LU92239I2 - Vésicules de membrane externe (VME) du groupe B deNeisseria meningitidis - Google Patents
Vésicules de membrane externe (VME) du groupe B deNeisseria meningitidisInfo
- Publication number
- LU92239I2 LU92239I2 LU92239C LU92239C LU92239I2 LU 92239 I2 LU92239 I2 LU 92239I2 LU 92239 C LU92239 C LU 92239C LU 92239 C LU92239 C LU 92239C LU 92239 I2 LU92239 I2 LU 92239I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- outer membrane
- pellet
- membrane vesicles
- collecting
- detergent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0220194.5A GB0220194D0 (en) | 2002-08-30 | 2002-08-30 | Improved vesicles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU92239I2 true LU92239I2 (fr) | 2013-09-04 |
Family
ID=9943238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU92239C LU92239I2 (fr) | 2002-08-30 | 2013-07-04 | Vésicules de membrane externe (VME) du groupe B deNeisseria meningitidis |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20060166344A1 (fr) |
| EP (5) | EP1534326B1 (fr) |
| JP (3) | JP2006503822A (fr) |
| CN (2) | CN102188700A (fr) |
| AT (1) | ATE366117T1 (fr) |
| AU (1) | AU2003263534B2 (fr) |
| BR (1) | BRPI0314094A8 (fr) |
| CA (1) | CA2497165C (fr) |
| CY (3) | CY1107737T1 (fr) |
| DE (1) | DE60314756T2 (fr) |
| DK (3) | DK1864679T3 (fr) |
| ES (4) | ES2289351T3 (fr) |
| FR (1) | FR13C0046I2 (fr) |
| GB (1) | GB0220194D0 (fr) |
| LU (1) | LU92239I2 (fr) |
| MX (1) | MXPA05002316A (fr) |
| NZ (1) | NZ538673A (fr) |
| PT (3) | PT1534326E (fr) |
| RU (1) | RU2325184C2 (fr) |
| SI (2) | SI2258389T1 (fr) |
| WO (1) | WO2004019977A2 (fr) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE446368T1 (de) * | 1998-01-14 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| ES2278446T3 (es) | 1998-05-29 | 2007-08-01 | Novartis Vaccines And Diagnostics, Inc. | Vacunas combinadas b/c contra la meningitis. |
| EP1179072A2 (fr) | 1999-05-19 | 2002-02-13 | Chiron S.P.A. | Compositions a base de combinaisons de neisseria |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| ES2588917T3 (es) | 2000-01-17 | 2016-11-07 | Glaxosmithkline Biologicals Sa | Vacuna de VME suplementada contra meningococo |
| MXPA03000822A (es) | 2000-07-27 | 2004-11-01 | Childrens Hosp & Res Ct Oak | Vacunas para proteccion de espectro amplio contra enfermedades causadas por neisseria meningitidis. |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| CU23377A1 (es) * | 2003-11-04 | 2009-05-28 | Ct De Ingenieria Genetica Y Biotecnologia | Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes |
| GB0416120D0 (en) | 2004-07-19 | 2004-08-18 | Health Prot Agency | Stable compositions containing OMV's |
| CA2576280A1 (fr) | 2004-08-13 | 2006-02-16 | Barry J. Marshall | Systeme liberation a base helicobacter pylori |
| US8029777B2 (en) | 2004-08-13 | 2011-10-04 | Marshall Barry J | Helicobacter system and uses thereof |
| GB0419627D0 (en) * | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| CN101107007B (zh) | 2005-01-27 | 2011-08-17 | 奥克兰儿童医院及研究中心 | 对脑膜炎奈瑟球菌所致疾病具有广谱保护作用的gna1870囊泡疫苗 |
| JP2008530245A (ja) * | 2005-02-18 | 2008-08-07 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 尿路病原性菌株由来の抗原 |
| WO2006123164A2 (fr) * | 2005-05-19 | 2006-11-23 | The Edward Jenner Institute For Vaccine Research | Procedes de traitement et de prevention des infections |
| HUE045482T2 (hu) | 2005-06-27 | 2019-12-30 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| AU2016204760A1 (en) * | 2006-04-26 | 2016-07-28 | Wyeth Llc | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| AU2014268186C1 (en) * | 2006-04-26 | 2017-12-07 | Wyeth Llc | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| HRP20120433T1 (en) | 2007-10-19 | 2012-07-31 | Novartis@Ag | Meningococcal vaccine formulations |
