LU86908A1 - Composes antibiotiques,leur preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Composes antibiotiques,leur preparation et les compositions pharmaceutiques qui les contiennent Download PDF

Info

Publication number: LU86908A1
Authority: LU; Luxembourg
Prior art keywords: radical; compound; formula; hydroxyl; hydroxyl radical
Prior art date: 1986-06-06

Application number

LU86908A

Other languages

English (en)

French (fr)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-06

Filing date

1987-06-05

Publication date

1988-01-20

1986-06-06 Priority claimed from GB868613790A external-priority patent/GB8613790D0/en

1986-10-29 Priority claimed from GB868625854A external-priority patent/GB8625854D0/en

1987-04-08 Priority claimed from GB878708423A external-priority patent/GB8708423D0/en

1987-06-05 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1988-01-20 Publication of LU86908A1 publication Critical patent/LU86908A1/fr

Links

150000001875 compounds Chemical class 0.000 title claims description 143
238000002360 preparation method Methods 0.000 title claims description 33
230000003115 biocidal effect Effects 0.000 title description 8
239000008194 pharmaceutical composition Substances 0.000 title description 4
-1 methoxycarbonyloxy, acetoxy, methoxy Chemical group 0.000 claims description 82
239000000203 mixture Substances 0.000 claims description 69
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 61
TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 claims description 34
238000006243 chemical reaction Methods 0.000 claims description 31
239000002253 acid Substances 0.000 claims description 27
238000000034 method Methods 0.000 claims description 27
150000003254 radicals Chemical class 0.000 claims description 24
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 claims description 18
150000003839 salts Chemical class 0.000 claims description 17
239000003814 drug Substances 0.000 claims description 16
239000003795 chemical substances by application Substances 0.000 claims description 15
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230000000361 pesticidal effect Effects 0.000 description 1
239000003444 phase transfer catalyst Substances 0.000 description 1
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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229910000027 potassium carbonate Inorganic materials 0.000 description 1
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244000144977 poultry Species 0.000 description 1
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CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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235000013580 sausages Nutrition 0.000 description 1
229910052624 sepiolite Inorganic materials 0.000 description 1
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239000002453 shampoo Substances 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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238000006884 silylation reaction Methods 0.000 description 1
ZVCDLGYNFYZZOK-UHFFFAOYSA-M sodium cyanate Chemical compound [Na]OC#N ZVCDLGYNFYZZOK-UHFFFAOYSA-M 0.000 description 1
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235000011152 sodium sulphate Nutrition 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
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238000003860 storage Methods 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
150000003871 sulfonates Chemical class 0.000 description 1
150000003457 sulfones Chemical class 0.000 description 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
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150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
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150000003512 tertiary amines Chemical class 0.000 description 1
238000010998 test method Methods 0.000 description 1
125000005207 tetraalkylammonium group Chemical group 0.000 description 1
DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
150000003573 thiols Chemical class 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
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125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 description 1
238000012546 transfer Methods 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
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238000009736 wetting Methods 0.000 description 1
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239000012138 yeast extract Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Plant Pathology (AREA)
Pest Control & Pesticides (AREA)
Dentistry (AREA)
Agronomy & Crop Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Insects & Arthropods (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

LU86908A 1986-06-06 1987-06-05 Composes antibiotiques,leur preparation et les compositions pharmaceutiques qui les contiennent LU86908A1 (fr)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB868613790A GB8613790D0 (en)	1986-06-06	1986-06-06	Chemical compounds
GB8613790		1986-06-06
GB8625854		1986-10-29
GB868625854A GB8625854D0 (en)	1986-10-29	1986-10-29	Chemical process
GB878708423A GB8708423D0 (en)	1987-04-08	1987-04-08	Chemical compounds
GB8708423		1987-04-08

Publications (1)

Publication Number	Publication Date
LU86908A1 true LU86908A1 (fr)	1988-01-20

Family

ID=27263057

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LU86908A LU86908A1 (fr)	1986-06-06	1987-06-05	Composes antibiotiques,leur preparation et les compositions pharmaceutiques qui les contiennent
LU88790C LU88790I2 (fr)	1986-06-06	1996-07-17	Moxidectin et ses dérivés pharmaceutiquement acceptables

