MEP89008A - Novel cyclosporin analog microemulsion preconcentrates - Google Patents

Novel cyclosporin analog microemulsion preconcentrates

Info

Publication number: MEP89008A
Authority: ME; Montenegro
Prior art keywords: microemulsion preconcentrates; novel cyclosporin; cyclosporin analog; cyclosporin; analog microemulsion
Prior art date: 2001-10-19

Application number

MEP-890/08A

Other languages

Bosnian (bs)

English (en)

Croatian (hr)

Inventor

Selvaraj Naicker

Randall W Yatscoff

Robert T Foster

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-19

Filing date

2002-10-17

Publication date

2011-12-20

2002-10-17 Application filed filed Critical

2011-12-20 Publication of MEP89008A publication Critical patent/MEP89008A/xx

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 6
239000004530 micro-emulsion Substances 0.000 title 1
229930105110 Cyclosporin A Natural products 0.000 abstract 3
108010036949 Cyclosporine Proteins 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
229960001265 ciclosporin Drugs 0.000 abstract 2
238000009472 formulation Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Biochemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Dispersion Chemistry (AREA)
Rheumatology (AREA)
Neurology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Endocrinology (AREA)
Cardiology (AREA)

MEP-890/08A 2001-10-19 2002-10-17 Novel cyclosporin analog microemulsion preconcentrates MEP89008A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US34620101P	2001-10-19	2001-10-19
US37059702P	2002-04-05	2002-04-05
PCT/CA2002/001561 WO2003032949A1 (en)	2001-10-19	2002-10-17	Novel cyclosporin analog microemulsion preconcentrates

Publications (1)

Publication Number	Publication Date
MEP89008A true MEP89008A (en)	2011-12-20

Family

ID=26994747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-890/08A MEP89008A (en)	2001-10-19	2002-10-17	Novel cyclosporin analog microemulsion preconcentrates

Country Status (28)

