JPS5826744B2 - シンキナプロピオンサン エステルユウドウタイノセイゾウホウ - Google Patents

シンキナプロピオンサン エステルユウドウタイノセイゾウホウ

Info

Publication number
JPS5826744B2
JPS5826744B2 JP50156799A JP15679975A JPS5826744B2 JP S5826744 B2 JPS5826744 B2 JP S5826744B2 JP 50156799 A JP50156799 A JP 50156799A JP 15679975 A JP15679975 A JP 15679975A JP S5826744 B2 JPS5826744 B2 JP S5826744B2
Authority
JP
Japan
Prior art keywords
general formula
propionic acid
group
represented
compound represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP50156799A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5278848A (en
Inventor
博之 井出
雄二 石倉
晃 中川
寛治 野田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP50156799A priority Critical patent/JPS5826744B2/ja
Priority to SE7613651A priority patent/SE433492B/xx
Priority to CA267,690A priority patent/CA1076134A/fr
Priority to CH1607276A priority patent/CH617919A5/fr
Priority to FR7638482A priority patent/FR2336126A1/fr
Priority to AU20878/76A priority patent/AU507661B2/en
Priority to NLAANVRAGE7614308,A priority patent/NL180381C/xx
Priority to DE2658610A priority patent/DE2658610C2/de
Priority to GB51350/76A priority patent/GB1573322A/en
Publication of JPS5278848A publication Critical patent/JPS5278848A/ja
Priority to US05/845,237 priority patent/US4150137A/en
Publication of JPS5826744B2 publication Critical patent/JPS5826744B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP50156799A 1975-12-24 1975-12-24 シンキナプロピオンサン エステルユウドウタイノセイゾウホウ Expired JPS5826744B2 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP50156799A JPS5826744B2 (ja) 1975-12-24 1975-12-24 シンキナプロピオンサン エステルユウドウタイノセイゾウホウ
SE7613651A SE433492B (sv) 1975-12-24 1976-12-06 Sett att framstella fenylettiksyraderivat
CA267,690A CA1076134A (fr) 1975-12-24 1976-12-13 Preparation de derives d'esters d'acides phenylacetiques
CH1607276A CH617919A5 (en) 1975-12-24 1976-12-21 Process for the preparation of new derivatives of esters of phenyl-acetic acid
FR7638482A FR2336126A1 (fr) 1975-12-24 1976-12-21 Derives d'esters d'acide phenylacetique
AU20878/76A AU507661B2 (en) 1975-12-24 1976-12-23 Phenylacetic acid ester derivatives
NLAANVRAGE7614308,A NL180381C (nl) 1975-12-24 1976-12-23 Werkwijze ter bereiding van een 2-(4-isobutylfenyl)propionzure ester bevattend geneesmiddel en werkwijze ter bereiding van de geneeskrachtige verbindingen.
DE2658610A DE2658610C2 (de) 1975-12-24 1976-12-23 Phenylessigsäureesterderivate
GB51350/76A GB1573322A (en) 1975-12-24 1976-12-24 Phenylactic acid ester derivatives
US05/845,237 US4150137A (en) 1975-12-24 1977-10-25 Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50156799A JPS5826744B2 (ja) 1975-12-24 1975-12-24 シンキナプロピオンサン エステルユウドウタイノセイゾウホウ

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP1176982A Division JPS57206640A (en) 1982-01-29 1982-01-29 Preparation of novel propionic ester derivative

Publications (2)

Publication Number Publication Date
JPS5278848A JPS5278848A (en) 1977-07-02
JPS5826744B2 true JPS5826744B2 (ja) 1983-06-04

Family

ID=15635562

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50156799A Expired JPS5826744B2 (ja) 1975-12-24 1975-12-24 シンキナプロピオンサン エステルユウドウタイノセイゾウホウ

Country Status (9)

