|
FR2645866B1
(fr)
*
|
1989-04-17 |
1991-07-05 |
Centre Nat Rech Scient |
Nouvelles lipopolyamines, leur preparation et leur emploi
|
|
US6509032B1
(en)
|
1991-08-28 |
2003-01-21 |
Mcmaster University |
Cationic amphiphiles
|
|
US5175103A
(en)
*
|
1991-10-21 |
1992-12-29 |
Trustees Of University Of Pennsylvania |
Preparation of pure cultures of post-mitotic human neurons
|
|
WO1993019768A1
(en)
*
|
1992-04-03 |
1993-10-14 |
The Regents Of The University Of California |
Self-assembling polynucleotide delivery system
|
|
US5334761A
(en)
*
|
1992-08-28 |
1994-08-02 |
Life Technologies, Inc. |
Cationic lipids
|
|
US5329029A
(en)
*
|
1992-11-05 |
1994-07-12 |
Wan Barbara Y |
Phosphatidylalkanolamine derivatives and their use in generating phospholipid conjugates
|
|
EP1624068A1
(de)
*
|
1993-06-01 |
2006-02-08 |
Life Technologies Inc. |
Genetische Impfung mit kationischen Lipidstoffen
|
|
US5674908A
(en)
*
|
1993-12-20 |
1997-10-07 |
Life Technologies, Inc. |
Highly packed polycationic ammonium, sulfonium and phosphonium lipids
|
|
FR2714830B1
(fr)
*
|
1994-01-10 |
1996-03-22 |
Rhone Poulenc Rorer Sa |
Composition contenant des acides nucléiques, préparation et utilisations.
|
|
US6989434B1
(en)
|
1994-02-11 |
2006-01-24 |
Invitrogen Corporation |
Reagents for intracellular delivery of macromolecules
|
|
US6075012A
(en)
*
|
1994-02-11 |
2000-06-13 |
Life Technologies, Inc. |
Reagents for intracellular delivery of macromolecules
|
|
US5651981A
(en)
*
|
1994-03-29 |
1997-07-29 |
Northwestern University |
Cationic phospholipids for transfection
|
|
US5777153A
(en)
*
|
1994-07-08 |
1998-07-07 |
Gilead Sciences, Inc. |
Cationic lipids
|
|
US5858140A
(en)
*
|
1994-07-22 |
1999-01-12 |
Minnesota Mining And Manufacturing Company |
Nonwoven surface finishing articles reinforced with a polymer backing layer and method of making same
|
|
US5908635A
(en)
*
|
1994-08-05 |
1999-06-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method for the liposomal delivery of nucleic acids
|
|
US5892071A
(en)
*
|
1994-09-30 |
1999-04-06 |
The Reagents Of The University Of California |
Cationic transport reagents
|
|
US5527928A
(en)
*
|
1994-09-30 |
1996-06-18 |
Nantz; Michael H. |
Cationic transport reagents
|
|
US5837533A
(en)
|
1994-09-28 |
1998-11-17 |
American Home Products Corporation |
Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
|
|
EP1179340A3
(de)
*
|
1994-09-30 |
2003-05-07 |
INEX Pharmaceutical Corp. |
Zusammensetzungen zum Einbringen polyanionischer Materialien in Zellen
|
|
US5753613A
(en)
*
|
1994-09-30 |
1998-05-19 |
Inex Pharmaceuticals Corporation |
Compositions for the introduction of polyanionic materials into cells
|
|
NZ291892A
(en)
*
|
1994-10-14 |
1999-04-29 |
Daiichi Seiyaku Co |
Gene transference using dic10-c20 alkylamide glycylspermine
|
|
FR2727679B1
(fr)
*
|
1994-12-05 |
1997-01-03 |
Rhone Poulenc Rorer Sa |
Nouveaux agents de transfection et leurs applications pharmaceutiques
|
|
US5719131A
(en)
*
|
1994-12-09 |
1998-02-17 |
Genzyme Corporation |
Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules
|
|
US5840710A
(en)
*
|
1994-12-09 |
1998-11-24 |
Genzyme Corporation |
Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules
|
|
US5747471A
(en)
*
|
1994-12-09 |
1998-05-05 |
Genzyme Corporation |
Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules
|
|
US5650096A
(en)
*
|
1994-12-09 |
1997-07-22 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
|
US6071890A
(en)
*
|
1994-12-09 |
2000-06-06 |
Genzyme Corporation |
Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
|
|
US6331524B1
(en)
|
1994-12-09 |
2001-12-18 |
Genzyme Corporation |
Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy
|
|
US5767099A
(en)
*
|
1994-12-09 |
1998-06-16 |
Genzyme Corporation |
Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
|
|
US5910487A
(en)
*
|
1994-12-09 |
1999-06-08 |
Genzyme Corporation |
Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
|
|
US5948767A
(en)
*
|
1994-12-09 |
1999-09-07 |
Genzyme Corporation |
Cationic amphiphile/DNA complexes
|
|
US6383814B1
(en)
|
1994-12-09 |
2002-05-07 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
|
US6630455B1
(en)
|
1995-01-13 |
2003-10-07 |
Vanderbilt University |
Methods for inducing mucosal immune responses
|
|
FR2730637B1
(fr)
|
1995-02-17 |
1997-03-28 |
Rhone Poulenc Rorer Sa |
Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
|
|
US5830430A
(en)
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
|
EP0840744A4
(de)
|
1995-06-07 |
1999-03-10 |
Genta Inc |
Auf phosphonsäure basierende kationische lipide
|
|
US5976567A
(en)
*
|
1995-06-07 |
1999-11-02 |
Inex Pharmaceuticals Corp. |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US5705385A
(en)
*
|
1995-06-07 |
1998-01-06 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
WO1996040726A1
(en)
*
|
1995-06-07 |
1996-12-19 |
Genta Incorporated |
Novel carbamate-based cationic lipids
|
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US6051429A
(en)
|
1995-06-07 |
2000-04-18 |
Life Technologies, Inc. |
Peptide-enhanced cationic lipid transfections
|
|
US5981501A
(en)
*
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
|
US6020526A
(en)
*
|
1995-07-21 |
2000-02-01 |
Genta, Incorporated |
Amide-based cationic lipids
|
|
US6339173B1
(en)
|
1996-07-22 |
2002-01-15 |
Promega Biosciences, Inc. |
Amide-based cationic lipids
|
|
US5869715A
(en)
*
|
1995-09-27 |
1999-02-09 |
The Reagents Of The University Of California |
Polyfunctional cationic cytofectins
|
|
FR2739292B1
(fr)
*
|
1995-09-28 |
1997-10-31 |
Rhone Poulenc Rorer Sa |
Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations
|
|
FR2741066B1
(fr)
|
1995-11-14 |
1997-12-12 |
Rhone Poulenc Rorer Sa |
Nouveaux agents de transfection et leurs applications pharmaceutiques
|
|
JP3919227B2
(ja)
|
