IL146659A0 - Porous drug matrices and method of manufacture thereof - Google Patents

Porous drug matrices and method of manufacture thereof

Info

Publication number: IL146659A0
Authority: IL; Israel
Prior art keywords: drug; porous matrix; forming agent; pore forming; volatile
Prior art date: 1999-05-27

Application number

IL14665900A

Other languages

English (en)

Original Assignee

Acusphere Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-27

Filing date

2000-05-25

Publication date

2002-07-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27495210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL146659(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-11-04 Priority claimed from US09/433,486 external-priority patent/US6395300B1/en

2000-05-25 Application filed by Acusphere Inc filed Critical Acusphere Inc

2002-07-25 Publication of IL146659A0 publication Critical patent/IL146659A0/xx

Links

229940079593 drug Drugs 0.000 title abstract 14
239000003814 drug Substances 0.000 title abstract 14
238000000034 method Methods 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
239000011159 matrix material Substances 0.000 abstract 7
239000002904 solvent Substances 0.000 abstract 5
239000003795 chemical substances by application Substances 0.000 abstract 4
239000011148 porous material Substances 0.000 abstract 4
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 2
229930012538 Paclitaxel Natural products 0.000 abstract 2
239000012736 aqueous medium Substances 0.000 abstract 2
239000002775 capsule Substances 0.000 abstract 2
238000004090 dissolution Methods 0.000 abstract 2
229960003668 docetaxel Drugs 0.000 abstract 2
239000000839 emulsion Substances 0.000 abstract 2
239000011859 microparticle Substances 0.000 abstract 2
229960001592 paclitaxel Drugs 0.000 abstract 2
238000010561 standard procedure Methods 0.000 abstract 2
239000000725 suspension Substances 0.000 abstract 2
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
239000003684 drug solvent Substances 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1
238000001694 spray drying Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Materials For Medical Uses (AREA)
Epoxy Compounds (AREA)

IL14665900A 1999-05-27 2000-05-25 Porous drug matrices and method of manufacture thereof IL146659A0 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US13632399P	1999-05-27	1999-05-27
US15865999P	1999-10-08	1999-10-08
US09/433,486 US6395300B1 (en)	1999-05-27	1999-11-04	Porous drug matrices and methods of manufacture thereof
US18631000P	2000-03-02	2000-03-02
PCT/US2000/014578 WO2000072827A2 (en)	1999-05-27	2000-05-25	Porous drug matrices and methods of manufacture thereof

Publications (1)

Publication Number	Publication Date
IL146659A0 true IL146659A0 (en)	2002-07-25

Family

ID=27495210

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL14665900A IL146659A0 (en)	1999-05-27	2000-05-25	Porous drug matrices and method of manufacture thereof
IL146659A IL146659A (en)	1999-05-27	2001-11-21	Methods for preparing a porous matrix of drug

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL146659A IL146659A (en)	1999-05-27	2001-11-21	Methods for preparing a porous matrix of drug

Country Status (18)