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LU88790C LU88790I2 (fr)	1986-06-06	1996-07-17	Moxidectin et ses dérivés pharmaceutiquement acceptables

Country Status (35)

Country	Link
US (1)	US4900753A (de)
JP (1)	JP2648147B2 (de)
KR (1)	KR950010077B1 (de)
CN (1)	CN1023858C (de)
AR (1)	AR244691A1 (de)
AT (1)	AT398571B (de)
AU (1)	AU609399B2 (de)
BE (1)	BE1000201A4 (de)
BR (1)	BR8702866A (de)
CA (1)	CA1296329C (de)
CH (1)	CH677670A5 (de)
DE (3)	DE3745133C2 (de)
DK (1)	DK166498B1 (de)
EG (1)	EG18752A (de)
ES (1)	ES2006479A6 (de)
FI (2)	FI90663C (de)
FR (1)	FR2599742B1 (de)
GB (1)	GB2192630B (de)
GE (1)	GEP19981388B (de)
GR (1)	GR870891B (de)
HU (1)	HU199847B (de)
IE (1)	IE60411B1 (de)
IL (1)	IL82776A (de)
IT (1)	IT1206015B (de)
LU (2)	LU86908A1 (de)
LV (2)	LV10280A (de)
NL (2)	NL193376C (de)
NZ (1)	NZ220587A (de)
OA (1)	OA08606A (de)
PH (1)	PH23948A (de)
PL (3)	PL155723B1 (de)
PT (1)	PT85018B (de)
SE (1)	SE503399C2 (de)
TR (1)	TR28970A (de)
UA (1)	UA45300C2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4886828A (en) *	1986-09-12	1989-12-12	American Cyanamid Company	Δ22 -derivatives of LL-F28249 compounds
DE3750355T2 (de) *	1986-09-12	1995-04-06	American Cyanamid Co	23-Oxo(keto) und 23-Imino-Derivate von LL-F28249-Verbindungen.
EP0260537A1 (de) *	1986-09-12	1988-03-23	American Cyanamid Company	13-Deoxy-23-oxo(keto)- und 23-imino-Derivate von 13-Deoxy-C-076-aglykon-Verbindungen
GB8721377D0 (en) *	1987-09-11	1987-10-21	Glaxo Group Ltd	Chemical compounds
GB8811036D0 (en) *	1988-05-10	1988-06-15	Glaxo Group Ltd	Chemical compounds
GB8813150D0 (en) *	1988-06-03	1988-07-06	American Cyanamid Co	Chemical compounds
GB8905605D0 (en) *	1989-03-11	1989-04-26	Beecham Group Plc	Novel compounds
NZ233680A (en) *	1989-05-17	1995-02-24	Beecham Group Plc	Avermectins and milbemycins and compositions thereof
US4988824A (en) *	1989-09-11	1991-01-29	Maulding Donald R	Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds
EP0561990B1 (de) *	1990-12-07	1998-10-07	Temple University	Stabilisierte, insektizide, nematode-enthaltende mittel
JP2855181B2 (ja)	1993-12-10	1999-02-10	敏雄鈴木	松類の枯損防止用組成物及び防止方法
DE60118132T2 (de)	2000-10-10	2006-10-19	Wyeth	Anthelmintika
US7348417B2 (en) *	2003-08-07	2008-03-25	Wyeth	Method of purifying moxidectin through crystallization
US20090214676A1 (en) *	2005-04-30	2009-08-27	Tissuetech, Inc.	Method for treating ocular demodex
JP4939025B2 (ja) *	2005-09-30	2012-05-23	三菱電線工業株式会社	電熱ヒータ付きハンドル用グリップ部材
EP1849363A1 (de) *	2006-03-09	2007-10-31	Cheminova A/S	Synergistische Kombinationen aus Glutaminsäure- und GABA-aktivierten Chloridkanälen agonistischen Pestiziden und mindestens eins von Vitamin E und Niacin
US8128968B2 (en) *	2007-08-29	2012-03-06	Tissuetech, Inc.	Compositions and methods for treating Demodex infestations
MX379693B (es) *	2011-12-02	2025-03-11	Merial Ltd	Formulaciones de moxidectina inyectables de larga acción y formas de cristal de moxidectina novedosas.
FR2995605B1 (fr) *	2012-09-18	2014-09-19	Sanofi Sa	Derives de macrolides, leur preparation et leur application therapeutique.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH15982A (en) *	1977-10-03	1983-05-18	Merck & Co Inc	Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4289760A (en) *	1980-05-02	1981-09-15	Merck & Co., Inc.	23-Keto derivatives of C-076 compounds
US4423209A (en) *	1982-02-26	1983-12-27	Merck & Co., Inc.	Processes for the interconversion of avermectin compounds
JPS59108785A (ja) *	1982-11-25	1984-06-23	Sankyo Co Ltd	ミルベマイシン類の５−オキシム誘導体
JPS60126289A (ja) *	1983-11-14	1985-07-05	Sankyo Co Ltd	ミルベマイシン類の５−カ−ボネ−ト誘導体
DK165119C (da) *	1984-06-05	1993-03-01	American Cyanamid Co	Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling
US4579864A (en) *	1984-06-11	1986-04-01	Merck & Co., Inc.	Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
ES8704545A1 (es) *	1984-09-14	1987-04-01	Glaxo Group Ltd	Un procedimiento para preparar un nuevo antibiotico por fer-mentacion
IL78621A (en) *	1985-04-30	1991-06-30	American Cyanamid Co	Mylbemycin analogs,their preparation and pesticidal compositions containing them
DE3750355T2 (de) *	1986-09-12	1995-04-06	American Cyanamid Co	23-Oxo(keto) und 23-Imino-Derivate von LL-F28249-Verbindungen.

