MA38227A1 - Nouveaux composés bicycliques et leur utilisation en tant qu'agents antibactériens et inhibiteurs de ?-lactamase - Google Patents

Nouveaux composés bicycliques et leur utilisation en tant qu'agents antibactériens et inhibiteurs de ?-lactamase

Info

Publication number
MA38227A1
MA38227A1 MA38227A MA38227A MA38227A1 MA 38227 A1 MA38227 A1 MA 38227A1 MA 38227 A MA38227 A MA 38227A MA 38227 A MA38227 A MA 38227A MA 38227 A1 MA38227 A1 MA 38227A1
Authority
MA
Morocco
Prior art keywords
lactamase
inhibitors
antibacterial agents
bicyclic compounds
novel bicyclic
Prior art date
Application number
MA38227A
Other languages
English (en)
Other versions
MA38227B1 (fr
Inventor
Samarendra N Maiti
Jehangir Khan
Dai Nguyen
Rong Ling
Original Assignee
Fedora Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fedora Pharmaceuticals Inc filed Critical Fedora Pharmaceuticals Inc
Publication of MA38227A1 publication Critical patent/MA38227A1/fr
Publication of MA38227B1 publication Critical patent/MA38227B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un composé de formule (i), dans laquelle m est hydrogène ou un cation formant un sel pharmaceutiquement acceptable; y est or1 ou nr2r3, et r1, r2, r3 et m sont tels que définis ici. L'invention concerne également des méthodes de traitement d'une infection bactérienne, des compositions pharmaceutiques, des complexes moléculaires et des procédés pour la préparation des composés.
MA38227A 2012-12-11 2012-12-11 Nouveaux composés bicycliques et leur utilisation en tant qu'agents antibactériens et inhibiteurs de ß-lactamase MA38227B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2012/002675 WO2014091268A1 (fr) 2012-12-11 2012-12-11 Nouveaux composés bicycliques et leur utilisation en tant qu'agents antibactériens et inhibiteurs de β-lactamase

Publications (2)

Publication Number Publication Date
MA38227A1 true MA38227A1 (fr) 2016-12-30
MA38227B1 MA38227B1 (fr) 2017-10-31

Family

ID=50933808

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38227A MA38227B1 (fr) 2012-12-11 2012-12-11 Nouveaux composés bicycliques et leur utilisation en tant qu'agents antibactériens et inhibiteurs de ß-lactamase

Country Status (18)

Country Link
EP (1) EP2931723B1 (fr)
JP (1) JP2016503000A (fr)
KR (1) KR20150093809A (fr)
CN (1) CN105873930B (fr)
AU (1) AU2012396338B2 (fr)
BR (1) BR112015013450A8 (fr)
CA (1) CA2893804C (fr)
CR (1) CR20150359A (fr)
EA (1) EA028633B1 (fr)
EC (1) ECSP15029636A (fr)
ES (1) ES2817785T3 (fr)
IL (1) IL239116B (fr)
MA (1) MA38227B1 (fr)
MX (1) MX2015007406A (fr)
PH (1) PH12015501303A1 (fr)
SG (1) SG11201504540TA (fr)
UA (1) UA111925C2 (fr)
WO (1) WO2014091268A1 (fr)