Country	Link
US (5)	US7060672B2 (pl)
EP (2)	EP2116228A1 (pl)
JP (3)	JP2005506990A (pl)
KR (1)	KR100978836B1 (pl)
CN (1)	CN1274294C (pl)
AR (1)	AR036852A1 (pl)
AT (1)	ATE437629T1 (pl)
AU (1)	AU2002333098B2 (pl)
BR (1)	BR0213661A (pl)
CA (1)	CA2461730C (pl)
CO (1)	CO5580835A2 (pl)
DE (1)	DE60233150D1 (pl)
DK (1)	DK1435910T3 (pl)
ES (1)	ES2330625T3 (pl)
HR (1)	HRP20040354B1 (pl)
IL (3)	IL160761A0 (pl)
MA (1)	MA26221A1 (pl)
ME (1)	MEP89008A (pl)
MX (1)	MXPA04003623A (pl)
MY (1)	MY145753A (pl)
NO (1)	NO20042028L (pl)
NZ (1)	NZ531946A (pl)
PL (1)	PL206018B1 (pl)
PT (1)	PT1435910E (pl)
RU (1)	RU2317067C2 (pl)
TN (1)	TNSN04070A1 (pl)
WO (1)	WO2003032949A1 (pl)
ZA (1)	ZA200402268B (pl)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2116228A1 (en) *	2001-10-19	2009-11-11	Isotechnika Inc.	Novel cyclosporin analog microemulsion preconcentrates
JP2006524232A (ja) *	2003-03-17	2006-10-26	アルバニーモレキュラーリサーチインコーポレーティッド	新規サイクロスポリン
GB0307440D0 (en) *	2003-03-31	2003-05-07	Novartis Ag	Organic compounds
US20050256097A1 (en) *	2004-05-11	2005-11-17	Kosan Biosciences, Inc.	Pharmaceutical solution formulations containing 17-AAG
EP1804823A4 (en) *	2004-09-29	2010-06-09	Amr Technology Inc	NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS
JP2008514701A (ja) *	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
US7361636B2 (en)	2004-10-06	2008-04-22	Amr Technology, Inc.	Cyclosporin alkynes and their utility as pharmaceutical agents
WO2008121096A1 (en) *	2005-05-19	2008-10-09	The Board Of Governors For Higher Education	Monitoring cyclosporine in saliva
EP2001439A2 (en) *	2006-03-07	2008-12-17	Novavax, Inc.	Nanoemulsions of poorly soluble pharmaceutical active ingredients and methods of making the same
US10137083B2 (en)	2006-03-07	2018-11-27	SGN Nanopharma Inc	Ophthalmic preparations
US11311477B2 (en)	2006-03-07	2022-04-26	Sgn Nanopharma Inc.	Ophthalmic preparations
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
JP2010508357A (ja) *	2006-10-31	2010-03-18	ワイスエルエルシー	ホスホリパーゼ酵素阻害剤の処方
US20100113443A1 (en) *	2006-10-31	2010-05-06	Wyeth	Liquid formulations of phospholipase enzyme inhibitors
US8435544B2 (en)	2007-10-08	2013-05-07	Lux Biosciences, Inc.	Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors
MX2010010214A (es)	2008-03-20	2010-12-21	Virun Inc	Derivados de vitamina e y sus usos.
EP2548456B1 (en)	2008-03-20	2015-07-08	Virun, Inc.	Emulsions including a PEG-derivative of tocopherol
US8252821B2 (en) *	2009-04-14	2012-08-28	Bristol-Myers Squibb Company	Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound
WO2010144194A1 (en)	2009-06-09	2010-12-16	Lux Biosciences, Inc.	Topical drug delivery systems for ophthalmic use
MX2012006450A (es) *	2009-12-10	2012-06-28	Merck Patent Gmbh	Composicion farmaceutica que comprende oligopeptidos.
CA2792330C (en) *	2010-03-23	2017-01-03	Virun, Inc	Nanoemulsion including a peg-derivative of vitamin e and a sucrose fatty acid ester
IT1404931B1 (it) *	2010-06-11	2013-12-09	Medivis S R L	Composizioni oftalmiche per la somministrazione di principi attivi liposolubili .
US8741373B2 (en)	2010-06-21	2014-06-03	Virun, Inc.	Compositions containing non-polar compounds
US20110319467A1 (en) *	2010-06-23	2011-12-29	Bhiku Patel	Absorption Enhancement of Statins and Omega Fatty Acids
EP2584915B1 (en) *	2010-06-25	2015-08-12	Firmenich SA	Ingredient delivery system