1987
- 1987-05-26 CA CA000537979A patent/CA1296329C/en not_active Expired - Lifetime
- 1987-06-02 OA OA59131A patent/OA08606A/xx unknown
- 1987-06-04 ES ES8701645A patent/ES2006479A6/es not_active Expired
- 1987-06-04 FI FI872517A patent/FI90663C/fi not_active IP Right Cessation
- 1987-06-04 EG EG32487A patent/EG18752A/xx active
- 1987-06-04 DK DK290287A patent/DK166498B1/da not_active IP Right Cessation
- 1987-06-05 FR FR878707915A patent/FR2599742B1/fr not_active Expired
- 1987-06-05 GB GB8713239A patent/GB2192630B/en not_active Expired - Lifetime
- 1987-06-05 CH CH2150/87A patent/CH677670A5/de not_active IP Right Cessation
- 1987-06-05 PL PL1987282198A patent/PL155723B1/pl unknown
- 1987-06-05 PT PT85018A patent/PT85018B/pt unknown
- 1987-06-05 IE IE149687A patent/IE60411B1/en not_active IP Right Cessation
- 1987-06-05 NL NL8701322A patent/NL193376C/nl not_active IP Right Cessation
- 1987-06-05 KR KR1019870005694A patent/KR950010077B1/ko not_active Expired - Lifetime
- 1987-06-05 AU AU73873/87A patent/AU609399B2/en not_active Expired
- 1987-06-05 US US07/058,856 patent/US4900753A/en not_active Expired - Lifetime
- 1987-06-05 BE BE8700626A patent/BE1000201A4/fr not_active IP Right Cessation
- 1987-06-05 LU LU86908A patent/LU86908A1/fr active Protection Beyond IP Right Term
- 1987-06-05 GR GR870891A patent/GR870891B/el unknown
- 1987-06-05 PL PL1987266100A patent/PL153226B1/pl unknown
- 1987-06-05 CN CN87104431A patent/CN1023858C/zh not_active Expired - Lifetime
- 1987-06-05 NZ NZ220587A patent/NZ220587A/xx unknown
- 1987-06-05 BR BR8702866A patent/BR8702866A/pt not_active IP Right Cessation
- 1987-06-05 IT IT8748023A patent/IT1206015B/it active
- 1987-06-05 SE SE8702361A patent/SE503399C2/sv not_active IP Right Cessation
- 1987-06-05 DE DE3745133A patent/DE3745133C2/de not_active Expired - Lifetime
- 1987-06-05 DE DE3718926A patent/DE3718926C2/de not_active Expired - Lifetime
- 1987-06-05 AT AT0143887A patent/AT398571B/de not_active IP Right Cessation
- 1987-06-05 AR AR87307796A patent/AR244691A1/es active
- 1987-06-05 IL IL82776A patent/IL82776A/xx not_active IP Right Cessation
- 1987-06-05 HU HU872583A patent/HU199847B/hu unknown
- 1987-06-05 JP JP62140139A patent/JP2648147B2/ja not_active Expired - Lifetime
- 1987-06-05 PH PH35347A patent/PH23948A/en unknown
- 1987-06-05 DE DE1998175029 patent/DE19875029I2/de active Active
- 1987-06-05 TR TR00392/87A patent/TR28970A/xx unknown
- 1987-06-05 PL PL1987283187A patent/PL153036B1/pl unknown
1992
- 1992-07-30 FI FI923445A patent/FI90549C/fi not_active IP Right Cessation
- 1992-12-30 LV LV920561A patent/LV10280A/xx unknown
1993
- 1993-08-25 GE GEAP19931498A patent/GEP19981388B/en unknown
- 1993-09-15 UA UA93003885A patent/UA45300C2/uk unknown
- 1993-11-15 LV LVP-93-1233A patent/LV10781B/lv unknown
1996
- 1996-07-17 LU LU88790C patent/LU88790I2/fr unknown
1999
- 1999-08-18 NL NL990026C patent/NL990026I2/nl unknown