Country	Link
EP (1)	EP1180020B2 (de)
JP (1)	JP4722295B2 (de)
KR (2)	KR100883477B1 (de)
CN (1)	CN1240373C (de)
AT (1)	ATE312601T1 (de)
AU (1)	AU768022B2 (de)
BR (1)	BR0010984A (de)
CA (1)	CA2371836C (de)
DE (1)	DE60024811T3 (de)
DK (1)	DK1180020T4 (de)
ES (1)	ES2250141T5 (de)
HK (1)	HK1048956B (de)
IL (2)	IL146659A0 (de)
MX (1)	MXPA01012106A (de)
NO (1)	NO323761B1 (de)
NZ (1)	NZ516083A (de)
TW (1)	TWI274589B (de)
WO (1)	WO2000072827A2 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6342533B1 (en)	1998-12-01	2002-01-29	Sepracor, Inc.	Derivatives of (−)-venlafaxine and methods of preparing and using the same
HUP0200898A3 (en)	1999-04-06	2005-09-28	Sepracor Inc	Derivatives of venlafaxine and methods of preparing and using the same
US8771740B2 (en) *	1999-12-20	2014-07-08	Nicholas J. Kerkhof	Process for producing nanoparticles by spray drying
US7473433B2 (en)	2000-12-21	2009-01-06	Nektar Therapeutics	Pulmonary delivery of polyene antifungal agents
MY120279A (en)	2000-05-26	2005-09-30	Pharmacia Corp	Use of a celecoxib composition for fast pain relief
US6589557B2 (en) *	2000-06-15	2003-07-08	Acusphere, Inc.	Porous celecoxib matrices and methods of manufacture thereof
US6613308B2 (en) *	2000-09-19	2003-09-02	Advanced Inhalation Research, Inc.	Pulmonary delivery in treating disorders of the central nervous system
US6514482B1 (en)	2000-09-19	2003-02-04	Advanced Inhalation Research, Inc.	Pulmonary delivery in treating disorders of the central nervous system
DE10059020A1 (de)	2000-11-28	2002-05-29	Gruenenthal Gmbh	Parenteral applizierbare Darreichungsformen
MXPA03006404A (es) *	2001-01-18	2004-12-02	Upjohn Co	Composiciones quimioterapeuticas de microemulsion de paclitaxel con biodisponibilidad oral mejorada.
US7115565B2 (en)	2001-01-18	2006-10-03	Pharmacia & Upjohn Company	Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
EP2319826A1 (de) †	2001-02-12	2011-05-11	Wyeth LLC	O-Desmethyl-Venlafaxine Succinat Salz
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US7766013B2 (en)	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
WO2002094231A1 (en) *	2001-05-24	2002-11-28	Alexza Molecular Delivery Corporation	Delivery of analgesics through an inhalation route
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
US6805853B2 (en)	2001-11-09	2004-10-19	Alexza Molecular Delivery Corporation	Delivery of diazepam through an inhalation route
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
JP2005503425A (ja)	2001-05-24	2005-02-03	アレックザモレキュラーデリヴァリーコーポレイション	所定の吸入ルートによる薬剤エステルの送出
WO2003007968A1 (en) *	2001-07-17	2003-01-30	Sun Pharmaceutical Industries Ltd.	A cardiotonic composition
US7005138B2 (en) *	2001-12-21	2006-02-28	Duramed Pharmaceuticals, Inc.	Method of systematically delivering SSRIs
HUE031167T2 (hu) *	2002-03-20	2017-07-28	Civitas Therapeutics Inc	A levodopa pulmonális bejuttatása
JP4452970B2 (ja)	2002-03-27	2010-04-21	日本臓器製薬株式会社	ジクロフェナクナトリウム経口製剤
US7959946B2 (en)	2002-09-20	2011-06-14	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en)	2002-09-20	2010-08-31	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en)	2002-09-20	2011-12-27	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en)	2002-09-20	2015-06-23	Actavis, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8980870B2 (en)	2002-09-24	2015-03-17	Boehringer Ingelheim International Gmbh	Solid telmisartan pharmaceutical formulations
CA2500065A1 (en) *	2002-09-30	2004-04-15	Acusphere, Inc.	Sustained release porous microparticles for inhalation
CA2520613C (en)	2003-03-31	2012-12-04	Titan Pharmaceuticals, Inc.	Implantable polymeric device for sustained release of dopamine agonist
US7276246B2 (en)	2003-05-09	2007-10-02	Cephalon, Inc.	Dissolvable backing layer for use with a transmucosal delivery device
