JP2019502660A5 - - Google Patents

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Publication number: JP2019502660A5
Authority: JP; Japan
Prior art keywords: item; compound according; membered; items; sulfur
Prior art date: 2016-11-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2018525693A

Other languages

English (en)

Japanese (ja)

Other versions

JP2019502660A (ja

Filing date

2016-11-22

Publication date

2020-01-30

2016-11-22 Application filed filed Critical

2016-11-22 Priority claimed from PCT/US2016/063386 external-priority patent/WO2017091600A1/en

2019-01-31 Publication of JP2019502660A publication Critical patent/JP2019502660A/ja

2020-01-30 Publication of JP2019502660A5 publication Critical patent/JP2019502660A5/ja

Status Pending legal-status Critical Current

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150000001875 compounds Chemical class 0.000 claims description 28
229910052739 hydrogen Inorganic materials 0.000 claims description 6
150000003839 salts Chemical class 0.000 claims description 6
239000001257 hydrogen Substances 0.000 claims description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
-1 2 - cyclopropyl Chemical group 0.000 claims 3
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 2
125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims 2
101150065749 Churc1 gene Proteins 0.000 claims 2
102100038239 Protein Churchill Human genes 0.000 claims 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
125000000547 substituted alkyl group Chemical group 0.000 claims 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 21
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 12
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 12
125000005842 heteroatom Chemical group 0.000 description 12
229910052757 nitrogen Inorganic materials 0.000 description 12
229910052760 oxygen Inorganic materials 0.000 description 12
239000001301 oxygen Substances 0.000 description 12
229910052717 sulfur Inorganic materials 0.000 description 12
239000011593 sulfur Substances 0.000 description 12
238000000034 method Methods 0.000 description 9
239000000203 mixture Substances 0.000 description 8
229920006395 saturated elastomer Polymers 0.000 description 7
125000002950 monocyclic group Chemical group 0.000 description 6
206010017533 Fungal infection Diseases 0.000 description 4
208000031888 Mycoses Diseases 0.000 description 4
125000000623 heterocyclic group Chemical group 0.000 description 4
230000002401 inhibitory effect Effects 0.000 description 4
125000001931 aliphatic group Chemical group 0.000 description 3
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
208000035143 Bacterial infection Diseases 0.000 description 2
208000030852 Parasitic disease Diseases 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
125000003118 aryl group Chemical group 0.000 description 2
208000022362 bacterial infectious disease Diseases 0.000 description 2
125000002619 bicyclic group Chemical group 0.000 description 2
239000012472 biological sample Substances 0.000 description 2
125000002837 carbocyclic group Chemical group 0.000 description 2
230000002538 fungal effect Effects 0.000 description 2
229910052736 halogen Inorganic materials 0.000 description 2
150000002367 halogens Chemical class 0.000 description 2
125000001183 hydrocarbyl group Chemical group 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000003071 parasitic effect Effects 0.000 description 2
0 *C(CN(CN1I*)c([s]c(*)c2*)c2C1=O)O* Chemical compound *C(CN(CN1I*)c([s]c(*)c2*)c2C1=O)O* 0.000 description 1
241000222122 Candida albicans Species 0.000 description 1
241000222173 Candida parapsilosis Species 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
241000235645 Pichia kudriavzevii Species 0.000 description 1
241001646398 Pseudomonas chlororaphis Species 0.000 description 1
239000012190 activator Substances 0.000 description 1
230000002293 adipogenic effect Effects 0.000 description 1
229940095731 candida albicans Drugs 0.000 description 1
229940055022 candida parapsilosis Drugs 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000010835 comparative analysis Methods 0.000 description 1
230000007123 defense Effects 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
239000000284 extract Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
244000053095 fungal pathogen Species 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
230000031146 intracellular signal transduction Effects 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
229930014626 natural product Natural products 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
230000008635 plant growth Effects 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

JP2018525693A 2015-11-25 2016-11-22 ピラゾールａｃｃ阻害剤およびその使用 Pending JP2019502660A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201562259973P	2015-11-25	2015-11-25
US62/259,973		2015-11-25
PCT/US2016/063386 WO2017091600A1 (en)	2015-11-25	2016-11-22	Pyrazole acc inhibitors and uses thereof

