MA40882A - Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf - Google Patents

Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf

Info

Publication number
MA40882A
MA40882A MA040882A MA40882A MA40882A MA 40882 A MA40882 A MA 40882A MA 040882 A MA040882 A MA 040882A MA 40882 A MA40882 A MA 40882A MA 40882 A MA40882 A MA 40882A
Authority
MA
Morocco
Prior art keywords
binding molecules
trimer
antigen binding
tnf family
molecules including
Prior art date
Application number
MA040882A
Other languages
English (en)
Other versions
MA40882B1 (fr
Inventor
Maria Amann
Peter Bruenker
Christina Claus
Koller Claudia Ferrara
Sandra Grau-Richards
Christian Klein
Viktor Levitsky
Ekkehard Moessner
Joerg Thomas Regula
Pablo Umaña
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54695680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40882(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA40882A publication Critical patent/MA40882A/fr
Publication of MA40882B1 publication Critical patent/MA40882B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Connection Of Plates (AREA)
  • Furniture Connections (AREA)

Abstract

L'invention concerne de nouvelles molécules de liaison à l'antigène comprenant un ligand trimérique de la famille du tnf comprenant (a) au moins une partie capable de se lier de manière spécifique à un antigène d'une cellule cible et (b) un premier et un second polypeptides liés l'un à l'autre par un pont disulfure, et caractérisés par le fait que le premier polypeptide comprend deux ectodomaines d'un membre de la famille des ligands du tnf ou des fragments de ce dernier, liés l'un à l'autre par un peptide lieur, et que le second polypeptide comprend un seul ectodomaine dudit membre de la famille des ligands du tnf ou un fragment de ce dernier.
MA40882A 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf MA40882B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14193260 2014-11-14
EP15183736 2015-09-03
EP15188142 2015-10-02
PCT/EP2015/076528 WO2016075278A1 (fr) 2014-11-14 2015-11-13 Molécules de liaison à l'antigène comprenant un ligand trimèrique de la famille du tnf

Publications (2)

Publication Number Publication Date
MA40882A true MA40882A (fr) 2017-10-04
MA40882B1 MA40882B1 (fr) 2020-05-29

Family

ID=54695680

Family Applications (2)

Application Number Title Priority Date Filing Date
MA40882A MA40882B1 (fr) 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
MA053242A MA53242A (fr) 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA053242A MA53242A (fr) 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf

Country Status (29)