US7306812B2 (en)	2003-05-09	2007-12-11	Cephalon, Inc.	Dissolvable backing layer for use with a transmucosal delivery device
US20040234699A1 (en)	2003-05-21	2004-11-25	Alexza Molecular Delivery Corporation	Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
GB0401947D0 (en)	2004-01-28	2004-03-03	Unilever Plc	Porous bodies and method of production thereof
KR100681660B1 (ko) *	2004-03-17	2007-02-09	주식회사종근당	방출제어 펠릿의 약제학적 조성물
US7540286B2 (en)	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (de)	2004-08-12	2012-11-21	Alexza Pharmaceuticals, Inc.	Aerosolverabreichungsvorrichtung mit Schlag gezündete Heizeinheit
GB0425758D0 (en)	2004-11-23	2004-12-22	Vectura Ltd	Preparation of pharmaceutical compositions
EP1681056A1 (de) *	2005-01-14	2006-07-19	Krka Tovarna Zdravil, D.D., Novo Mesto	Verfahren zur Herstellung von Lansoprazol
AU2006264407B2 (en) *	2005-07-04	2012-08-30	Ramu Krishnan	Improved drug or pharmaceutical compounds and a preparation thereof
GB0517688D0 (en) *	2005-08-31	2005-10-05	Cambridge Biostability Ltd	Improvements in the stabilisation of biological materials
GB0523638D0 (en)	2005-11-21	2005-12-28	Cambridge Biostability Ltd	Pharmaceutical device for the administration of substances to patients
AR054215A1 (es) *	2006-01-20	2007-06-13	Eriochem Sa	Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit
AU2007208998A1 (en) *	2006-01-27	2007-08-02	The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin	A method of producing porous microparticles
KR100917809B1 (ko) *	2006-05-22	2009-09-18	에스케이케미칼주식회사	우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물
GB0613925D0 (en)	2006-07-13	2006-08-23	Unilever Plc	Improvements relating to nanodispersions
EP2121088B1 (de)	2007-03-09	2016-07-13	Alexza Pharmaceuticals, Inc.	Erhitzungseinheit zur verwendung in einer arzneimittelabgabevorrichtung
BRPI0810606B1 (pt)	2007-04-27	2018-10-16	Endo Pharmaceuticals Solutions	dispositivo de implante e processo para sua preparação
PT103743B (pt) *	2007-05-16	2013-01-15	Hovione Farmaciencia S A	Processo para preparar derivados de 21-disódio fosfato de pregnanos.
GB0716591D0 (en) *	2007-08-24	2007-10-03	Vereniging Het Nl Kanker I	Composition
MX2010002179A (es)	2007-08-24	2010-04-27	Stichting Het Nl Kanker I	Composicion para el tratamiento de enfermedades neoplasicas.
MX2010003923A (es) *	2007-10-09	2010-05-05	Novartis Ag	Formulacion farmaceutica de valsartan.
US9801818B2 (en)	2007-12-31	2017-10-31	Samyang Biopharmaceuticals Corporation	Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
KR101024742B1 (ko) *	2007-12-31	2011-03-24	주식회사 삼양사	탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
US20110206770A1 (en) *	2008-07-25	2011-08-25	Alphapharm Pty. Ltd.	Atovaquone with a particle size diameter range (d90) of greater than 3 microns to about 10 microns
JP2012500788A (ja) *	2008-08-22	2012-01-12	スティヒティングヘットネーデルランドカンケルインスティテュート	組成物
WO2010102066A1 (en)	2009-03-05	2010-09-10	Bend Research, Inc.	Dextran polymer powder for inhalation administration of pharmaceuticals
WO2010111132A2 (en)	2009-03-27	2010-09-30	Bend Research, Inc.	Spray-drying process
PT2611530T (pt)	2010-09-03	2019-05-09	Bend Res Inc	Aparelho de secagem por pulverização e métodos de utilização do mesmo
EP2611529B1 (de)	2010-09-03	2019-01-23	Bend Research, Inc.	Sprühtrocknungsverfahren
EP2618924A1 (de)	2010-09-24	2013-07-31	Bend Research, Inc.	Hochtemperatur-sprühtrocknungsverfahren und verfahren
WO2012114342A1 (en)	2011-02-23	2012-08-30	Coeruleus Ltd.	Flumazenil complexes, compositions comprising same and uses thereof
US9060938B2 (en)	2011-05-10	2015-06-23	Bend Research, Inc.	Pharmaceutical compositions of active agents and cationic dextran polymer derivatives