Publications (2)

Publication Number	Publication Date
JP2019502660A JP2019502660A (ja)	2019-01-31
JP2019502660A5 true JP2019502660A5 (2)	2020-01-30

Family

ID=57543206

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2018525693A Pending JP2019502660A (ja)	2015-11-25	2016-11-22	ピラゾールａｃｃ阻害剤およびその使用

Country Status (18)

Country	Link
US (2)	US20170166582A1 (2)
EP (1)	EP3380480B1 (2)
JP (1)	JP2019502660A (2)
KR (1)	KR20180082556A (2)
CN (1)	CN108349995B (2)
AR (1)	AR106798A1 (2)
AU (1)	AU2016361412A1 (2)
BR (1)	BR112018010113B1 (2)
CA (1)	CA3004796C (2)
CL (1)	CL2018001356A1 (2)
CO (1)	CO2018005368A2 (2)
EA (1)	EA201890913A1 (2)
ES (1)	ES2939833T3 (2)
MX (1)	MX2018006286A (2)
PL (1)	PL3380480T3 (2)
PT (1)	PT3380480T (2)
SI (1)	SI3380480T1 (2)
WO (1)	WO2017091600A1 (2)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RS57157B1 (sr)	2011-11-11	2018-07-31	Gilead Apollo Llc	Acc inhibitori i njihove primene
EP3099677A4 (en)	2014-01-31	2017-07-26	Dana-Farber Cancer Institute, Inc.	Diaminopyrimidine benzenesulfone derivatives and uses thereof
US10793571B2 (en)	2014-01-31	2020-10-06	Dana-Farber Cancer Institute, Inc.	Uses of diazepane derivatives
EP3347021A4 (en)	2015-09-11	2019-07-24	Dana-Farber Cancer Institute, Inc.	CYANOTHIENOTRIAZOLDIAZEPINE AND USES THEREOF
RU2018112953A (ru)	2015-09-11	2019-10-14	Дана-Фарбер Кэнсер Инститьют, Инк.	Ацетамидтиенотриазолодиазепины и пути их применения
AR106472A1 (es)	2015-10-26	2018-01-17	Gilead Apollo Llc	Inhibidores de acc y usos de los mismos
MX2018006499A (es)	2015-11-25	2018-08-01	Dana Farber Cancer Inst Inc	Inhibidores de bromodominio bivalentes y usos de los mismos.
EA201890949A1 (ru)	2015-11-25	2018-12-28	Джилид Аполло, Ллс	СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
BR112018009212B1 (pt)	2015-11-25	2022-06-14	Gilead Apollo, Llc	Método para controlar patógenos fúngicos agrícolas
AU2016361412A1 (en)	2015-11-25	2018-05-24	Gilead Apollo, Llc	Pyrazole ACC inhibitors and uses thereof
PL3380479T3 (pl)	2015-11-25	2023-05-08	Gilead Apollo, Llc	Triazolowe inhibitory acc i ich zastosowania
SG11201807077RA (en) *	2016-03-02	2018-09-27	Gilead Apollo Llc	Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
EP3571205B1 (en)	2017-01-22	2023-08-30	Sunshine Lake Pharma Co., Ltd.	Thienopyrimidine derivative and use thereof in medicine
WO2018161008A1 (en)	2017-03-03	2018-09-07	Gilead Apollo, Llc	Processes for the preparation of fungicidal compounds
CN110431143B (zh) *	2017-03-24	2022-08-12	浙江海正药业股份有限公司	杂芳基并嘧啶酮类衍生物及其制备方法和用途
SI4122464T1 (sl)	2017-03-28	2024-07-31	Gilead Sciences, Inc.	Terapevtske kombinacije za zdravljenje bolezni jeter
CN110709402B (zh) *	2017-06-15	2022-05-10	浙江海正药业股份有限公司	杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途
CN111201234A (zh) *	2017-07-17	2020-05-26	南京瑞捷医药科技有限公司	新型化合物及其作为acc抑制剂的用途
CN110950884B (zh) *	2018-09-27	2024-03-26	上海翰森生物医药科技有限公司	含二并环类衍生物抑制剂、其制备方法和应用
WO2020092239A1 (en)	2018-10-29	2020-05-07	Gilead Apollo, Llc	Processes for the preparation of fungicidal compounds
CN111484504B (zh) *	2019-01-25	2024-05-10	南京圣和药业股份有限公司	Acc抑制剂的光学异构体及其应用
EP3995498A4 (en)	2019-07-02	2023-03-01	Sunshine Lake Pharma Co., Ltd.	THIENOPYRIMIDI DERIVATIVES WITH STEREO CONFIGURATION AND THEIR USE IN MEDICINE
AR119594A1 (es)	2019-08-09	2021-12-29	Gilead Sciences Inc	Derivados de tienopirimidina como inhibidores acc y usos de los mismos
CN110746439B (zh) *	2019-10-18	2020-10-30	南京瑞捷医药科技有限公司	一种噻吩并嘧啶二酮化合物的制备方法
CN111039880B (zh) *	2019-12-10	2022-06-21	河南大学	咪康唑及其衍生物作为tgr5激动剂的应用
US11478533B2 (en)	2020-04-27	2022-10-25	Novo Nordisk A/S	Semaglutide for use in medicine
CN113968871A (zh) *	2020-07-25	2022-01-25	南京圣和药业股份有限公司	苯基取代类acc抑制剂的晶型
US20220192956A1 (en) *	2020-12-18	2022-06-23	The Procter & Gamble Company	Superior efficacy of azoxystrobin and other strobilurins