Country Link
US (6) US10392445B2 (fr)
EP (3) EP3738609B1 (fr)
JP (2) JP6873901B2 (fr)
KR (3) KR20250158074A (fr)
CN (4) CN120574325A (fr)
AU (3) AU2015345024B2 (fr)
CL (2) CL2017001000A1 (fr)
CO (1) CO2017003212A2 (fr)
CR (1) CR20170194A (fr)
DK (2) DK3489256T3 (fr)
EA (1) EA037557B1 (fr)
ES (2) ES2788979T3 (fr)
HR (2) HRP20200679T1 (fr)
HU (2) HUE054122T2 (fr)
IL (2) IL282922B (fr)
LT (2) LT3224275T (fr)
MA (2) MA40882B1 (fr)
MX (2) MX391388B (fr)
MY (1) MY191428A (fr)
PE (2) PE20221909A1 (fr)
PH (1) PH12017500892B1 (fr)
PL (2) PL3224275T3 (fr)
PT (1) PT3224275T (fr)
RS (2) RS61870B1 (fr)
SG (1) SG11201703597TA (fr)
SI (2) SI3224275T1 (fr)
TW (2) TWI757803B (fr)
UA (1) UA125577C2 (fr)
WO (1) WO2016075278A1 (fr)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
UA119320C2 (uk) 2013-02-26 2019-06-10 Рош Глікарт Аг Активуюча т-клітини біспецифічна антигензв'язувальна молекула
KR20240122922A (ko) 2013-03-27 2024-08-13 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
EP4105236A1 (fr) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anticorps contre tl1a (tnfsf15) pour le traitement des maladies inflammatoires de l'intestin
DK3489256T3 (da) 2014-11-14 2021-05-25 Hoffmann La Roche Antigenbindende molekyler omfattende en TNF-familieligandtrimer
MA41460A (fr) 2015-02-03 2017-12-12 Oncomed Pharm Inc Agents de liaison à la tnfrsf et leurs utilisations
EP3973980A1 (fr) 2015-03-31 2022-03-30 F. Hoffmann-La Roche AG Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
AR106188A1 (es) * 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
MA43017A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf
KR20180073561A (ko) * 2015-10-02 2018-07-02 에프. 호프만-라 로슈 아게 이중특이적 항-ceaxcd3 t 세포 활성화 항원 결합 분자
EP3913000A1 (fr) * 2015-10-02 2021-11-24 F. Hoffmann-La Roche AG Anti-cd19xcd3 molécules bispécifiques de liaison à l'antigène activant des lymphocytes t
SMT202100506T1 (it) 2015-10-02 2021-11-12 Hoffmann La Roche Anticorpi bispecifici specifici per pd1 e tim3
KR102761077B1 (ko) * 2015-10-02 2025-02-04 에프. 호프만-라 로슈 아게 높은 친화성을 갖는 항-인간 cd19 항체
US10988543B2 (en) 2015-11-11 2021-04-27 Opi Vi—Ip Holdco Llc Humanized anti-tumor necrosis factor alpha receptor 2 (anti-TNFR2) antibodies and methods of use thereof to elicit an immune response against a tumor
AR107303A1 (es) 2016-01-08 2018-04-18 Hoffmann La Roche Métodos de tratamiento de cánceres positivos para ace utilizando antagonistas de unión a eje pd-1 y anticuerpos biespecíficos anti-ace / anti-cd3, uso, composición, kit
CN109462996A (zh) 2016-03-17 2019-03-12 西达-赛奈医疗中心 通过rnaset2诊断炎性肠病的方法
JP7285076B2 (ja) * 2016-05-11 2023-06-01 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｔｎｆファミリーリガンドトリマーとテネイシン結合部分とを含む抗原結合分子
EP3243836A1 (fr) * 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG Molécules de liaison à un antigène contenant un trimère d'un ligand de la famille du tnf fusionné en terminaison c
EP3243832A1 (fr) * 2016-05-13 2017-11-15 F. Hoffmann-La Roche AG Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf et un fragment de liaison pd1
JP7213180B2 (ja) 2016-10-19 2023-01-26 エフ．ホフマン－ラ ロシュ アーゲー 免疫コンジュゲートを製造するための方法
CN110121509B (zh) 2016-10-26 2024-05-07 西达-赛奈医疗中心 中和抗tl1a单克隆抗体
IL267284B2 (en) * 2016-12-19 2023-03-01 Hoffmann La Roche Combination therapy with a targeted 4-bb1 agonist (cd137)
KR102692708B1 (ko) 2016-12-20 2024-08-07 에프. 호프만-라 로슈 아게 항-cd20/항-cd3 이중특이성 항체 및 4-1bb(cd137) 작용물질의 병용 요법
EP3565843A1 (fr) 2017-01-03 2019-11-13 H. Hoffnabb-La Roche Ag Molécules bispécifiques de liaison à l'antigène comprenant un clone 20h4.9 anti-4-1bb
