MA43000B1 - Polythérapie pour le traitement de tumeurs malignes - Google Patents

Polythérapie pour le traitement de tumeurs malignes

Info

Publication number
MA43000B1
MA43000B1 MA43000A MA43000A MA43000B1 MA 43000 B1 MA43000 B1 MA 43000B1 MA 43000 A MA43000 A MA 43000A MA 43000 A MA43000 A MA 43000A MA 43000 B1 MA43000 B1 MA 43000B1
Authority
MA
Morocco
Prior art keywords
treatment
combination therapy
malignant tumors
combination
idh1
Prior art date
Application number
MA43000A
Other languages
English (en)
Other versions
MA43000A (fr
Inventor
Samuel Agresta
Krishnan Viswanadhan
Jorge Dimartino
Vivek Saroj Chopra
Kyle Macbeth
Robert Knight
Laurie Kenvin
Qiang Xu
Original Assignee
Celgene Corp
Les Laboratoires Servier Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp, Les Laboratoires Servier Sas filed Critical Celgene Corp
Publication of MA43000A publication Critical patent/MA43000A/fr
Publication of MA43000B1 publication Critical patent/MA43000B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des méthodes et des compositions pour le traitement de cancers chez des patients présentant une mutation de idh1 au moyen d'une combinaison d'un inhibiteur d'une enzyme idh1 mutante et d'un agent de déméthylation d'adn.
MA43000A 2015-10-15 2016-10-14 Polythérapie pour le traitement de tumeurs malignes MA43000B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562242282P 2015-10-15 2015-10-15
PCT/US2016/057042 WO2017066571A1 (fr) 2015-10-15 2016-10-14 Polythérapie pour le traitement de tumeurs malignes

Publications (2)

Publication Number Publication Date
MA43000A MA43000A (fr) 2021-05-12
MA43000B1 true MA43000B1 (fr) 2021-11-30

Family

ID=58518368

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43000A MA43000B1 (fr) 2015-10-15 2016-10-14 Polythérapie pour le traitement de tumeurs malignes

Country Status (28)

Country Link
US (2) US10653710B2 (fr)
EP (1) EP3362066B1 (fr)
JP (1) JP7033061B2 (fr)
KR (1) KR102699521B1 (fr)
CN (1) CN108697698B (fr)
AU (1) AU2016338557B2 (fr)
CA (1) CA3002068A1 (fr)
CL (1) CL2018000943A1 (fr)
CY (1) CY1124951T1 (fr)
DK (1) DK3362066T3 (fr)
EA (1) EA039829B1 (fr)
ES (1) ES2897959T3 (fr)
HR (1) HRP20211790T1 (fr)
HU (1) HUE057263T2 (fr)
IL (1) IL258685B (fr)
LT (1) LT3362066T (fr)
MA (1) MA43000B1 (fr)
MD (1) MD3362066T2 (fr)
MX (1) MX386735B (fr)
PL (1) PL3362066T3 (fr)
PT (1) PT3362066T (fr)
RS (1) RS62829B1 (fr)
SG (2) SG10202111435UA (fr)
SI (1) SI3362066T1 (fr)
SM (1) SMT202100658T1 (fr)
UA (1) UA123400C2 (fr)
WO (1) WO2017066571A1 (fr)
ZA (1) ZA201803166B (fr)

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US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
WO2015003360A2 (fr) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs méthodes d'utilisation
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
KR20240010105A (ko) 2014-03-14 2024-01-23 아지오스 파마슈티컬스 아이엔씨. 치료적으로 활성인 화합물의 약제학적 조성물
SG11201803088PA (en) 2015-10-15 2018-05-30 Agios Pharmaceuticals Inc Combination therapy for treating malignancies
PT3362066T (pt) 2015-10-15 2021-11-16 Celgene Corp Terapia de combinação para tratar malignidades
TWI821189B (zh) 2017-06-12 2023-11-11 法商施維雅藥廠 使用組合療法治療腦腫瘤之方法
WO2019025256A1 (fr) * 2017-08-01 2019-02-07 Bayer Aktiengesellschaft Combinaison d'inhibiteurs de midh1 et d'agents d'hypométhylation (ahm) d'adn
WO2019099653A1 (fr) * 2017-11-16 2019-05-23 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs procédés d'utilisation
US10980788B2 (en) * 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
MX2021000068A (es) * 2018-07-06 2021-03-25 Agios Pharmaceuticals Inc Formas y composiciones farmaceuticas de ivosidenib.
CN109224061B (zh) * 2018-11-16 2022-01-07 上海市肺科医院 化合物ag120或其药学上可接受的盐在制备预防或治疗结核病的药物中的用途
BR112021025537A2 (pt) 2019-06-20 2022-03-03 Celgene Quanticel Res Inc Azacitidina em combinação com venetoclax, gilteritinibe, midostaurina ou outros compostos para o tratamento de leucemia ou síndrome mielodisplásica
GB201912411D0 (en) * 2019-08-29 2019-10-16 Johnson Matthey Plc Crystalline forms of ivosidenib
US12168005B2 (en) 2019-10-07 2024-12-17 University Hospitals Cleveland Medical Center Methods for treating wild type isocitrate dehydrogenase 1 cancers
GB2590601B (en) * 2019-11-13 2024-01-31 Thermo Fisher Scient Bremen Gmbh Method of mass spectrometry
CN115335060B (zh) 2020-03-23 2024-11-12 伊莱利利公司 使用突变idh抑制剂的组合疗法

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