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3060084A (en)	1961-06-09	1962-10-23	Du Pont	Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en)	1964-06-01	1967-01-24	Olin Mathieson	Water soluble film containing agricultural chemicals
US3325503A (en)	1965-02-18	1967-06-13	Diamond Alkali Co	Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation
US3296272A (en)	1965-04-01	1967-01-03	Dow Chemical Co	Sulfinyl- and sulfonylpyridines
US4144050A (en)	1969-02-05	1979-03-13	Hoechst Aktiengesellschaft	Micro granules for pesticides and process for their manufacture
US3920442A (en)	1972-09-18	1975-11-18	Du Pont	Water-dispersible pesticide aggregates
US4172714A (en)	1976-12-20	1979-10-30	E. I. Du Pont De Nemours And Company	Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en)	1981-03-30	1984-10-24	Avon Packers Ltd	Formulation of agricultural chemicals
DE3338292A1 (de)	1983-10-21	1985-05-02	Basf Ag, 6700 Ludwigshafen	7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
CA1249832A (en)	1984-02-03	1989-02-07	Shionogi & Co., Ltd.	Azolyl cycloalkanol derivatives and agricultural fungicides
US5304732A (en)	1984-03-06	1994-04-19	Mgi Pharma, Inc.	Herbicide resistance in plants
BR8600161A (pt)	1985-01-18	1986-09-23	Plant Genetic Systems Nv	Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio
DE3545319A1 (de)	1985-12-20	1987-06-25	Basf Ag	Acrylsaeureester und fungizide, die diese verbindungen enthalten
ATE57390T1 (de)	1986-03-11	1990-10-15	Plant Genetic Systems Nv	Durch gentechnologie erhaltene und gegen glutaminsynthetase-inhibitoren resistente pflanzenzellen.
US4670560A (en)	1986-04-28	1987-06-02	Ortho Pharmaceutical Corporation	Thienopyrimidine-2,4-dione derivatives and intermediates thereof
CN1050538A (zh)	1986-05-02	1991-04-10	施托福化学公司	杀真菌性吡啶基亚胺组合物及杀真菌方法
ES2011602T3 (es)	1986-08-12	1994-07-16	Mitsubishi Chem Ind	Derivados de piridinacarboxamida y su uso como fungicidas.
FR2629098B1 (fr)	1988-03-23	1990-08-10	Rhone Poulenc Agrochimie	Gene chimerique de resistance herbicide
US5180587A (en)	1988-06-28	1993-01-19	E. I. Du Pont De Nemours And Company	Tablet formulations of pesticides
EP0374753A3 (de)	1988-12-19	1991-05-29	American Cyanamid Company	Insektizide Toxine, Gene, die diese Toxine kodieren, Antikörper, die sie binden, sowie transgene Pflanzenzellen und transgene Pflanzen, die diese Toxine exprimieren
JPH02225485A (ja)	1989-02-27	1990-09-07	Taiho Yakuhin Kogyo Kk	チエノピリミジン―３―酢酸誘導体
EP0392225B1 (en)	1989-03-24	2003-05-28	Syngenta Participations AG	Disease-resistant transgenic plants
DK0777964T3 (da)	1989-08-30	2002-03-11	Kynoch Agrochemicals Proprieta	Fremgangsmåde til fremstilling af et doseringssystem
EP0427529B1 (en)	1989-11-07	1995-04-19	Pioneer Hi-Bred International, Inc.	Larvicidal lectins and plant insect resistance based thereon
AU628229B2 (en)	1989-11-10	1992-09-10	Agro-Kanesho Co. Ltd.	Hexahydrotriazine compounds and insecticides
PL167613B1 (pl)	1990-03-12	1995-09-30	Du Pont	Granulowana kompozycja rozpuszczalna lub dyspergowalna w wodzie PL
CA2083948C (en)	1990-06-25	2001-05-15	Ganesh M. Kishore	Glyphosate tolerant plants
DE69122201T2 (de)	1990-10-11	1997-02-06	Sumitomo Chemical Co	Pestizide Zusammensetzung
JP2828186B2 (ja)	1991-09-13	1998-11-25	宇部興産株式会社	アクリレート系化合物、その製法及び殺菌剤
UA48104C2 (uk)	1991-10-04	2002-08-15	Новартіс Аг	Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
DE4322211A1 (de)	1993-07-03	1995-01-12	Basf Ag	Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung
TW276256B (2)	1993-08-26	1996-05-21	Takeda Pharm Industry Co Ltd
JP3811196B2 (ja)	1993-08-26	2006-08-16	武田薬品工業株式会社	エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法