PT3565828T (pt) 2017-01-05 2022-02-08 Kahr Medical Ltd Proteína de fusão sirp1 alfa-41bbl e seus métodos de utilização
WO2018127916A1 (fr) 2017-01-05 2018-07-12 Kahr Medical Ltd. Protéine de fusion pd1-cd70 et ses procédés d'utilisation
HRP20230937T1 (hr) 2017-01-05 2023-11-24 Kahr Medical Ltd. Pd1-41bbl fuzijski protein i metode korištenja istog
US20200291089A1 (en) * 2017-02-16 2020-09-17 Elstar Therapeutics, Inc. Multifunctional molecules comprising a trimeric ligand and uses thereof
WO2018178055A1 (fr) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf
WO2018178076A1 (fr) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf
KR20190121816A (ko) 2017-04-03 2019-10-28 에프. 호프만-라 로슈 아게 항-pd-1 항체와 돌연변이 il-2 또는 il-15의 면역접합체
MA49039A (fr) 2017-04-04 2020-02-12 Hoffmann La Roche Nouvelles molécules bispécifiques de liaison à l'antigène capables de se lier spécifiquement à cd40 et à fap
PL3606955T3 (pl) 2017-04-05 2025-02-24 F. Hoffmann-La Roche Ag Przeciwciała dwuswoiste swoiście wiążące się z PD1 i LAG3
EP3615564A1 (fr) * 2017-04-24 2020-03-04 Alexion Pharmaceuticals, Inc. Protéines de fusion d'inhibiteur de cellules immunitaires d'anticorps
AU2018281306B2 (en) 2017-06-07 2025-04-17 Spark Therapeutics, Inc. Enhancing agents for improved cell transfection and/or rAAV vector production
CN111246884A (zh) * 2017-11-01 2020-06-05 豪夫迈·罗氏有限公司 新颖的含有tnf家族配体三聚体的抗原结合分子
EP3502140A1 (fr) * 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Thérapie de combinaison d'agonistes d'icos ciblés contre la tumeur avec des molécules bispécifiques à cellules t
JP6996825B2 (ja) * 2018-01-15 2022-01-17 アイ－エムエービー バイオファーマ ユーエス リミテッド 修飾ＣκおよびＣＨ１ドメイン
TWI841551B (zh) * 2018-03-13 2024-05-11 瑞士商赫孚孟拉羅股份公司 使用靶向4-1bb (cd137)之促效劑的組合療法
IL277174B2 (en) * 2018-03-13 2025-12-01 Hoffmann La Roche Therapeutic combination of 4-1 bb agonists with anti-cd20 antibodies
WO2019197600A1 (fr) * 2018-04-13 2019-10-17 F. Hoffmann-La Roche Ag Molécules de liaison à l'antigène ciblant her2 comprenant 4-1bbl
MA52366A (fr) 2018-04-25 2021-03-03 Prometheus Biosciences Inc Anticorps anti-tl1a optimisés
CN112424228B (zh) * 2018-07-04 2024-08-09 豪夫迈·罗氏有限公司 新型双特异性激动性4-1bb抗原结合分子
KR20210044220A (ko) * 2018-07-11 2021-04-22 카 메디컬 리미티드 SIRPalpha-4-1BBL 변이체 융합 단백질 및 이의 사용 방법
SG11202013170RA (en) * 2018-07-11 2021-01-28 Kahr Medical Ltd Pd1-4-1bbl variant fusion protein and methods of use thereof
PE20211863A1 (es) 2018-10-01 2021-09-21 Hoffmann La Roche Moleculas de union a antigeno biespecificas que comprenden el clon 212 anti-fap
TWI839395B (zh) * 2018-10-09 2024-04-21 瑞士商Ｎｕｍａｂ治療公司 靶向cd137的抗體及其使用方法
WO2020127618A1 (fr) 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Molécules de liaison à l'antigène cd28 agonistes de ciblage de tumeurs
AU2020289080A1 (en) 2019-06-04 2021-12-23 Molecular Partners Ag Multispecific proteins
KR20220044266A (ko) * 2019-06-12 2022-04-07 옵시디안 테라퓨틱스, 인크. 조정 가능한 조절을 위한 ca2 조성물 및 방법
HRP20250475T1 (hr) 2019-06-26 2025-06-06 F. Hoffmann - La Roche Ag Stanične linije sisavaca s deaktivacijom gena sirt-1
WO2020260329A1 (fr) 2019-06-26 2020-12-30 F. Hoffmann-La Roche Ag Fusion d'un anticorps se liant à cea et 4-1bbl
AR119382A1 (es) 2019-07-12 2021-12-15 Hoffmann La Roche Anticuerpos de pre-direccionamiento y métodos de uso
PH12022550978A1 (en) 2019-10-24 2023-10-09 Cedars Sinai Medical Center Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof
EP4087866A1 (fr) * 2020-01-09 2022-11-16 F. Hoffmann-La Roche AG Nouvelles molécules de liaison à l'antigène contenant un trimère de 4-1bbl
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
