐 수용체 분해제의 고형 경구제
GB2631397A (en) 2023-06-28 2025-01-08 Sevenless Therapeutics Ltd New treatments for pain
CN121729233A (zh) 2023-08-14 2026-03-24 纽瑞姆制药（1991）有限公司 Gal475组合物及其使用方法
GB2633813A (en) 2023-09-21 2025-03-26 Sevenless Therapeutics Ltd New treatments for pain
WO2025074305A1 (fr) 2023-10-04 2025-04-10 Takeda Pharmaceutical Company Limited Dérivés de n-(1-(aminométhyl)cyclopropyl)(aryl ou hétéroaryl)carboxamide
WO2025083426A1 (fr) 2023-10-20 2025-04-24 Sevenless Therapeutics Limited Nouveaux traitements de la douleur
GB202319181D0 (en) 2023-12-14 2024-01-31 Imperial College Innovations Ltd Nora Inhibitors
WO2025146548A1 (fr) 2024-01-04 2025-07-10 Sevenless Therapeutics Limited Inhibiteurs de sos1 utiles pour traiter la douleur et le cancer
WO2025168601A1 (fr) 2024-02-05 2025-08-14 Evexta Bio Composés d'azétidine de quinazoline carboxamide destinés à être utilisés dans le traitement de maladies hormono-dépendantes
WO2025229624A2 (fr) 2024-05-02 2025-11-06 Napa Therapeutics Limited Nouveaux inhibiteurs de cd38
WO2025231370A1 (fr) 2024-05-02 2025-11-06 Napa Therapeutics Limited Inhibiteurs de cd38
WO2025233837A1 (fr) 2024-05-07 2025-11-13 Takeda Pharmaceutical Company Limited Dérivés de 4h-pyrimido[1,2-a]pyrimidin-4-one destinés à être utilisés en tant qu'inhibiteurs de l'inflammasome nlrp3 pour le traitement d'un trouble neurodégénératif
WO2025247951A1 (fr) 2024-05-28 2025-12-04 Institut Gustave Roussy Inhibiteurs de fyn kinase, combinaisons et utilisations associées
GB202408928D0 (en) 2024-06-21 2024-08-07 Mission Therapeutics Ltd Novel compounds
WO2026025013A2 (fr) 2024-07-26 2026-01-29 Pfizer Inc. Polythérapie utilisant des inhibiteurs de cdk4 pour des traitements contre le cancer
GB202411060D0 (en) 2024-07-29 2024-09-11 Mission Therapeutics Ltd Novel compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
US5233053A (en) * 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives
PT93637A (pt) * 1989-04-20 1990-11-20 Procter & Gamble Metodo para o tratamento de desordens funcionais intestinais/colonicas, especialmente o sindrome de irritacao intestinal
GB9400600D0 (en) * 1994-01-14 1994-03-09 Pfizer Ltd Treatment of motion seckness

