IL88810A - 1, 2, 3, 4, 6, 7, 8, 12b-octahydro 7-(mercaptomethyl)- 6-oxopyrido (2,1-a) (2)- benzazepine-4-carboxylic acid, esters thereof and pharmaceutical compositions containing same - Google Patents

1, 2, 3, 4, 6, 7, 8, 12b-octahydro 7-(mercaptomethyl)- 6-oxopyrido (2,1-a) (2)- benzazepine-4-carboxylic acid, esters thereof and pharmaceutical compositions containing same

Info

Publication number: IL88810A
Authority: IL; Israel
Prior art keywords: oxopyrido; benzazepine; mercaptomethyl; octahydro; esters
Prior art date: 1987-12-30

Application number

IL88810A

Other languages

English (en)

Other versions

IL88810A0 (en

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-30

Filing date

1988-12-27

Publication date

1993-08-18

1988-12-27 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-07-31 Publication of IL88810A0 publication Critical patent/IL88810A0/xx

1993-08-18 Publication of IL88810A publication Critical patent/IL88810A/xx

Links

VOBYAAOXHXIEJG-UHFFFAOYSA-N 6-oxo-7-(sulfanylmethyl)-2,3,4,7,8,12b-hexahydro-1h-pyrido[2,1-a][2]benzazepine-4-carboxylic acid Chemical compound O=C1C(CS)CC2=CC=CC=C2C2CCCC(C(=O)O)N21 VOBYAAOXHXIEJG-UHFFFAOYSA-N 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
206010063837 Reperfusion injury Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
150000003951 lactams Chemical class 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)
Cephalosporin Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL88810A 1987-12-30 1988-12-27 1, 2, 3, 4, 6, 7, 8, 12b-octahydro 7-(mercaptomethyl)- 6-oxopyrido (2,1-a) (2)- benzazepine-4-carboxylic acid, esters thereof and pharmaceutical compositions containing same IL88810A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/139,485 US4824832A (en)	1987-12-30	1987-12-30	Sulfhydryl containing tricyclic lactams and their pharmacological methods of use

Publications (2)

Publication Number	Publication Date
IL88810A0 IL88810A0 (en)	1989-07-31
IL88810A true IL88810A (en)	1993-08-18

Family

ID=22486887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL88810A IL88810A (en)	1987-12-30	1988-12-27	1, 2, 3, 4, 6, 7, 8, 12b-octahydro 7-(mercaptomethyl)- 6-oxopyrido (2,1-a) (2)- benzazepine-4-carboxylic acid, esters thereof and pharmaceutical compositions containing same

Country Status (18)