1996-05-02 |
2007-05-23 |
テルモ株式会社 |
アミジン誘導体及びそれを構成成分とする薬物担体
|
|
US5935936A
(en)
*
|
1996-06-03 |
1999-08-10 |
Genzyme Corporation |
Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules
|
|
US6093816A
(en)
*
|
1996-06-27 |
2000-07-25 |
Isis Pharmaceuticals, Inc. |
Cationic lipids
|
|
FR2754828B1
(fr)
*
|
1996-10-23 |
1998-12-24 |
Univ Toulouse |
Structure membranaire artificielle, procede et polymere pour sa preparation, procede de preparation de ce polymere, particule et film comprenant cette structure
|
|
ES2392246T3
(es)
*
|
1996-11-12 |
2012-12-07 |
The Regents Of The University Of California |
Preparación de formulaciones estables de complejos de lípido-ácido nucleico para el suministro eficaz in vivo
|
|
US5877220A
(en)
*
|
1997-03-06 |
1999-03-02 |
Genta, Incorporated |
Amide-based oligomeric cationic lipids
|
|
US6034135A
(en)
*
|
1997-03-06 |
2000-03-07 |
Promega Biosciences, Inc. |
Dimeric cationic lipids
|
|
US5925628A
(en)
*
|
1997-03-31 |
1999-07-20 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
|
US5912239A
(en)
*
|
1997-04-04 |
1999-06-15 |
Genzyme Corporation |
Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules
|
|
US5948925A
(en)
*
|
1997-05-06 |
1999-09-07 |
Genzyme Corporation |
Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids
|
|
US5952516A
(en)
*
|
1997-05-08 |
1999-09-14 |
Genzyme Corporation |
Cationic amphiphiles containing multiplesteroid lipophilic groups
|
|
US5942634A
(en)
*
|
1997-05-09 |
1999-08-24 |
Genzyme Corporation |
Cationic amphiphiles for cell transfections
|
|
US20030073640A1
(en)
*
|
1997-07-23 |
2003-04-17 |
Ribozyme Pharmaceuticals, Inc. |
Novel compositions for the delivery of negatively charged molecules
|
|
CA2299429C
(en)
*
|
1997-08-13 |
2010-04-20 |
Biontex Laboratories Gmbh |
New lipopolyamines,their preparation and the use thereof
|
|
US5998482A
(en)
*
|
1997-11-10 |
1999-12-07 |
David; Sunil A. |
Use of synthetic polycationic amphiphilic substances with fatty acid or hydrocarbon substituents as anti-sepsis agents
|
|
GB9726073D0
(en)
|
1997-12-09 |
1998-02-04 |
Smithkline Beecham Plc |
Novel compounds
|
|
US20010003580A1
(en)
|
1998-01-14 |
2001-06-14 |
Poh K. Hui |
Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
|
|
JP2002501762A
(ja)
|
1998-01-30 |
2002-01-22 |
アバンテイス・フアルマ・エス・アー |
還元性条件に感受性のトランスフェクション用組成物、該組成物を含有する医薬組成物及びそれらの用途
|
|
EP1068188A1
(de)
*
|
1998-04-02 |
2001-01-17 |
Aventis Pharma S.A. |
Nucleinsäure-transfer derivate,zusammensetzungen die sie enthalten und ihre verwendung
|
|
FR2777017B1
(fr)
*
|
1998-04-02 |
2002-08-23 |
Rhone Poulenc Rorer Sa |
Nouveaux agents de transfert d'acides nucleiques, compositions les contenant et leurs applications
|
|
AU5588199A
(en)
*
|
1998-08-27 |
2000-03-21 |
Alberto Haces |
Novel polycationic lipids
|
|
NZ512244A
(en)
|
1998-11-12 |
2003-12-19 |
Invitrogen Corp |
Polycationic transfection reagents for introducing anions into a cell
|
|
US6770740B1
(en)
|
1999-07-13 |
2004-08-03 |
The Regents Of The University Of Michigan |
Crosslinked DNA condensate compositions and gene delivery methods
|
|
US7429466B2
(en)
*
|
2000-01-24 |
2008-09-30 |
Hypromatrix, Inc |
Methods and arrays for detecting biological molecules
|
|
US8143195B2
(en)
*
|
2000-01-24 |
2012-03-27 |
Yingjian Wang |
Arrays for bringing two or more reagents in contact with one or more biological targets and methods for making and using the arrays
|
|
US20030212022A1
(en)
*
|
2001-03-23 |
2003-11-13 |
Jean-Marie Vogel |
Compositions and methods for gene therapy
|
|
DE01918975T1
(de)
|
2000-03-24 |
2006-04-13 |
Biosphere Medical, Inc., Rockland |
Mikrokügelchen zur aktiven Embolisierung
|
|
GB0031068D0
(en)
*
|
2000-12-19 |
2001-01-31 |
Smithkline Beecham Plc |
Novel compounds
|
|
US20030096414A1
(en)
*
|
2001-03-27 |
2003-05-22 |
Invitrogen Corporation |
Culture medium for cell growth and transfection
|
|
WO2002080981A2
(en)
|
2001-04-04 |
2002-10-17 |
Nordic Vaccine Technology A/S |
Polynucleotide binding complexes comprising sterols and saponins
|
|
DE10117043A1
(de)
*
|
2001-04-05 |
2002-11-07 |
Gerhard Puetz |
Verfahren zur Eliminierung von potentiell toxischen und/oder schädlichen Stoffen
|
|
WO2002087541A1
(en)
*
|
2001-04-30 |
2002-11-07 |
Protiva Biotherapeutics Inc. |
Lipid-based formulations for gene transfer
|
|
US20030134423A1
(en)
*
|
2002-01-04 |
2003-07-17 |
Chu Yong Liang |
Compounds for delivering substances into cells
|
|
WO2003097805A2
(en)
|
2002-05-15 |
2003-11-27 |
California Pacific Medical Center |
Delivery of nucleic acid-like compounds
|
|
EP1519714B1
(de)
|
2002-06-28 |
2010-10-20 |
Protiva Biotherapeutics Inc. |
Verfahren und vorrichtung zur herstellung von liposomen
|
|
CA2518475C
(en)
|
2003-03-07 |
2014-12-23 |
Alnylam Pharmaceuticals, Inc. |
Irna agents comprising asymmetrical modifications
|
|
WO2004090108A2
(en)
*
|
2003-04-03 |
2004-10-21 |
Alnylam Pharmaceuticals |
Irna conjugates
|
|
US20070179100A1
(en)
*
|
2003-04-09 |
2007-08-02 |
Muthiah Manoharan |
Protected monomers
|
|
ES2702942T3
(es)
|
2003-04-17 |
2019-03-06 |
Alnylam Pharmaceuticals Inc |
Agentes de ARNi modificados
|
|
US20070178066A1
(en)
*
|
2003-04-21 |
2007-08-02 |
Hall Frederick L |
Pathotropic targeted gene delivery system for cancer and other disorders
|
|
EP2353389B1
(de)
|
2003-04-21 |
2015-11-04 |
Epeius Biotechnologies Corporation |
Zusammensetzungen zur Behandlung von Erkrankungen
|
|
US7906122B2
(en)
|
2003-06-18 |
2011-03-15 |
Yissum Research Development Company Of The Hebrew University Of Jersusalem |
Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
|
|
EP1638919B1
(de)
*
|
2003-06-18 |
2012-09-26 |
Biolab Ltd. |
Sphingolipid polyalkylamine konjugate
|
|
CA2532228C
(en)
*
|
2003-07-16 |
2017-02-14 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
FR2858628B1
(fr)
*
|
2003-08-04 |