US5530195A (en)	1994-06-10	1996-06-25	Ciba-Geigy Corporation	Bacillus thuringiensis gene encoding a toxin active against insects
EP0846119B1 (en)	1995-08-17	2002-11-13	Takeda Chemical Industries, Ltd.	Thienopyrimidine derivatives, their production and use as endothelin antagonists
JPH09110873A (ja)	1995-08-17	1997-04-28	Takeda Chem Ind Ltd	チエノピリミジン誘導体、その製造法および用途
US5773704A (en)	1996-04-29	1998-06-30	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Herbicide resistant rice
AU2407997A (en)	1996-04-30	1997-11-19	Takeda Chemical Industries Ltd.	Combined use of gnrh agonist and antagonist
JP2007302703A (ja)	1996-04-30	2007-11-22	Takeda Chem Ind Ltd	医薬組成物
US5773702A (en)	1996-07-17	1998-06-30	Board Of Trustees Operating Michigan State University	Imidazolinone herbicide resistant sugar beet plants
DE69736841T2 (de)	1996-07-17	2007-02-01	Michigan State University, East Lansing	Imidazolinon-herbizid-resistente zuckerrüben-pflanzen
DE19650197A1 (de)	1996-12-04	1998-06-10	Bayer Ag	3-Thiocarbamoylpyrazol-Derivate
TW460476B (en)	1997-04-14	2001-10-21	American Cyanamid Co	Fungicidal trifluoromethylalkylamino-triazolopyrimidines
SE9702001D0 (sv)	1997-05-28	1997-05-28	Astra Pharma Prod	Novel compounds
US6984644B2 (en)	1997-05-28	2006-01-10	Astrazeneca Ab	Treatment of skin disorders using thieno[2,3-D]pyrimidinediones
PL193553B1 (pl)	1997-09-18	2007-02-28	Basf Ag	Pochodne benzamidoksymu, benzamidoksymy, zastosowanie pochodnych benzamidoksymu i środek grzybobójczy
DE19750012A1 (de)	1997-11-12	1999-05-20	Bayer Ag	Isothiazolcarbonsäureamide
BR9813376A (pt)	1997-12-04	2001-06-19	Dow Agrosciences Llc	Composição fungicidas e métodos e compostos para a preparação das mesmas
DE19754082A1 (de)	1997-12-05	1999-06-10	Knoll Ag	Methode zur Bekämpfung der Fettleibigkeit
US6348643B1 (en)	1998-10-29	2002-02-19	American Cyanamid Company	DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
US6576631B1 (en)	1998-11-17	2003-06-10	Kumiai Chemical Industry Co., Ltd.	Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural bactericides
IT1303800B1 (it)	1998-11-30	2001-02-23	Isagro Ricerca Srl	Composti dipeptidici aventi elevata attivita' fungicida e loroutilizzo agronomico.
JP3417862B2 (ja)	1999-02-02	2003-06-16	新東工業株式会社	酸化チタン光触媒高担持シリカゲルおよびその製造方法
AU770077B2 (en)	1999-03-11	2004-02-12	Dow Agrosciences Llc	Heterocyclic substituted isoxazolidines and their use as fungicides
CA2369981A1 (en)	1999-04-09	2000-10-19	Cell Therapeutics, Inc.	Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same
US6586617B1 (en)	1999-04-28	2003-07-01	Sumitomo Chemical Takeda Agro Company, Limited	Sulfonamide derivatives
UA73307C2 (uk)	1999-08-05	2005-07-15	Куміаі Кемікал Індастрі Ко., Лтд.	Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення
DE10021412A1 (de)	1999-12-13	2001-06-21	Bayer Ag	Fungizide Wirkstoffkombinationen
WO2001054501A2 (en)	2000-01-25	2001-08-02	Syngenta Participations Ag	Herbicidal composition
US6376548B1 (en)	2000-01-28	2002-04-23	Rohm And Haas Company	Enhanced propertied pesticides
IL167958A (en)	2000-02-04	2010-11-30	Sumitomo Chemical Co	2-thio 3-hydroxypyridine derivatives
BR0110410A (pt)	2000-04-28	2003-07-01	Basf Ag	Uso do gene ahas 2 mutante x112 de milho e herbicidas de imidazolinona para seleção de mudas transgênicas de monocotiledÈneas de milho, arroz e trigo resistentes aos herbicidas de imidazolinona
AU2001285900B2 (en)	2000-08-25	2005-02-17	Syngenta Participations Ag	Novel insecticidal toxins derived from bacillus thuringiensis insecticidal crystal proteins
EP1322614A2 (en)	2000-09-18	2003-07-02	E. I. du Pont de Nemours and Company	Pyridinyl amides and imides for use as fungicides
US6815556B2 (en)	2000-11-17	2004-11-09	Dow Agrosciences Llc	Compounds having fungicidal activity and processes to make and use same