| AU2009215364B2 (en) | 2008-02-21 | 2014-09-18 | Glaxosmithkline Biologicals S.A. | Meningococcal fHBP polypeptides |
| GB0819633D0 (en) * | 2008-10-25 | 2008-12-03 | Isis Innovation | Composition |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| AU2009329193A1 (en) | 2008-12-17 | 2011-07-14 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| CN104548082A (zh) | 2009-03-24 | 2015-04-29 | 诺华股份有限公司 | 为脑膜炎球菌因子h结合蛋白添加佐剂 |
| US9266942B2 (en) * | 2009-04-30 | 2016-02-23 | Children's Hospital & Research Center Oakland | Chimeric factor H binding proteins (fHbp) and methods of use |
| CA2765112A1 (fr) | 2009-06-10 | 2010-12-16 | Novartis Ag | Vaccins contenant de la benzonaphtyridine |
| WO2011022228A2 (fr) * | 2009-08-20 | 2011-02-24 | Srisuda Dhamwichukorn | Appareil et procédé de dislocation et d'extraction améliorés de matières intracellulaires à partir de cellules microbiennes |
| WO2011024072A2 (fr) | 2009-08-27 | 2011-03-03 | Novartis Ag | Polypeptides hybrides contenant des séquences fhbp à méningocoques |
| AU2010288239B2 (en) | 2009-08-27 | 2014-01-16 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
| WO2011027971A2 (fr) | 2009-09-01 | 2011-03-10 | 주식회사이언메딕스 | Vésicules extracellulaires dérivées de la flore intestinale, et procédé de recherche d'un modèle de maladie, d'un vaccin et d'un médicament candidat, et de diagnostic utilisant ce dernier |
| WO2011027956A2 (fr) | 2009-09-04 | 2011-03-10 | 주식회사이언메딕스 | Vésicules extracellulaires issues de bactéries à gram positif, et modèle de maladie utilisant celles-ci |
| US9950062B2 (en) | 2009-09-02 | 2018-04-24 | Glaxosmithkline Biologicals Sa | Compounds and compositions as TLR activity modulators |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
| CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
| CA2779816A1 (fr) | 2009-10-27 | 2011-05-05 | Novartis Ag | Polypeptides fhbp meningococciques modifies |
| WO2011057148A1 (fr) | 2009-11-05 | 2011-05-12 | Irm Llc | Composés et compositions permettant de moduler l'activité des tlr-7 |
| JP5814933B2 (ja) | 2009-12-15 | 2015-11-17 | ノバルティス アーゲー | 免疫増強化合物の均質な懸濁物およびその使用 |
| WO2012020326A1 (fr) | 2010-03-18 | 2012-02-16 | Novartis Ag | Vaccins adjuvantés contre le méningocoque de sérogroupe b |
| EA031379B1 (ru) | 2010-03-23 | 2018-12-28 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
| US9066971B2 (en) | 2010-07-01 | 2015-06-30 | Postech Academy-Industry Foundation | Method for treating and diagnosing cancer by using cell-derived microvesicles |
| CA2808975C (fr) | 2010-08-23 | 2018-10-30 | Wyeth Llc | Formulations stables des antigenes rlp2086 de neisseria meningitidis |
| KR101584871B1 (ko) | 2010-09-10 | 2016-01-22 | 와이어쓰 엘엘씨 | 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체 |
| CA2810971C (fr) | 2010-09-10 | 2020-11-03 | Novartis Ag | Developpements apportes a des vesicules membranaires externes meningococciques |
| US20150147356A1 (en) | 2011-05-12 | 2015-05-28 | Alan Kimura | Antipyretics to enhance tolerability of vesicle-based vaccines |
| EP2729167B1 (fr) * | 2011-07-07 | 2018-03-14 | De Staat der Nederlanden, vert. door de Minister van VWS | Procédé de production sans détergent de vésicules de membrane externe de bactéries gram-négatives |
| MX2014008988A (es) | 2012-02-02 | 2014-08-27 | Novartis Ag | Promotores para aumento de expresion de proteinas en meningococo. |
| WO2013132040A2 (fr) | 2012-03-08 | 2013-09-12 | Novartis Ag | Dosage de puissance in vitro pour des vaccins méningococciques à base de protéine |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CA2865745C (fr) | 2012-03-09 | 2018-01-09 | Pfizer Inc. | Compositions de neisseria meningitidis et procedes associes |