US9044394B2 (en)	2010-10-18	2015-06-02	PruGen IP Holdings, Inc.	Bioavailability enhancement delivery composition
US20120095098A1 (en) *	2010-10-18	2012-04-19	Bhiku Patel	Bioavailability Enhancement Delivery System
JP6144627B2 (ja)	2010-12-15	2017-06-07	コントラヴィアファーマシューティカルズ、インク．	アミノ酸１および３で修飾されたシクロスポリン類似体分子
US8609684B2 (en) *	2011-12-12	2013-12-17	PruGen IP Holdings, Inc.	Solubilization and bioavailability of acetaminophen
US8937081B2 (en)	2011-12-12	2015-01-20	PruGen IP Holdings, Inc.	Statin bioavailability enhancement delivery composition
WO2014032026A1 (en)	2012-08-24	2014-02-27	Mitra Ashim K	Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions
GB201222455D0 (en) *	2012-12-13	2013-01-30	Perioc Ltd	Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
US9351517B2 (en)	2013-03-15	2016-05-31	Virun, Inc.	Formulations of water-soluble derivatives of vitamin E and compositions containing same
CN106456556A (zh)	2014-06-18	2017-02-22	豪夫迈·罗氏有限公司	包含非离子性表面活性剂的新型药物组合物
US9861611B2 (en)	2014-09-18	2018-01-09	Virun, Inc.	Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same
PL3373976T3 (pl)	2015-11-10	2024-06-24	Sun Pharmaceutical Industries Limited	Preparaty do stosowania miejscowego i ich zastosowanie
MX2018010395A (es)	2016-02-29	2018-11-29	Sun Pharma Global Fze	Formulaciones topicas que contienen cliclosporina y usos de las mismas.
WO2018100096A1 (en)	2016-12-01	2018-06-07	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Use of anti-uchl1 igg plasma concentration for diagnosing idiopathic steroid sensitive nephrotic syndrome
US20190224275A1 (en)	2017-05-12	2019-07-25	Aurinia Pharmaceuticals Inc.	Protocol for treatment of lupus nephritis
US10286036B2 (en)	2017-05-12	2019-05-14	Aurinia Pharmaceuticals Inc.	Protocol for treatment of lupus nephritis
WO2019077123A1 (en)	2017-10-20	2019-04-25	INSERM (Institut National de la Santé et de la Recherche Médicale)	METHODS AND KITS FOR IDENTIFYING WHETHER A SUBJECT IS REACHED OR RISK OF BEING WITH AUTOIMMUNE MYOPATHY
SMT202300139T1 (it) *	2018-11-26	2023-07-20	Hepion Pharmaceuticals Inc	Formulazioni farmaceutiche di analoghi della ciclosporina
WO2020115262A1 (en)	2018-12-07	2020-06-11	INSERM (Institut National de la Santé et de la Recherche Médicale)	Use of cd26 and cd39 as new phenotypic markers for assessing maturation of foxp3+ t cells and uses thereof for diagnostic purposes
KR20210121077A (ko)	2019-01-15	2021-10-07	인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔)	돌연변이된 인터루킨-34 (il-34) 폴리펩티드 및 요법에서의 이의 용도
EP3981432B1 (en)	2019-03-27	2024-07-31	Tokyo Medical University	Therapeutic agent for wolfram syndrome
WO2021224890A1 (en)	2020-05-07	2021-11-11	Aurinia Pharmaceuticals Inc.	Methods of treating or preventing coronavirus infection
KR102449537B1 (ko) *	2022-01-27	2022-10-05	주식회사 나노메디팜	근적외선을 이용하여 진단 생검 또는 종양 제거 수술 중에 종양 식별과 절제면 구분을 위한 종양 표적 진단 조영제
WO2024153636A1 (en)	2023-01-17	2024-07-25	Institut National de la Santé et de la Recherche Médicale	Vasorin as a biomarker and biotarget in nephrology
WO2025021782A1 (en)	2023-07-24	2025-01-30	Institut National de la Santé et de la Recherche Médicale	Methods of determining whether a subject suffering from lupus nephritis (ln) will achieve a response with an induction therapy
WO2025045894A1 (en)	2023-08-28	2025-03-06	Institut National de la Santé et de la Recherche Médicale	Methods and kits for diagnosing cause of nephrotic syndrome and guiding therapy

