JP6594438B2 - 改善されたｉｌ−６抗体 - Google Patents

改善されたｉｌ−６抗体 Download PDF

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Publication number
JP6594438B2
JP6594438B2 JP2017543332A JP2017543332A JP6594438B2 JP 6594438 B2 JP6594438 B2 JP 6594438B2 JP 2017543332 A JP2017543332 A JP 2017543332A JP 2017543332 A JP2017543332 A JP 2017543332A JP 6594438 B2 JP6594438 B2 JP 6594438B2
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Japan
Prior art keywords
antibody
antigen
seq
binding fragment
sequence
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Japanese (ja)
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JP2017535285A5 (2
JP2017535285A (ja
Inventor
マイケル マーチ シュミット，
アリソン ティスデール，
エリック スティーブン ファーファイン，
グリゴリオス ザービス−パパストートシス，
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セセン バイオ， インコーポレイテッド
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Publication of JP2017535285A5 publication Critical patent/JP2017535285A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017543332A 2014-11-07 2015-11-06 改善されたｉｌ−６抗体 Active JP6594438B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462077105P 2014-11-07 2014-11-07
US62/077,105 2014-11-07
US201462087448P 2014-12-04 2014-12-04
US62/087,448 2014-12-04
US201562247705P 2015-10-28 2015-10-28
US62/247,705 2015-10-28
PCT/US2015/059532 WO2016073890A1 (en) 2014-11-07 2015-11-06 Improved il-6 antibodies

Publications (3)

Publication Number Publication Date
JP2017535285A JP2017535285A (ja) 2017-11-30
JP2017535285A5 JP2017535285A5 (2) 2018-12-13
JP6594438B2 true JP6594438B2 (ja) 2019-10-23

Family

ID=54602042

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017543332A Active JP6594438B2 (ja) 2014-11-07 2015-11-06 改善されたｉｌ−６抗体

Country Status (33)

Country Link
US (3) US11142571B2 (2)
EP (3) EP3215530B9 (2)
JP (1) JP6594438B2 (2)
KR (2) KR102636726B1 (2)
CN (1) CN107249631B (2)
AU (1) AU2015342882B2 (2)
CA (1) CA2965689C (2)
CL (1) CL2017001135A1 (2)
CO (1) CO2017005404A2 (2)
CR (1) CR20170231A (2)
DK (2) DK4268843T3 (2)
EA (1) EA035199B1 (2)
ES (2) ES3051832T3 (2)
FI (1) FI4268843T3 (2)
HR (2) HRP20251312T1 (2)
HU (1) HUE046181T2 (2)
IL (1) IL251858B (2)
LT (1) LT4268843T (2)
MA (2) MA62787B1 (2)
MX (2) MX385206B (2)
MY (1) MY185114A (2)
PE (1) PE20171107A1 (2)
PH (1) PH12017500809B1 (2)
PL (2) PL3215530T3 (2)
PT (2) PT3215530T (2)
RS (2) RS67353B1 (2)
SA (1) SA517381458B1 (2)
SG (2) SG10202103420PA (2)
SI (2) SI3215530T1 (2)
SM (1) SMT202500415T1 (2)
UA (1) UA122673C2 (2)
WO (1) WO2016073890A1 (2)
ZA (1) ZA201702985B (2)

