MA30228B1 - Pipéridinoylpyrrolidines agonistes du récepteur de mélanocortine de type 4 - Google Patents
Pipéridinoylpyrrolidines agonistes du récepteur de mélanocortine de type 4Info
- Publication number
- MA30228B1 MA30228B1 MA31190A MA31190A MA30228B1 MA 30228 B1 MA30228 B1 MA 30228B1 MA 31190 A MA31190 A MA 31190A MA 31190 A MA31190 A MA 31190A MA 30228 B1 MA30228 B1 MA 30228B1
- Authority
- MA
- Morocco
- Prior art keywords
- piperidinoylpyrrolidines
- monomocortin
- type
- receptor agonist
- mcr4
- Prior art date
Links
- IOONOXRAIWLNPF-UHFFFAOYSA-N piperidin-1-yl(pyrrolidin-1-yl)methanone Chemical class C1CCCCN1C(=O)N1CCCC1 IOONOXRAIWLNPF-UHFFFAOYSA-N 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000336 melanocortin receptor agonist Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Pipéridinoylpyrrolidines agonistes du récepteur de mélanocortine de type 4 La présente invention concerne une catégorie d'agonistes du récepteur de mélanocortine MCR4, de formule générale (I), dans laquelle les variables et les substituants sont tels que définis dans le présent mémoire et, en particulier, des composés agonistes de MCR4 sélectifs, leur utilisation en médecine, en particulier dans le traitement d'un dysfonctionnement sexuel et de l'obésité, des intermédiaires utiles dans leur synthèse ainsi que des compositions les contenant.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77629506P | 2006-02-23 | 2006-02-23 | |
| US88784007P | 2007-02-02 | 2007-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA30228B1 true MA30228B1 (fr) | 2009-02-02 |
Family
ID=38169450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA31190A MA30228B1 (fr) | 2006-02-23 | 2008-08-22 | Pipéridinoylpyrrolidines agonistes du récepteur de mélanocortine de type 4 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8138188B2 (fr) |
| EP (1) | EP1989196B1 (fr) |
| KR (1) | KR101036981B1 (fr) |
| AP (1) | AP2008004602A0 (fr) |
| AU (1) | AU2007219236B2 (fr) |
| BR (1) | BRPI0708264A2 (fr) |
| CA (1) | CA2642922C (fr) |
| CR (1) | CR10219A (fr) |
| DK (1) | DK1989196T3 (fr) |
| EA (1) | EA200801738A1 (fr) |
| EC (1) | ECSP088688A (fr) |
| ES (1) | ES2402581T3 (fr) |
| IL (1) | IL193279A (fr) |
| MA (1) | MA30228B1 (fr) |
| ME (1) | MEP6808A (fr) |
| MX (1) | MX2008010899A (fr) |
| NO (1) | NO20083480L (fr) |
| RS (1) | RS20080371A (fr) |
| SG (1) | SG185849A1 (fr) |
| TN (1) | TNSN08337A1 (fr) |
| WO (1) | WO2007096763A2 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2019100A1 (fr) * | 2007-07-19 | 2009-01-28 | Santhera Pharmaceuticals (Schweiz) AG | Dérivés substitués d'hétéroarylpipéridine en tant que modulateurs du récepteur de la mélanocortine-4 |
| EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
| US9603062B2 (en) | 2007-11-16 | 2017-03-21 | Qualcomm Incorporated | Classifying access points using pilot identifiers |
| US8737295B2 (en) | 2007-11-16 | 2014-05-27 | Qualcomm Incorporated | Sector identification using sector parameters signatures |
| US8902867B2 (en) | 2007-11-16 | 2014-12-02 | Qualcomm Incorporated | Favoring access points in wireless communications |
| US8848656B2 (en) | 2007-11-16 | 2014-09-30 | Qualcomm Incorporated | Utilizing broadcast signals to convey restricted association information |
| EP2103614A1 (fr) * | 2008-03-18 | 2009-09-23 | Santhera Pharmaceuticals (Schweiz) AG | Dérivés d'imidazopyrimidine, d'imidazopyrazine et d' imidazopyridazine substitués en tant que modulateur de récepteur de la mélanocortine-4 |
| US8588773B2 (en) | 2008-08-04 | 2013-11-19 | Qualcomm Incorporated | System and method for cell search and selection in a wireless communication system |
| UA99555C2 (en) | 2008-11-12 | 2012-08-27 | Элджи Лайф Саенсез Лтд. | Melanocortin receptor agonists |
| EP2722045B1 (fr) | 2009-11-18 | 2016-07-06 | Helsinn Healthcare SA | Compositions pour traiter les nausées et vomissements à médiation centrale |