EP1370562A1 (en)	2001-02-14	2003-12-17	Warner-Lambert Company LLC	Thieno[2,3-d]pyrimidindione derivatives as matrix metalloproteinase inhibitors
JP5034142B2 (ja)	2001-04-20	2012-09-26	住友化学株式会社	植物病害防除剤組成物
DE10136065A1 (de)	2001-07-25	2003-02-13	Bayer Cropscience Ag	Pyrazolylcarboxanilide
AR037228A1 (es)	2001-07-30	2004-11-03	Dow Agrosciences Llc	Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada
FR2828196A1 (fr)	2001-08-03	2003-02-07	Aventis Cropscience Sa	Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture
AU2002319037B2 (en)	2001-08-09	2008-05-29	University Of Saskatchewan	Wheat plants having increased resistance to imidazolinone herbicides
ES2417012T3 (es)	2001-08-09	2013-08-05	Northwest Plant Breeding Co.	Plantas de trigo que exhiben resistencia aumentada a los herbicidas de imidazolinona
WO2003014356A1 (en)	2001-08-09	2003-02-20	University Of Saskatchewan	Wheat plants having increased resistance to imidazolinone herbicides
US7655658B2 (en)	2001-08-10	2010-02-02	Palatin Technologies, Inc.	Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
CN1543455B (zh)	2001-08-17	2012-07-11	三井化学Agro株式会社	3-苯氧基-4-哒嗪醇衍生物以及含有它的除草剂组合物
US7230167B2 (en)	2001-08-31	2007-06-12	Syngenta Participations Ag	Modified Cry3A toxins and nucleic acid sequences coding therefor
AR037856A1 (es)	2001-12-17	2004-12-09	Syngenta Participations Ag	Evento de maiz
AU2002354251A1 (en)	2001-12-21	2003-07-09	Nissan Chemical Industries, Ltd.	Bactericidal composition
TWI327462B (en)	2002-01-18	2010-07-21	Sumitomo Chemical Co	Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
DE10204390A1 (de)	2002-02-04	2003-08-14	Bayer Cropscience Ag	Disubstituierte Thiazolylcarboxanilide
CN1642599A (zh)	2002-02-27	2005-07-20	辉瑞产品公司	Acc抑制剂
KR100818540B1 (ko)	2002-03-05	2008-04-01	신젠타 파티서페이션즈 아게	Ｏ-사이클로프로필-카복스아닐리드 및 이를 포함하는 살진균 조성물
EP1551218B1 (en)	2002-07-10	2017-05-17	The Department of Agriculture, Western Australia	Wheat plants having increased resistance to imidazolinone herbicides
AU2003253165A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidine fused bicyclic metalloproteinase inhibitors
GB0227966D0 (en)	2002-11-29	2003-01-08	Syngenta Participations Ag	Organic Compounds
WO2004060058A2 (en)	2003-01-06	2004-07-22	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Herbicides inhibiting the action of plant acetyl-coa carboxylase for use as pesticides.
EP1591446B1 (en)	2003-01-29	2013-03-06	Takeda Pharmaceutical Company Limited	Thienopyrimidine compounds and use thereof
WO2004083193A1 (ja)	2003-03-17	2004-09-30	Sumitomo Chemical Company, Limited	アミド化合物およびこれを含有する殺菌剤組成物
PL1633875T3 (pl)	2003-05-28	2012-12-31	Basf Se	Rośliny pszenicy o zwiększonej tolerancji na herbicydy imidazolinonowe
MXPA06002155A (es)	2003-08-29	2007-01-25	Inst Nac De Technologia Agrope	Plantas de arroz que tienen una tolerancia incrementada a los herbicidas de imidazolinona.
TWI355894B (en)	2003-12-19	2012-01-11	Du Pont	Herbicidal pyrimidines
EA009883B1 (ru)	2004-03-10	2008-04-28	Басф Акциенгезельшафт	5, 6-диалкил-7-амино-триазолопиримидины, способ их получения и их применение для борьбы с патогенными растениями, а также содержащие их средства
US9487519B2 (en)	2004-03-10	2016-11-08	Basf Se	5,6-Dialkyl-7-aminotriazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
CA2564813A1 (en)	2004-06-03	2005-12-22	E.I. Du Pont De Nemours And Company	Fungicidal mixtures of amidinylphenyl compounds
JP2008502625A (ja)	2004-06-18	2008-01-31	ビーエーエスエフ　アクチェンゲゼルシャフト	Ｎ−（オルト−フェニル）−１−メチル−３−トリフルオロメチルピラゾール−４−カルボキシアニリドおよびそれらの殺菌剤としての使用
US20080108686A1 (en)	2004-06-18	2008-05-08	Basf Aktiengesellschaft	N-(Ortho-Phenyl)-1-Methyl-3-Difluoromethylpyrazole-4-Carboxanilides And Their Use As Fungicides