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (pl)	1975-11-04	1979-12-28	Sandoz Ag
DE2819094A1 (de)	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
SE445174B (sv)	1978-03-07	1986-06-09	Sandoz Ag	Farmaceutisk komposition innehallande en cyklosporin och en berarsubstans
CH641356A5 (en)	1979-02-27	1984-02-29	Sandoz Ag	Pharmaceutical compositions containing cyclosporin
DE3260468D1 (en)	1981-01-09	1984-09-06	Sandoz Ag	Novel cyclosporins
CH667274A5 (de)	1984-03-23	1988-09-30	Sandoz Ag	Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
GB8903804D0 (en)	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
EP0194972B1 (en)	1985-03-11	1992-07-29	Sandoz Ag	Novel cyclosporins
US4764503A (en)	1986-11-19	1988-08-16	Sandoz Ltd.	Novel cyclosporins
NL194638C (nl)	1986-12-19	2002-10-04	Novartis Ag	Hydrosol die vaste deeltjes van een farmaceutisch actieve stof bevat en farmaceutisch preparaat dat deze hydrosol bevat.
JP2577049B2 (ja)	1987-06-04	1997-01-29	三共株式会社	シクロスポリン製剤
ES2059558T3 (es)	1987-06-17	1994-11-16	Sandoz Ag	Ciclosporins y su uso como productos farmaceuticos.
ATE110784T1 (de)	1987-06-19	1994-09-15	Sandoz Ag	Zyklische peptolide.
DE3830494B4 (de)	1987-09-15	2006-05-18	Novartis Ag	Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
DE68900991D1 (de)	1988-01-29	1992-04-23	Sankyo Co	Cyclosporin-zusammensetzungen.
HU201567B (en)	1988-07-21	1990-11-28	Gyogyszerkutato Intezet	Process for production of intravenous medical compositions containing cyclosphorin
JP2792862B2 (ja)	1988-07-30	1998-09-03	寛治高田	経口腸溶製剤
US5350741A (en)	1988-07-30	1994-09-27	Kanji Takada	Enteric formulations of physiologically active peptides and proteins
KR0148748B1 (ko)	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
US5342625A (en)	1988-09-16	1994-08-30	Sandoz Ltd.	Pharmaceutical compositions comprising cyclosporins
US6007840A (en)	1988-09-16	1999-12-28	Novartis Ag	Pharmaceutical compositions comprising cyclosporins
GB8823621D0 (en)	1988-10-07	1988-11-16	Madhok R	Compositions containing cyclosporins
DE3843241A1 (de)	1988-12-22	1990-06-28	Skrezek Christian	Nephroprotektive infusionsloesung
BE1003009A5 (fr)	1989-02-09	1991-10-22	Sandoz Sa	Nouvelles compositions pharmaceutiques a base de cyclosporines.
US4996193A (en)	1989-03-03	1991-02-26	The Regents Of The University Of California	Combined topical and systemic method of administration of cyclosporine
US5540931A (en)	1989-03-03	1996-07-30	Charles W. Hewitt	Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US5284826A (en)	1989-07-24	1994-02-08	Sandoz Ltd.	0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins
US5356633A (en)	1989-10-20	1994-10-18	Liposome Technology, Inc.	Method of treatment of inflamed tissues
US5681964A (en)	1990-10-23	1997-10-28	University Of Kentucky Research Foundation	Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents
ATE148469T1 (de)	1990-11-02	1997-02-15	Sandoz Ag	Zyklosporine
GB9105705D0 (en)	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
AU657961B2 (en)	1991-04-19	1995-03-30	Nexstar Pharmaceuticals, Inc.	Pharmaceutical formulation and process
US5620971A (en)	1991-05-09	1997-04-15	Vertex Pharmaceuticals Incorporated	Biologically active acylated amino acid derivatives
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en)	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
US5248499A (en)	1991-10-07	1993-09-28	Genentech, Inc.	Control of microbial infections in transplant patients
GB9203886D0 (en)	1992-02-24	1992-04-08	Sandoz Ltd	Improvements in or relating to organic compounds
GB9208712D0 (en)	1992-04-22	1992-06-10	Sandoz Ltd	Pharmaceutical compositions containing cyclosporin derivates
US5759566A (en)	1992-07-28	1998-06-02	Poli Industria Chimica Spa	Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
US5654000A (en)	1992-07-28	1997-08-05	Poli Industria Chimica S.P.A.	Pharmaceutical compositions for transmucosal delivery of peptides
CZ278863B6 (en)	1992-09-07	1994-07-13	Galena	Medicinal preparations with n-methylated cyclic undecapeptides
DK0589843T3 (da)	1992-09-25	2002-04-02	Novartis Ag	Cyclosporinholdige farmaceutiske præparater
WO1994008603A1 (en)	1992-10-16	1994-04-28	Smithkline Beecham Corporation	Compositions
WO1994008605A1 (en)	1992-10-16	1994-04-28	Smithkline Beecham Corporation	Therapeutic microemulsions
JPH08504811A (ja)	1992-12-24	1996-05-28	ヘマジェン／ピーエフシー	フルオロカーボンのエマルジョン
US6113921A (en)	1993-03-23	2000-09-05	Pharmos Corp.	Topical and transdermal delivery system utilizing submicron oil spheres
NZ247516A (en)	1993-04-28	1995-02-24	Bernard Charles Sherman	Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
CH686761A5 (de)	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
CN1077800C (zh)	1993-07-01	2002-01-16	韩美药品工业株式会社	环孢菌素软胶囊组合物