CN103301095B (zh) *	2012-03-13	2016-04-13	中国科学院上海药物研究所	一种用于提高普罗布考口服吸收的多孔复合载药组合物及其制备方法
US20150150788A1 (en) *	2012-06-22	2015-06-04	The University Of Queensland	Method and composition for delivering a compound through a biological barrier
EP3082428A4 (de)	2013-12-09	2017-08-02	Respira Therapeutics, Inc.	Pde5-inhibitorpulverformulierungen und zugehörige verfahren
EP3154528B1 (de)	2014-06-11	2023-04-05	SpecGx LLC	Sprühgetrocknete zusammensetzungen mit verschiedenen auflösungsprofilen und verfahren zu deren herstellung
EP3212169B1 (de)	2014-10-31	2021-01-13	Bend Research, Inc.	Verfahren zur herstellung von in einer matrix dispergierten aktiven domänen
CA2971440C (en) *	2014-12-18	2024-02-13	Windgap Medical, Inc.	Method and compositions for dissolving or solubilizing therapeutic agents
JP6921759B2 (ja)	2015-06-04	2021-08-18	クリティテック・インコーポレイテッド	捕集装置および使用法
AU2016323770A1 (en)	2015-09-16	2018-03-29	Dfb Soria, Llc	Delivery of drug nanoparticles and methods of use thereof
SG10201913409VA (en)	2016-04-04	2020-03-30	Crititech Inc	Methods for solid tumor treatment
US10076494B2 (en)	2016-06-16	2018-09-18	Dexcel Pharma Technologies Ltd.	Stable orally disintegrating pharmaceutical compositions
KR101965708B1 (ko) *	2016-08-30	2019-04-04	이화여자대학교 산학협력단	스폰지 유사 구조를 갖는 고분자 미립자 및 이의 제조방법
JP2020514359A (ja)	2017-03-15	2020-05-21	ディーエフビーソリアリミテッドライアビリティカンパニー	タキサンのナノ粒子を用いる皮膚悪性腫瘍処置のための局所療法
SG11201909840TA (en)	2017-06-09	2019-11-28	Crititech Inc	Treatment of epithelial cysts by intracystic injection of antineoplastic particles
CN115919815A (zh)	2017-06-14	2023-04-07	克里蒂泰克公司	治疗肺部疾病的方法
KR20200064112A (ko)	2017-10-03	2020-06-05	크리티테크, 인크.	암의 치료를 위한 면역치료제의 전신 전달과 조합된 항신생물성 입자의 국소 전달
US11278492B2 (en)	2018-01-05	2022-03-22	Impel Neuropharma, Inc.	Intranasal delivery of olanzapine by precision olfactory device
US12214118B2 (en)	2018-02-02	2025-02-04	Alexza Pharmaceuticals, Inc.	Electrical condensation aerosol device
KR20200132963A (ko)	2018-03-16	2020-11-25	디에프비 소리아, 엘엘씨	탁산의 나노입자를 사용하는 자궁경부 상피내 신생물 (cin) 및 자궁경부 암의 치료를 위한 국소적 요법
MX2021009038A (es)	2019-01-29	2021-08-16	Bayer Healthcare Llc	Composiciones topicas de naproxeno en gel.
WO2020227816A1 (en) *	2019-05-10	2020-11-19	Anomera Inc.	Porous cellulose microparticles and methods of manufacture thereof
PT4037666T (pt)	2020-12-08	2024-06-25	Ruminant Biotech Corp Ltd	Aperfeiçoamentos de dispositivos e métodos para administração de substâncias a animais
CN113081971A (zh) *	2021-05-14	2021-07-09	江西中医药大学	一种中药多孔核壳型复合粒子粉体及其制备方法和应用
CN117538462B (zh) *	2024-01-10	2024-03-26	地奥集团成都药业股份有限公司	一种氨氯地平贝那普利胶囊有关物质的检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1265615A (de) *	1970-09-10	1972-03-01
NL7313626A (nl) †	1973-10-04	1975-04-08	Philips Nv	Gecombineerde inrichting voor het produceren en sselen van warmte met een warmte ver- ende inrichting.
GB8322007D0 (en) †	1983-08-16	1983-09-21	Wellcome Found	Pharmaceutical delivery system
IL82245A (en) *	1986-04-25	1990-07-26	Basf Ag	Preparation of spray-dried granules of active ingredients
EP0655237A1 (de) *	1993-11-27	1995-05-31	Hoechst Aktiengesellschaft	Medizinische Aerosolformulierung
US5762961A (en) *	1996-02-09	1998-06-09	Quadrant Holdings Cambridge Ltd.	Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
ES2236832T3 (es) *	1997-01-16	2005-07-16	Massachusetts Institute Of Technology	Preparacion de particulas para inhalacion.
DE69813853T3 (de) *	1997-09-29	2011-05-12	Novartis Ag	Perforierte mikroteilchen und deren verwendung
JP4758525B2 (ja) *	1998-03-20	2011-08-31	武田薬品工業株式会社	生理活性ポリペプチドの徐放性製剤およびその製造法
US6423345B2 (en) †	1998-04-30	2002-07-23	Acusphere, Inc.	Matrices formed of polymer and hydrophobic compounds for use in drug delivery

