IN2014CN00408A - - Google Patents

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Publication number
IN2014CN00408A
IN2014CN00408A IN408CHN2014A IN2014CN00408A IN 2014CN00408 A IN2014CN00408 A IN 2014CN00408A IN 408CHN2014 A IN408CHN2014 A IN 408CHN2014A IN 2014CN00408 A IN2014CN00408 A IN 2014CN00408A
Authority
IN
India
Prior art keywords
formula
relates
pyridine ring
present
membered fused
Prior art date
Application number
Other languages
English (en)
Inventor
Tjeerd A Barf
Christiaan Gerardus Johannes Maria Jans
De Adrianus Petrus Antonius Man
Arthur A Oubrie
Hans C A Raaijmakers
Johannes Bernardus Maria Rewinkel
Jan Gerard Sterrenburg
Jacobus C H M Wijkmans
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014CN00408(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of IN2014CN00408A publication Critical patent/IN2014CN00408A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IN408CHN2014 2011-07-19 2012-07-11 IN2014CN00408A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509397P 2011-07-19 2011-07-19
EP11174578 2011-07-19
PCT/EP2012/063552 WO2013010868A1 (fr) 2011-07-19 2012-07-11 4-imidazopyridazin-1-yl-benzamides et 4-imidazotriazin-1-yl-benzamides en tant qu'inhibiteurs de btk

Publications (1)

Publication Number Publication Date
IN2014CN00408A true IN2014CN00408A (fr) 2015-04-03

Family

ID=47557677

Family Applications (1)

Application Number Title Priority Date Filing Date
IN408CHN2014 IN2014CN00408A (fr) 2011-07-19 2012-07-11

Country Status (38)

Country Link
US (8) US9290504B2 (fr)
EP (4) EP3689878B1 (fr)
JP (6) JP5826931B2 (fr)
KR (2) KR101802689B1 (fr)
CN (2) CN106243113B (fr)
AU (4) AU2012285987C1 (fr)
BR (1) BR112014001255B1 (fr)
CA (1) CA2841886C (fr)
CL (1) CL2014000130A1 (fr)
CO (1) CO6940411A2 (fr)
CR (1) CR20140030A (fr)
CY (2) CY2021010I2 (fr)
DK (2) DK3689878T3 (fr)
DO (1) DOP2014000008A (fr)
EA (2) EA034558B1 (fr)
EC (1) ECSP14013217A (fr)
ES (3) ES2708224T3 (fr)
GT (1) GT201400009A (fr)
HR (2) HRP20190135T1 (fr)
HU (3) HUE056249T2 (fr)
IL (3) IL230511B (fr)
IN (1) IN2014CN00408A (fr)
LT (1) LT2734522T (fr)
MA (1) MA35348B1 (fr)
MX (1) MX342983B (fr)
MY (1) MY192354A (fr)
PE (1) PE20141681A1 (fr)
PH (2) PH12014500148A1 (fr)
PL (2) PL3689878T3 (fr)
PT (1) PT3689878T (fr)
RS (2) RS58177B1 (fr)
SG (1) SG10201605913VA (fr)
SI (2) SI2734522T1 (fr)
SM (2) SMT202100729T1 (fr)
TN (1) TN2014000027A1 (fr)
UA (1) UA115312C2 (fr)
WO (1) WO2013010868A1 (fr)
ZA (1) ZA202109164B (fr)

Families Citing this family (118)