US5639474A (en)	1993-07-01	1997-06-17	Hanmi Pharm. Ind., Ltd.	Cyclosporin soft capsule composition
ES2308955T5 (es)	1993-09-28	2012-04-03	R.P. Scherer Gmbh	Fabricación de cápsulas de gelatina blanda
US5840707A (en)	1993-10-04	1998-11-24	Albany Medical College	Stabilizing and delivery means of biological molecules
US6022852A (en)	1993-10-22	2000-02-08	Hexal Ag	Pharmaceutical composition containing cyclosporin A
US5567592A (en)	1994-02-02	1996-10-22	Regents Of The University Of California	Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
EP0694308A4 (en)	1994-02-17	1997-09-10	Shiseido Co Ltd	CYCLOSPORIN EMULSION COMPOSITION
CA2185803C (en)	1994-03-18	2006-07-11	Edward M. Rudnic	Emulsified drug delivery systems
US5474979A (en)	1994-05-17	1995-12-12	Allergan, Inc.	Nonirritating emulsions for sensitive tissue
FI100692B (fi)	1994-05-24	1998-02-13	Leiras Oy	Menetelmä farmaseuttisten koostumusten valmistamiseksi, jolloin koostu mukset pohjautuvat mikroemulsiogeeleihin sekä uusia mikroemulsioihin p ohjautuvia geelejä
US5739105A (en)	1994-06-01	1998-04-14	Yuhan Corporation	Cyclosporin containing composition and process for the preparation thereof
CH686865A5 (de)	1994-06-15	1996-07-31	Gergely Gerhard	Pharmazeutische Zubereitung mit einem hydrophoben Wirkstoff und einem Brausesystem, sowie Verfahren zur Herstellung der Zubereitung.
EP0697214A1 (en)	1994-07-19	1996-02-21	Vestar, Inc.	Liposomal cyclosporin pharmaceutical formulations
JPH10504291A (ja)	1994-07-22	1998-04-28	ジー．ディー．サールアンドカンパニー	自己乳化性ドラッグデリバリーシステム
US5635159A (en)	1994-08-26	1997-06-03	Abbott Laboratories	Aerosol drug formulations containing polyglycolyzed glycerides
IL129547A (en)	1994-10-26	2001-01-11	Novartis Ag	Pharmaceutical compositions comprising a macrolide and an acid
US5603951A (en)	1994-11-09	1997-02-18	Hanmi Pharm. Ind. Co., Ltd.	Cyclosporin-containing soft capsule compositions
HU215966B (hu) *	1994-11-21	1999-07-28	BIOGAL Gyógyszergyár Rt.	Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
KR0167613B1 (ko) *	1994-12-28	1999-01-15	한스 루돌프 하우스, 니콜 케르커	사이클로스포린-함유 연질캅셀제 조성물
KR100239799B1 (ko)	1995-01-21	2000-02-01	손경식	경구투여용 사이클로스포린 에이 고체미셀분산체, 이의 제조 방법 및 고형제제
GB9512100D0 (en)	1995-06-14	1995-08-09	Sandoz Nutrition Ltd	Improvements in or relating to organic compounds
IE75744B1 (en)	1995-04-03	1997-09-24	Elan Corp Plc	Controlled release biodegradable micro- and nanospheres containing cyclosporin
AU692255B2 (en)	1995-04-24	1998-06-04	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Self-emulsifiable formulation producing an oil-in-water emulsion
EP0825849A1 (en)	1995-05-19	1998-03-04	Abbott Laboratories	Self-emulsifying formulations of lipophilic drugs
US5635161A (en)	1995-06-07	1997-06-03	Abbott Laboratories	Aerosol drug formulations containing vegetable oils
US5693336A (en)	1995-06-07	1997-12-02	Nexstar Pharmaceuticals, Inc.	Blood stable liposomal cyclosporin formulations
US5656287A (en)	1995-06-07	1997-08-12	Nexstar Pharmaceuticals, Inc.	Liposomal cyclosporin formulations as agents for immunosuppression and multiple drug resistant indications
DE19521974A1 (de)	1995-06-16	1996-12-19	Hexal Pharmaforschung Gmbh	Pharmazeutische Zubereitung mit Cyclosporin A
US5827822A (en)	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
US5962019A (en)	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
MX9702809A (es)	1995-08-25	1998-02-28	Sangstat Medical Corp	Formulaciones orales de ciclosporina.
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5834017A (en)	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
EP0760237A1 (en)	1995-08-30	1997-03-05	Cipla Limited	Oil-in-water microemulsions
NZ280689A (en)	1995-12-15	1997-08-22	Bernard Charles Sherma Sherman	Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
CZ288631B6 (cs)	1996-01-18	2001-08-15	Galena, A. S.	Léčivé přípravky s obsahem cyklosporinu
KR970064620A (ko)	1996-03-05	1997-10-13	임성기	사이클로스포린-함유 외용약제 조성물
AU723905B2 (en)	1996-03-12	2000-09-07	Picower Institute For Medical Research, The	Treatment of HIV-infection by interfering with host cell cyclophilin receptor activity
US5660858A (en)	1996-04-03	1997-08-26	Research Triangle Pharmaceuticals	Cyclosporin emulsions
ID18663A (id)	1996-04-12	1998-04-30	Novartis Ag	Komposisi farmasi berlapis enterik
US5958876A (en)	1996-06-19	1999-09-28	Novartis Ag	Cyclosporin-containing pharmaceutical compositions
DK0869810T3 (da)	1996-06-19	2005-02-07	Novartis Ag	Cyclosporinholdige blöde kapselpræparater
KR980008239A (ko)	1996-07-26	1998-04-30	김충환	사이클로스포린-함유 약학적 조성물
WO1998004279A1 (en)	1996-07-30	1998-02-05	Novartis Ag	Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin
CZ288739B6 (cs)	1996-08-01	2001-08-15	Galena, A. S.	Cyklosporin obsahující léčivé přípravky
