MA28684B1 - 1-aza-bicyclo[3.3.1]nonanes - Google Patents

1-aza-bicyclo[3.3.1]nonanes

Info

Publication number
MA28684B1
MA28684B1 MA29564A MA29564A MA28684B1 MA 28684 B1 MA28684 B1 MA 28684B1 MA 29564 A MA29564 A MA 29564A MA 29564 A MA29564 A MA 29564A MA 28684 B1 MA28684 B1 MA 28684B1
Authority
MA
Morocco
Prior art keywords
substituted
unsubstituted
alkyl
formula
group
Prior art date
Application number
MA29564A
Other languages
English (en)
Inventor
Dominik Feuerbach
Werner Mueller
Bernard Lucien Roy
Thomas J Troxler
Konstanze Hurth
Mathias Frederiksen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA28684B1 publication Critical patent/MA28684B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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Abstract

L'invention concerne des dérivés de 1-aza-bicycloalkyle de formule (I), dans laquelle les substituants sont tels que définis dans la description, ainsi que des procédés de production de ces dérivés et leur utilisation dans des médicaments et des compositions pharmaceutiques. Formule (I), dans laquelle : A représente O ou N(R1) ; Y représente un groupe de formule (I), (2), (3), (4), (5) ou (6), dans laquelle la liaison gauche est fixée sur le groupe A et la liaison droite est fixée sur le groupe R ; R représente aryle C5-C10 substitué ou non substitué, hétéro-C5-C10aryle substitué ou non substitué, un groupe N(R1)(R4) OU un groupe N(R2)(CHP3R4) ; R1 représente hydrogène, alkyle C1-C4 ou CF3 ; R2 représente hydrogène, alkyle C1-C4 ou CF3 ; R3 représente hydrogène, alkyle C1-C4 ou CF3 ; R4 représente aryle C5-C10 substitué ou non substitué ou hétéroaryle C5-C10 substitué ou non substitué ; sous forme de base libre ou de sel d'addition acide.
MA29564A 2004-06-18 2006-12-28 1-aza-bicyclo[3.3.1]nonanes MA28684B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58102004P 2004-06-18 2004-06-18

Publications (1)

Publication Number Publication Date
MA28684B1 true MA28684B1 (fr) 2007-06-01

Family

ID=35045272

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29564A MA28684B1 (fr) 2004-06-18 2006-12-28 1-aza-bicyclo[3.3.1]nonanes

Country Status (32)

Country Link
US (3) US20070249657A1 (fr)
EP (2) EP2336129A1 (fr)
JP (1) JP4944772B2 (fr)
KR (3) KR101174173B1 (fr)
CN (1) CN1964968A (fr)
AR (1) AR049401A1 (fr)
AT (1) ATE506362T1 (fr)
AU (1) AU2005254689B2 (fr)
BR (1) BRPI0510940A (fr)
CA (1) CA2566155C (fr)
CY (1) CY1111528T1 (fr)
DE (1) DE602005027567D1 (fr)
DK (1) DK1761533T3 (fr)
EC (1) ECSP067053A (fr)
ES (1) ES2364971T3 (fr)
HR (1) HRP20110535T1 (fr)
IL (2) IL179611A (fr)
MA (1) MA28684B1 (fr)
MX (1) MXPA06014697A (fr)
MY (1) MY147262A (fr)
NO (1) NO20070339L (fr)
NZ (1) NZ551198A (fr)
PE (1) PE20060437A1 (fr)
PL (1) PL1761533T3 (fr)
PT (1) PT1761533E (fr)
RU (1) RU2445313C2 (fr)
SG (1) SG153834A1 (fr)
SI (1) SI1761533T1 (fr)
TN (1) TNSN06407A1 (fr)
TW (1) TWI370128B (fr)
WO (1) WO2005123732A1 (fr)
ZA (1) ZA200609255B (fr)

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BR112015016992A8 (pt) * 2013-01-15 2018-01-23 Novartis Ag uso de agonistas do receptor alfa 7 nicotínico de acetilcolina
JP7312749B2 (ja) 2017-08-04 2023-07-21 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングをモジュレートする方法および組成物
JP7551629B2 (ja) 2019-02-05 2024-09-17 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
WO2020163405A1 (fr) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Procédés et compositions pour moduler l'épissage
JP7603594B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物

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US20110034475A1 (en) 2011-02-10
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