Also Published As

Publication number Publication date
JP3403203B2 (ja) 2003-05-06
MY125662A (en) 2006-08-30
DE69626397T2 (de) 2003-07-17
EP1245231B1 (fr) 2004-06-16
CN1303998C (zh) 2007-03-14
NL300190I1 (nl) 2005-07-01
HU225236B1 (en) 2006-08-28
DE122005000024I2 (de) 2006-11-23
EP0850059B1 (fr) 2003-02-26
MX9802026A (es) 1998-08-30
NL300190I2 (nl) 2005-08-01
HU0500976D0 (en) 2005-12-28
BR9610153A (pt) 1999-01-05
NZ316924A (en) 1999-06-29
ES2188782T3 (es) 2003-07-01
EP1245231A3 (fr) 2003-01-15
EP1245231A2 (fr) 2002-10-02
PT1245231E (pt) 2004-10-29
BR122012014331B8 (pt) 2021-05-25
KR19990044653A (ko) 1999-06-25
US6106864A (en) 2000-08-22
CY2005007I1 (el) 2009-11-04
DE122005000024I1 (de) 2005-08-04
DE69626397D1 (de) 2003-04-03
CA2230314C (fr) 2003-06-24
EP0850059A1 (fr) 1998-07-01
DE69632753D1 (de) 2004-07-22
ES2224002T3 (es) 2005-03-01
ZA967745B (en) 1998-03-13
RU2163803C2 (ru) 2001-03-10
NO2005009I2 (no) 2006-11-27
AU703866B2 (en) 1999-04-01
PL185604B1 (pl) 2003-06-30
TW442300B (en) 2001-06-23
CO4750822A1 (es) 1999-03-31
NO981073L (no) 1998-03-11
CZ294024B6 (cs) 2004-09-15
FR05C0019I2 (fr) 2005-11-04
KR100348585B1 (ko) 2002-10-31
NO981073D0 (no) 1998-03-11
DE69632753T2 (de) 2005-07-14
DK0850059T3 (da) 2003-03-31
EG23826A (en) 2007-09-25
WO1997009980A1 (fr) 1997-03-20
CZ73298A3 (cs) 1999-03-17
AU6927596A (en) 1997-04-01
CA2230314A1 (fr) 1997-03-20
BR122012014331A2 (fr) 1999-01-05
CY2005007I2 (el) 2009-11-04
GB9518953D0 (en) 1995-11-15
LU91163I2 (fr) 2005-06-20
ATE233090T1 (de) 2003-03-15
NO314783B1 (no) 2003-05-26
AR005231A1 (es) 1999-04-28
CY2585B2 (en) 2009-11-04
NO2005009I1 (no) 2005-04-18
ATE269076T1 (de) 2004-07-15
FR05C0019I1 (fr) 2005-05-27
BR122012014331B1 (pt) 2019-10-08
HUP9802339A3 (en) 1999-09-28
IL122746A0 (en) 1998-08-16
HU227397B1 (en) 2011-05-30
CY2468B1 (en) 2005-06-03
JPH10511112A (ja) 1998-10-27
HUP9802339A2 (hu) 1999-08-30
CN1195984A (zh) 1998-10-14
PL325598A1 (en) 1998-08-03
TR199800461T1 (xx) 1998-05-21
BR122012014331A8 (pt) 2018-07-31
DK1245231T3 (da) 2004-10-25

Similar Documents

Publication Publication Date Title
CY2585B2 (en) Pharmaceutical formulations containing darifenacin
AP9600883A0 (en) Pharmaceutical formulations
HUP9802999A3 (en) Pharmaceutical composition containing n-propargyl-1-aminoindan
ZA953236B (en) Pharmaceutical formulations
GB9519363D0 (en) Pharmaceutical formulation
ZA951781B (en) Pharmaceutical formulations
EP0862431A4 (fr) Preparation pharmaceutique
GB9523566D0 (en) Pharmaceutical formulation
ZA9610426B (en) Pharmaceutical composition
GB9502695D0 (en) Pharmaceutical composition
ZA96392B (en) Pharmaceutical formulations
GB9413542D0 (en) Pharmaceutical formulations
ZA967542B (en) Pharmaceutical combination preparation comprising keto-profen
GB9500978D0 (en) Pharmaceutical formulations
HUP9602732A2 (en) Pharmaceutical composition comprising lanperisone
GB9516584D0 (en) Pharmaceutical formulations
GB9508989D0 (en) Pharmaceutical formulations
GB9503752D0 (en) Pharmaceutical formulations
GB9417953D0 (en) Pharmaceutical formulations
GB9408162D0 (en) Pharmaceutical formulations
GB9414216D0 (en) Pharmaceutical formulations
GB9408164D0 (en) Pharmaceutical formulations
GB9408163D0 (en) Pharmaceutical formulations
GB9401738D0 (en) Pharmaceutical formulations
GB9426113D0 (en) Pharmaceutical formulations

Legal Events

Date Code Title Description
FF Patent granted
KB20 Patent renewed for 20 years
HP Change in proprietorship
EXP Patent expired