Also Published As

Publication number	Publication date
NL8701322A (nl)	1988-01-04
NL193376C (nl)	1999-08-03
LU88790I2 (fr)	1997-03-18
NL193376B (nl)	1999-04-01
LV10781A (lv)	1995-08-20
PT85018B (pt)	1990-03-08
DK290287D0 (da)	1987-06-04
PH23948A (en)	1990-01-23
KR950010077B1 (ko)	1995-09-06
DK166498B1 (da)	1993-06-01
CH677670A5 (de)	1991-06-14
CN1023858C (zh)	1994-02-23
DE3718926C2 (de)	1998-01-15
FI872517A0 (fi)	1987-06-04
IT1206015B (it)	1989-04-05
NZ220587A (en)	1990-05-28
AR244691A1 (es)	1993-11-30
JPS6354375A (ja)	1988-03-08
PL153036B1 (en)	1991-02-28
HU199847B (en)	1990-03-28
AU609399B2 (en)	1991-05-02
FR2599742A1 (fr)	1987-12-11
US4900753A (en)	1990-02-13
IE871496L (en)	1987-12-06
ATA143887A (de)	1994-05-15
PL153226B1 (en)	1991-03-29
PL266100A1 (en)	1988-07-21
LV10781B (en)	1996-10-20
GB2192630A (en)	1988-01-20
FI923445L (fi)	1992-07-30
OA08606A (en)	1988-11-30
UA45300C2 (uk)	2002-04-15
FR2599742B1 (fr)	1989-05-19
GB2192630B (en)	1990-05-23
CA1296329C (en)	1992-02-25
AT398571B (de)	1994-12-27
PT85018A (en)	1987-07-01
HUT44254A (en)	1988-02-29
IL82776A (en)	1992-02-16
IE60411B1 (en)	1994-07-13
GB8713239D0 (en)	1987-07-08
AU7387387A (en)	1987-12-10
SE503399C2 (sv)	1996-06-10
NL990026I1 (nl)	1999-11-01
FI90549C (fi)	1994-02-25
FI90663C (fi)	1994-03-10
IL82776A0 (en)	1987-12-20
PL155723B1 (en)	1991-12-31
DE19875029I2 (de)	2001-11-22
EG18752A (en)	1993-12-30
JP2648147B2 (ja)	1997-08-27
FI90663B (fi)	1993-11-30
CN87104431A (zh)	1987-12-30
LV10280A (lv)	1994-10-20
DK290287A (da)	1987-12-07
IT8748023A0 (it)	1987-06-05
FI923445A0 (fi)	1992-07-30
BR8702866A (pt)	1988-03-01
SE8702361L (sv)	1987-12-07
BE1000201A4 (fr)	1988-08-23
DE3718926A1 (de)	1987-12-10
ES2006479A6 (es)	1989-05-01
NL990026I2 (nl)	1999-12-01
TR28970A (tr)	1997-07-21
DE3745133C2 (de)	1998-01-02
SE8702361D0 (sv)	1987-06-05
GEP19981388B (en)	1998-11-10
FI90549B (fi)	1993-11-15
GR870891B (en)	1987-10-02
KR880000441A (ko)	1988-03-25
FI872517A7 (fi)	1987-12-07

