IT1274549B - Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno - Google Patents

Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno

Info

Publication number
IT1274549B
IT1274549B ITMI951047A ITMI951047A IT1274549B IT 1274549 B IT1274549 B IT 1274549B IT MI951047 A ITMI951047 A IT MI951047A IT MI951047 A ITMI951047 A IT MI951047A IT 1274549 B IT1274549 B IT 1274549B
Authority
IT
Italy
Prior art keywords
silicristin
silidianin
mixtures
effective amount
therapeutically effective
Prior art date
Application number
ITMI951047A
Other languages
English (en)
Inventor
Ezio Bombardelli
Paolo Morazzoni
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of ITMI951047A0 publication Critical patent/ITMI951047A0/it
Priority to ITMI951047A priority Critical patent/IT1274549B/it
Priority to ES95935927T priority patent/ES2222466T3/es
Priority to PCT/EP1995/003993 priority patent/WO1996037209A1/en
Priority to EP95935927A priority patent/EP0828500B1/en
Priority to DE69533112T priority patent/DE69533112T2/de
Priority to DK95935927T priority patent/DK0828500T3/da
Priority to HU9801682A priority patent/HU220627B1/hu
Priority to PT95935927T priority patent/PT828500E/pt
Priority to HK98104797.0A priority patent/HK1006222B/en
Priority to CNB951978616A priority patent/CN1148181C/zh
Priority to RU97121286/14A priority patent/RU2161488C2/ru
Priority to CA002221753A priority patent/CA2221753C/en
Priority to US08/952,415 priority patent/US5912265A/en
Priority to JP53528596A priority patent/JP3178844B2/ja
Priority to KR1019970708287A priority patent/KR100290030B1/ko
Priority to SI9530704T priority patent/SI0828500T1/xx
Priority to AU38051/95A priority patent/AU709802B2/en
Priority to PL95323450A priority patent/PL182064B1/pl
Priority to AT95935927T priority patent/ATE268183T1/de
Publication of ITMI951047A1 publication Critical patent/ITMI951047A1/it
Application granted granted Critical
Publication of IT1274549B publication Critical patent/IT1274549B/it
Priority to FI974268A priority patent/FI119100B/fi
Priority to NO19975334A priority patent/NO317153B1/no
Priority to US09/287,103 priority patent/US6218369B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ITMI951047A 1995-05-23 1995-05-23 Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno IT1274549B (it)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ITMI951047A IT1274549B (it) 1995-05-23 1995-05-23 Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
RU97121286/14A RU2161488C2 (ru) 1995-05-23 1995-10-10 Применение флаванолигнанов в качестве лекарственных средств, обладающих антипролиферативной активностью в отношении опухолей матки, яичника и молочной железы
US08/952,415 US5912265A (en) 1995-05-23 1995-10-10 Pharmaceutical compositions containing flavanolignanes and methods for using same as an antiproliferative
EP95935927A EP0828500B1 (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
DE69533112T DE69533112T2 (de) 1995-05-23 1995-10-10 Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken
DK95935927T DK0828500T3 (da) 1995-05-23 1995-10-10 Anvendelse af flavanyllignaner til fremstilling af lægemidler med proliferativ aktivitet i uturus, ovarie og bryst
HU9801682A HU220627B1 (hu) 1995-05-23 1995-10-10 Flavanolignánok alkalmazása II. típusú ösztrogénreceptor antagonista és antiproliferatív hatású gyógyszerkészítmények előállítására
PT95935927T PT828500E (pt) 1995-05-23 1995-10-10 Utilizacao de flavanolignanos para a preparacao de medicamentos com actividade antiproliferativa no utero ovarios e mama
HK98104797.0A HK1006222B (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
CNB951978616A CN1148181C (zh) 1995-05-23 1995-10-10 黄酮木酯素在制备对子宫、卵巢和乳腺具有抗增殖活性的药物中的应用
ES95935927T ES2222466T3 (es) 1995-05-23 1995-10-10 Uso de flavanolignanos para la preparacion de medicamentos con actividad antiproliferativa en utero, ovario y mama.
CA002221753A CA2221753C (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
PCT/EP1995/003993 WO1996037209A1 (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
JP53528596A JP3178844B2 (ja) 1995-05-23 1995-10-10 子宮、卵巣及び乳房における抗増殖活性を有する薬剤の製造のためのフラバノリグナンの利用
KR1019970708287A KR100290030B1 (ko) 1995-05-23 1995-10-10 자궁, 난소 및 유방암의 항증식작용을 갖는 약제제조시의 후라바노리그난류의 용도
SI9530704T SI0828500T1 (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
AU38051/95A AU709802B2 (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
PL95323450A PL182064B1 (pl) 1995-05-23 1995-10-10 Srodek farmaceutyczny wykazujacy dzialanie antagonistyczne na receptory estrogenowe typu II i dzialanie antyproliferacyjne PL
AT95935927T ATE268183T1 (de) 1995-05-23 1995-10-10 Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken
FI974268A FI119100B (fi) 1995-05-23 1997-11-18 Flavanolignaanien käyttö valmistettaessa lääkkeitä, joilla on antiproliferatiivista vaikutusta kohdussa, munasarjoissa ja rintarauhasessa
NO19975334A NO317153B1 (no) 1995-05-23 1997-11-20 Anvendelse av flavanolignaner for fremstilling av medikamenter med antiproliferativ aktivitet i uterus, ovarium og bryst
US09/287,103 US6218369B1 (en) 1995-05-23 1999-04-07 Pharmaceutical compositions containing flavanolignanes and methods for using same as an antiproliferative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI951047A IT1274549B (it) 1995-05-23 1995-05-23 Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno

Publications (3)

Publication Number Publication Date
ITMI951047A0 ITMI951047A0 (it) 1995-05-23
ITMI951047A1 ITMI951047A1 (it) 1996-11-23
IT1274549B true IT1274549B (it) 1997-07-17

Family

ID=11371650

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI951047A IT1274549B (it) 1995-05-23 1995-05-23 Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno

Country Status (20)

Country Link
US (2) US5912265A (it)
EP (1) EP0828500B1 (it)
JP (1) JP3178844B2 (it)
KR (1) KR100290030B1 (it)
CN (1) CN1148181C (it)
AT (1) ATE268183T1 (it)
AU (1) AU709802B2 (it)
CA (1) CA2221753C (it)
DE (1) DE69533112T2 (it)
DK (1) DK0828500T3 (it)
ES (1) ES2222466T3 (it)
FI (1) FI119100B (it)
HU (1) HU220627B1 (it)
IT (1) IT1274549B (it)
NO (1) NO317153B1 (it)
PL (1) PL182064B1 (it)
PT (1) PT828500E (it)
RU (1) RU2161488C2 (it)
SI (1) SI0828500T1 (it)
WO (1) WO1996037209A1 (it)

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EP0828500A1 (en) 1998-03-18
EP0828500B1 (en) 2004-06-02
US5912265A (en) 1999-06-15
ES2222466T3 (es) 2005-02-01
CN1185112A (zh) 1998-06-17
KR19990014941A (ko) 1999-02-25
HU220627B1 (hu) 2002-03-28
JP3178844B2 (ja) 2001-06-25
FI119100B (fi) 2008-07-31
ITMI951047A1 (it) 1996-11-23
PL323450A1 (en) 1998-03-30
ITMI951047A0 (it) 1995-05-23
PT828500E (pt) 2004-08-31
CA2221753C (en) 2001-07-24
NO975334D0 (no) 1997-11-20
SI0828500T1 (en) 2004-10-31
FI974268L (fi) 1997-12-02
ATE268183T1 (de) 2004-06-15
RU2161488C2 (ru) 2001-01-10
CN1148181C (zh) 2004-05-05
AU709802B2 (en) 1999-09-09
HUT77966A (hu) 1998-12-28
NO975334L (no) 1997-11-20
US6218369B1 (en) 2001-04-17
PL182064B1 (pl) 2001-10-31
JPH10511685A (ja) 1998-11-10
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FI974268A0 (fi) 1997-11-18
AU3805195A (en) 1996-12-11
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CA2221753A1 (en) 1996-11-28
DE69533112T2 (de) 2004-10-21
KR100290030B1 (ko) 2001-05-15
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WO1996037209A1 (en) 1996-11-28
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