CZ267796A3 (cs)	1996-09-12	1998-04-15	Galena A.S.	Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů
CA2185600A1 (en)	1996-09-16	1998-03-17	Bernard Charles Sherman	Water-soluble concentrates containing cyclosporins
US5798333A (en)	1996-09-17	1998-08-25	Sherman; Bernard C.	Water-soluble concentrates containing cyclosporins
FR2757521B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757520B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2757522B1 (fr)	1996-12-24	1999-01-29	Rhone Poulenc Rorer Sa	Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
NZ314060A (en)	1997-01-13	1997-08-22	Bernard Charles Sherman	Pharmaceutical microemulsion preconcentrate comprising cyclosporin dissolved in a solvent system comprising hydrophobic solvent(s) and surfactant(s)
KR20050084502A (ko)	1997-01-30	2005-08-26	노파르티스 아게	오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
CA2282411A1 (en)	1997-02-27	1998-09-03	Nippon Shinyaku Co., Ltd.	Fat emulsion for oral administration
KR100966245B1 (ko)	1997-03-12	2010-06-28	아보트 러보러터리즈	사이클로스포린 투여용 친수성 2원 시스템
NZ314702A (en)	1997-04-29	1998-07-28	Bernard Charles Sherman	Pharmaceutical composition comprising a cyclosporin in a solvent system of acetylated monoglycerides and a surfactant and optionally a hydrophilic solvent
AR012627A1 (es)	1997-04-29	2000-11-08	Sherman Bernard Charles	Pre-concentrado de emulsion que comprende una ciclosporina y monoglicerido acetilado
FR2762843B1 (fr)	1997-04-30	1999-12-10	Rhone Poulenc Rorer Sa	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
US6187747B1 (en)	1997-09-08	2001-02-13	Panacea Biotech Limited	Pharmaceutical composition comprising cyclosporin
IN188719B (pl)	1997-09-08	2002-11-02	Panacea Biotec Ltd
US6008191A (en)	1997-09-08	1999-12-28	Panacea Biotec Limited	Pharmaceutical compositions containing cyclosporin
US6346511B1 (en)	1997-09-08	2002-02-12	Panacea Biotec Limited	Pharmaceutical composition comprising cyclosporin
DK0942780T3 (da) *	1997-09-09	2003-10-27	Lyotropic Therapeutics Inc	Overtrukne partikler, fremgangsmåder til fremstilling deraf og anvendelse deraf
NZ328751A (en)	1997-09-16	1999-01-28	Bernard Charles Sherman	Solid medicament containing an anionic surfactant and cyclosporin
AU750245B2 (en) *	1997-10-08	2002-07-11	Aurinia Phamaceuticals Inc.	Deuterated cyclosporine analogs and their use as immunomodulating agents
UA65587C2 (en)	1997-10-09	2004-04-15	Baker Norton Pharma	Method for preventing nephrotoxicity induced by cyclosporins or tacrolimus
US5891845A (en)	1997-11-21	1999-04-06	Fuisz Technologies Ltd.	Drug delivery systems utilizing liquid crystal structures
AU1508899A (en)	1997-12-02	1999-06-16	Chong Kun Dang Corporation	Pharmaceutical composition comprising cyclosporin solid-state microemulsion
US6028067A (en)	1997-12-05	2000-02-22	Chong Kun Dang Corp.	Cyclosporin-containing microemulsion preconcentrate composition
US6063762A (en) *	1997-12-05	2000-05-16	Chong Kun Dang Corp.	Cyclosporin-containing microemulsion preconcentrate composition
KR100587551B1 (ko)	1997-12-10	2006-06-08	싸이클로스포린 테라퓨틱스 리미티드	오메가-3 지방산 오일을 함유하는 약학 조성물
US20030216303A1 (en) *	1998-03-06	2003-11-20	Michael Ambuhl	Emulsion preconcentrates containing cyclosporin or a macrolide
DE19810655A1 (de)	1998-03-12	1999-09-16	Univ Eberhard Karls	Arzneimittel mit einem Gehalt an Ciclosporin
PT982035E (pt)	1998-08-18	2004-08-31	Panacea Biotec Ltd	Composicao de ciclosporina compreendendo um veiculo hidrofilo
US6294192B1 (en) *	1999-02-26	2001-09-25	Lipocine, Inc.	Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
JP2003509453A (ja) *	1999-09-21	2003-03-11	アールティーピー・ファーマ・インコーポレーテッド	生物学的に活性な物質の、表面改質された粒状組成物
AU7638200A (en) *	1999-10-20	2001-04-30	Vesifact Ag	Microemulsion preconcentrates which contain cyclosporines and corresponding microemulsions
JP2001122779A (ja)	1999-10-26	2001-05-08	Toyo Capsule Kk	経口投与用シクロスポリン含有ミクロエマルジョン濃縮液
JP2001240558A (ja)	2000-02-29	2001-09-04	Nippon Suisan Kaisha Ltd	多価不飽和脂肪酸を経粘膜吸収促進剤として含有する固形製剤。
DE10015463B4 (de)	2000-03-29	2008-01-10	Heide, Peter Edgar, Dr.	Creme in Form einer überwässerten Wasser-in-Öl-Emulsion
ATE290876T1 (de)	2000-05-04	2005-04-15	Panacea Biotec Ltd	Pharmazeutische zusammensetzung enthaltend cyclosprin als aktiven bestandteil
AU2001261738A1 (en)	2000-05-17	2001-11-26	London Health Sciences Centre	Compositions and methods for promoting immunosuppression
DE10029404B4 (de)	2000-06-15	2009-10-29	Jagotec Ag	Arzneiformulierung enthaltend Ciclosporin und deren Verwendung
US6740636B2 (en)	2000-07-31	2004-05-25	Schering Aktiengesellschaft	Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
EP2116228A1 (en) *	2001-10-19	2009-11-11	Isotechnika Inc.	Novel cyclosporin analog microemulsion preconcentrates