Legal Events

Date	Code	Title	Description
1997-03-18	CCP	Supplementary protection certificate	Free format text: 88790, EXPIRES:20091230

Publication	Publication Date	Title
FR2587344A1 (fr)	1987-03-20	Antibiotiques du type des macrolides et leur preparation
FR2570390A1 (fr)	1986-03-21	Nouveaux composes antibiotiques et procede de preparation
FR2599742A1 (fr)	1987-12-11	Composes antibiotiques, leur preparation et les compositions pharmaceutiques qui les contiennent
KR960004941B1 (ko)	1996-04-18	Ll-f28249 화합물의 23-옥소(케토) 및 23-이미노 유도체
IE862443L (en)	1987-03-13	Fused oxygen heterocyclics
EP0238258B1 (de)	1994-01-26	Makrolid-Verbindungen
DK170344B1 (da)	1995-08-07	Makrolidforbindelser, farmaceutiske, veterinære og ikke-terapeutisk pesticide præparater indeholdende forbindelser, ikke-terapeutisk fremgangsmåde til bekæmpelse af skadedyr samt fremgangsmåde til fremstilling af forbindelserne
JPH07506361A (ja)	1995-07-13	アベルメクチンジフルオロ誘導体
JPH0678342B2 (ja)	1994-10-05	新規マクロライド化合物
CA1301165C (en)	1992-05-19	23-oxo (keto) and 23-imino derivatives of mono- and diepoxy ll-f28249 compounds
IE61058B1 (en)	1994-09-21	Macrolide antibiotics and their preparation
DK171063B1 (da)	1996-05-13	Makrolidforbindelser, præparater indeholdende makrolidforbindelser til anvendelse i human medicin, veterinær medicin, og præparat til kontrol af skadedyr, ikke-terapeutisk fremgangsmåde til bekæmpelse af skadedyr, fremgangsmåde til fremstilling af forbindelserne samt fremgangsmåde til fremstilling af mellemprodukter
EP0341972B1 (de)	1996-09-04	Makrolid-Derivate
RU2099334C1 (ru)	1997-12-20	Макролидные соединения, композиция, обладающая антибиотической активностью, ветеринарная композиция, инсектоакарицидонематоцидная композиция и способ уничтожения насекомых и/или клещей, нематод
NL8700581A (nl)	1987-10-01	Antibioticum, preparaat dat dat bevat, werkwijze voor de bereiding daarvan, werkwijze voor het bestrijden van plagen en nieuwe streptomyces-mutant.
KR950010078B1 (ko)	1995-09-06	마크롤라이드 화합물
DK171255B1 (da)	1996-08-12	Makrolidforbindelser, præparater indeholdende forbindelser til anvendelse i human medicin, veterinær medicin, og præparat til kontrol af skadedyr, ikke-terapeutisk fremgangsmåde til bekæmpelse af skadedyr samt fremgangsmåde til fremstilling af forbindelserne
AP38A (en)	1989-04-13	Macrolide Compounds.
AT397096B (de)	1994-01-25	Macrolid-verbindungen, diese enthaltende mittel und verfahren zu deren herstellung
JPS60142991A (ja)	1985-07-29	５−ジデヒドロミルベマイシン５−オキシム誘導体
HRP920589A2 (en)	1995-06-30	Macrolide compounds