MA33832B1 - Isoquinolinones et quinazolinones substituées - Google Patents

Isoquinolinones et quinazolinones substituées

Info

Publication number
MA33832B1
MA33832B1 MA34976A MA34976A MA33832B1 MA 33832 B1 MA33832 B1 MA 33832B1 MA 34976 A MA34976 A MA 34976A MA 34976 A MA34976 A MA 34976A MA 33832 B1 MA33832 B1 MA 33832B1
Authority
MA
Morocco
Prior art keywords
isokinolinones
quinolones
alternative
medied
mdm4
Prior art date
Application number
MA34976A
Other languages
Arabic (ar)
English (en)
Inventor
Joerg Berghausen
Nicole Buschmann
Pascal Furet
François Gessier
Lisztwan Joanna Hergovich
Philipp Holzer
Edgar Jacoby
Joerg Kallen
Keiichi Masuya
Soldermann Carole Pissot
Haixia Ren
Stefan Stutz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA33832B1 publication Critical patent/MA33832B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C07D239/82—Oxygen atoms with an aryl radical attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Paints Or Removers (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES HÉTÉROCYCLES BICYCLIQUES CONTENANT DES ATOMES D'AZOTES SUBSTITUÉS DE FORMULE (I) : DANS LAQUELLE Z EST CH2 OU N-R4 ET X, R1, R2, R4, R6, R7 ET N SONT TELS QUE DÉFINIS DANS LA DESCRIPTION. CES COMPOSÉS SONT ADAPTÉS POUR LE TRAITEMENT D'UN TROUBLE OU D'UNE MALADIE MÉDIÉ/MÉDIÉE PAR L'ACTIVITÉ DE MDM2 ET/OU DE MDM4, OU DES VARIANTS DE CEUX-CI.
MA34976A 2009-12-22 2012-06-15 Isoquinolinones et quinazolinones substituées MA33832B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28899209P 2009-12-22 2009-12-22
CN2010078927 2010-11-19
PCT/EP2010/070364 WO2011076786A1 (fr) 2009-12-22 2010-12-21 Isoquinolinones et quinazolinones substituées

Publications (1)

Publication Number Publication Date
MA33832B1 true MA33832B1 (fr) 2012-12-03

Family

ID=43530866

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34976A MA33832B1 (fr) 2009-12-22 2012-06-15 Isoquinolinones et quinazolinones substituées

Country Status (41)

Country Link
US (2) US8440693B2 (fr)
EP (1) EP2516009B1 (fr)
JP (1) JP5542962B2 (fr)
KR (2) KR101473068B1 (fr)
AR (1) AR079663A1 (fr)
AU (1) AU2010334890B2 (fr)
BR (1) BR112012018412B1 (fr)
CA (1) CA2785340C (fr)
CL (1) CL2012001688A1 (fr)
CO (1) CO6561772A2 (fr)
CR (1) CR20120333A (fr)
DK (1) DK2516009T3 (fr)
DO (1) DOP2012000172A (fr)
EA (1) EA021126B1 (fr)
EC (1) ECSP12011990A (fr)
ES (1) ES2527001T3 (fr)
GE (1) GEP20146042B (fr)
GT (1) GT201200208A (fr)
HN (1) HN2012001332A (fr)
HR (1) HRP20141259T1 (fr)
IL (1) IL220492A (fr)
IN (1) IN2012DN05467A (fr)
JO (1) JO2974B1 (fr)
MA (1) MA33832B1 (fr)
MX (1) MX2012007336A (fr)
MY (1) MY156438A (fr)
NI (1) NI201200111A (fr)
NZ (1) NZ600716A (fr)
PE (1) PE20121510A1 (fr)
PH (1) PH12012501291A1 (fr)
PL (1) PL2516009T3 (fr)
PT (1) PT2516009E (fr)
RS (1) RS53676B1 (fr)
SG (1) SG181734A1 (fr)
SI (1) SI2516009T1 (fr)
SM (1) SMT201400193B (fr)
TN (1) TN2012000309A1 (fr)
TW (1) TWI629264B (fr)
UY (1) UY33131A (fr)
WO (1) WO2011076786A1 (fr)
ZA (1) ZA201204467B (fr)

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US9051279B2 (en) 2015-06-09
ECSP12011990A (es) 2012-09-28
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RS53676B1 (sr) 2015-04-30
US20130281473A1 (en) 2013-10-24
IL220492A0 (en) 2012-08-30
PT2516009E (pt) 2015-01-08
AU2010334890A1 (en) 2012-07-12
KR20120112618A (ko) 2012-10-11
JP5542962B2 (ja) 2014-07-09
WO2011076786A1 (fr) 2011-06-30
HK1170972A1 (en) 2013-03-15
US20110230457A1 (en) 2011-09-22
CA2785340A1 (fr) 2011-06-30
TWI629264B (zh) 2018-07-11
UY33131A (es) 2011-07-29
KR20140140602A (ko) 2014-12-09
US8440693B2 (en) 2013-05-14
HRP20141259T1 (hr) 2015-02-27
CL2012001688A1 (es) 2012-11-30
MY156438A (en) 2016-02-26
AR079663A1 (es) 2012-02-08
CA2785340C (fr) 2017-02-14
CO6561772A2 (es) 2012-11-15
EA021126B1 (ru) 2015-04-30
BR112012018412A2 (pt) 2016-04-19
GEP20146042B (en) 2014-02-10
AU2010334890B2 (en) 2014-04-17
JP2013515038A (ja) 2013-05-02
IL220492A (en) 2016-08-31
NI201200111A (es) 2012-08-17
DOP2012000172A (es) 2012-08-31
PL2516009T3 (pl) 2015-03-31
TN2012000309A1 (en) 2013-12-12
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KR101473068B1 (ko) 2014-12-15
BR112012018412B1 (pt) 2021-09-28

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