2002
- 2002-10-17 EP EP09166128A patent/EP2116228A1/en not_active Withdrawn
- 2002-10-17 AU AU2002333098A patent/AU2002333098B2/en not_active Ceased
- 2002-10-17 HR HRP20040354AA patent/HRP20040354B1/hr not_active IP Right Cessation
- 2002-10-17 AR ARP020103917A patent/AR036852A1/es not_active Application Discontinuation
- 2002-10-17 DE DE60233150T patent/DE60233150D1/de not_active Expired - Lifetime
- 2002-10-17 US US10/274,419 patent/US7060672B2/en not_active Expired - Lifetime
- 2002-10-17 ME MEP-890/08A patent/MEP89008A/xx unknown
- 2002-10-17 PT PT02801263T patent/PT1435910E/pt unknown
- 2002-10-17 JP JP2003535753A patent/JP2005506990A/ja active Pending
- 2002-10-17 EP EP02801263A patent/EP1435910B9/en not_active Expired - Lifetime
- 2002-10-17 PL PL370560A patent/PL206018B1/pl unknown
- 2002-10-17 ES ES02801263T patent/ES2330625T3/es not_active Expired - Lifetime
- 2002-10-17 IL IL16076102A patent/IL160761A0/xx unknown
- 2002-10-17 MX MXPA04003623A patent/MXPA04003623A/es active IP Right Grant
- 2002-10-17 KR KR1020047005700A patent/KR100978836B1/ko not_active Expired - Fee Related
- 2002-10-17 CA CA2461730A patent/CA2461730C/en not_active Expired - Lifetime
- 2002-10-17 NZ NZ531946A patent/NZ531946A/en not_active IP Right Cessation
- 2002-10-17 AT AT02801263T patent/ATE437629T1/de active
- 2002-10-17 RU RU2004110936/15A patent/RU2317067C2/ru not_active IP Right Cessation
- 2002-10-17 WO PCT/CA2002/001561 patent/WO2003032949A1/en not_active Ceased
- 2002-10-17 CN CNB02820641XA patent/CN1274294C/zh not_active Expired - Lifetime
- 2002-10-17 MY MYPI20023883A patent/MY145753A/en unknown
- 2002-10-17 BR BR0213661-9A patent/BR0213661A/pt not_active IP Right Cessation
- 2002-10-17 DK DK02801263T patent/DK1435910T3/da active
2004
- 2004-03-05 IL IL160761A patent/IL160761A/en active IP Right Grant
- 2004-03-23 ZA ZA2004/02268A patent/ZA200402268B/en unknown
- 2004-03-26 MA MA27599A patent/MA26221A1/fr unknown
- 2004-04-16 TN TNP2004000070A patent/TNSN04070A1/en unknown
- 2004-04-19 CO CO04035664A patent/CO5580835A2/es not_active Application Discontinuation
- 2004-05-14 NO NO20042028A patent/NO20042028L/no not_active Application Discontinuation
2006
- 2006-03-13 US US11/375,532 patent/US7429562B2/en not_active Expired - Lifetime
2008
- 2008-08-22 US US12/197,199 patent/US7829533B2/en not_active Expired - Lifetime
- 2008-11-07 JP JP2008287205A patent/JP2009073850A/ja active Pending
- 2008-12-11 IL IL195892A patent/IL195892A/en active IP Right Grant
2010
- 2010-11-08 US US12/941,907 patent/US20110136744A1/en not_active Abandoned
2012
- 2012-05-24 JP JP2012118377A patent/JP2012158609A/ja active Pending
2014
- 2014-03-09 US US14/201,872 patent/US20140249092A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US7829533B2 (en)	2010-11-09
US20140249092A1 (en)	2014-09-04
HRP20040354B1 (en)	2012-10-31
CA2461730A1 (en)	2003-04-24
US20090054311A1 (en)	2009-02-26
DK1435910T3 (da)	2009-11-09
JP2012158609A (ja)	2012-08-23
PT1435910E (pt)	2009-09-07
NO20042028L (no)	2004-05-14
ATE437629T1 (de)	2009-08-15
EP1435910B9 (en)	2010-02-03
HK1062525A1 (en)	2004-11-12
US20060217309A1 (en)	2006-09-28
PL370560A1 (pl)	2005-05-30
JP2009073850A (ja)	2009-04-09
CN1274294C (zh)	2006-09-13
EP2116228A1 (en)	2009-11-11
US7429562B2 (en)	2008-09-30
KR20050037418A (ko)	2005-04-21
US20030171264A1 (en)	2003-09-11
WO2003032949A1 (en)	2003-04-24
MA26221A1 (fr)	2004-07-01
RU2317067C2 (ru)	2008-02-20
TNSN04070A1 (en)	2006-06-01
NZ531946A (en)	2005-09-30
PL206018B1 (pl)	2010-06-30
CA2461730C (en)	2012-05-15
BR0213661A (pt)	2004-10-26
AR036852A1 (es)	2004-10-06
CO5580835A2 (es)	2005-11-30
AU2002333098B2 (en)	2006-03-16
ZA200402268B (en)	2005-05-25
RU2004110936A (ru)	2005-05-27
US20110136744A1 (en)	2011-06-09
MY145753A (en)	2012-03-30
MXPA04003623A (es)	2004-12-02
DE60233150D1 (de)	2009-09-10
KR100978836B1 (ko)	2010-08-30
IL195892A (en)	2013-09-30
US7060672B2 (en)	2006-06-13
EP1435910B1 (en)	2009-07-29
IL160761A0 (en)	2004-08-31
EP1435910A1 (en)	2004-07-14
IL160761A (en)	2010-11-30
HRP20040354A2 (en)	2005-02-28
CN1571657A (zh)	2005-01-26
JP2005506990A (ja)	2005-03-10
ES2330625T3 (es)	2009-12-14