US7947691B2 (en)	2004-07-21	2011-05-24	Athersys, Inc.	Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof
GB0418048D0 (en)	2004-08-12	2004-09-15	Syngenta Participations Ag	Method for protecting useful plants or plant propagation material
DE102005007160A1 (de)	2005-02-16	2006-08-24	Basf Ag	Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen
DE502006001074D1 (de)	2005-02-16	2008-08-21	Basf Se	5-alkoxyalkyl-6-alkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
DE102005009458A1 (de)	2005-03-02	2006-09-07	Bayer Cropscience Ag	Pyrazolylcarboxanilide
CA2612176C (en)	2005-06-14	2015-02-17	Aska Pharmaceutical Co., Ltd.	Dihydrothieno[2,3-d]pyramidine-6-carboxylic acid derivatives as pde9 inhibitors
MY143535A (en)	2006-01-13	2011-05-31	Dow Agrosciences Llc	6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
EP1983832A2 (en)	2006-02-09	2008-10-29	Syngeta Participations AG	A method of protecting a plant propagation material, a plant, and/or plant organs
CA2644996A1 (en)	2006-03-02	2007-09-13	Cv Therapeutics, Inc.	A2a adenosine receptor antagonists
JPWO2008143262A1 (ja)	2007-05-21	2010-08-12	武田薬品工業株式会社	複素環化合物およびその用途
WO2010050445A1 (ja)	2008-10-27	2010-05-06	武田薬品工業株式会社	二環性化合物
US8623880B2 (en)	2009-03-23	2014-01-07	Glenmark Pharmaceuticals S.A.	Fused pyrimidine-dione derivatives as TRPA1 modulators
DK2519527T3 (da)	2009-12-29	2014-01-27	Poxel	Thieno[2,3-b]pyridindion-aktivatorer af ampk og terapeutiske anvendelser deraf
EP2569450A4 (en)	2010-05-14	2013-12-25	Univ Rochester	COMPOSITIONS AND METHODS FOR TARGETING A3G: RNA COMPLEXES
JP5826848B2 (ja)	2010-09-02	2015-12-02	モンサントテクノロジーエルエルシー	線虫を防除する新規組成物および方法
RS57157B1 (sr)	2011-11-11	2018-07-31	Gilead Apollo Llc	Acc inhibitori i njihove primene
JP6417401B2 (ja) *	2013-05-10	2018-11-07	ギリアドアポロ，エルエルシー	Ａｃｃ阻害剤及びその使用
JP6417402B2 (ja)	2013-05-10	2018-11-07	ギリアドアポロ，エルエルシー	Ａｃｃ阻害剤及びその使用
EP2994139B1 (en)	2013-05-10	2019-04-10	Gilead Apollo, LLC	Acc inhibitors and uses thereof
AU2014262547A1 (en) *	2013-05-10	2015-11-26	Gilead Apollo, Llc	ACC inhibitors and uses thereof
TWI652012B (zh)	2013-05-20	2019-03-01	杜邦股份有限公司	殺真菌吡唑的固態形式
WO2015003881A1 (en) *	2013-07-08	2015-01-15	Syngenta Participations Ag	Microbiocidal heterobicyclic derivatives
WO2015003879A1 (en) *	2013-07-08	2015-01-15	Syngenta Participations Ag	Microbiocidal heterobicylic derivatives
WO2015007451A1 (en) *	2013-07-15	2015-01-22	Syngenta Participations Ag	Microbiocidal heterobicyclic derivatives
EA201791258A1 (ru) *	2015-01-09	2017-12-29	Джилид Аполло, Ллс	Комбинированная терапия с применением ингибитора ацетил-коа-карбоксилазы (acc) для лечения неалкогольной жировой болезни печени
AR106472A1 (es)	2015-10-26	2018-01-17	Gilead Apollo Llc	Inhibidores de acc y usos de los mismos
PL3380479T3 (pl)	2015-11-25	2023-05-08	Gilead Apollo, Llc	Triazolowe inhibitory acc i ich zastosowania
DK3888658T3 (da)	2015-11-25	2024-03-18	Effector Therapeutics Inc	Eif4-a-inhiberende forbindelser og fremgangsmåder relateret dertil
MX2018006499A (es)	2015-11-25	2018-08-01	Dana Farber Cancer Inst Inc	Inhibidores de bromodominio bivalentes y usos de los mismos.
BR112018009212B1 (pt)	2015-11-25	2022-06-14	Gilead Apollo, Llc	Método para controlar patógenos fúngicos agrícolas
AU2016361412A1 (en)	2015-11-25	2018-05-24	Gilead Apollo, Llc	Pyrazole ACC inhibitors and uses thereof
EA201890949A1 (ru)	2015-11-25	2018-12-28	Джилид Аполло, Ллс	СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
SG11201807077RA (en)	2016-03-02	2018-09-27	Gilead Apollo Llc	Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
US10131670B2 (en)	2016-12-16	2018-11-20	Cystic Fibrosis Foundation Therapeutics, Inc.	Bicyclic heteroaryl derivatives as CFTR potentiators