2008-01-04 |
Polyplus Transfection |
Nouveaux complexes d'acides nucleiques actifs pour l'arn interference et leur utilisation pour inhibiber l'expression de proteines
|
|
EP1664316B1
(de)
*
|
2003-09-15 |
2012-08-29 |
Protiva Biotherapeutics Inc. |
Polyethylenglycol-modifizierte lipidverbindungen und verwendungen davon
|
|
JP4764426B2
(ja)
|
2004-06-07 |
2011-09-07 |
プロチバ バイオセラピューティクス インコーポレイティッド |
カチオン性脂質および使用方法
|
|
CA2569664C
(en)
|
2004-06-07 |
2013-07-16 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
EP1773857A4
(de)
*
|
2004-07-02 |
2009-05-13 |
Protiva Biotherapeutics Inc |
Das immunsystem stimulierende sirna-moleküle und anwendungen davon
|
|
US20060051405A1
(en)
*
|
2004-07-19 |
2006-03-09 |
Protiva Biotherapeutics, Inc. |
Compositions for the delivery of therapeutic agents and uses thereof
|
|
CA2587411A1
(en)
*
|
2004-11-17 |
2006-05-26 |
Protiva Biotherapeutics, Inc. |
Sirna silencing of apolipoprotein b
|
|
KR20140090270A
(ko)
|
2005-05-09 |
2014-07-16 |
바이오스피어 메디칼 에스.에이. |
마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및 방법
|
|
US20060286082A1
(en)
*
|
2005-06-20 |
2006-12-21 |
Kurzweil Raymond C |
Systems and methods for generating biological material
|
|
US20070054873A1
(en)
*
|
2005-08-26 |
2007-03-08 |
Protiva Biotherapeutics, Inc. |
Glucocorticoid modulation of nucleic acid-mediated immune stimulation
|
|
CN101346393B
(zh)
*
|
2005-11-02 |
2015-07-22 |
普洛体维生物治疗公司 |
修饰的siRNA分子及其应用
|
|
WO2007070705A2
(en)
*
|
2005-12-15 |
2007-06-21 |
The Trustees Of The University Of Pennsylvania |
Cationic lipid-mediated vectors
|
|
NZ593080A
(en)
|
2006-05-05 |
2012-12-21 |
Molecular Transfer Inc |
Novel reagents for transfection of eukaryotic cells
|
|
US7915399B2
(en)
*
|
2006-06-09 |
2011-03-29 |
Protiva Biotherapeutics, Inc. |
Modified siRNA molecules and uses thereof
|
|
JP5072275B2
(ja)
|
2006-07-03 |
2012-11-14 |
テルモ株式会社 |
閉鎖小胞の分離方法、製剤の製造方法および評価方法
|
|
GB0613753D0
(en)
|
2006-07-11 |
2006-08-23 |
Norwegian Radium Hospital Res |
Method
|
|
JP5080779B2
(ja)
|
2006-10-25 |
2012-11-21 |
テルモ株式会社 |
リポソーム製剤の製造方法
|
|
AU2007337897A1
(en)
*
|
2006-12-22 |
2008-07-03 |
Imuthes Limited |
Lipids and their use as non-viral delivery vehicle
|
|
DE102007015377A1
(de)
|
2007-03-28 |
2008-10-02 |
Qiagen Gmbh |
Verfahren zur Herstellung einer transformierten Zelle
|
|
CN101918566A
(zh)
|
2007-11-22 |
2010-12-15 |
Biontex实验室有限公司 |
通过影响先天性免疫系统改进非病毒输送系统的转染结果
|
|
DE102008023913A1
(de)
|
2008-05-16 |
2009-11-19 |
Biontex Laboratories Gmbh |
Verbesserung von Transfektionsergebnissen nicht-viraler Genliefersysteme durch Beeinflussung des angeborenen Immunsystems
|
|
DE102007056488A1
(de)
|
2007-11-22 |
2009-07-23 |
Biontex Laboratories Gmbh |
Steigerung von Transfektionseffizienzen nicht-viraler Genliefersysteme durch Blockierung des angeborenen Immunsystems
|
|
DE102008016275A1
(de)
|
2008-03-28 |
2009-11-19 |
Biontex Laboratories Gmbh |
Verbesserung von Transfektionsergebnissen nicht-viraler Genliefersysteme durch Blockierung des angeborenen Immunsystems
|
|
WO2009073809A2
(en)
|
2007-12-04 |
2009-06-11 |
Alnylam Pharmaceuticals, Inc. |
Carbohydrate conjugates as delivery agents for oligonucleotides
|
|
CA2721183C
(en)
|
2008-04-11 |
2019-07-16 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
CA2721333C
(en)
|
2008-04-15 |
2020-12-01 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for nucleic acid delivery
|
|
EP2321414B1
(de)
*
|
2008-07-25 |
2018-01-10 |
Alnylam Pharmaceuticals, Inc. |
Verbesserung der sirna-silencing-aktivität unter verwendung universeller basen oder fehlpaarungen im sense-strang
|
|
WO2010026537A1
(en)
|
2008-09-05 |
2010-03-11 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Novel multimodular assembly useful for intracellular delivery
|
|
CA2740000C
(en)
|
2008-10-09 |
2017-12-12 |
Tekmira Pharmaceuticals Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
|
EP3269395A1
(de)
|
2008-11-07 |
2018-01-17 |
Massachusetts Institute Of Technology |
Aminoalkohol-lipoide und verwendungen davon
|
|
AU2010221419B2
(en)
|
2009-03-02 |
2015-10-01 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
|
US9018187B2
(en)
|
2009-07-01 |
2015-04-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
WO2011000107A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for delivery of therapeutic agents to solid tumors
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
EP3318248B1
(de)
|
2009-12-01 |
2019-04-10 |
Translate Bio, Inc. |
Ausgabe von mrna zur vermehrung von proteinen und enzymen bei humangenetischen erkrankungen
|
|
WO2011109427A2
(en)
|
2010-03-01 |
2011-09-09 |
Alnylam Pharmaceuticals, Inc. |
Improving the biological activity of sirna through modulation of its thermodynamic profile
|
|
US9102938B2
(en)
|
2010-04-01 |
2015-08-11 |
Alnylam Pharmaceuticals, Inc. |
2′ and 5′ modified monomers and oligonucleotides
|
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
|
WO2011133868A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
|
US9193827B2
(en)
|
2010-08-26 |
2015-11-24 |
Massachusetts Institute Of Technology |
Poly(beta-amino alcohols), their preparation, and uses thereof
|
|
EP2691443B1
(de)
|
2011-03-28 |
2021-02-17 |
Massachusetts Institute of Technology |
Konjugierte lipomers und ihre verwendung
|
|
RU2013154295A
(ru)
|
2011-06-08 |
2015-07-20 |
Шир Хьюман Дженетик Терапис, Инк. |
КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК
|
|
ES2795110T3
(es)
|
2011-06-08 |
2020-11-20 |
Translate Bio Inc |
Lípidos escindibles
|
|
EP2723758B1
(de)
|
2011-06-21 |
2018-06-20 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-3 (angptl3)-irna-zusammensetzungen und verwendungsverfahren dafür
|
|
CN103857440B
(zh)
|
2011-06-22 |
2018-09-25 |
维奥姆生物科学有限公司 |
基于缀合物的抗真菌和抗细菌前药
|
|
PE20181541A1
(es)
|
2011-10-27 |
2018-09-26 |
Massachusetts Inst Technology |
Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco
|
|
SI3366775T2
(sl)
|
2011-11-18 |
2025-12-31 |
Alnylam Pharmaceuticals, Inc. |
Modificirana sredstva RNAI
|
|
EP3730618A1
(de)
|
2011-11-18 |
2020-10-28 |
Alnylam Pharmaceuticals, Inc. |
Rnai-mittel, zusammensetzungen daraus und verfahren zur verwendung davon zur behandlung von mit transthyretin (ttr) assoziierten krankheiten
|
|
US11073451B2
(en)
|
2011-12-19 |
2021-07-27 |
Kode Biotech Limited |
Biocompatible method of functionalising substrates with inert surfaces
|
|
BR112014024131A2
(pt)
|
2012-03-29 |
2017-07-25 |
Shire Human Genetic Therapies |
lipídios catiônicos ionizáveis
|
|
AU2013237874B2
(en)
|
2012-03-29 |
2018-01-18 |
Translate Bio, Inc. |
Lipid-derived neutral nanoparticles
|
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
|
JP6473079B2
(ja)
|
2012-05-02 |
2019-02-20 |
ライフ テクノロジーズ コーポレーション |
高密度増殖およびトランスフェクション培地並びに発現増強物質の固有の組み合わせを用いる、哺乳類細胞における高収率一過性発現
|
|
EP2858679B2
(de)
|
2012-06-08 |
2024-06-05 |
Translate Bio, Inc. |
Pulmonale verabreichung von mrns an nicht pulmonale zielzellen
|
|
WO2013185067A1
(en)
|
2012-06-08 |
2013-12-12 |
Shire Human Genetic Therapies, Inc. |
Nuclease resistant polynucleotides and uses thereof
|
|
EP2861256B1
(de)
|
2012-06-15 |
2019-10-23 |
The Brigham and Women's Hospital, Inc. |
Zusammensetzungen zur behandlung von krebs und verfahren zur herstellung davon
|
|
AU2013296321B2
(en)
|
2012-08-03 |
2019-05-16 |
Alnylam Pharmaceuticals, Inc. |
Modified RNAi agents
|
|
WO2014028487A1
(en)
|
2012-08-13 |
2014-02-20 |
Massachusetts Institute Of Technology |
Amine-containing lipidoids and uses thereof
|
|
EP2912045A4
(de)
*
|
2012-10-29 |
2016-07-13 |
Molecular Transfer Inc |
Polykationische methylphospholipide zur verbesserten freisetzung von nukleinsäuren in eukaryotischen zellen
|
|
IL292159B1
(en)
|
2012-12-05 |
2026-04-01 |
Alnylam Pharmaceuticals Inc |
PCSK9 iRNA compositions and methods of using them
|
|
EP4331620A3
(de)
|
2012-12-07 |
2024-12-04 |
Translate Bio, Inc. |
Lipidnanopartikel zur mrna-abgabe
|
|
BR112015022855A2
(pt)
|
2013-03-14 |
2017-11-07 |
Shire Human Genetic Therapies |
composições e método para produção de um anticorpo in vitro
|
|
EP2970940B1
(de)
|
2013-03-14 |
2018-07-25 |
Translate Bio, Inc. |
Therapeutische mrna-zusammensetzungen und verwendung zur behandlung von krankheiten und störungen
|
|
RS57739B1
(sr)
|
2013-03-14 |
2018-12-31 |
Translate Bio Inc |
Kompozicije cftr irnk i postupci i upotrebe u vezi sa njima
|
|
IL288931B2
(en)
|
2013-03-14 |
2025-05-01 |
Alnylam Pharmaceuticals Inc |
Compositions comprising a complementary portion of C5 IRNA and methods of using them
|
|
JP6586075B2
(ja)
|
2013-03-14 |
2019-10-02 |
トランスレイト バイオ, インコーポレイテッド |
メッセンジャーrnaの精製方法
|
|
AU2014236208B2
(en)
|
2013-03-14 |
2018-07-19 |
Genvivo, Inc. |
Thymidine kinase diagnostic assay for gene therapy applications
|
|
EP3388834B1
(de)
|
2013-03-15 |
2020-04-15 |
Translate Bio, Inc. |
Synergistische verbesserung der abgabe von nukleinsäuren durch gemischte formulierungen
|
|
WO2014179562A1
(en)
|
2013-05-01 |
2014-11-06 |
Massachusetts Institute Of Technology |
1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
|
|
KR102234623B1
(ko)
|
2013-05-22 |
2021-04-02 |
알닐람 파마슈티칼스 인코포레이티드 |
Tmprss6 조성물 및 이의 사용 방법
|
|
EA038792B1
(ru)
|
2013-05-22 |
2021-10-20 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ НА ОСНОВЕ RNAi Serpina1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
|
AU2014278011B2
(en)
|
2013-06-14 |
2020-03-19 |
Alyssum Therapeutics, Inc. |
Lipid-based platinum compounds and nanoparticles
|
|
WO2015042564A1
(en)
|
2013-09-23 |
2015-03-26 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing transthyretin (ttr) associated diseases
|
|
CN106413811A
(zh)
|
2013-10-22 |
2017-02-15 |
夏尔人类遗传性治疗公司 |
精氨基琥珀酸合成酶缺乏症的mrna疗法
|
|
AU2014340149B2
(en)
|
2013-10-22 |
2020-12-24 |
Shire Human Genetic Therapies, Inc. |
CNS delivery of mRNA and uses thereof
|
|
ES3032935T3
(en)
|
2013-10-22 |
2025-07-29 |
Translate Bio Inc |
Lipid formulations for delivery of messenger rna
|
|
JP6506749B2
(ja)
|
2013-10-22 |
2019-04-24 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
フェニルケトン尿症のためのmRNA療法
|
|
SG10201804960RA
(en)
|
2013-12-12 |
2018-07-30 |
Alnylam Pharmaceuticals Inc |
Complement component irna compositions and methods of use thereof
|
|
BR112016013516A8
(pt)
|
2013-12-12 |
2020-05-19 |
Life Technologies Corp |
complexo de transfecção e seu uso para aumentar transporte de molécula de carga em células e para o tratamento de câncer e terapia gênica, bem como método in vitro para fornecer um poliânion a uma célula
|
|
US10119136B2
(en)
|
2014-01-09 |
2018-11-06 |
Alnylam Pharmaceuticals, Inc. |
RNAi agents modified at the 4′-C position
|
|
EA201691534A1
(ru)
|
2014-01-29 |
2016-12-30 |
Вайоми Байосайенсиз Пвт. Лтд. |
Лечение устойчивых угрей
|
|
CN113057959B
(zh)
|
2014-02-11 |
2024-07-16 |
阿尔尼拉姆医药品有限公司 |
己酮糖激酶(KHK)iRNA组合物及其使用方法
|
|
US20170143848A1
(en)
|
2014-03-24 |
2017-05-25 |
Shire Human Genetic Therapies, Inc. |
Mrna therapy for the treatment of ocular diseases
|
|
BR112016022499A2
(pt)
|
2014-04-03 |
2017-08-15 |
Invictus Oncology Pvt Ltd |
Produtos terapêuticos combinatórios supramoleculares
|
|
US9850269B2
(en)
|
2014-04-25 |
2017-12-26 |
Translate Bio, Inc. |
Methods for purification of messenger RNA
|
|
AU2015264038B2
(en)
|
2014-05-22 |
2021-02-11 |
Alnylam Pharmaceuticals, Inc. |
Angiotensinogen (AGT) iRNA compositions and methods of use thereof
|
|
JP6557722B2
(ja)
|
2014-05-30 |
2019-08-07 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
核酸の送達のための生分解性脂質
|
|
KR102559979B1
(ko)
|
2014-06-24 |
2023-07-25 |
샤이어 휴먼 지네틱 테라피즈 인크. |
핵산의 전달용 입체화학적으로 풍부한 조성물
|
|
BR112016030852A2
(pt)
|
2014-07-02 |
2018-01-16 |
Shire Human Genetic Therapies |