Country	Link
US (1)	US4824832A (fr)
EP (1)	EP0322914B1 (fr)
JP (1)	JP2681291B2 (fr)
KR (1)	KR0128158B1 (fr)
CN (1)	CN1034721A (fr)
AT (1)	ATE100453T1 (fr)
AU (1)	AU611984B2 (fr)
CA (1)	CA1336191C (fr)
DE (1)	DE3887307T2 (fr)
DK (1)	DK725988A (fr)
ES (1)	ES2061621T3 (fr)
FI (1)	FI886005A7 (fr)
HU (2)	HU204050B (fr)
IL (1)	IL88810A (fr)
NO (1)	NO885812L (fr)
NZ (1)	NZ227432A (fr)
PT (1)	PT89346B (fr)
ZA (1)	ZA889542B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2053340C (fr) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Derives de mercaptoacetylamide utiles comme inhibiteurs de l'encephalinase et de l'ace
EP0492369B1 (fr) *	1990-12-21	1997-09-17	Merrell Pharmaceuticals Inc.	Nouveaux composés tricycliques avec nitro ou amino groupements, utiles comme inhibiteurs d'ACE
US5208230A (en) *	1990-12-21	1993-05-04	Merrell Dow Pharmaceuticals	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5308841A (en) *	1990-12-21	1994-05-03	Merrell Dow Pharmaceuticals Inc.	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
CA2078759C (fr) *	1991-09-27	2003-09-16	Alan M. Warshawsky	Derives carboxyalkyliques, utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DE69220744T2 (de) *	1991-09-27	1997-11-13	Merrell Pharma Inc	2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
AU668707B2 (en) *	1992-02-14	1996-05-16	Merrell Pharmaceuticals Inc.	Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
DK0640086T3 (da) *	1992-05-15	1999-12-06	Merrell Pharma Inc	Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer
US5238932A (en) *	1992-05-20	1993-08-24	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5420271A (en) *	1992-08-24	1995-05-30	Merrell Dow Pharmaceuticals, Inc.	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
DE69329701T2 (de) *	1992-10-30	2001-05-10	Merrell Pharmaceuticals Inc., Cincinnati	Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace-hemmer
US5654294A (en) *	1993-05-13	1997-08-05	Bristol-Myers Squibb	Spiro lactam dual action inhibitors
US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
FI962045A7 (fi) *	1993-11-19	1996-05-14	Merrell Pharma Inc	Uusi menetelmä (S)-1-/2(S)-(1,3-dihydro-1,3-dioksoisoindo-2-yyli)-1-ok so-3-fenyylipropyyli/-1,2,3,4-tetrahydro-2-pyridiinikarboksyylihappome tyyliesterin ja sen välituotteiden valmistamiseksi
DE69516128T2 (de) *	1994-02-14	2000-12-21	Merrell Pharmaceuticals Inc., Cincinnati	Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren
CN1142831A (zh) *	1994-02-14	1997-02-12	默里尔药物公司	用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
ATE177098T1 (de) *	1994-02-14	1999-03-15	Merrell Pharma Inc	Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
HUT74584A (en) *	1994-02-14	1997-01-28	Merrell Pharma Inc	Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
ATE189392T1 (de) *	1994-03-24	2000-02-15	Merrell Pharma Inc	Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
FI963784A0 (fi) *	1994-03-24	1996-09-23	Merrell Pharma Inc	Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamididisulfidijohdannaisia
US5641880A (en) *	1994-12-21	1997-06-24	Hoechst Marion Roussel, Inc.	Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
PT800527E (pt) *	1994-12-21	2000-06-30	Hoechst Marion Roussel Inc	Novos processos para a preparacao de intermediarios de inibidores da encefalinase e de enzima conversora da angiotensina e os seus intermediarios
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en)	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use
US20030229007A1 (en) *	2002-05-30	2003-12-11	Roberto Levi	Form of human renin and its use as a target in treatments for cardiac ischemia and arrhythmia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3185680A (en) *	1962-10-16	1965-05-25	American Home Prod	Reduced benzodiazepinium compounds
US4584294A (en) *	1984-11-07	1986-04-22	Merck & Co., Inc.	Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
ZA874107B (fr) *	1986-06-13	1987-12-09

1987
- 1987-12-30 US US07/139,485 patent/US4824832A/en not_active Expired - Lifetime
1988
- 1988-12-21 ZA ZA889542A patent/ZA889542B/xx unknown
- 1988-12-21 AU AU27368/88A patent/AU611984B2/en not_active Ceased
- 1988-12-21 NZ NZ227432A patent/NZ227432A/en unknown
- 1988-12-21 CA CA000586691A patent/CA1336191C/fr not_active Expired - Lifetime
- 1988-12-22 HU HU895880A patent/HU204050B/hu not_active IP Right Cessation
- 1988-12-22 HU HU886576A patent/HU200181B/hu not_active IP Right Cessation
- 1988-12-23 JP JP63323844A patent/JP2681291B2/ja not_active Expired - Lifetime
- 1988-12-27 PT PT89346A patent/PT89346B/pt not_active IP Right Cessation
- 1988-12-27 IL IL88810A patent/IL88810A/xx unknown
- 1988-12-28 DK DK725988A patent/DK725988A/da not_active Application Discontinuation
- 1988-12-28 FI FI886005A patent/FI886005A7/fi not_active Application Discontinuation
- 1988-12-28 KR KR1019880017625A patent/KR0128158B1/ko not_active Expired - Fee Related
- 1988-12-29 AT AT88121850T patent/ATE100453T1/de not_active IP Right Cessation
- 1988-12-29 DE DE88121850T patent/DE3887307T2/de not_active Expired - Lifetime
- 1988-12-29 NO NO88885812A patent/NO885812L/no unknown
- 1988-12-29 ES ES88121850T patent/ES2061621T3/es not_active Expired - Lifetime
- 1988-12-29 EP EP88121850A patent/EP0322914B1/fr not_active Expired - Lifetime
- 1988-12-29 CN CN88105629A patent/CN1034721A/zh active Pending