| HRP20140759T1 (hr) * | 2009-11-18 | 2014-10-24 | Helsinn Healthcare S.A. | Kompozicije za lijeäśenje središnje posredovane muäśnine i povraä†anja |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683704B1 (fr) | 2011-03-08 | 2014-12-17 | Sanofi | Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation |
| EP2766349B1 (fr) | 2011-03-08 | 2016-06-01 | Sanofi | Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| KR20180032585A (ko) | 2015-08-04 | 2018-03-30 | 아스테라스 세이야쿠 가부시키가이샤 | 피페라진 유도체 |
| EP3870292A4 (fr) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | Combinaison d'un inhibiteur de réabsorption spécifique de la sérotonine et d'un agoniste partiel du récepteur de la sérotonine 1a pour réduire la dyskinésie induite par l-dopa |
| PT4161927T (pt) | 2020-06-09 | 2024-10-08 | Pfizer | Compostos de espiro como antagonistas do recetor de melanocortina 4 e utilizações dos mesmos |
| CA3241470A1 (fr) | 2021-12-06 | 2023-06-15 | Pfizer Inc. | Antagonistes du recepteur 4 de la melanocortine et leurs utilisations |
| WO2025228895A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Indazoles et benzimidazoles à substitution hétaryle utilisés en tant qu'antagonistes de sting et leur utilisation en tant que médicament |
| WO2025228889A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Composés hétérocycliques monoaryliques utilisés en tant qu'antagonistes de sting et leur utilisation en tant que médicament |
| WO2025228900A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Indazoles substitués par arylamide et leur utilisation en tant que médicament |
| WO2025228902A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Acides hétérocycliques en tant qu'antagonistes de sting et leur utilisation en tant que médicament |
| US20250333398A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228899A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Autres composés hétérocycliques utilisés en tant qu'antagonistes de sting et leur utilisation en tant que médicament |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH507249A (de) | 1968-05-31 | 1971-05-15 | Sandoz Ag | Verfahren zur Herstellung von 2-Brom-a-ergokryptin |
| GB8531071D0 (en) | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
| US5274143A (en) | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| CA2098167C (fr) | 1992-06-24 | 2006-12-19 | Dorothea Isler | Aliments pour humains et animaux contenant un inhibiteur de la lipase |
| TW381025B (en) | 1993-08-05 | 2000-02-01 | Hoffmann La Roche | Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor |
| US5596106A (en) | 1994-07-15 | 1997-01-21 | Eli Lilly And Company | Cannabinoid receptor antagonists |
| DE4435477A1 (de) | 1994-10-04 | 1996-04-11 | Bayer Ag | Cycloalkano-indol- und -azaindol-derivate |
| US5521186A (en) | 1994-10-27 | 1996-05-28 | Janssen Pharmaceutica N.V. | Apolipoprotein-β synthesis inhibitors |
| WO1996013499A1 (fr) | 1994-10-27 | 1996-05-09 | Janssen Pharmaceutica N.V. | Inhibiteurs de synthese d'apolipoproteines-b |
| WO2000035298A1 (fr) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing-gum contenant des agents medicamenteux actifs |
| IL141769A0 (en) | 1998-09-11 | 2002-03-10 | Aventis Pharma Sa | Azetidine derivatives, preparation and medicines containing them |
| FR2789079B3 (fr) | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| CA2431800C (fr) | 2000-12-14 | 2014-07-08 | Amylin Pharmaceuticals, Inc. | Peptide yy et antagonistes de peptides yy destines au traitement des troubles du metabolisme |
| JP4104983B2 (ja) * | 2001-02-28 | 2008-06-18 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン−4受容体作動薬としてのアシル化ピペリジン誘導体 |
| DE60215132T2 (de) | 2001-02-28 | 2007-08-23 | Merck & Co., Inc. | Acylierte piperidin-derivate als melanocortin-4-rezeptor-agonisten |