Country Link
JP (1) JPS5826744B2 (fr)
AU (1) AU507661B2 (fr)
CA (1) CA1076134A (fr)
CH (1) CH617919A5 (fr)
DE (1) DE2658610C2 (fr)
FR (1) FR2336126A1 (fr)
GB (1) GB1573322A (fr)
NL (1) NL180381C (fr)
SE (1) SE433492B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54144336A (en) * 1978-07-24 1979-11-10 Teikoku Seiyaku Kk Propionic acid propylester derivative*its manufacture and antiiinflammatory and sedative agent containing it
JPS5517358A (en) * 1978-07-24 1980-02-06 Teikoku Seiyaku Kk Butyl propionate derivative, its preparation, and antiphlogistic and analgesic comprising it
JPS5587770A (en) * 1978-12-27 1980-07-02 Hisamitsu Pharmaceut Co Inc Preparation of 2-(p-isobutylphenyl)propionic acid 2-pyridinemethyl ester
JPS57203035A (en) * 1981-06-05 1982-12-13 Taisho Pharmaceut Co Ltd Carboxylic acid ester
DE3225290A1 (de) * 1982-07-07 1984-01-12 Merck Patent Gmbh Ringverbindungen
YU43408B (en) * 1985-04-26 1989-06-30 Lek Tovarna Farmacevtskih Process for preparation of 2-(4-isobuthylphenyl)-prophiohydroxamic acid
JPH0635378B2 (ja) * 1985-06-27 1994-05-11 ポ−ラ化成工業株式会社 化粧料
ES2004447A6 (es) * 1987-07-06 1989-01-01 Sune Coma Nuria Procedimiento de obtencion de un nuevo ester del acido 2-(p-isobutilfeni)-propionico
DE3811118C1 (fr) * 1988-03-31 1989-10-12 Merckle Gmbh, 7902 Blaubeuren, De
IT1217589B (it) * 1988-05-13 1990-03-30 Pulitzer Italiana Agente antiinfiammatorio per la terapia dell'ipertrofia prostatica,sua preparazione e relative composizioni farmaceutiche
JPH0639449B2 (ja) * 1989-04-10 1994-05-25 エーザイ株式会社 ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬
UA34430C2 (uk) 1991-05-13 2001-03-15 Дзе Бутс Компані Плс S(-)-2-(4-ізобутилфеніл)пропіонат натрію дигідрат, придатний для лікування запалення, болю і гіпертермії, фармацевтична композиція на його основі та спосіб одержання s(-)-2-(4-ізобутилфеніл)пропіонату натрію
US6399618B1 (en) * 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
CN103948571A (zh) * 2006-07-18 2014-07-30 天津昕晨泰飞尔医药科技有限公司 具有快速皮肤穿透率的带正电荷的水溶性布洛芬前药
JP5424880B2 (ja) * 2006-08-15 2014-02-26 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ
KR20150058566A (ko) 2007-06-04 2015-05-28 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 ｎｓａｉａ 약물전구체 및 이들의 새로운 의약적 용도
EP2773378B1 (fr) 2011-10-31 2016-08-10 Larsen, Claus Selch Promédicaments d'agents anti-inflammatoires non stéroïdiens (ains)
US9557087B2 (en) 2012-12-13 2017-01-31 Whirlpool Corporation Clear ice making apparatus having an oscillation frequency and angle
US9470448B2 (en) 2012-12-13 2016-10-18 Whirlpool Corporation Apparatus to warm plastic side of mold
US9759472B2 (en) 2012-12-13 2017-09-12 Whirlpool Corporation Clear ice maker with warm air flow
US9500398B2 (en) 2012-12-13 2016-11-22 Whirlpool Corporation Twist harvest ice geometry
CN105461731B (zh) * 2014-08-07 2017-05-24 富力 连翘脂素布洛芬酯、其制备及其应用
WO2016065269A2 (fr) 2014-10-23 2016-04-28 Whirlpool Corporation Procédé et appareil permettant d'augmenter la vitesse de production de glace dans une machine à glaçons automatique
JP6153264B2 (ja) * 2015-01-05 2017-06-28 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
CN109134262A (zh) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 一种洛索洛芬衍生物
CN109134261A (zh) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 一种洛索洛芬衍生物
US10907874B2 (en) 2018-10-22 2021-02-02 Whirlpool Corporation Ice maker downspout
CA3199426A1 (fr) * 2020-06-05 2021-12-09 Chongxi Yu Administration topique de propionate de 2-(diethylamino)ethyl-2-(4-isobutylphenyle) pour le traitement de maladies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents

Also Published As

Publication number Publication date
AU507661B2 (en) 1980-02-21
NL7614308A (nl) 1977-06-28
DE2658610C2 (de) 1982-12-23
CA1076134A (fr) 1980-04-22
NL180381C (nl) 1987-02-16
DE2658610A1 (de) 1977-07-07
FR2336126A1 (fr) 1977-07-22
SE433492B (sv) 1984-05-28
GB1573322A (en) 1980-08-20
SE7613651L (sv) 1977-06-25
CH617919A5 (en) 1980-06-30
AU2087876A (en) 1978-06-29
JPS5278848A (en) 1977-07-02
NL180381B (nl) 1986-09-16
FR2336126B1 (fr) 1979-03-09

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