| US9808517B2 (en) | 2012-04-06 | 2017-11-07 | Cornell University | Subunit vaccine delivery platform for robust humoral and cellular immune responses |
| ES2847923T3 (es) | 2012-06-14 | 2021-08-04 | Glaxosmithkline Biologicals Sa | Vacunas contra el meningococo del serogrupo X |
| CN104736563A (zh) | 2012-07-27 | 2015-06-24 | 国家健康与医学研究院 | Cd147作为受体用于脑膜炎球菌至血管内皮的菌毛介导的粘附 |
| BR112015005056A2 (pt) | 2012-09-06 | 2017-11-21 | Novartis Ag | vacinas de combinação com sorogrupo b meningococcus e d/t/p |
| AU2013320313B2 (en) | 2012-09-18 | 2018-07-12 | Glaxosmithkline Biologicals Sa | Outer membrane vesicles |
| BR112015018877A2 (pt) | 2013-02-07 | 2017-08-22 | Externautics Spa | Método para preparar uma composição farmacêutica, e, composição farmacêutica imunogênica |
| CA2903716C (fr) | 2013-03-08 | 2019-04-09 | Pfizer Inc. | Polypeptides immunogenes de fusion |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| CN106661092B (zh) | 2014-02-28 | 2021-07-06 | 葛兰素史密丝克莱恩生物有限公司 | 修饰的脑膜炎球菌fHbp多肽 |
| KR20190049940A (ko) | 2015-02-19 | 2019-05-09 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
| US11066453B2 (en) | 2015-05-18 | 2021-07-20 | Biomvis Srl | Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof |
| CA3004924A1 (fr) * | 2015-11-10 | 2017-05-18 | Ohio State Innovation Foundation | Methodes et compositions associees a une affinite humorale acceleree |
| JP7104027B2 (ja) | 2016-09-02 | 2022-07-20 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 淋菌に対するワクチン |
| US11447738B2 (en) | 2016-10-28 | 2022-09-20 | Vedanta Biosciences, Inc. | Methods and compositions for preserving bacteria |
| SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| CN110891599A (zh) * | 2017-03-31 | 2020-03-17 | 印度医学研究理事会 | 基于来自伤寒样沙门菌物种的两种不同菌株的外膜囊泡的肠热疫苗 |
| AU2018330322A1 (en) | 2017-09-08 | 2020-03-19 | Evelo Biosciences, Inc. | Bacterial extracellular vesicles |
| US10793865B2 (en) | 2018-06-05 | 2020-10-06 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Transferrable mechanism of generating inducible, BAR domain protein-mediated bacterial outer membrane extensions |
| EP3607967A1 (fr) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Polypeptides modifiés du méningocoque fhbp |
| US12128094B2 (en) | 2018-11-06 | 2024-10-29 | Glaxosmithkline Biologicals Sa | Immunogenic compositions comprising OMVs, an acellular pertussis antigen, a tetanus toxoid and a diphtheria toxoid |
| JP2022520999A (ja) * | 2019-02-22 | 2022-04-04 | エヴェロ バイオサイエンシズ,インコーポレーテッド | 細菌の膜調製物 |
| WO2021031270A1 (fr) * | 2019-08-22 | 2021-02-25 | 四川大学 | Vésicules de membrane bactérienne, et système de séparation et de préparation et méthode associée |
| CN110563829B (zh) * | 2019-09-17 | 2021-03-26 | 中国人民解放军国防科技大学 | 用于调控脂质体囊泡行为、功能的反光蛋白体系及其应用 |
| CA3155669A1 (fr) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Compositions de neisseria meningitidis et methodes associees |
| EP3799884A1 (fr) | 2019-10-01 | 2021-04-07 | GlaxoSmithKline Biologicals S.A. | Compositions immunogènes |
| IL300922A (en) | 2020-09-11 | 2023-04-01 | Glaxosmithkline Biologicals Sa | outer membrane vesicles |
| GB202115077D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Assay |
| WO2023097652A1 (fr) * | 2021-12-03 | 2023-06-08 | National Center For Nanoscience And Technology | Cellule modifiée et son application |
| GB202211033D0 (en) | 2022-07-28 | 2022-09-14 | Glaxosmithkline Biologicals Sa | Purification process |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
| US4707543A (en) * | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
| JPH01125328A (ja) | 1987-07-30 | 1989-05-17 | Centro Natl De Biopreparados | 髄膜炎菌ワクチン |