2000
- 2000-05-25 WO PCT/US2000/014578 patent/WO2000072827A2/en not_active Ceased
- 2000-05-25 MX MXPA01012106A patent/MXPA01012106A/es active IP Right Grant
- 2000-05-25 HK HK03101310.8A patent/HK1048956B/zh not_active IP Right Cessation
- 2000-05-25 KR KR1020077012286A patent/KR100883477B1/ko not_active Expired - Fee Related
- 2000-05-25 AU AU54459/00A patent/AU768022B2/en not_active Ceased
- 2000-05-25 JP JP2000620939A patent/JP4722295B2/ja not_active Expired - Fee Related
- 2000-05-25 ES ES00939365T patent/ES2250141T5/es not_active Expired - Lifetime
- 2000-05-25 IL IL14665900A patent/IL146659A0/xx unknown
- 2000-05-25 NZ NZ516083A patent/NZ516083A/en not_active IP Right Cessation
- 2000-05-25 AT AT00939365T patent/ATE312601T1/de active
- 2000-05-25 EP EP00939365A patent/EP1180020B2/de not_active Expired - Lifetime
- 2000-05-25 CN CNB008081611A patent/CN1240373C/zh not_active Expired - Fee Related
- 2000-05-25 CA CA002371836A patent/CA2371836C/en not_active Expired - Fee Related
- 2000-05-25 DK DK00939365T patent/DK1180020T4/da active
- 2000-05-25 DE DE60024811T patent/DE60024811T3/de not_active Expired - Lifetime
- 2000-05-25 BR BR0010984-3A patent/BR0010984A/pt not_active IP Right Cessation
- 2000-05-25 KR KR1020017015052A patent/KR100752000B1/ko not_active Expired - Fee Related
- 2000-05-29 TW TW089110363A patent/TWI274589B/zh not_active IP Right Cessation
2001
- 2001-11-21 IL IL146659A patent/IL146659A/en not_active IP Right Cessation
- 2001-11-26 NO NO20015753A patent/NO323761B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK1180020T4 (da)	2009-10-05
DE60024811T2 (de)	2006-09-14
EP1180020B2 (de)	2009-06-24
ES2250141T3 (es)	2006-04-16
NO323761B1 (no)	2007-07-02
NO20015753L (no)	2002-01-28
NZ516083A (en)	2003-08-29
IL146659A (en)	2010-05-31
KR100752000B1 (ko)	2007-08-28
CA2371836C (en)	2006-01-31
JP4722295B2 (ja)	2011-07-13
DE60024811T3 (de)	2010-01-07
AU5445900A (en)	2000-12-18
DE60024811D1 (de)	2006-01-19
KR100883477B1 (ko)	2009-02-16
BR0010984A (pt)	2002-04-30
WO2000072827A9 (en)	2002-01-31
HK1048956A1 (en)	2003-04-25
CN1240373C (zh)	2006-02-08
CA2371836A1 (en)	2000-12-07
ATE312601T1 (de)	2005-12-15
EP1180020B1 (de)	2005-12-14
TWI274589B (en)	2007-03-01
KR20020011992A (ko)	2002-02-09
CN1365274A (zh)	2002-08-21
HK1094775A1 (zh)	2007-04-13
EP1180020A2 (de)	2002-02-20
WO2000072827A2 (en)	2000-12-07
AU768022B2 (en)	2003-11-27
ES2250141T5 (es)	2009-11-05
JP2003500438A (ja)	2003-01-07
NO20015753D0 (no)	2001-11-26
KR20070069219A (ko)	2007-07-02
DK1180020T3 (da)	2006-03-27
HK1048956B (zh)	2006-07-28
MXPA01012106A (es)	2003-06-30
WO2000072827A3 (en)	2001-01-25