| ATE284872T1 (de) | 2001-03-22 | 2005-01-15 | Solvay Pharm Bv | 4,5-dihydro-1h-pyrazolderivate mit cb1- antagonistischer wirkung |
| JP2005514008A (ja) | 2001-09-24 | 2005-05-19 | オレゴン ヘルス アンド サイエンス ユニバーシティー | 摂食行動を改変する薬剤をスクリーニングするための、弓状核におけるニューロンの評価方法 |
| US20050171161A1 (en) | 2002-03-06 | 2005-08-04 | Fong Tung M. | Method of treatment or prevention of obesity |
| PL375441A1 (en) | 2002-07-29 | 2005-11-28 | F.Hoffmann-La Roche Ag | Novel benzodioxoles |
| AU2003257145B2 (en) | 2002-08-02 | 2008-11-13 | Merck Sharp & Dohme Corp. | Substituted furo (2,3-b) pyridine derivatives |
| US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| MY134457A (en) | 2002-11-22 | 2007-12-31 | Merck & Co Inc | Substituted amides |
| US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7151097B2 (en) | 2003-11-07 | 2006-12-19 | Pfizer Inc. | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof |
| GB0402492D0 (en) | 2004-02-04 | 2004-03-10 | Pfizer Ltd | Pharmaceutically active compounds |
| US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
| EP1912968A1 (fr) | 2005-08-04 | 2008-04-23 | Pfizer Limited | Composes piperidinoyl-pyrrolidine et piperidinoyl-piperidine |
| US8592403B2 (en) | 2008-08-06 | 2013-11-26 | Pfizer Limited | Diazepine and diazocane compounds as MC4 agonists |
-
2007
- 2007-02-19 CA CA2642922A patent/CA2642922C/fr not_active Expired - Fee Related
- 2007-02-19 WO PCT/IB2007/000456 patent/WO2007096763A2/fr not_active Ceased
- 2007-02-19 DK DK07705650.5T patent/DK1989196T3/da active
- 2007-02-19 AU AU2007219236A patent/AU2007219236B2/en not_active Ceased
- 2007-02-19 KR KR1020087023101A patent/KR101036981B1/ko not_active Expired - Fee Related
- 2007-02-19 AP AP2008004602A patent/AP2008004602A0/xx unknown
- 2007-02-19 ES ES07705650T patent/ES2402581T3/es active Active
- 2007-02-19 SG SG2011037132A patent/SG185849A1/en unknown
- 2007-02-19 ME MEP-68/08A patent/MEP6808A/xx unknown
- 2007-02-19 EA EA200801738A patent/EA200801738A1/ru unknown
- 2007-02-19 US US12/280,444 patent/US8138188B2/en not_active Expired - Fee Related
- 2007-02-19 MX MX2008010899A patent/MX2008010899A/es active IP Right Grant
- 2007-02-19 BR BRPI0708264-9A patent/BRPI0708264A2/pt not_active Application Discontinuation
- 2007-02-19 EP EP07705650A patent/EP1989196B1/fr active Active
- 2007-02-19 RS RSP-2008/0371A patent/RS20080371A/sr unknown
-
2008
- 2008-08-06 IL IL193279A patent/IL193279A/en not_active IP Right Cessation
- 2008-08-11 NO NO20083480A patent/NO20083480L/no not_active Application Discontinuation
- 2008-08-19 CR CR10219A patent/CR10219A/es unknown
- 2008-08-21 EC EC2008008688A patent/ECSP088688A/es unknown
- 2008-08-22 TN TNP2008000337A patent/TNSN08337A1/fr unknown
- 2008-08-22 MA MA31190A patent/MA30228B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20083480L (no) | 2008-09-10 |
| ES2402581T3 (es) | 2013-05-06 |
| KR20080095918A (ko) | 2008-10-29 |
| KR101036981B1 (ko) | 2011-05-25 |
| DK1989196T3 (da) | 2013-04-15 |
| ECSP088688A (es) | 2008-10-31 |
| EP1989196A2 (fr) | 2008-11-12 |
| IL193279A0 (en) | 2009-02-11 |
| CA2642922C (fr) | 2011-08-02 |
| IL193279A (en) | 2012-12-31 |
| RS20080371A (sr) | 2009-07-15 |
| MX2008010899A (es) | 2008-11-27 |
| WO2007096763A2 (fr) | 2007-08-30 |
| WO2007096763A3 (fr) | 2007-10-18 |
| HK1126489A1 (en) | 2009-09-04 |
| EP1989196B1 (fr) | 2013-02-13 |
| EA200801738A1 (ru) | 2008-12-30 |
| US8138188B2 (en) | 2012-03-20 |
| CR10219A (es) | 2008-09-23 |
| AU2007219236A1 (en) | 2007-08-30 |
| AP2008004602A0 (en) | 2008-10-31 |
| TNSN08337A1 (fr) | 2009-12-29 |
| AU2007219236B2 (en) | 2012-06-21 |
| BRPI0708264A2 (pt) | 2011-05-24 |
| SG185849A1 (en) | 2012-12-28 |
| MEP6808A (xx) | 2010-02-10 |
| CA2642922A1 (fr) | 2007-08-30 |
| US20090036459A1 (en) | 2009-02-05 |
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