encapsulação de rna mensageiro
|
|
US9840479B2
(en)
|
2014-07-02 |
2017-12-12 |
Massachusetts Institute Of Technology |
Polyamine-fatty acid derived lipidoids and uses thereof
|
|
EP3169310A1
(de)
|
2014-07-15 |
2017-05-24 |
Life Technologies Corporation |
Zusammensetzungen mit lipidaggregaten und verfahren zur effizienten bereitstellung von molekülen an zellen
|
|
GB201414464D0
(en)
|
2014-08-14 |
2014-10-01 |
Technion Res & Dev Foundation |
Compositions and methods for therapeutics prescreening
|
|
IL316808A
(en)
|
2014-08-20 |
2025-01-01 |
Alnylam Pharmaceuticals Inc |
Modified double-stranded RNA materials and their uses
|
|
WO2016040589A1
(en)
|
2014-09-12 |
2016-03-17 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
|
WO2016057693A1
(en)
|
2014-10-10 |
2016-04-14 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhalation delivery of conjugated oligonucleotide
|
|
TW202503057A
(zh)
|
2014-10-10 |
2025-01-16 |
美商艾爾妮蘭製藥公司 |
用於抑制hao1(羥酸氧化酶1(乙醇酸鹽氧化酶))基因表現的組合物及方法
|
|
WO2016061487A1
(en)
|
2014-10-17 |
2016-04-21 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
|
EP3212794B1
(de)
|
2014-10-30 |
2021-04-07 |
Genzyme Corporation |
Polynukleotidwirkstoffe mit abzielung auf serpinc1 (at3) und verfahren zur verwendung davon
|
|
KR102545316B1
(ko)
|
2014-11-10 |
2023-06-22 |
알닐람 파마슈티칼스 인코포레이티드 |
B형 간염 바이러스(hbv) irna 조성물 및 그의 이용 방법
|
|
JP2017535552A
(ja)
|
2014-11-17 |
2017-11-30 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
アポリポタンパク質C3(APOC3)iRNA組成物およびその使用方法
|
|
JP6767976B2
(ja)
|
2014-12-05 |
2020-10-14 |
トランスレイト バイオ, インコーポレイテッド |
関節疾患の治療のためのメッセンジャーrna治療法
|
|
JP2018504380A
(ja)
|
2014-12-18 |
2018-02-15 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
Reversir(商標)化合物
|
|
CA2976445A1
(en)
|
2015-02-13 |
2016-08-18 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
|
WO2016149508A1
(en)
|
2015-03-19 |
2016-09-22 |
Shire Human Genetic Therapies, Inc. |
Mrna therapy for pompe disease
|
|
US10745702B2
(en)
|
2015-04-08 |
2020-08-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the LECT2 gene
|
|
JP6695902B2
(ja)
|
2015-05-06 |
2020-05-20 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
第XII因子(ハーゲマン因子)(F12)、カリクレインB、血漿(フレッチャー因子)1(KLKB1)、及びキニノーゲン1(KNG1)iRNA組成物及びその使用方法
|
|
MX378821B
(es)
|
2015-05-19 |
2025-03-10 |
Akamara Therapeutics Inc |
Proceso para preparar compuestos basados en platino supramoleculares.
|
|
EP3303286B1
(de)
|
2015-06-01 |
2023-10-04 |
Cedars-Sinai Medical Center |
An rela von nf-kb anbindende verbindungen zur verwendung bei der behandlung von krebs
|
|
WO2016201301A1
(en)
|
2015-06-12 |
2016-12-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
|
EP3310918B1
(de)
|
2015-06-18 |
2020-08-05 |
Alnylam Pharmaceuticals, Inc. |
Gegen hydroxysäureoxidase (glycolat-oxidase, hao1) gerichtete polynukleotidwirkstoffe und verfahren zur verwendung davon
|
|
WO2016205691A1
(en)
|
2015-06-19 |
2016-12-22 |
Massachusetts Institute Of Technology |
Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
|
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
|
KR102669726B1
(ko)
|
2015-07-13 |
2024-05-29 |
라이프 테크놀로지스 코포레이션 |
Cho 세포에서의 개선된 일시적 단백질 발현을 위한 시스템 및 방법
|
|
CA2996873A1
(en)
|
2015-09-02 |
2017-03-09 |
Alnylam Pharmaceuticals, Inc. |
Programmed cell death 1 ligand 1 (pd-l1) irna compositions and methods of use thereof
|
|
WO2017048620A1
(en)
|
2015-09-14 |
2017-03-23 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
|
|
EP3362458A1
(de)
|
2015-10-16 |
2018-08-22 |
Invictus Oncology Pvt. Ltd. |
Fluoreszierende antikrebs-platinwirkstoffe
|
|
EP3387129A1
(de)
|
2015-12-10 |
2018-10-17 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen aus sterolregulatorischem element-bindendem protein (srep) chaperone (scap) irna und verfahren zur verwendung davon
|
|
EP3825400B1
(de)
|
2016-04-08 |
2024-12-25 |
Translate Bio, Inc. |
Multimere codierende nukleinsäure und verwendungen davon
|
|
EP3469083A1
(de)
|
2016-06-10 |
2019-04-17 |
Alnylam Pharmaceuticals, Inc. |
Gegen komplementkomponente c5 gerichtete irna-zusammensetzungen und verfahren zur verwendung davon zur behandlung von paroxysmaler nächtlicher hämoglobinurie (pnh)
|
|
EP3469074B1
(de)
|
2016-06-13 |
2020-12-09 |
Translate Bio, Inc. |
Messenger-rna-therapie zur behandlung von ornithintranscarbamylasemangel
|
|
IL246378A0
(en)
|
2016-06-21 |
2016-11-30 |
Technion Res & Dev Foundation |
A hybrid matrix of polymers that adhere to the mucosa and a lipidic drug release system for the treatment of oral cancer
|
|
CN118108847A
(zh)
|
2016-08-07 |
2024-05-31 |
诺华股份有限公司 |
mRNA介导的免疫方法
|
|
MA46761A
(fr)
|
2016-11-10 |
2019-09-18 |
Translate Bio Inc |
Administration sous-cutanée d'arn messager
|
|
AU2017357758B2
(en)
|
2016-11-10 |
2023-11-16 |
Translate Bio, Inc. |
Improved process of preparing mRNA-loaded lipid nanoparticles
|
|
TWI788312B
(zh)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
|
WO2018112320A1
(en)
|
2016-12-16 |
2018-06-21 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
|
|
DK3565891T3
(da)
|
2017-01-09 |
2023-07-24 |
Whitehead Inst Biomedical Res |
Fremgangsmåder til ændring af genekspression ved forstyrrelse af transkriptionsfaktor-multimere, der strukturerer regulatoriske sløjfer
|
|
EA201991747A1
(ru)
|
2017-02-27 |
2020-06-04 |
Транслейт Био, Инк. |
НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR
|
|
MA47824A
(fr)
|
2017-03-07 |
2020-01-15 |
Translate Bio Inc |
Administration polyanionique d'acides nucléiques
|
|
CA3059446A1
(en)
|
2017-04-18 |
2018-10-25 |
Alnylam Pharmaceuticals, Inc. |
Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
|
|
EP4295895A3
(de)
|
2017-05-11 |
2024-03-27 |
Tc1 Llc |
Thermische verbindung für implantierbare blutpumpe
|
|
MX2019013752A
(es)
|
2017-05-16 |
2020-07-20 |
Translate Bio Inc |
Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones.