Publication	Publication Date	Title
HRP20040354B1 (en)	2012-10-31	Novel cyclosporin analog microemulsion preconcentrates
PY0225477A (es)	2004-05-03	Nuevas formulaciones de analogos de ciclosporina
ATE270557T1 (de)	2004-07-15	Hochkonzentrierte, lyophilisierte und flüssige faktor-ix formulierungen
ATE508735T1 (de)	2011-05-15	Pulmonale verabreichung von aminoglykosiden
CO5700784A2 (es)	2006-11-30	Polipeptidos de virus de papiloma humano y composiciones in- munogenas
DK0758231T3 (da)	2001-09-24	Farmaceutiske præparater på basis af derivater tilhørende taxanklassen
EA200000548A1 (ru)	2000-12-25	Сфероиды, способ получения и фармацевтические композиции
DK1091975T3 (da)	2006-04-18	Ny cyclosporin med forbedret aktivitetsprofil
CO5050376A1 (es)	2001-06-27	Estructureas novedosas utiles como hojas limpiadoras de pol- vo pelusa, cabello, arena, migajas de alimentos, pasta y similares
ATE328068T1 (de)	2006-06-15	Papillomavirus vakzine
FR2757521B1 (fr)	1999-01-29	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
ATE373721T1 (de)	2007-10-15	Verpackung von replikon-partikeln eines positiv- strängigen rna-virus
ES2164098T3 (es)	2002-02-16	Composiciones farmaceuticas que contienen una proteina bactericida aumentadora de la permeabilidad y un tensioactivo.
NO20100324L (no)	2000-12-28	Fremgangsmate for trinnvis festing av polyetylenglykol (PEG) andeler i serie til et polypeptid
ATE549028T1 (de)	2012-03-15	Stabile analoga von glp-1
ATA27290A (de)	1998-05-15	Neue cyclosporin enthaltende galenische formulierungen
ATE250924T1 (de)	2003-10-15	Cyklosporin, hyaluronsäure und polysorbate enthaltenes augenarzneimittel
ES2151921T3 (es)	2001-01-16	Analogo de dolastatina.
MXPA02007478A (es)	2004-08-23	Vacuna contra el virus de inmunodeficiencia humana.
DK1511761T3 (da)	2006-11-27	Fremgangsmåde til fremstilling af cykliske peptider
FR2842209B1 (fr)	2007-11-23	Nouvelle protease aspartique dite saspase et son utilisation dans le domaine cosmetique et therapeutique
DE60042816D1 (de)	2009-10-08	T-helferzellen-epitope
DE69900495D1 (de)	2002-01-10	Flüssigkristalle des cyclosporins
GB0003085D0 (en)	2000-03-29	Arch structure
ES2194237T3 (es)	2003-11-16	Preparaciones cosmeticas.