LV10949B - Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation - Google Patents

Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation Download PDF

Info

Publication number
LV10949B
LV10949B LVP-93-1042A LV931042A LV10949B LV 10949 B LV10949 B LV 10949B LV 931042 A LV931042 A LV 931042A LV 10949 B LV10949 B LV 10949B
Authority
LV
Latvia
Prior art keywords
formula
compound
preparation
hjih
compounds
Prior art date
Application number
LVP-93-1042A
Other languages
English (en)
Latvian (lv)
Other versions
LV10949A (lv
Inventor
Anna-Lena Ask
Rune Verner Sandberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of LV10949A publication Critical patent/LV10949A/xx
Publication of LV10949B publication Critical patent/LV10949B/lv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LVP-93-1042A 1989-12-21 1993-08-27 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation LV10949B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8904298A SE8904298D0 (sv) 1989-12-21 1989-12-21 New compounds
PCT/SE1990/000818 WO1991009845A1 (fr) 1989-12-21 1990-12-17 4-phenyle-4-piperidinecarboxamides substitues avec effet anesthesique et analgesique local et procedes pour leur preparation

Publications (2)

Publication Number Publication Date
LV10949A LV10949A (lv) 1995-12-20
LV10949B true LV10949B (en) 1996-06-20

Family

ID=20377821

Family Applications (2)

Application Number Title Priority Date Filing Date
LVP-93-1042A LV10949B (en) 1989-12-21 1993-08-27 Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
LV960262A LV5766B4 (lv) 1989-12-21 1996-07-17 Aizvietoti 4-fenil-4-piperidinkarboksamidi ar lokalu anestezejosu un analgetisku daribu ka ari to iegusanas metodes

Family Applications After (1)

Application Number Title Priority Date Filing Date
LV960262A LV5766B4 (lv) 1989-12-21 1996-07-17 Aizvietoti 4-fenil-4-piperidinkarboksamidi ar lokalu anestezejosu un analgetisku daribu ka ari to iegusanas metodes

Country Status (40)

Country Link
US (2) US5227389A (fr)
EP (1) EP0506778B1 (fr)
JP (1) JP2656152B2 (fr)
KR (1) KR0179382B1 (fr)
CN (1) CN1037841C (fr)
AT (1) ATE138650T1 (fr)
AU (1) AU647068B2 (fr)
BG (1) BG60912B1 (fr)
BR (1) BR1100379A (fr)
CA (1) CA2069608C (fr)
CZ (1) CZ278035B6 (fr)
DE (1) DE69027221T2 (fr)
DK (1) DK0506778T3 (fr)
DZ (1) DZ1468A1 (fr)
EG (1) EG19361A (fr)
ES (1) ES2087280T3 (fr)
FI (1) FI100881B (fr)
HK (1) HK22997A (fr)
HR (1) HRP920591B1 (fr)
HU (1) HU213110B (fr)
IE (1) IE74855B1 (fr)
IL (1) IL96636A (fr)
IS (1) IS1664B (fr)
LT (1) LT4005B (fr)
LV (2) LV10949B (fr)
NO (1) NO178858C (fr)
NZ (1) NZ236293A (fr)
PL (1) PL163591B1 (fr)
PT (1) PT96303B (fr)
RO (1) RO112864B1 (fr)
RU (1) RU2039043C1 (fr)
SA (1) SA91110209B1 (fr)
SE (1) SE8904298D0 (fr)
SG (1) SG46413A1 (fr)
SI (1) SI9012346B (fr)
SK (1) SK278283B6 (fr)
UA (1) UA26403A (fr)
WO (1) WO1991009845A1 (fr)
YU (1) YU48086B (fr)
ZA (1) ZA909903B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3916092B2 (ja) * 1993-09-17 2007-05-16 杏林製薬株式会社 イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) * 1994-02-11 1994-02-11 Astra Ab New compounds
SE9404438D0 (sv) * 1994-12-21 1994-12-21 Astra Ab New process
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
GB9600235D0 (en) * 1996-01-05 1996-03-06 Pfizer Ltd Therapeutic agents
DE19642591A1 (de) * 1996-10-15 1998-04-16 Basf Ag Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
RU2125878C1 (ru) * 1996-12-26 1999-02-10 Новокузнецкий научно-исследовательский химико-фармацевтический институт Анальгетическое средство
RU2117481C1 (ru) * 1997-07-15 1998-08-20 Государственный научно-исследовательский институт органической химии и технологии Анальгетическое средство и способ его приготовления
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US20020102291A1 (en) * 1997-12-15 2002-08-01 Noven Pharmaceuticals, Inc. Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
SE9803240D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
SE9803239D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab Composition for the treatment of acute pain
CA2443672C (fr) * 2001-04-12 2011-03-29 Pharmacopeia, Inc. Aryl et biaryl piperidines utilisees en tant qu'antagonistes de la mch
RU2203041C1 (ru) * 2001-12-27 2003-04-27 Закрытое акционерное общество "Брынцалов-А" Спазмолитические таблетки бралангин
ATE496028T1 (de) * 2002-02-08 2011-02-15 Ono Pharmaceutical Co Piperidinderivatverbindungen und arzneimittel, die diese verbindungen als wirkstoff enthalten
CN1744899A (zh) * 2002-12-13 2006-03-08 史密丝克莱恩比彻姆公司 作为ccr5拮抗剂的哌啶衍生物
US20100210633A1 (en) * 2006-10-12 2010-08-19 Epix Delaware, Inc. Carboxamide compounds and their use
AU2008335135A1 (en) 2007-12-11 2009-06-18 Cytopathfinder, Inc. Carboxamide compounds and their use as chemokine receptor agonists
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
EP3914246A1 (fr) 2019-01-22 2021-12-01 ICM (Institut du Cerveau et de la Moelle Épinière) Anesthésique local pour le traitement de symptômes neurologiques résultant de dysfonctionnements cérébraux