|
|
EP3641834B1
(de)
|
2017-06-19 |
2023-10-04 |
Translate Bio, Inc. |
Messenger-rna-therapie zur behandlung von friedreich-ataxie
|
|
SG11202002940QA
(en)
|
2017-11-01 |
2020-04-29 |
Alnylam Pharmaceuticals Inc |
Complement component c3 irna compositions and methods of use thereof
|
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
|
US11167043B2
(en)
|
2017-12-20 |
2021-11-09 |
Translate Bio, Inc. |
Composition and methods for treatment of ornithine transcarbamylase deficiency
|
|
EP3728281A1
(de)
|
2017-12-21 |
2020-10-28 |
Alnylam Pharmaceuticals Inc. |
Chiral angereicherte doppelsträngige rna-wirkstoffe
|
|
EP3746496A1
(de)
|
2018-02-02 |
2020-12-09 |
Translate Bio, Inc. |
Kationische polymere
|
|
AU2019271132B2
(en)
|
2018-05-15 |
2026-02-05 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger RNA
|
|
US11964051B2
(en)
|
2018-05-16 |
2024-04-23 |
Translate Bio, Inc. |
Ribose cationic lipids
|
|
JP7488193B2
(ja)
|
2018-05-24 |
2024-05-21 |
トランスレイト バイオ, インコーポレイテッド |
チオエステルカチオン性脂質
|
|
CA3101484A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Phosphoester cationic lipids
|
|
US12240824B2
(en)
|
2018-05-30 |
2025-03-04 |
Translate Bio, Inc. |
Vitamin cationic lipids
|
|
CA3101454A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Messenger rna vaccines and uses thereof
|
|
WO2019232208A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Cationic lipids comprising a steroidal moiety
|
|
JP7422977B2
(ja)
|
2018-07-23 |
2024-01-29 |
トランスレイト バイオ, インコーポレイテッド |
メッセンジャーrna用乾燥粉末製剤
|
|
KR102950141B1
(ko)
|
2018-08-24 |
2026-04-07 |
트랜슬레이트 바이오 인코포레이티드 |
전령 rna의 정제 방법
|
|
KR20210091120A
(ko)
|
2018-08-29 |
2021-07-21 |
트랜슬레이트 바이오 인코포레이티드 |
Mrna-로딩된 지질 나노입자를 제조하는 개선된 공정
|
|
EP3849617A1
(de)
|
2018-09-14 |
2021-07-21 |
Translate Bio, Inc. |
Zusammensetzung und verfahren zur behandlung von methylmalonazidämie
|
|
US20210332367A1
(en)
|
2018-09-18 |
2021-10-28 |
Alnylam Pharmaceuticals, Inc. |
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
CA3112837A1
(en)
|
2018-10-19 |
2020-04-23 |
Translate Bio, Inc. |
Pumpless encapsulation of messenger rna
|
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
|
AU2019376660B2
(en)
|
2018-11-09 |
2025-06-26 |
Translate Bio, Inc. |
2,5-dioxopiperazine lipids with intercalated ester, thioester, disulfide and anhydride moieities
|
|
EP3876914A2
(de)
|
2018-11-09 |
2021-09-15 |
Translate Bio, Inc. |
Messenger-rna-therapie zur behandlung von augenerkrankungen
|
|
AU2019374871B2
(en)
|
2018-11-09 |
2025-09-11 |
Translate Bio, Inc. |
PEG lipidoid compounds
|
|
AU2019377525B2
(en)
|
2018-11-09 |
2025-10-16 |
Translate Bio, Inc. |
Multi-PEG lipid compounds
|
|
CA3119449A1
(en)
|
2018-11-12 |
2020-05-22 |
Translate Bio, Inc. |
Methods for inducing immune tolerance
|
|
WO2020106946A1
(en)
|
2018-11-21 |
2020-05-28 |
Translate Bio, Inc. |
TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR
|
|
CA3119976A1
(en)
|
2018-11-21 |
2020-05-28 |
Translate Bio, Inc. |
Cationic lipid compounds
|
|
WO2020117706A1
(en)
|
2018-12-03 |
2020-06-11 |
Triplet Therapeutics, Inc. |
Methods for the treatment of trinucleotide repeat expansion disorders associated with mlh3 activity
|
|
WO2020117840A2
(en)
|
2018-12-05 |
2020-06-11 |
Empirico Inc. |
Process to inhibit or eliminate eosinophilic diseases of the airway and related conditions
|
|
AU2019406186A1
(en)
|
2018-12-20 |
2021-07-15 |
Praxis Precision Medicines, Inc. |
Compositions and methods for the treatment of KCNT1 related disorders
|
|
JP2022516356A
(ja)
|
2019-01-07 |
2022-02-25 |
トランスレイト バイオ, インコーポレイテッド |
原発性線毛機能不全症の治療のための組成物および方法
|
|
WO2020150265A1
(en)
|
2019-01-15 |
2020-07-23 |
Empirico Inc. |
Prodrugs of alox-15 inhibitors and methods of using the same
|
|
US20220168261A1
(en)
|
2019-02-14 |
2022-06-02 |
Akamara Therapeutics, Inc. |
Compounds and methods for managing cancer through immune system
|
|
US20220177423A1
(en)
|
2019-04-18 |
2022-06-09 |
Translate Bio, Inc. |
Cystine cationic lipids
|
|
US20220233444A1
(en)
|
2019-04-22 |
2022-07-28 |
Translate Bio, Inc. |
Thioester cationic lipids
|
|
WO2020227085A1
(en)
|
2019-05-03 |
2020-11-12 |
Translate Bio, Inc. |
Di-thioester cationic lipids
|
|
CA3140423A1
(en)
|
2019-05-14 |
2020-11-19 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
AU2020279101B2
(en)
|
2019-05-17 |
2025-07-24 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
|
BR112021023411A2
(pt)
|
2019-05-22 |
2022-02-01 |
Massachusetts Inst Technology |
Composições e métodos de rna circular
|
|
WO2020243540A1
(en)
|
2019-05-31 |
2020-12-03 |
Translate Bio, Inc. |
Macrocyclic lipids
|
|
CA3144457A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Tricine and citric acid lipids
|
|
WO2020257611A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Cationic lipids comprising an hydroxy moiety
|
|
US20230181483A1
(en)
|
2019-07-08 |
2023-06-15 |
Translate Bio, Inc. |
Improved mrna-loaded lipid nanoparticles and processes of making the same
|
|
CA3146675A1
(en)
|
2019-07-23 |
2021-01-28 |
Translate Bio, Inc. |
Stable compositions of mrna-loaded lipid nanoparticles and processes of making
|
|
AU2020322014B2
(en)
|
2019-07-30 |
2026-04-02 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR
|
|
EP4013870A1
(de)
|
2019-08-13 |
2022-06-22 |
Alnylam Pharmaceuticals, Inc. |
Irna-wirkstoffzusammensetzungen der kleinen ribosomalen proteinuntereinheit 25 (rps25) und verfahren zu ihrer verwendung
|
|
EP4031662A1
(de)
|
2019-09-20 |
2022-07-27 |
Translate Bio, Inc. |
Mrna-codierendes technisches cftr
|
|
WO2021072172A1
(en)
|
2019-10-09 |
2021-04-15 |
Translate Bio, Inc. |
Compositions, methods and uses of messenger rna
|
|
CN115279418A
(zh)
|
2019-10-21 |
2022-11-01 |
川斯勒佰尔公司 |
信使rna的组合物、方法和用途
|
|
EP4051795A1
(de)
|
2019-11-01 |
2022-09-07 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt)-irna-wirkstoffzusammensetzungen und verfahren zu deren verwendung
|
|
US12565653B2
(en)
|
2019-11-22 |
2026-03-03 |
Alnylam Pharmaceuticals, Inc. |
ATAXIN3 (ATXN3) RNAi agent compositions and methods of use thereof
|
|
CN121422256A
(zh)
|
2019-12-04 |
2026-01-30 |
奥纳治疗公司 |
环状rna组合物和方法
|
|
KR20220115995A
(ko)
|
2019-12-13 |
2022-08-19 |
알닐람 파마슈티칼스 인코포레이티드 |