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| AU640118B2 (en) | 1988-12-19 | 1993-08-19 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur | Meningococcal class 1 outer-membrane protein vaccine |
| CA2006700A1 (fr) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Peptides synthetiques et leur utilisation comme porteurs universels pour la preparation de conjugats immunogenes convenant a la mise au point de vaccins synthetiques |
| WO1990014837A1 (fr) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Composition d'adjuvant comprenant une emulsion de gouttelettes d'huile d'une taille inferieure au micron |
| AU651949B2 (en) | 1989-07-14 | 1994-08-11 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| CU22302A1 (es) * | 1990-09-07 | 1995-01-31 | Cigb | Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales |
| ATE128628T1 (de) | 1990-08-13 | 1995-10-15 | American Cyanamid Co | Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff. |
| US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
| US5993826A (en) | 1993-03-02 | 1999-11-30 | Board Of Regents, The University Of Texas | Methods and compositions relating to useful antigens of moraxella catarrhalis |
| AU3630093A (en) | 1992-03-02 | 1993-10-05 | Biocine S.P.A. | Helicobacter pylori proteins useful for vaccines and diagnostics |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| FR2692592B1 (fr) * | 1992-06-19 | 1995-03-31 | Pasteur Merieux Serums Vacc | Fragments d'ADN codant pour les sous-unités du récepteur de la transferrine de Neisseria meningitidis et procédés les exprimant. |
| DE69313134T2 (de) | 1992-06-25 | 1998-02-26 | Smithkline Beecham Biolog | Adjuvantien enthaltende impfstoffzusammensetzung |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| NL9201716A (nl) | 1992-10-02 | 1994-05-02 | Nederlanden Staat | Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. |
| DK0624376T3 (da) | 1993-05-13 | 2000-07-24 | American Cyanamid Co | Fremstilling og anvendelse af LOS-udtømte ydre membranproteiner af gram-negative cocci |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| DK0710118T3 (da) * | 1994-04-20 | 1999-08-09 | Us Army | Vaccine mod infektioner med gram-negative bakterier |
| JPH10502365A (ja) | 1994-07-01 | 1998-03-03 | リカン・リミテッド | ヘリコバクタータンパク質およびワクチン |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| AU713040B2 (en) | 1994-07-15 | 1999-11-18 | University Of Iowa Research Foundation, The | Immunomodulatory oligonucleotides |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| US6180111B1 (en) * | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
| GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| BR9609882A (pt) | 1995-08-04 | 1999-07-27 | Univ Guelph | Vacina processos para preparar a mesma para tratar uma doença infecciosa para inserir uma molécula de ácido nucleico em uma célula de marcaç o para administrar um agente terapêutico a um hospedeiro e para triar um antígeno imunogênico de um patógeno uso de uma vesícula de membrana composição farmacêutica sistema de liberação de drogas e vesícula de membrana |
| EP0909323B1 (fr) | 1996-01-04 | 2007-02-28 | Novartis Vaccines and Diagnostics, Inc. | Bacterioferritine de helicobacter pilori |
| DE19630390A1 (de) | 1996-07-26 | 1998-01-29 | Chiron Behring Gmbh & Co | Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung |
| WO1998016247A1 (fr) | 1996-10-11 | 1998-04-23 | The Regents Of The University Of California | Conjugues polynucleotide immunostimulateur/molecule immunomodulatrice |
| ES2195317T3 (es) | 1997-01-30 | 2003-12-01 | Chiron Corp | Uso de microparticulas con antigeno adsorbido para estimular respuestas inmunitarias. |