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE96980C1 (fr)
US2486796A (en) * 1943-06-25 1949-11-01 Ciba Pharm Prod Inc Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) * 1964-10-20 1967-08-01 Aldrich Chem Co Inc N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) * 1967-06-26 1970-11-10 Janssen Pharm 4-aryl-4-aminoalkoxy-piperidines
CH498836A (de) * 1968-12-20 1970-11-15 Geigy Ag J R Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) * 1968-12-30 1973-06-05 Ciba Geigy Corp Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) * 1971-10-21 1973-06-01 Synthelabo 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) * 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

Also Published As

Publication number Publication date
DK0506778T3 (da) 1996-10-07
EG19361A (en) 1994-12-30
EP0506778B1 (fr) 1996-05-29
HU9202044D0 (en) 1992-09-28
LV10949A (lv) 1995-12-20
SK658190A3 (en) 1996-08-07
PT96303A (pt) 1991-09-30
HU213110B (en) 1997-02-28
SK278283B6 (en) 1996-08-07
LTIP1731A (en) 1995-07-25
KR927003531A (ko) 1992-12-18
FI922806L (fi) 1992-06-17
JPH05502869A (ja) 1993-05-20
SA91110209B1 (ar) 2004-05-08
IE74855B1 (en) 1997-08-13
LT4005B (en) 1996-07-25
IL96636A (en) 1994-11-28
NO922380D0 (no) 1992-06-17
YU234690A (sh) 1993-10-20
CZ278035B6 (en) 1993-07-14
CZ658190A3 (en) 1993-01-13
DE69027221T2 (de) 1996-10-10
UA26403A (uk) 1999-08-30
LV5766B4 (lv) 1997-06-20
YU48086B (sh) 1997-01-08
RU2039043C1 (ru) 1995-07-09
SI9012346A (sl) 1998-08-31
FI922806A0 (fi) 1992-06-17
HRP920591A2 (en) 1997-08-31
SI9012346B (sl) 1999-08-31
BG96513A (bg) 1993-12-24
AU647068B2 (en) 1994-03-17
ATE138650T1 (de) 1996-06-15
NZ236293A (en) 1992-10-28
BR1100379A (pt) 1999-12-07
WO1991009845A1 (fr) 1991-07-11
HRP920591B1 (en) 1998-12-31
BG60912B1 (bg) 1996-06-28
JP2656152B2 (ja) 1997-09-24
DZ1468A1 (fr) 2004-09-13
IS1664B (is) 1997-07-04
IL96636A0 (en) 1991-09-16
CA2069608C (fr) 2001-07-10
PL288409A1 (en) 1991-12-02
SG46413A1 (en) 1998-02-20
CN1053605A (zh) 1991-08-07
HK22997A (en) 1997-02-27
US5227389A (en) 1993-07-13
LV5766A4 (lv) 1996-12-20
CN1037841C (zh) 1998-03-25
CA2069608A1 (fr) 1991-06-22
PL163591B1 (pl) 1994-04-29
ES2087280T3 (es) 1996-07-16
PT96303B (pt) 1998-07-31
NO178858C (no) 1996-06-19
EP0506778A1 (fr) 1992-10-07
NO922380L (no) 1992-06-17
NO178858B (no) 1996-03-11
SE8904298D0 (sv) 1989-12-21
RO112864B1 (ro) 1998-01-30
FI100881B (fi) 1998-03-13
DE69027221D1 (de) 1996-07-04
IE904534A1 (en) 1991-07-03
IS3659A7 (is) 1991-06-22
KR0179382B1 (ko) 1999-03-20
AU6978391A (en) 1991-07-24
HUT64518A (en) 1994-01-28
US5360805A (en) 1994-11-01
ZA909903B (en) 1991-08-28

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