인간 염색체 9 개방 판독 프레임 72 (C9orf72) iRNA 제제 조성물 및 이의 사용 방법
|
|
CN115515559B
(zh)
|
2019-12-20 |
2026-03-24 |
翻译生物公司 |
信使rna的直肠递送
|
|
JP2023508881A
(ja)
|
2019-12-20 |
2023-03-06 |
トランスレイト バイオ, インコーポレイテッド |
Mrna担持脂質ナノ粒子を調製する改善されたプロセス
|
|
WO2021142245A1
(en)
|
2020-01-10 |
2021-07-15 |
Translate Bio, Inc. |
Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues
|
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
|
CN115427021A
(zh)
|
2020-02-25 |
2022-12-02 |
翻译生物公司 |
制备负载mrna的脂质纳米颗粒的改进方法
|
|
EP4114947A1
(de)
|
2020-03-05 |
2023-01-11 |
Alnylam Pharmaceuticals, Inc. |
Komplementkomponenten-c3-irna-zusammensetzungen und verfahren zur verwendung davon zur behandlung oder prävention von mit komplementkomponenten-c3-assoziierten erkrankungen
|
|
TW202204615A
(zh)
|
2020-03-26 |
2022-02-01 |
美商阿尼拉製藥公司 |
冠狀病毒iRNA組成物及其使用方法
|
|
US12534731B2
(en)
|
2020-04-01 |
2026-01-27 |
Alnylam Pharmaceuticals, Inc. |
Alpha-2A adrenergic receptor (ADRA2A) iRNA agent compositions and methods of use thereof
|
|
EP4133076A1
(de)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen aus angiotensin-konvertierendem enzym 2 (ace2) und verfahren zur verwendung davon
|
|
EP4133077A1
(de)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen mit transmembran-serinprotease 2 (tmprss2) und verfahren zur verwendung davon
|
|
IL297702A
(en)
|
2020-04-27 |
2022-12-01 |
Alnylam Pharmaceuticals Inc |
Apolipoprotein e (apoe) irna agent compositions and methods of use thereof
|
|
WO2021226468A1
(en)
|
2020-05-07 |
2021-11-11 |
Translate Bio, Inc. |
Improved compositions for cftr mrna therapy
|
|
EP4146265A1
(de)
|
2020-05-07 |
2023-03-15 |
Translate Bio, Inc. |
Für sars-cov-2-antigene codierende optimierte nukleotidsequenzen
|
|
EP4146680A1
(de)
|
2020-05-07 |
2023-03-15 |
Translate Bio, Inc. |
Zusammensetzung und verfahren zur behandlung von primärer ziliardyskinesie
|
|
US12514932B2
(en)
|
2020-05-14 |
2026-01-06 |
Translate Bio, Inc. |
PEG lipidoid compounds
|
|
WO2021231680A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
|
JP2023526284A
(ja)
|
2020-05-15 |
2023-06-21 |
トランスレイト バイオ, インコーポレイテッド |
mRNA送達のための脂質ナノ粒子製剤
|
|
WO2021231673A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
|
|
WO2021231685A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
|
WO2021231698A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
|
EP4150090A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von otoflin (otof)
|
|
WO2021231675A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
|
EP4150087A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung des gap-junction-proteins beta 2 (gjb2)
|
|
WO2021231691A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
|
|
WO2021236855A1
(en)
|
2020-05-19 |
2021-11-25 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
AR122534A1
(es)
|
2020-06-03 |
2022-09-21 |
Triplet Therapeutics Inc |
Métodos para el tratamiento de los trastornos de expansión por repetición de nucleótidos asociados con la actividad de msh3
|
|
EP4162050A1
(de)
|
2020-06-09 |
2023-04-12 |
Alnylam Pharmaceuticals, Inc. |
Rnai-zusammensetzungen und verfahren zur verwendung davon zur verabreichung durch inhalation
|
|
WO2021252649A2
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Sirna compositions and methods for silencing gpam (glycerol-3-phosphate acyltransferase 1, mitochondrial) expression
|
|
US20240307556A1
(en)
|
2020-07-02 |
2024-09-19 |
Maritime Therapeutics, Inc. |
Compositions and methods for reverse gene therapy
|
|
KR20230050336A
(ko)
|
2020-07-10 |
2023-04-14 |
인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸) |
뇌전증을 치료하기 위한 방법과 조성물
|
|
WO2022066847A1
(en)
|
2020-09-24 |
2022-03-31 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
|
EP4225917A1
(de)
|
2020-10-05 |
2023-08-16 |
Alnylam Pharmaceuticals, Inc. |
G-protein-gekoppelter rezeptor-75 (gpr75)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
US20220133631A1
(en)
|
2020-10-12 |
2022-05-05 |
Translate Bio, Inc. |
Process of preparing ice-based lipid nanoparticles
|
|
KR20230087536A
(ko)
|
2020-10-12 |
2023-06-16 |
트랜슬레이트 바이오 인코포레이티드 |
Mrna-로딩된 지질 나노입자를 제조하는 개선된 프로세스
|
|
CA3198823A1
(en)
|
2020-10-21 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
|
EP4232582A1
(de)
|
2020-10-23 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Mucin-5b (muc5b)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
AU2021373892A1
(en)
|
2020-11-09 |
2023-07-06 |
Translate Bio, Inc. |
Improved compositions for delivery of codon-optimized mrna
|
|
WO2022115645A1
(en)
|
2020-11-25 |
2022-06-02 |
Akagera Medicines, Inc. |
Lipid nanoparticles for delivery of nucleic acids, and related methods of use
|
|
CN116723829A
(zh)
|
2020-11-25 |
2023-09-08 |
翻译生物公司 |
稳定的液体脂质纳米颗粒配制品
|
|
TW202237150A
(zh)
|
2020-12-01 |
2022-10-01 |
美商艾拉倫製藥股份有限公司 |
用於抑制hao1(羥基酸氧化酶1(乙醇酸氧化酶))基因表現的方法及組成物
|
|
WO2022155404A1
(en)
|
2021-01-14 |
2022-07-21 |
Translate Bio, Inc. |
Methods and compositions for delivering mrna coded antibodies
|
|
EP4291654A2
(de)
|
2021-02-12 |
2023-12-20 |
Alnylam Pharmaceuticals, Inc. |
Superoxid-dismutase-1 (sod1)-irna-zusammensetzungen und verfahren zur verwendung davon zur behandlung oder vorbeugung von mit superoxid-dismutase 1 (sod1-) assoziierten neurodegenerativen erkrankungen
|
|
EP4298220A1
(de)
|
2021-02-25 |
2024-01-03 |
Alnylam Pharmaceuticals, Inc. |
Prionprotein (prnp)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
WO2022192519A1
(en)
|
2021-03-12 |
2022-09-15 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
|
EP4313115A1
(de)
|
2021-03-25 |
2024-02-07 |
Translate Bio, Inc. |
Optimierte nukleotidsequenzen, die die extrazelluläre domäne des humanen ace2-proteins oder eines teils davon kodieren
|
|
EP4314296A2
(de)
|
2021-03-29 |
2024-02-07 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt)-irna-wirkstoffzusammensetzungen und verfahren zur verwendung davon
|
|
JP2024515668A
(ja)
|
2021-04-19 |
2024-04-10 |
トランスレイト バイオ, インコーポレイテッド |
Mrnaの送達のための改善された組成物
|
|
WO2022232343A1
(en)
|
2021-04-29 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
|
EP4341401A1
(de)
|
2021-05-18 |
2024-03-27 |
Alnylam Pharmaceuticals, Inc. |
Natriumglucose-cotransporter-2-(sglt2)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