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IN2014MU00194A (fr) * 2014-01-21 2015-08-28 Wockhardt Ltd
CN105801579A (zh) * 2014-12-31 2016-07-27 卢来春 一种β-内酰胺酶抑制剂
WO2016120752A1 (fr) * 2015-01-28 2016-08-04 Wockhardt Limited Procédé de préparation de (2s, 5r)-n-(2-aminoéthoxy)-6-(sulfooxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
WO2017002087A1 (fr) * 2015-07-02 2017-01-05 Wockhardtlimited Composés bicycliques contenant de l'azote et leur utilisation dans le traitement d'infections bactériennes
EP3281942A4 (fr) 2015-09-16 2018-08-15 Xuanzhu Pharma Co., Ltd. Inhibiteur de ss-lactamase et son application
CA3000087A1 (fr) 2015-10-02 2017-04-06 Legochem Biosciences, Inc. Compositions et methodes pour inhiber la beta-lactamase
WO2017081615A1 (fr) * 2015-11-09 2017-05-18 Wockhardt Limited 7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1] octane contenant des composés et leur utilisation dans le traitement d'infections bactériennes
US10501464B2 (en) 2015-12-11 2019-12-10 Wockhardt Limited 7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide containing compounds and their use in treating bacterial infections
US11021514B2 (en) 2016-06-01 2021-06-01 Athira Pharma, Inc. Compounds
WO2017206948A1 (fr) * 2016-06-03 2017-12-07 南京明德新药研发股份有限公司 Nouveau diazabicyclo b-lactamase inhibiteurs
AU2017274131B2 (en) * 2016-06-03 2020-10-08 Qilu Pharmaceutical Co., Ltd. Novel β-lactamase inhibitors
WO2017216763A1 (fr) * 2016-06-17 2017-12-21 Wockhardt Limited Dérivés de n-phénylalcoxy-7-oxo-6-sulfooxy-1,6-diazabicyclo[3.2.1]octane-2-carboxamide et leur utilisation en tant qu'agents antibactériens
WO2017216764A1 (fr) * 2016-06-17 2017-12-21 Wockhardt Limited Dérivés de n-(alcanoyl)-7-oxo-6-sulfooxy-1,6-diazabicyclo[3.2.1]octane-2-carbonylhydrazide et leur utilisation comme agents antibactériens
RU2019130048A (ru) * 2017-03-02 2021-04-02 Вокхардт Лимитед Антибактериальные соединения
CN106831772B (zh) * 2017-03-04 2019-12-17 丽珠医药集团股份有限公司 一种阿维巴坦中间体的合成方法
WO2018203197A1 (fr) * 2017-05-02 2018-11-08 Wockhardt Limited Dérivés de diazabicyclooctane comprenant un groupe oxyimino destiné à être utilisé en tant qu'agents antibactériens
WO2018203194A1 (fr) * 2017-05-02 2018-11-08 Wockhardt Limited Dérivés de diazabicyclooctane comprenant un groupe d'ammonium quaternaire destiné à être utilisé en tant qu'agents antibactériens
CN107383034A (zh) * 2017-06-29 2017-11-24 上海药明康德新药开发有限公司 外消旋‑5‑(叔丁氧羰基)‑八氢呋喃并[3,2‑c]吡啶‑3a‑羧酸的合成方法
ES2946917T3 (es) 2017-07-21 2023-07-27 Antabio Sas Compuestos químicos
KR20200091395A (ko) * 2017-09-27 2020-07-30 페도라 파마슈티칼스 인코포레이티드 디아자비시클로옥탄 유도체의 결정형 및 그의 제조 방법
JP6974614B2 (ja) * 2017-12-01 2021-12-01 チールー ファーマシューティカル カンパニー、リミテッド β−ラクタマーゼ阻害剤の結晶形およびその製造方法
EP3572411A1 (fr) 2018-05-21 2019-11-27 Antabio SAS Dérivés de thiazole comme inhibiteurs de métallo-bêta-lactamases
SG11202101255UA (en) * 2018-08-09 2021-03-30 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
EP3608318A1 (fr) * 2018-08-09 2020-02-12 Antabio SAS Derives de diaazabicyclooctanone comme antibiotiques
CN113292499B (zh) * 2020-02-24 2024-05-28 齐鲁制药有限公司 一种β-内酰胺酶抑制剂的新制备方法及其中间体
CN117384169B (zh) * 2022-07-05 2025-10-17 福安药业集团重庆三禾兴医药科技有限公司 一类噻唑胺-二氮杂双环辛酮缀合衍生物及其用途

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BR112015003592B1 (pt) 2012-08-25 2020-04-14 Wockhardt Ltd derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas

Also Published As

Publication number Publication date
CA2893804A1 (fr) 2014-06-19
CN105873930B (zh) 2019-02-19
AU2012396338B2 (en) 2017-09-28
WO2014091268A1 (fr) 2014-06-19
SG11201504540TA (en) 2015-07-30
CR20150359A (es) 2015-08-20
IL239116B (en) 2019-05-30
KR20150093809A (ko) 2015-08-18
NZ709355A (en) 2017-09-29
IL239116A0 (en) 2015-07-30
EA201500544A1 (ru) 2015-12-30
BR112015013450A2 (pt) 2017-07-11
CN105873930A (zh) 2016-08-17
UA111925C2 (uk) 2016-06-24
EA028633B1 (ru) 2017-12-29
EP2931723B1 (fr) 2020-08-26
MA38227B1 (fr) 2017-10-31
JP2016503000A (ja) 2016-02-01
EP2931723A4 (fr) 2016-06-01
MX2015007406A (es) 2015-12-03
BR112015013450A8 (pt) 2019-10-08
PH12015501303A1 (en) 2015-08-24
CA2893804C (fr) 2021-05-18
AU2012396338A1 (en) 2015-07-16
ES2817785T3 (es) 2021-04-08
EP2931723A1 (fr) 2015-10-21
ECSP15029636A (es) 2016-01-29

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