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US20120101113A1 (en) * 2007-03-28 2012-04-26 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
NZ772688A (en) 2010-06-03 2022-09-30 Pharmacyclics Llc The use of inhibitors of bruton’s tyrosine kinase (btk)
EA025496B1 (ru) 2011-05-17 2016-12-30 Принсипиа Биофарма Инк. Ингибиторы тирозинкиназы
WO2012158795A1 (fr) 2011-05-17 2012-11-22 Principia Biopharma Inc. Dérivés de pyrazolopyrimidine utilisés comme inhibiteurs de tyrosine kinase
EA201490265A1 (ru) 2011-07-13 2014-12-30 Фармасайкликс, Инк. Ингибиторы тирозинкиназы брутона
AU2012285987C1 (en) * 2011-07-19 2016-09-08 Merck Sharp & Dohme B.V. 4 - imidazopyridazin- 1 -yl-benzamides and 4 - imidazotriazin- 1 - yl - benzamides as Btk- inhibitors
EP2548877A1 (fr) 2011-07-19 2013-01-23 MSD Oss B.V. Dérivés de 4-(pyridine condensée à 5 chaînons)benzamide comme inhibiteurs de BTK
AU2013293087B2 (en) 2012-07-24 2017-08-31 Pharmacyclics Llc Mutations associated with resistance to inhibitors of Bruton's tyrosine kinase (BTK)
US9266895B2 (en) 2012-09-10 2016-02-23 Principia Biopharma Inc. Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
MX2015003874A (es) * 2012-09-26 2015-12-16 Univ California Modulacion de ire1.
US9296703B2 (en) * 2012-10-04 2016-03-29 University Of Utah Research Foundation Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
KR102229478B1 (ko) 2012-11-01 2021-03-18 인피니티 파마슈티칼스, 인코포레이티드 Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
WO2014113942A1 (fr) * 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Inhibiteurs de btk
WO2014114185A1 (fr) 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Inhibiteurs de btk
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
ES2834638T3 (es) * 2013-05-30 2021-06-18 Infinity Pharmaceuticals Inc Tratamiento de cánceres usando moduladores de isoforma de PI3 cinasa
MX367085B (es) * 2013-07-31 2019-08-05 Merck Patent Gmbh Piridinas, pirimidinas y pirazinas como inhibidores de tirosina cinasa de bruton e inhibidores y usos de las mismas.
WO2015057992A1 (fr) * 2013-10-16 2015-04-23 Izumi Raquel Inhibiteurs btk pour la mobilisation hématopoïétique
EA201691169A1 (ru) 2013-12-05 2016-09-30 Асерта Фарма Б.В. Терапевтическая комбинация ингибитора pi3k и ингибитора btk
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MY192354A (en) 2022-08-17
US20210230166A1 (en) 2021-07-29
IL230511B (en) 2019-05-30
SMT202100729T1 (it) 2022-01-10
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RS62760B1 (sr) 2022-01-31
JP2019108395A (ja) 2019-07-04
JP6617130B2 (ja) 2019-12-11
EA034558B1 (ru) 2020-02-20
DOP2014000008A (es) 2014-04-30
JP2014520870A (ja) 2014-08-25
IL291489A (en) 2022-05-01
HRP20190135T1 (hr) 2019-03-22
PH12014500148A1 (en) 2014-03-31
ECSP14013217A (es) 2015-03-31
CO6940411A2 (es) 2014-05-09
NZ716110A (en) 2017-07-28
PE20141681A1 (es) 2014-11-14
EP4249076A3 (fr) 2023-11-01
AU2016203837A1 (en) 2016-06-30
JP5826931B2 (ja) 2015-12-02
EP3689878A1 (fr) 2020-08-05
MX2014000746A (es) 2014-05-07
EP3495368B1 (fr) 2023-05-31
JP6251220B2 (ja) 2017-12-20
EA201992270A3 (ru) 2020-03-31
JP2020189865A (ja) 2020-11-26
EP3495368A1 (fr) 2019-06-12
CY1125613T1 (el) 2024-02-16
HUE041987T2 (hu) 2019-06-28
EP4249076A2 (fr) 2023-09-27
EA201490300A1 (ru) 2014-05-30
KR20140036324A (ko) 2014-03-25
PL2734522T3 (pl) 2019-04-30
AU2017279778A1 (en) 2018-01-25
US20140155385A1 (en) 2014-06-05
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US20190276456A1 (en) 2019-09-12
BR112014001255A2 (pt) 2017-02-21
US10239883B2 (en) 2019-03-26
MA35348B1 (fr) 2014-08-01
PT3689878T (pt) 2022-01-05
US20160151364A1 (en) 2016-06-02
US20230331729A1 (en) 2023-10-19
KR101802689B1 (ko) 2017-11-28
IL230511A0 (en) 2014-03-31
SMT201900029T1 (it) 2019-02-28
KR101702727B1 (ko) 2017-02-06
MX342983B (es) 2016-10-19
US20180179212A1 (en) 2018-06-28
US10934296B2 (en) 2021-03-02
PL3689878T3 (pl) 2022-02-14
ZA202109164B (en) 2025-04-30
WO2013010868A1 (fr) 2013-01-24
EP2734522A1 (fr) 2014-05-28
US20160159810A1 (en) 2016-06-09
DK3689878T3 (da) 2021-11-08
CY2021010I1 (el) 2021-06-25
CN103889987A (zh) 2014-06-25
JP2016034968A (ja) 2016-03-17
EP3689878B1 (fr) 2021-10-06
US9290504B2 (en) 2016-03-22
NZ620085A (en) 2016-05-27
AU2019275591A1 (en) 2020-01-02
DK2734522T3 (en) 2019-02-18
RS58177B1 (sr) 2019-03-29
HRP20212021T1 (hr) 2022-04-01
TN2014000027A1 (en) 2015-07-01
ES2904707T3 (es) 2022-04-05
AU2017279778B2 (en) 2019-09-19
EA037644B1 (ru) 2021-04-26
CL2014000130A1 (es) 2014-08-22
ES2708224T3 (es) 2019-04-09
CN106243113A (zh) 2016-12-21
JP2022088618A (ja) 2022-06-14
PH12017500166A1 (en) 2017-09-04
AU2016203837B2 (en) 2018-01-25
CN106243113B (zh) 2018-12-18
CY2021010I2 (el) 2021-06-25
CN103889987B (zh) 2016-09-14
EA201992270A2 (ru) 2020-01-16
US9790226B2 (en) 2017-10-17
EP2734522B1 (fr) 2018-10-31
CA2841886C (fr) 2016-08-16
AU2012285987A1 (en) 2014-02-06
CA2841886A1 (fr) 2013-01-24
UA115312C2 (uk) 2017-10-25
IL266894A (en) 2019-07-31
GT201400009A (es) 2017-09-28
ES2950569T3 (es) 2023-10-11
HUS2100012I1 (hu) 2021-05-28
IL266894B (en) 2022-04-01
JP2018035184A (ja) 2018-03-08
SI3689878T1 (sl) 2021-12-31
AU2012285987B2 (en) 2016-03-10
JP7054721B2 (ja) 2022-04-14
PH12017500166B1 (en) 2018-10-26

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