CN113234139A (zh) * 2020-04-17 2021-08-10 百奥赛图江苏基因生物技术有限公司 Tnfsf9基因人源化的非人动物及其构建方法和应用
EP4149964A2 (fr) 2020-05-15 2023-03-22 Apogenix AG Modulateurs immunitaires multi-spécifiques
TWI852680B (zh) 2020-06-19 2024-08-11 瑞士商赫孚孟拉羅股份公司 與 cd3 及 cd19 結合之抗體
EP4178985A1 (fr) 2020-07-10 2023-05-17 F. Hoffmann-La Roche AG Anticorps se liant à des cellules cancéreuses et ciblant ces cellules avec des radionucléides
KR20230066552A (ko) * 2020-07-24 2023-05-16 에프. 호프만-라 로슈 아게 항체-다량체-융합체의 발현 방법
EP4277705A1 (fr) 2021-01-12 2023-11-22 F. Hoffmann-La Roche AG Anticorps fragmentés se liant à des cellules cancéreuses et ciblant ces cellules avec des radionucléides
WO2022152701A1 (fr) 2021-01-13 2022-07-21 F. Hoffmann-La Roche Ag Polythérapie
WO2022189377A1 (fr) 2021-03-09 2022-09-15 F. Hoffmann-La Roche Ag Polythérapie d'immunoconjugués variants d'il-2 ciblant pd-1 et de molécules de liaison fap/4-1bb
WO2022243261A1 (fr) 2021-05-19 2022-11-24 F. Hoffmann-La Roche Ag Molécules de liaison à l'antigène cd40 agonistes ciblant cea
IL308660A (en) * 2021-05-21 2024-01-01 Beigene Switzerland Gmbh Multispecific antibodies directed against CEA and against 137CD and methods of using them
KR20240015671A (ko) * 2021-06-01 2024-02-05 얀센 바이오테크 인코포레이티드 항-cd79b 항체에 대한 항-이디오타입 항체
EP4148067A1 (fr) * 2021-09-08 2023-03-15 F. Hoffmann-La Roche AG Procédé d'expression d'une fusion anticorps-multimère
JP2024540174A (ja) 2021-11-01 2024-10-31 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｈｌａ－ａ２／ｗｔ１×ｃｄ３二重特異性抗体および４－１ｂｂ（ｃｄ１３７）アゴニストを用いたがんの治療
WO2023088889A1 (fr) 2021-11-16 2023-05-25 Apogenix Ag Ligand cd137
WO2023088876A1 (fr) 2021-11-16 2023-05-25 Apogenix Ag Modulateurs immunitaires multi-spécifiques
WO2023110788A1 (fr) 2021-12-14 2023-06-22 F. Hoffmann-La Roche Ag Traitement du cancer à l'aide d'un anticorps bispécifique hla-a2/mage-a4 x cd3 et d'un agoniste de 4-1bb (cd137)
CN114349869B (zh) * 2021-12-20 2023-09-26 上海恩凯细胞技术有限公司 一种双特异性的nk细胞激动剂及制备方法和应用
CN114426585B (zh) * 2022-02-15 2023-10-03 广东香雪干细胞再生医学科技有限公司 融合蛋白及其表达细胞株与应用
CN116462769A (zh) * 2022-04-02 2023-07-21 广东东阳光药业有限公司 一种嵌合受体及其应用
CN114805564B (zh) * 2022-06-10 2023-06-06 郑州大学 特异性识别SARS-CoV-2 S蛋白NTD区域的单克隆抗体及应用
CN119998330A (zh) 2022-09-15 2025-05-13 艾维迪治疗知识产权有限公司 用于刺激nk细胞的多特异性抗原结合蛋白及其用途
CN120152989A (zh) 2022-11-03 2025-06-13 豪夫迈·罗氏有限公司 抗cd19/抗cd28双特异性抗体的组合疗法
CN116574189A (zh) 2023-01-30 2023-08-11 北京智仁美博生物科技有限公司 针对人il-36r和/或人il-1r3的多种抗体及其用途
CN120826234A (zh) 2023-03-06 2025-10-21 豪夫迈·罗氏有限公司 抗EGFRvIII/抗CD3抗体与肿瘤靶向性4-1BB激动剂的组合疗法
WO2024188966A1 (fr) 2023-03-13 2024-09-19 F. Hoffmann-La Roche Ag Traitement du cancer à l'aide d'un anticorps bispécifique anti-hla-g/anti-cd3 et d'un agoniste de 4-1bb (cd137)
CN118894934A (zh) 2023-05-05 2024-11-05 北京智仁美博生物科技有限公司 抗人il-15的抗体及其用途
CN119552258B (zh) 2023-09-01 2025-11-07 北京智仁美博生物科技有限公司 结合hla-a02/mage-a4复合体的多种抗体及其用途
TW202540200A (zh) 2023-12-01 2025-10-16 美商基利科學股份有限公司 抗ｆａｐ－ｌｉｇｈｔ融合蛋白及其用途
WO2025140212A1 (fr) * 2023-12-26 2025-07-03 Laekna Therapeutics Shanghai Co., Ltd. Agents de liaison multispécifiques comprenant des anticorps anti-protéine d'activation des fibroblastes (fap) et un ou plusieurs pièges à ligands monovalents et leurs utilisations
WO2025191133A1 (fr) 2024-03-15 2025-09-18 Avidicure Ip B.V. Mutéines d'il-21, protéines de fusion les comprenant et leurs utilisations
WO2025191137A1 (fr) * 2024-03-15 2025-09-18 Avidicure Ip B.V. Conjugués de protéines de liaison à l'antigène spécifiques de trop2 et de cytokines
WO2025191136A1 (fr) 2024-03-15 2025-09-18 Avidicure Ip B.V. Mutéines de domaine extracellulaire de ligand 4-1 bb, protéines de fusion les comprenant et leurs utilisations