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US20200347143A1 (en) * 2016-12-19 2020-11-05 Glenmark Pharmaceuticals S.A. Novel tnfr agonists and uses thereof
MA49279A (fr) 2017-03-22 2020-02-05 Hoffmann La Roche Compositions d'anticorps optimisées pour le traitement de troubles oculaires
AR111190A1 (es) 2017-03-22 2019-06-12 Genentech Inc Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados
CN109867723B (zh) * 2017-12-05 2022-06-17 南京金斯瑞生物科技有限公司 抗人il6单克隆抗体及其制备方法和用途
PE20230252A1 (es) 2020-03-13 2023-02-07 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos de estos
AU2021242249A1 (en) 2020-03-24 2022-08-18 Genentech, Inc. Tie2-binding agents and methods of use
JP2023546112A (ja) 2020-10-15 2023-11-01 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 長時間作用型眼送達用非共有結合タンパク質－ヒアルロナンコンジュゲート
CN116355825A (zh) * 2022-02-25 2023-06-30 南京工业大学 一种强化纤维素合成来提高人表皮生长因子分泌生产效率的方法
CN115343483B (zh) * 2022-08-12 2024-11-26 苏州邦器生物技术有限公司 一种自身免疫性糖尿病检测用试剂盒及其制备方法
IL318765A (en) * 2022-10-24 2025-04-01 Hoffmann La Roche Predicting response to IL-6 antagonists

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MX385206B (es) 2025-03-14
IL251858A0 (en) 2017-06-29
PE20171107A1 (es) 2017-08-07
SG10202103420PA (en) 2021-05-28
NZ731090A (en) 2024-03-22
KR102770849B1 (ko) 2025-02-20
SA517381458B1 (ar) 2020-07-09
PL3215530T3 (pl) 2020-05-18
US11142571B2 (en) 2021-10-12
MA62787B1 (fr) 2025-11-28
HRP20251312T1 (hr) 2025-12-05
EP4268843A2 (en) 2023-11-01
HUE046181T2 (hu) 2020-02-28
US20220169719A1 (en) 2022-06-02
KR102636726B1 (ko) 2024-02-13
EP4268843B1 (en) 2025-09-03
US20250059270A1 (en) 2025-02-20
ES3051832T3 (en) 2025-12-30
CA2965689A1 (en) 2016-05-12
ES2756275T9 (es) 2020-10-29
PT4268843T (pt) 2025-10-31
US20190194312A1 (en) 2019-06-27
KR20240023450A (ko) 2024-02-21
EP3215530B9 (en) 2020-09-09
EP4268843A3 (en) 2023-12-27
EP3215530A1 (en) 2017-09-13
SMT202500415T1 (it) 2026-01-12
RS59805B1 (sr) 2020-02-28
KR20170077196A (ko) 2017-07-05
WO2016073890A1 (en) 2016-05-12
FI4268843T3 (fi) 2025-11-14
DK4268843T3 (da) 2025-11-10
UA122673C2 (uk) 2020-12-28
AU2015342882A1 (en) 2017-05-18
MA51554A (fr) 2020-11-18
PH12017500809B1 (en) 2023-09-20
RS67353B1 (sr) 2025-11-28
ZA201702985B (en) 2019-10-30
CL2017001135A1 (es) 2017-12-15
CN107249631A (zh) 2017-10-13
EP3215530B1 (en) 2019-08-21
JP2017535285A (ja) 2017-11-30
CA2965689C (en) 2022-03-22
ES2756275T3 (es) 2020-04-27
CR20170231A (es) 2017-09-25
BR112017008672A2 (pt) 2018-03-20
PT3215530T (pt) 2019-11-21
SI3215530T1 (sl) 2020-02-28
CO2017005404A2 (es) 2017-10-31
LT4268843T (lt) 2025-11-25
SG11201703574VA (en) 2017-05-30
MX2017005992A (es) 2017-09-15
PH12017500809A1 (en) 2017-10-02
IL251858B (en) 2022-09-01
AU2015342882B2 (en) 2021-05-20
MX2021008663A (es) 2021-08-19
HK1244008A1 (en) 2018-07-27
EP3632931A1 (en) 2020-04-08
EA201791005A1 (ru) 2017-09-29
HRP20191945T1 (hr) 2020-01-24
SI4268843T1 (sl) 2026-01-30
MY185114A (en) 2021-04-30
EA035199B1 (ru) 2020-05-14
DK3215530T3 (da) 2019-11-25
CN107249631B (zh) 2021-11-23
PL4268843T3 (pl) 2025-12-15

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