| CA2281838A1 (fr) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | Utilisation d'acides nucleiques contenant des dinucleotides cpg non methyles dans le traitement des troubles associes aux lipopolysaccharides |
| AU753688B2 (en) | 1997-03-10 | 2002-10-24 | Ottawa Civic Loeb Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| EP1003531B1 (fr) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Procedes de preparation de constructions d'acides nucleiques |
| WO1998055609A1 (fr) | 1997-06-06 | 1998-12-10 | The Regents Of The University Of California | Inhibiteurs de l'activite de sequences immunostimulatrices de l'adn |
| GB9711964D0 (en) | 1997-06-09 | 1997-08-06 | Medical Res Council | Live attenuated vaccines |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| JP2001510169A (ja) * | 1997-07-17 | 2001-07-31 | ノース アメリカン ワクチン, インコーポレイテッド | B型髄膜炎菌性ポーリンおよびH.influenzae多糖体を含む免疫原性結合体 |
| DE69738472T2 (de) | 1997-08-21 | 2009-01-02 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Neue mutanten der gram-negativen mukosalen bakterien und ihre verwendung als impfstoffe |
| EP1279401B1 (fr) | 1997-09-05 | 2008-01-09 | GlaxoSmithKline Biologicals S.A. | Emulsions du type huile-dans-l'eau contenant des saponines |
| BR9813930A (pt) | 1997-11-06 | 2006-12-19 | Chiron Spa | antìgeno neisserial |
| KR20010032336A (ko) | 1997-11-21 | 2001-04-16 | 브랑디 빠스깔 | 클라미디아 뉴모니아 게놈 서열과 폴리펩티드, 이의 단편및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도 |
| GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
| KR100760221B1 (ko) | 1997-11-28 | 2007-10-30 | 세로노 제네틱스 인스티튜트 에스.에이. | 클라미디아 트라코마티스 게놈 서열과 폴리펩티드, 이의단편 및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도 |
| ATE446368T1 (de) | 1998-01-14 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| GB9806456D0 (en) * | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
| BR9909915A (pt) | 1998-04-09 | 2000-12-26 | Smithkline Beecham Biolog | Composições adjuvantes |
| MX343752B (es) | 1998-05-01 | 2016-11-22 | Novartis Vaccines & Diagnostics Inc | Antigenos de neisseria meningitidis y composiciones que los contienen. |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| BR9914374A (pt) * | 1998-10-09 | 2002-09-17 | Chiron Corp | Sequências genÈmicas de neisseria e métodos para seu uso |
| ES2284287T3 (es) | 1998-10-16 | 2007-11-01 | Glaxosmithkline Biologicals S.A. | Sistemas adyuvantes y vacunas. |
| GB9823978D0 (en) | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| EP1133572A4 (fr) | 1998-11-12 | 2005-06-15 | Univ California | Sequence genomique de chlamydia pneumoniae |
| GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| ATE413188T1 (de) * | 1999-02-05 | 2008-11-15 | Merck & Co Inc | Menschliche papillomavirus impfstoff- formulierungen |
| US7081244B2 (en) * | 1999-02-22 | 2006-07-25 | Health Protection Agency | Neisserial vaccine compositions and methods |
| DK1154791T3 (da) | 1999-02-22 | 2008-06-16 | Health Prot Agency | Neisseria-vaccinesammensætninger og fremgangsmåder |
| EP1154793B1 (fr) | 1999-02-26 | 2010-09-15 | Novartis Vaccines and Diagnostics, Inc. | Utilisation de systemes bioadhesifs et d'adjuvants pour l'administration mucosale d'antigenes |
| CA2366152A1 (fr) | 1999-03-19 | 2000-09-28 | Smithkline Beecham Biologicals S.A. | Vaccin |
| US6245568B1 (en) * | 1999-03-26 | 2001-06-12 | Merck & Co., Inc. | Human papilloma virus vaccine with disassembled and reassembled virus-like particles |
| WO2000061761A2 (fr) | 1999-04-09 | 2000-10-19 | Techlab, Inc. | Support proteique recombinant de la toxine a pour vaccins conjugues polysaccharides |
| DK1187629T3 (da) | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
| AUPQ005499A0 (en) * | 1999-04-30 | 1999-05-27 | Townsend, Roy Leslie | Printing process |