2016
- 2016-11-22 AU AU2016361412A patent/AU2016361412A1/en not_active Abandoned
- 2016-11-22 CA CA3004796A patent/CA3004796C/en active Active
- 2016-11-22 US US15/358,627 patent/US20170166582A1/en not_active Abandoned
- 2016-11-22 KR KR1020187016696A patent/KR20180082556A/ko not_active Withdrawn
- 2016-11-22 BR BR112018010113-3A patent/BR112018010113B1/pt active IP Right Grant
- 2016-11-22 CN CN201680067509.5A patent/CN108349995B/zh active Active
- 2016-11-22 MX MX2018006286A patent/MX2018006286A/es unknown
- 2016-11-22 SI SI201631675T patent/SI3380480T1/sl unknown
- 2016-11-22 PT PT168101897T patent/PT3380480T/pt unknown
- 2016-11-22 EA EA201890913A patent/EA201890913A1/ru unknown
- 2016-11-22 JP JP2018525693A patent/JP2019502660A/ja active Pending
- 2016-11-22 PL PL16810189.7T patent/PL3380480T3/pl unknown
- 2016-11-22 EP EP16810189.7A patent/EP3380480B1/en active Active
- 2016-11-22 WO PCT/US2016/063386 patent/WO2017091600A1/en not_active Ceased
- 2016-11-22 ES ES16810189T patent/ES2939833T3/es active Active
- 2016-11-23 AR ARP160103590A patent/AR106798A1/es not_active Application Discontinuation
2018
- 2018-05-18 CL CL2018001356A patent/CL2018001356A1/es unknown
- 2018-05-23 CO CONC2018/0005368A patent/CO2018005368A2/es unknown
2019
- 2019-01-03 US US16/239,360 patent/US10941158B2/en active Active