Publication	Publication Date	Title
MXPA01012106A (es)	2003-06-30	Matrices porosas de farmaco y metodo de fabricacion de las mismas.
RU2420290C2 (ru)	2011-06-10	Твердые, пригодные для орального употребления фармацевтические формы применения, содержащие ривароксабан с модифицированным высвобождением
AU2002222567B2 (en)	2007-05-10	Composition improved in solubility or oral absorbability
FI91826C (fi)	1994-08-25	Menetelmä kiinteän valmisteen valmistamiseksi, josta aktiivista yhdistettä vapautuu pidennetyn ajanjakson ajan
WO2001095877A3 (en)	2002-05-02	Porous celecoxib matrices and methods of manufacture thereof
JP2000229846A (ja)	2000-08-22	放出制御型剤形
CA2317769A1 (en)	2001-12-28	Sustained release microparticle and method for preparing the same
ATE77946T1 (de)	1992-07-15	Injizierbares langwirkendes mikroteilchenpr\|parat zur verabreichung entzuendungshemmender mittel.
CN120091810A (zh)	2025-06-03	用于治疗病毒性疾病的方法和生物利用度高渗透性化合物
Plöger et al.	2020	Biowaiver monographs for immediate release solid oral dosage forms: cephalexin monohydrate
JP2000256195A (ja)	2000-09-19	ニフェジピン小丸薬およびニフェジピン小丸薬の調製方法
JP4401778B2 (ja)	2010-01-20	超臨界流体を用いて活性物質と多孔質支持体とを相互反応させた物質の製造方法
KR100583065B1 (ko)	2006-06-08	프로그램화 및 펄스화 방출식 다립형 의약 제형 및 그의 제조 방법
AU2003235156B2 (en)	2007-07-05	Solid dispersion composition
JPS58116414A (ja)	1983-07-11	ニカルジピン持続性製剤用球形顆粒およびその製造法
JPS6153214A (ja)	1986-03-17	調節された方法による有効成分の放出を可能にする医薬組成物
Minocha et al.	2019	SOlubility enhancement of poorly water soluble drugs by various techniques
CN100333729C (zh)	2007-08-29	灯盏花素渗透泵控释制剂
KR100981750B1 (ko)	2010-09-10	분무-건조 과립 및 그의 제조방법
JP2005298472A (ja)	2005-10-27	イトラコナゾールを含む経口投与用組成物
EP0323762B1 (de)	1993-07-14	Hustenstillende Zusammensetzungen und ein Verfahren zu deren Herstellung
WO2007064084A1 (en)	2007-06-07	Granules containing pranlukast and processes for the preparation thereof
JPH06128147A (ja)	1994-05-10	水難溶性薬品の溶解性改善方法およびそれにより得られた薬品組成物
JP2616946B2 (ja)	1997-06-04	肝類洞小孔拡張・増加剤
OGiso et al.	1984	ABSORPTION AND BIOAVAILABILITY OF CALCIUM AND MAGNESIUM SALTS OF INDOMETHACIN FROM RECTAL SUPPOSITO-RIES