| NZ571167A (en) | 1999-04-30 | 2010-05-28 | Novartis Vaccines & Diagnostic | Fragments from Neisseria protein ORF 953 and their use in medicaments and diagnostic reagents |
| EP1179072A2 (fr) | 1999-05-19 | 2002-02-13 | Chiron S.P.A. | Compositions a base de combinaisons de neisseria |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| IL148671A0 (en) | 1999-09-24 | 2002-09-12 | Smithkline Beecham Biolog | Adjuvant comprising a polyxyethylene alkyl ether or ester and at least one nonionic surfactant |
| HK1049106A1 (zh) | 1999-09-24 | 2003-05-02 | Smithkline Beecham Biologicals S.A. | 聚氧化乙烯山梨糖酯和octooxynol的聯用做為佐劑和其在疫苗中的用途 |
| WO2001034642A2 (fr) | 1999-11-12 | 2001-05-17 | University Of Iowa Research Foundation | Commande de la synthese de membrane de neisseria |
| ES2588917T3 (es) | 2000-01-17 | 2016-11-07 | Glaxosmithkline Biologicals Sa | Vacuna de VME suplementada contra meningococo |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| GB0007433D0 (en) * | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Recombinant transferrin binding proteins |
| NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| ATE440861T1 (de) | 2000-07-03 | 2009-09-15 | Novartis Vaccines & Diagnostic | Immunisierung gegen chlamydia pneumoniae |
| GB0017149D0 (en) | 2000-07-12 | 2000-08-30 | Chiron Spa | Helicobacter pylori mutants |
| MXPA03000822A (es) * | 2000-07-27 | 2004-11-01 | Childrens Hosp & Res Ct Oak | Vacunas para proteccion de espectro amplio contra enfermedades causadas por neisseria meningitidis. |
| GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| WO2002026212A2 (fr) | 2000-09-28 | 2002-04-04 | Chiron Corporation | Compositions de microparticules et procede de fabrication desdites compositions |
| US7939087B2 (en) | 2000-10-27 | 2011-05-10 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from Streptococcus groups A & B |
| GB0103171D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| GB0103424D0 (en) | 2001-02-12 | 2001-03-28 | Chiron Spa | Gonococcus proteins |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0118249D0 (en) * | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| CN100350972C (zh) | 2001-07-26 | 2007-11-28 | 启龙股份公司 | 含有铝佐剂和组氨酸的疫苗 |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| GB0130123D0 (en) * | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| CN1674933B (zh) * | 2002-08-02 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗组合物 |
-
2002
- 2002-08-30 GB GBGB0220194.5A patent/GB0220194D0/en not_active Ceased
-
2003
- 2003-09-01 CN CN2011101128386A patent/CN102188700A/zh active Pending
- 2003-09-01 RU RU2005108994/15A patent/RU2325184C2/ru not_active IP Right Cessation
- 2003-09-01 ES ES03791150T patent/ES2289351T3/es not_active Expired - Lifetime
- 2003-09-01 SI SI200332269T patent/SI2258389T1/sl unknown
- 2003-09-01 PT PT03791150T patent/PT1534326E/pt unknown
- 2003-09-01 EP EP03791150A patent/EP1534326B1/fr not_active Revoked
- 2003-09-01 AU AU2003263534A patent/AU2003263534B2/en not_active Ceased
- 2003-09-01 DK DK07012893.9T patent/DK1864679T3/da active
- 2003-09-01 DK DK10179783.5T patent/DK2258389T3/da active
- 2003-09-01 BR BRPI0314094A patent/BRPI0314094A8/pt not_active IP Right Cessation
- 2003-09-01 JP JP2004532626A patent/JP2006503822A/ja not_active Withdrawn
- 2003-09-01 WO PCT/IB2003/004293 patent/WO2004019977A2/fr not_active Ceased
- 2003-09-01 DK DK03791150T patent/DK1534326T3/da active
- 2003-09-01 DE DE60314756T patent/DE60314756T2/de not_active Expired - Lifetime
- 2003-09-01 ES ES10179783T patent/ES2423019T3/es not_active Expired - Lifetime
- 2003-09-01 MX MXPA05002316A patent/MXPA05002316A/es active IP Right Grant
- 2003-09-01 US US10/526,113 patent/US20060166344A1/en not_active Abandoned