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1096187A (fr) 1977-04-18 1981-02-24 Souhei Monden Traduction non-disponible
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
FI903489A0 (fi) 1988-11-11 1990-07-10 Medical Res Council Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
EP0940468A1 (fr) 1991-06-14 1999-09-08 Genentech, Inc. Domaine variable d'un anticorps humanisé
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
DE69333807T2 (de) 1992-02-06 2006-02-02 Chiron Corp., Emeryville Marker für krebs und biosynthetisches bindeprotein dafür
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
ES2244066T3 (es) 1997-06-24 2005-12-01 Genentech, Inc. Procedimiento y composiciones de glicoproteinas galactosiladas.
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
EP1028751B1 (fr) 1997-10-31 2008-12-31 Genentech, Inc. Compositions renfermant des glycoformes de glycoproteine et methodes afferentes
AU760562B2 (en) 1997-12-05 2003-05-15 Scripps Research Institute, The Humanization of murine antibody
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
ES2434961T5 (es) 1998-04-20 2018-01-18 Roche Glycart Ag Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
DE60022369T2 (de) 1999-10-04 2006-05-18 Medicago Inc., Sainte Foy Verfahren zur regulation der transkription von fremden genen in gegenwart von stickstoff
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
ES2637801T3 (es) 2000-04-11 2017-10-17 Genentech, Inc. Anticuerpos multivalentes y usos de los mismos
CA2421447C (fr) 2000-09-08 2012-05-08 Universitat Zurich Groupes de proteines a domaines de repetition comprenant des modules de repetition
RU2321630C2 (ru) 2001-08-03 2008-04-10 Гликарт Биотекнолоджи АГ Гликозилированные антитела (варианты), обладающие повышенной антителозависимой клеточной цитотоксичностью
US20030157108A1 (en) 2001-10-25 2003-08-21 Genentech, Inc. Glycoprotein compositions
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
US7432063B2 (en) 2002-02-14 2008-10-07 Kalobios Pharmaceuticals, Inc. Methods for affinity maturation
US20070010658A1 (en) 2002-10-29 2007-01-11 Holtet Thor L Trimeric binding proteins for trimeric cytokines
US20060235201A1 (en) 2003-02-06 2006-10-19 Roman Kischel Enduring T cell response
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
ATE416190T1 (de) 2003-07-04 2008-12-15 Affibody Ab Polypeptide mit bindungsaffinität für her2
AU2003275958A1 (en) 2003-08-25 2005-03-10 Pieris Proteolab Ag Muteins of tear lipocalin
ES2672640T3 (es) 2003-11-05 2018-06-15 Roche Glycart Ag Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas
JP5006651B2 (ja) 2003-12-05 2012-08-22 ブリストル−マイヤーズ スクウィブ カンパニー ２型血管内皮増殖因子受容体の阻害剤
RU2386638C2 (ru) 2004-03-31 2010-04-20 Дженентек, Инк. Гуманизированные анти-тфр-бета-антитела
CN1942483B (zh) 2004-04-13 2012-09-26 弗·哈夫曼-拉罗切有限公司 抗p型选凝素抗体
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
KR101270829B1 (ko) 2004-09-23 2013-06-07 제넨테크, 인크. 시스테인 유전자조작 항체 및 접합체
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
AU2013263717B2 (en) 2005-05-06 2016-05-19 Providence Health & Services - Oregon Trimeric OX40L-immunoglobulin fusion protein and methods of use
AU2011265482B2 (en) * 2005-05-06 2013-08-29 Providence Health & Services - Oregon Trimeric OX40L-immunoglobulin fusion protein and methods of use