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AR108697A1 (es)	2018-09-19	Oxadiazoles sustituidos para combatir hongos fitopatógenos
JPH08507505A (ja)	1996-08-13	殺菌剤としてのジハロトリアゾロピリミジン誘導体
EP0550113A2 (en)	1993-07-07	Triazolopyrimidine derivatives with fungicidal activity
MA32089B1 (fr)	2011-02-01	Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
AR065876A1 (es)	2009-07-08	Compuestos activos para 11 beta -hsd1
JP2020520955A5 (2)	2021-05-13
CA2681972A1 (en)	2008-10-09	Substituted dibenzoic acid derivatives and use thereof
ATE421322T1 (de)	2009-02-15	Chinolin-2-on-derivate zur behandlung von erkankungen der atemwege
IL275891B2 (en)	2023-03-01	herbicide preparations
EA200600214A1 (ru)	2006-08-25	Арилконденсированные 3-арилпиридиновые соединения и их применение для борьбы с патогенными грибами
PH12017501227B1 (en)	2018-01-15	Method for enhancing the rate of the formation of the reaction product of a carboylic acid and a urea via acid addition
US3517104A (en)	1970-06-23	Fungicidal compositions and methods employing dialkyltin,1,4-endoalkylene - 2,3 - dihydrophthages and -1,2,3,6-tetrahydrophthalates
US3736328A (en)	1973-05-29	Certain 3-halo-5-sulfinyl-1,2,4-thiadiazoles
US3495012A (en)	1970-02-10	Soil fungicides and their use
US3478043A (en)	1969-11-11	3-oxa-tricyclo(4.2.1.0**2,5)nonanes