- 2003-09-01 EP EP07012893.9A patent/EP1864679B1/fr not_active Expired - Lifetime
- 2003-09-01 AT AT03791150T patent/ATE366117T1/de active
- 2003-09-01 EP EP10179783.5A patent/EP2258389B1/fr not_active Expired - Lifetime
- 2003-09-01 PT PT70128939T patent/PT1864679E/pt unknown
- 2003-09-01 EP EP10179782.7A patent/EP2258388B1/fr not_active Expired - Lifetime
- 2003-09-01 PT PT101797835T patent/PT2258389E/pt unknown
- 2003-09-01 CN CNA038237237A patent/CN1688334A/zh active Pending
- 2003-09-01 NZ NZ538673A patent/NZ538673A/en not_active IP Right Cessation
- 2003-09-01 CA CA2497165A patent/CA2497165C/fr not_active Expired - Fee Related
- 2003-09-01 ES ES10179782.7T patent/ES2520392T3/es not_active Expired - Lifetime
- 2003-09-01 EP EP10179787A patent/EP2258390A1/fr not_active Withdrawn
- 2003-09-01 ES ES07012893.9T patent/ES2483592T3/es not_active Expired - Lifetime
- 2003-09-01 SI SI200332378T patent/SI1864679T1/sl unknown
-
2007
- 2007-09-17 CY CY20071101197T patent/CY1107737T1/el unknown
-
2010
- 2010-03-23 JP JP2010067009A patent/JP2010150287A/ja not_active Withdrawn
-
2013
- 2013-03-29 JP JP2013072014A patent/JP5808358B2/ja not_active Expired - Fee Related
- 2013-07-04 LU LU92239C patent/LU92239I2/fr unknown
- 2013-07-31 FR FR13C0046C patent/FR13C0046I2/fr active Active
- 2013-09-02 CY CY20131100752T patent/CY1114570T1/el unknown
-
2014
- 2014-09-11 CY CY20141100736T patent/CY1115777T1/el unknown
-
2015
- 2015-06-01 US US14/727,248 patent/US20150258188A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1534326T3 (da) | Bakteriel ydre membran-vesikler | |
| JP2006503822A5 (fr) | ||
| NO963508L (no) | Urease-basert vaksine og behandling av Helicobacter-infeksjon | |
| DE60045034D1 (de) | Überstände von mesenchymstammzellen zur vorbeugung und behandlung von immunantworten in transplantationen | |
| NO20055817L (no) | Apparat og fremgangsmate for behandling av injeksjonsfluid. | |
| MY149398A (en) | Multivalent pcv2 immunogenic compositions and methods of producing such compositions | |
| CN104073537A (zh) | 一种利用复合蛋白酶制备活性胶原蛋白的方法 | |
| DK0909323T3 (da) | Helicobacter pylori-bakterioferritin | |
| CO5221126A1 (es) | Metodo parta la preparacion de ingredientes alimenticios proteinicos de soya e ingredientes asi obtenidos | |
| CN105131139B (zh) | 一种肺炎链球菌荚膜多糖的纯化方法 | |
| DK71686A (da) | Vaccine mod sygdomme foraarsaget af mikroorganismer, saasom mycoplasmaer, dens fremstilling og mikroorganisme-membraner som aktivt princip | |
| Fan et al. | rgpA DNA vaccine induces antibody response and prevents alveolar bone loss in experimental peri‐implantitis | |
| ATE356633T1 (de) | Vakzin für einen nicht typisierbaren haemophilus influenzae stamm | |
| CH662056A5 (fr) | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies. | |
| WO2002043651A3 (fr) | Methodes d'utilisation de lymphocytes t mis en culture et n'induisant pas de reaction du greffon contre l'hote (gvhd) pour traiter des maladies | |
| WO2024149109A1 (fr) | Procédé de détoxification de la toxine pertussique et vaccin combiné contre la diphtérie, le tétanos et la coqueluche acellulaire | |
| CN1279978C (zh) | 博代氏杆菌所产皮肤坏死毒素和类毒素的纯化方法 | |
| AU2003303319A1 (en) | Woodworking method and device | |
| CN118598936A (zh) | 水解角蛋白的制备工艺及其离心过滤装置 | |
| CN101412988A (zh) | 孔雀石绿等三苯基甲烷类染料降解酶TpmD的制备方法 | |
| CN120310873A (zh) | 一种抗衰抗氧化复合肽的制备方法和应用 | |
| CN116139329A (zh) | 胎盘来源的基质凝胶及其制备方法 | |
| HYUN et al. | Five Cases of Laser Goniopuncture after Deep Sclerectomy with Collagen implant | |
| Liang et al. | New Protocol to Treat Corneal Ulcer: 2 Years Retrospective Experience | |
| ZHANG et al. | Maxilla reconstruction with the free iliac osteomuscular flap and simultaneous osseointegrated implant embeding |