EP1736482A1 (fr) 2005-06-20 2006-12-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Ligand recombinant trimeric de 4-1BB
DE102005036542A1 (de) 2005-08-03 2007-02-08 Universität Stuttgart CTL-Prodrug
JP5825756B2 (ja) 2006-08-14 2015-12-02 ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． Ｃｄ１９を標的とする最適化抗体
EP1958957A1 (fr) 2007-02-16 2008-08-20 NascaCell Technologies AG Polypeptide comprenant un partie caractéristique des protéines appellées "Knottins"
EP2009022A1 (fr) 2007-06-26 2008-12-31 Apogenix GmbH Ligands trimériques avec activité améliorée (tenascine)
GB0718843D0 (en) 2007-09-26 2007-11-07 Cancer Rec Tech Ltd Materials and methods relating to modifying the binding of antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
SI2235064T1 (sl) 2008-01-07 2016-04-29 Amgen Inc. Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov
ES2571879T3 (es) * 2008-07-21 2016-05-27 Apogenix Ag Moléculas de una sola cadena de TNFSF
WO2010037395A2 (fr) * 2008-10-01 2010-04-08 Dako Denmark A/S Multimères de mhc dans des vaccins et la surveillance immunitaire contre le cancer
MX2012002014A (es) 2009-08-17 2012-06-13 Roche Glycart Ag Inmunoconjugados dirigidos.
CA2773515C (fr) 2009-09-29 2015-04-28 Roche Glycart Ag Anticorps agonistes bispecifiques du recepteur de mort
CA3253628A1 (en) 2010-03-05 2025-11-29 The Johns Hopkins University Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
WO2011147834A1 (fr) 2010-05-26 2011-12-01 Roche Glycart Ag Anticorps contre cd19 et utilisations associées
SG187746A1 (en) 2010-08-13 2013-03-28 Roche Glycart Ag Anti-fap antibodies and methods of use
US8552024B2 (en) 2010-08-13 2013-10-08 Hoffman-La Roche Inc. Azacyclic compounds
US9266938B2 (en) 2011-02-10 2016-02-23 Roche Glycart Ag Mutant interleukin-2 polypeptides
BR112013024574B1 (pt) 2011-03-29 2022-08-09 Roche Glycart Ag Anticorpo e uso do anticorpo
US9822179B2 (en) 2011-04-01 2017-11-21 Universitat Stuttgart Recombinant TNF ligand family member polypeptides with antibody binding domain and uses therefor
JP2013055204A (ja) 2011-09-02 2013-03-21 Toshiba Corp 半導体記憶装置
MY174248A (en) 2012-04-30 2020-04-01 Biocon Ltd Targeted/immunomodulatory fusion proteins and methods for making same
PE20150645A1 (es) 2012-08-08 2015-05-11 Roche Glycart Ag Proteinas de fusion de interleuquina 10 y usos de las mismas
WO2014116846A2 (fr) * 2013-01-23 2014-07-31 Abbvie, Inc. Procédés et compositions pour moduler une réponse immunitaire
UA119320C2 (uk) * 2013-02-26 2019-06-10 Рош Глікарт Аг Активуюча т-клітини біспецифічна антигензв'язувальна молекула
UA118028C2 (uk) 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
KR20160005345A (ko) 2013-05-07 2016-01-14 에프. 호프만-라 로슈 아게 삼량체성 항원 결합 분자
RU2016135788A (ru) 2014-02-06 2018-03-07 Ф.Хоффманн-Ля Рош Аг Иммуноконъюгаты интерлейкина 10
UA117289C2 (uk) 2014-04-02 2018-07-10 Ф. Хоффманн-Ля Рош Аг Мультиспецифічне антитіло
US9718870B2 (en) 2014-05-29 2017-08-01 Medimmune, Llc OX40L fusion proteins and uses thereof
TWI742423B (zh) 2014-05-29 2021-10-11 美商宏觀基因股份有限公司 特異性結合多種癌症抗原的三特異性結合分子和其使用方法
DK3489256T3 (da) 2014-11-14 2021-05-25 Hoffmann La Roche Antigenbindende molekyler omfattende en TNF-familieligandtrimer