EP4341405A1
(de)
|
2021-05-20 |
2024-03-27 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen für adar-vermittelte bearbeitung
|
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
|
EP4347822A2
(de)
|
2021-06-04 |
2024-04-10 |
Alnylam Pharmaceuticals, Inc. |
Irna-wirkstoffzusammensetzungen mit offenem leserahmen 72 (c9orf72) auf menschlichem chromosom 9 und verfahren zur verwendung davon
|
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
|
EP4363574A1
(de)
|
2021-06-29 |
2024-05-08 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen für adar-vermittelte bearbeitung
|
|
JP2024527541A
(ja)
|
2021-07-01 |
2024-07-25 |
トランスレイト バイオ, インコーポレイテッド |
Mrnaの送達のための組成物
|
|
AU2022316139A1
(en)
|
2021-07-23 |
2024-01-18 |
Alnylam Pharmaceuticals, Inc. |
Beta-catenin (ctnnb1) irna compositions and methods of use thereof
|
|
TW202328449A
(zh)
|
2021-09-24 |
2023-07-16 |
美商艾拉倫製藥公司 |
微管相關蛋白TAU(MAPT)iRNA試劑組合物及其使用方法
|
|
WO2023069603A1
(en)
|
2021-10-22 |
2023-04-27 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
|
EP4423272A2
(de)
|
2021-10-29 |
2024-09-04 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt)-irna-wirkstoffzusammensetzungen und verfahren zur verwendung davon
|
|
TW202334080A
(zh)
|
2021-11-08 |
2023-09-01 |
美商歐納醫療公司 |
用於遞送環狀聚核苷酸之脂質奈米粒子組合物
|
|
WO2023086893A1
(en)
|
2021-11-10 |
2023-05-19 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
KR20240126870A
(ko)
|
2021-12-22 |
2024-08-21 |
캠프4 테라퓨틱스 코포레이션 |
조절 rna들을 표적으로 하는 안티센스 올리고뉴클레오티드를 사용한 유전자 전사의 조절
|
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
|
EP4519685A1
(de)
|
2022-05-01 |
2025-03-12 |
Yeda Research and Development Co. Ltd |
Neuexpression von hnf4a zur linderung von krebsassoziierter kachexie
|
|
CA3256897A1
(en)
|
2022-05-25 |
2023-11-30 |
Akagera Medicines, Inc. |
Lipid nanoparticles for the administration of nucleic acids and their methods of use
|
|
IL317425A
(en)
|
2022-06-10 |
2025-02-01 |
Camp4 Therapeutics Corp |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory RNAs
|
|
US12297285B2
(en)
|
2022-06-24 |
2025-05-13 |
Orna Therapeutics, Inc. |
Circular RNA encoding chimeric antigen receptors targeting BCMA
|
|
EP4569113A1
(de)
|
2022-09-15 |
2025-06-18 |
Regeneron Pharmaceuticals, Inc. |
17b-hydroxysteroiddehydrogenase-typ-13 (hsd17b13)-irna-zusammensetzungen und verfahren zu ihrer verwendung
|
|
WO2024102677A1
(en)
|
2022-11-08 |
2024-05-16 |
Orna Therapeutics, Inc. |
Circular rna compositions
|
|
WO2024102762A1
(en)
|
2022-11-08 |
2024-05-16 |
Orna Therapeutics, Inc. |
Lipids and lipid nanoparticle compositions for delivering polynucleotides
|
|
WO2024102730A1
(en)
|
2022-11-08 |
2024-05-16 |
Orna Therapeutics, Inc. |
Lipids and nanoparticle compositions for delivering polynucleotides
|
|
EP4622630A1
(de)
|
2022-11-21 |
2025-10-01 |
Translate Bio, Inc. |
Zusammensetzungen aus trockenpulverformulierungen von messenger-rna und verfahren zur verwendung davon
|
|
EP4627084A1
(de)
|
2022-12-01 |
2025-10-08 |
Camp4 Therapeutics Corporation |
Modulation der syngap1-gentranskription unter verwendung von gegen regulatorische rnas gerichteten antisense-oligonukleotiden
|
|
AU2023398825A1
(en)
|
2022-12-15 |
2025-06-26 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
WO2024126809A1
(en)
|
2022-12-15 |
2024-06-20 |
Sanofi |
Mrna encoding influenza virus-like particle
|
|
EP4637813A1
(de)
|
2022-12-20 |
2025-10-29 |
Sanofi Pasteur |
Rhinovirus-mrna-impfstoff
|
|
TW202449152A
(zh)
|
2023-02-09 |
2024-12-16 |
美商艾拉倫製藥股份有限公司 |
Reversir分子及其使用方法
|
|
WO2024205657A2
(en)
|
2023-03-29 |
2024-10-03 |
Orna Therapeutics, Inc. |
Lipids and lipid nanoparticle compositions for delivering polynucleotides
|
|
WO2024218166A1
(en)
|
2023-04-17 |
2024-10-24 |
Sanofi |
Reconstitutable dry powder formulations and methods of use thereof
|
|
EP4705481A2
(de)
|
2023-05-05 |
2026-03-11 |
Orna Therapeutics, Inc. |
Zirkuläre rna-zusammensetzungen und verfahren
|
|
WO2025015338A1
(en)
|
2023-07-13 |
2025-01-16 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
WO2025015335A1
(en)
|
2023-07-13 |
2025-01-16 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
KR20260049597A
(ko)
|
2023-08-04 |
2026-04-14 |
알닐람 파마슈티칼스 인코포레이티드 |
Ctnnb1-관련 질환을 치료하기 위한 방법 및 조성물
|
|
WO2025059215A1
(en)
|
2023-09-12 |
2025-03-20 |
Aadigen, Llc |
Methods and compositions for treating or preventing cancer
|
|
WO2025096809A1
(en)
|
2023-10-31 |
2025-05-08 |
Korro Bio, Inc. |
Oligonucleotides comprising phosphoramidate internucleotide linkages
|
|
WO2025101501A1
(en)
|
2023-11-07 |
2025-05-15 |
Orna Therapeutics, Inc. |
Circular rna compositions
|
|
WO2025128799A1
(en)
|
2023-12-12 |
2025-06-19 |
Korro Bio, Inc. |
Double-stranded rna-editing oligonucleotides and uses thereof
|
|
WO2025193628A2
(en)
|
2024-03-09 |
2025-09-18 |
Aadigen, Llc |
Compositions for treating cancer with kras mutations and uses thereof
|
|
WO2025196065A1
(en)
|
2024-03-20 |
2025-09-25 |
Sanofi |
Novel homocysteine based lipids and their use for delivery of nucleic acids
|
|
WO2025250751A1
(en)
|
2024-05-31 |
2025-12-04 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
WO2025252759A1
(en)
|
2024-06-03 |
2025-12-11 |
Bio-Sourcing |
Transient expression by lipid nanoparticle formulations
|
|
WO2025255388A1
(en)
|
2024-06-05 |
2025-12-11 |
Camp4 Therapeutics Corporation |
Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
|
|
WO2026008743A1
(en)
|
2024-07-02 |
2026-01-08 |
Sanofi Pasteur Inc. |
Water-soluble polyanionic polymer as adjuvant for carrier-formulated nucleic acid
|
|
WO2026020171A2
(en)
|
2024-07-19 |
2026-01-22 |
Aera Therapeutics, Inc. |
Chimeric antigen receptor constructs
|
|
WO2026033123A1
(en)
|
2024-08-08 |
2026-02-12 |
Sanofi Pasteur Inc. |
Lipid nanoparticle formulations for mrna delivery
|
|
WO2026036019A1
(en)
|
2024-08-09 |
2026-02-12 |
Life Technologies Corporation |
Method of producing a recombinant protein in hek-293 cells
|
|
WO2026050243A1
(en)
|
2024-08-26 |
2026-03-05 |
Korro Bio, Inc. |
Galnac conjugated oligonucleotides for rna editing
|
|
WO2026055342A1
(en)
|
2024-09-04 |
2026-03-12 |
Arsenal Biosciences, Inc. |
Synthetic pathway activators
|