Also Published As

Publication number	Publication date
HU895880D0 (en)	1990-02-28
CN1034721A (zh)	1989-08-16
DE3887307D1 (de)	1994-03-03
KR0128158B1 (ko)	1998-04-04
ZA889542B (en)	1989-09-27
NO885812L (no)	1989-07-03
IL88810A0 (en)	1989-07-31
HU204050B (en)	1991-11-28
NZ227432A (en)	1990-11-27
PT89346B (pt)	1993-08-31
EP0322914A3 (en)	1990-12-27
FI886005A7 (fi)	1989-07-01
CA1336191C (fr)	1995-07-04
JP2681291B2 (ja)	1997-11-26
JPH01203382A (ja)	1989-08-16
EP0322914A2 (fr)	1989-07-05
DK725988D0 (da)	1988-12-28
AU611984B2 (en)	1991-06-27
ATE100453T1 (de)	1994-02-15
HU200181B (en)	1990-04-28
KR890009927A (ko)	1989-08-04
US4824832A (en)	1989-04-25
PT89346A (pt)	1989-12-29
ES2061621T3 (es)	1994-12-16
EP0322914B1 (fr)	1994-01-19
DE3887307T2 (de)	1994-05-05
HUT49137A (en)	1989-08-28
DK725988A (da)	1989-07-01
NO885812D0 (no)	1988-12-29
AU2736888A (en)	1989-07-06

Legal Events

Date

Code

Title

Description

2006-09-05

HC

Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.

Publication	Publication Date	Title
IL88810A (en)	1993-08-18	1, 2, 3, 4, 6, 7, 8, 12b-octahydro 7-(mercaptomethyl)- 6-oxopyrido (2,1-a) (2)- benzazepine-4-carboxylic acid, esters thereof and pharmaceutical compositions containing same
IE882929L (en)	1989-03-28	"immunomodulatory azaspiranes"
NO180719C (no)	1997-06-04	Analogifremgangsmåte for fremstilling av terapeutisk aktive A-nor-steroid-3-carboxylsyrederivater
NZ212750A (en)	1989-04-26	3-acylamino-2-azetidinone derivatives useful as intermediates in the preparation of antibacterial agents
EP0262399A3 (en)	1989-04-26	Cyclic enol derivatives, production and use thereof
ATE121939T1 (de)	1995-05-15	Ascorbinsäure-tocopheryl-phosphatdiester zur hemmung der maillard-reaktion.
PL268455A1 (en)	1988-09-01	The method of manufacture of new derivatives of benzimidazole
PT82032A (en)	1986-03-01	Process for the preparation of anticonvulsant amino acid derivatives and of pharmaceutical compositions containing the same
BG103194A (en)	1999-09-30	Pharmaceutical products for the treatment and prevention of diseases caused by the impairment of the vascular endothelial cells
EP0207681A3 (en)	1988-06-01	Pyrrolidone derivatives
IL75987A (en)	1991-07-18	Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
ATE92315T1 (de)	1993-08-15	Aminosaeurederivate enthaltende antikonvulsive zusammensetzungen und verwendung dieser aminosaeurederivate.
LT2199B (lt)	1993-10-15	2-triazolidinono dariniu gavimo budas
DE3063105D1 (en)	1983-06-16	Clavulanic acid derivatives, process for their preparation and pharmaceutical compositions containing them