EP3973980A1 (fr) 2015-03-31 2022-03-30 F. Hoffmann-La Roche AG Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
KR102761077B1 (ko) 2015-10-02 2025-02-04 에프. 호프만-라 로슈 아게 높은 친화성을 갖는 항-인간 cd19 항체
US20170129962A1 (en) 2015-10-02 2017-05-11 Hoffmann-La Roche Inc. Multispecific antibodies
EP3913000A1 (fr) 2015-10-02 2021-11-24 F. Hoffmann-La Roche AG Anti-cd19xcd3 molécules bispécifiques de liaison à l'antigène activant des lymphocytes t
MA43017A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf
AU2016334623A1 (en) 2015-10-07 2018-02-15 F. Hoffmann-La Roche Ag Bispecific antibodies with tetravalency for a costimulatory TNF receptor
EP3231813A1 (fr) 2016-03-29 2017-10-18 F. Hoffmann-La Roche AG Molécules de liaison d'antigène costimulantes trimères contenant un ligand de la famille du tnf
EP3243836A1 (fr) 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG Molécules de liaison à un antigène contenant un trimère d'un ligand de la famille du tnf fusionné en terminaison c
JP7285076B2 (ja) 2016-05-11 2023-06-01 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｔｎｆファミリーリガンドトリマーとテネイシン結合部分とを含む抗原結合分子
EP3243832A1 (fr) 2016-05-13 2017-11-15 F. Hoffmann-La Roche AG Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf et un fragment de liaison pd1
CN109791067B (zh) 2016-07-08 2021-09-07 豪夫迈·罗氏有限公司 用于处理实验室样品的装置、实验室自动化系统和用于对实验室样品进行移液的方法
IL267284B2 (en) 2016-12-19 2023-03-01 Hoffmann La Roche Combination therapy with a targeted 4-bb1 agonist (cd137)
KR102692708B1 (ko) 2016-12-20 2024-08-07 에프. 호프만-라 로슈 아게 항-cd20/항-cd3 이중특이성 항체 및 4-1bb(cd137) 작용물질의 병용 요법
EP3565843A1 (fr) 2017-01-03 2019-11-13 H. Hoffnabb-La Roche Ag Molécules bispécifiques de liaison à l'antigène comprenant un clone 20h4.9 anti-4-1bb
WO2018178055A1 (fr) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf
WO2018178076A1 (fr) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf
MA49039A (fr) 2017-04-04 2020-02-12 Hoffmann La Roche Nouvelles molécules bispécifiques de liaison à l'antigène capables de se lier spécifiquement à cd40 et à fap
CN111246884A (zh) 2017-11-01 2020-06-05 豪夫迈·罗氏有限公司 新颖的含有tnf家族配体三聚体的抗原结合分子
MY205342A (en) 2017-11-01 2024-10-16 Hoffmann La Roche Bispecific 2+1 contorsbodies
TWI841551B (zh) 2018-03-13 2024-05-11 瑞士商赫孚孟拉羅股份公司 使用靶向4-1bb (cd137)之促效劑的組合療法
IL277174B2 (en) 2018-03-13 2025-12-01 Hoffmann La Roche Therapeutic combination of 4-1 bb agonists with anti-cd20 antibodies
WO2019197600A1 (fr) 2018-04-13 2019-10-17 F. Hoffmann-La Roche Ag Molécules de liaison à l'antigène ciblant her2 comprenant 4-1bbl
CN112424228B (zh) 2018-07-04 2024-08-09 豪夫迈·罗氏有限公司 新型双特异性激动性4-1bb抗原结合分子
PE20211863A1 (es) 2018-10-01 2021-09-21 Hoffmann La Roche Moleculas de union a antigeno biespecificas que comprenden el clon 212 anti-fap
CN112654641A (zh) 2018-10-01 2021-04-13 豪夫迈·罗氏有限公司 具有与cd40的三价结合的双特异性抗原结合分子
EP3952996A1 (fr) 2019-04-12 2022-02-16 F. Hoffmann-La Roche AG Molécules bispécifiques de liaison à un antigène comprenant des mutéines de lipocalines
WO2020260329A1 (fr) 2019-06-26 2020-12-30 F. Hoffmann-La Roche Ag Fusion d'un anticorps se liant à cea et 4-1bbl
EP4087866A1 (fr) 2020-01-09 2022-11-16 F. Hoffmann-La Roche AG Nouvelles molécules de liaison à l'antigène contenant un trimère de 4-1bbl
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap

