MA51291A - Protéines de fusion il-2 fc modifiées - Google Patents

Protéines de fusion il-2 fc modifiées

Info

Publication number
MA51291A
MA51291A MA051291A MA51291A MA51291A MA 51291 A MA51291 A MA 51291A MA 051291 A MA051291 A MA 051291A MA 51291 A MA51291 A MA 51291A MA 51291 A MA51291 A MA 51291A
Authority
MA
Morocco
Prior art keywords
modified
fusion proteins
fusion
proteins
Prior art date
Application number
MA051291A
Other languages
English (en)
Inventor
Matthew J Bernett
John Desjarlais
Rumana Rashid
Suzanne Schubbert
Rajat Varma
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of MA51291A publication Critical patent/MA51291A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MA051291A 2017-12-19 2018-11-30 Protéines de fusion il-2 fc modifiées MA51291A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762607850P 2017-12-19 2017-12-19
US201862675070P 2018-05-22 2018-05-22

Publications (1)

Publication Number Publication Date
MA51291A true MA51291A (fr) 2020-10-28

Family

ID=65009801

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051291A MA51291A (fr) 2017-12-19 2018-11-30 Protéines de fusion il-2 fc modifiées

Country Status (12)

Country Link
US (3) US11319355B2 (fr)
EP (1) EP3728302A1 (fr)
JP (2) JP7765181B2 (fr)
KR (1) KR102722731B1 (fr)
CN (1) CN111655718B (fr)
AU (2) AU2018390418B2 (fr)
CA (1) CA3086199A1 (fr)
IL (1) IL275426B2 (fr)
MA (1) MA51291A (fr)
MX (1) MX2020006322A (fr)
SG (1) SG11202005732XA (fr)
WO (1) WO2019125732A1 (fr)

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US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
EP3728302A1 (fr) * 2017-12-19 2020-10-28 Xencor, Inc. Protéines de fusion il-2 fc modifiées
CN112638406B (zh) 2018-06-22 2025-04-22 科优基因公司 白介素-2变体及其使用方法
TWI791894B (zh) 2018-09-21 2023-02-11 大陸商信達生物製藥（蘇州）有限公司 新型白介素２及其用途
TW202110885A (zh) 2019-05-20 2021-03-16 美商潘迪恩治療公司 靶向ＭＡｄＣＡＭ之免疫耐受性
CN114245802B (zh) 2019-06-20 2024-10-15 石药集团巨石生物制药有限公司 修饰的il-2蛋白、peg偶联物及其用途
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MX2022001971A (es) * 2019-08-15 2022-05-11 Cytimm Therapeutics Inc Polipeptidos de interleucina 2 (il-2) modificados, conjugados y usos de los mismos.
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TW202136317A (zh) 2019-12-20 2021-10-01 美商再生元醫藥公司 新穎之ｉｌ２促效劑及其使用方法（二）
US11633488B2 (en) 2020-01-10 2023-04-25 Bright Peak Therapeutics Ag Modified IL-2 polypeptides and uses thereof
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WO2022009123A1 (fr) * 2020-07-09 2022-01-13 Eutilex Co., Ltd. Variants d'il-2
TW202406932A (zh) 2020-10-22 2024-02-16 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
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KR20250007039A (ko) * 2020-12-23 2025-01-13 머크 샤프 앤드 돔 엘엘씨 자가면역 및 염증성 질환을 치료하기 위한 il-2 뮤테인
TW202317623A (zh) 2021-06-14 2023-05-01 美商再生元醫藥公司 基於il2之治療劑及其使用方法
AU2022307460A1 (en) * 2021-07-09 2024-01-04 Bright Peak Therapeutics Ag Checkpoint inhibitors conjugated to il-2, and uses thereof
CA3222359A1 (fr) * 2021-07-09 2023-01-12 Bright Peak Therapeutics Ag Conjugues d'inhibiteurs de point de controle avec il-2, et leurs utilisations
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JP2024527629A (ja) * 2021-07-22 2024-07-25 ユニバーシティ オブ ダンディー 治療用ムテイン
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TWI875131B (zh) * 2022-08-16 2025-03-01 國立陽明交通大學 介白素-2變異體及其於治療癌症的用途
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CN118359730A (zh) * 2023-01-17 2024-07-19 上海君赛生物科技有限公司 包含细胞因子的靶向型融合蛋白
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WO2024193670A1 (fr) * 2023-03-21 2024-09-26 弗维塔生物制药（新加坡）有限公司 Préparation contenant un immunoconjugué anti-pd-1/il-2 mutante
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