Also Published As

Publication number Publication date
IL251317A0 (en) 2017-05-29
EP3489256A1 (fr) 2019-05-29
PH12017500892B1 (en) 2023-08-18
HUE049982T2 (hu) 2020-11-30
CN113372434B (zh) 2024-06-04
JP6873901B2 (ja) 2021-05-19
SI3224275T1 (sl) 2020-07-31
EP3224275B1 (fr) 2020-03-04
KR102877243B1 (ko) 2025-10-29
AU2020264337B2 (en) 2021-12-02
AU2015345024A1 (en) 2017-04-20
CO2017003212A2 (es) 2017-09-20
TW202041527A (zh) 2020-11-16
EP3224275A1 (fr) 2017-10-04
JP7184938B2 (ja) 2022-12-06
RS61870B1 (sr) 2021-06-30
US11267903B2 (en) 2022-03-08
US20200247904A1 (en) 2020-08-06
KR20170085552A (ko) 2017-07-24
US12441812B2 (en) 2025-10-14
EA037557B1 (ru) 2021-04-14
AU2022201144A1 (en) 2022-03-17
MA40882B1 (fr) 2020-05-29
ES2788979T3 (es) 2020-10-23
HUE054122T2 (hu) 2021-08-30
KR20230146133A (ko) 2023-10-18
CN113372434A (zh) 2021-09-10
CN114634570B (zh) 2025-05-06
TWI713474B (zh) 2020-12-21
CN120574325A (zh) 2025-09-02
TWI757803B (zh) 2022-03-11
MX380253B (es) 2025-03-12
CN108064237B (zh) 2022-02-11
EP3738609B1 (fr) 2025-06-18
PE20170896A1 (es) 2017-07-12
US20250101135A1 (en) 2025-03-27
NZ767674A (en) 2024-07-05
SI3489256T1 (sl) 2021-08-31
KR102588377B1 (ko) 2023-10-12
US11306154B2 (en) 2022-04-19
HK1255482A1 (zh) 2019-08-16
PE20221909A1 (es) 2022-12-23
TW201629094A (zh) 2016-08-16
KR20250158074A (ko) 2025-11-05
AU2022201144B2 (en) 2025-03-06
PH12017500892A1 (en) 2017-11-06
US10392445B2 (en) 2019-08-27
US20190382507A1 (en) 2019-12-19
EP3489256B1 (fr) 2021-03-17
HRP20200679T1 (hr) 2020-07-24
IL282922B (en) 2022-08-01
SG11201703597TA (en) 2017-06-29
LT3489256T (lt) 2021-06-10
EA201791057A1 (ru) 2017-10-31
PL3489256T3 (pl) 2021-08-23
DK3489256T3 (da) 2021-05-25
RS60201B1 (sr) 2020-06-30
EP3738609C0 (fr) 2025-06-18
CA2963718A1 (fr) 2016-05-19
AU2015345024B2 (en) 2020-10-15
IL251317B (en) 2021-05-31
PL3224275T3 (pl) 2020-09-07
CL2017001000A1 (es) 2018-01-12
CR20170194A (es) 2017-07-10
JP2018503356A (ja) 2018-02-08
UA125577C2 (uk) 2022-04-27
WO2016075278A1 (fr) 2016-05-19
HRP20210739T1 (hr) 2021-06-25
MX391388B (es) 2025-03-21
MX2020012798A (es) 2022-04-07
EP3738609A1 (fr) 2020-11-18
MY191428A (en) 2022-06-27
NZ730933A (en) 2024-02-23
US20220259327A1 (en) 2022-08-18
JP2021097674A (ja) 2021-07-01
ES2871045T3 (es) 2021-10-28
CN114634570A (zh) 2022-06-17
BR112017009006A2 (pt) 2018-04-10
MX2017006250A (es) 2017-11-17
US20220259326A1 (en) 2022-08-18
MA53242A (fr) 2021-06-23
IL282922A (en) 2021-06-30
AU2020264337A1 (en) 2021-01-28
LT3224275T (lt) 2020-05-25
DK3224275T3 (da) 2020-05-04
CN108064237A (zh) 2018-05-22
PT3224275T (pt) 2020-05-04
CL2019003728A1 (es) 2020-07-17
NZ767672A (en) 2024-02-23
US20160200833A1 (en) 2016-07-14

Similar Documents

Publication Publication Date Title
MA40882A (fr) Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
PH12018502367A1 (en) Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
MX2022015847A (es) Proteinas de union a cd123 y composiciones y metodos relacionados.
MA40801B2 (fr) Anticorps anti-cd3, anticorps anti-cd123 et anticorps bispécifiques se liant spécifiquement à cd3 et/ou cd123
MY195993A (en) Antibodies and Antibody Fragments for Site-Specific Conjugation
MX356433B (es) Polipéptidos de fusión con domino de proteína ácida del suero, y métodos de uso de los mismos.
PE20211272A1 (es) POLIPEPTIDOS DE IL-22 Y PROTEINAS DE FUSION DE IL-22 Fc Y METODOS DE USO
EA201790438A1 (ru) Антигенсвязывающие белки, которые связываются с cxcr5
MX2020003503A (es) Proteinas de union al antigeno del receptor de oncostatina m.
PE20170768A1 (es) Anticuerpos de union a protofibrillas ab mejorados
MA38797A1 (fr) Protéine de fusion thérapeutique
MX2017001038A (es) Variantes de proteina de unión al factor h y metodos de uso de estas.
MX2017005467A (es) Polipéptidos de fusión de serpina y métodos para utilizar los mismos.
CY1120803T1 (el) Πρωτεϊνες δεσμευσης με αντιγονο ειδικες για το συστατικο ρ αμυλοειδους ορου
MX2018005831A (es) Gradientes de ph-sal opuestos para separaciones de proteina mejoradas.
HK1258507A1 (zh) 改进的p2x7受体结合剂和包含其的多肽
DE602006020333D1 (de) Multimere fc-rezeptor-polypeptide
MX2021004684A (es) Anticuerpos especificos para apoj glucosilada y usos de los mismos.
MA47671B1 (fr) Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
WO2017089781A3 (fr) Peptides
MX2020002643A (es) Variantes relacionadas con el receptor de inmunoglobulina interleucina 1 simple (sigirr) y usos de estas.
MA38497B1 (fr) Polypeptides d'il-22 et protéines de fusion fc il-22 et leurs procédés d'utilisation
TH1801005983A (th) นีโอแอนติเจน และวิธีของการใช้สิ่งเหล่านั้น