NO20005807L - Nye kamptotekinanaloge forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem - Google Patents

Nye kamptotekinanaloge forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem

Info

Publication number: NO20005807L
Authority: NO; Norway
Prior art keywords: alkyl; aryl; groups; cycloalkyl; optionally substituted
Prior art date: 1999-11-18

Application number

NO20005807A

Other languages

English (en)

Other versions

NO20005807D0 (no

NO318464B1 (no

Inventor

Gilbert Lavielle

Patrick Hautefaye

Alain Pierre

Ghanem Atassi

John Hickman

Bernard Cimetiere

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-18

Filing date

2000-11-17

Publication date

2001-05-21

2000-11-17 Application filed by Adir filed Critical Adir

2000-11-17 Publication of NO20005807D0 publication Critical patent/NO20005807D0/no

2001-05-21 Publication of NO20005807L publication Critical patent/NO20005807L/no

2005-03-21 Publication of NO318464B1 publication Critical patent/NO318464B1/no

Links

150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 8
125000003545 alkoxy group Chemical group 0.000 abstract 5
125000003342 alkenyl group Chemical group 0.000 abstract 4
125000000304 alkynyl group Chemical group 0.000 abstract 4
229910003827 NRaRb Inorganic materials 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
125000003107 substituted aryl group Chemical group 0.000 abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 2
-1 diastereoisomers Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000000466 oxiranyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20005807A 1999-11-18 2000-11-17 Nye kamptotekinanaloge forbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem NO318464B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9914499A FR2801309B1 (fr)	1999-11-18	1999-11-18	Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number	Publication Date
NO20005807D0 NO20005807D0 (no)	2000-11-17
NO20005807L true NO20005807L (no)	2001-05-21
NO318464B1 NO318464B1 (no)	2005-03-21

Family

ID=9552253

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005807A NO318464B1 (no)	1999-11-18	2000-11-17	Nye kamptotekinanaloge forbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem

Country Status (22)

Country	Link
US (1)	US6509345B2 (no)
EP (1)	EP1101765B1 (no)
JP (1)	JP3545332B2 (no)
KR (1)	KR100460785B1 (no)
CN (2)	CN1158282C (no)
AT (1)	ATE222253T1 (no)
AU (1)	AU772609B2 (no)
BR (1)	BR0005486A (no)
CA (1)	CA2325776C (no)
DE (1)	DE60000328T2 (no)
DK (1)	DK1101765T3 (no)
EA (1)	EA003206B1 (no)
ES (1)	ES2180501T3 (no)
FR (1)	FR2801309B1 (no)
HU (1)	HUP0004573A3 (no)
MX (1)	MXPA00011238A (no)
NO (1)	NO318464B1 (no)
NZ (1)	NZ508248A (no)
PL (1)	PL202231B1 (no)
PT (1)	PT1101765E (no)
SI (1)	SI1101765T1 (no)
ZA (1)	ZA200006730B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2461572C (en)	2001-10-05	2011-02-15	F. Hoffmann-La Roche Ag	Polycyclic compounds having anti-tumor activity
US7071204B2 (en) *	2003-06-30	2006-07-04	Research Triangle Institute	Camptothecin analogs having an E-ring ketone
FR2889527A1 (fr) *	2005-08-05	2007-02-09	Servier Lab	Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2889528B1 (fr) *	2005-08-05	2007-09-07	Servier Lab	Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892418B1 (fr) *	2005-10-24	2010-10-22	Servier Lab	Nouveaux composes aminoesterifies a cycle e hydrocarbone a six chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892417B1 (fr) *	2005-10-24	2010-10-22	Servier Lab	Nouveaux composes aminoesterifies a cycle e hydrocarbone a sept chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US8410045B2 (en)	2006-03-30	2013-04-02	Drais Pharmaceuticals, Inc.	Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
CN103288842B (zh) *	2012-02-24	2016-01-13	中国人民解放军第二军医大学	氟取代e环喜树碱类似物及其作为药物的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5829793B2 (ja) *	1975-02-07	1983-06-24	日本ケミフア（株）	７−アルコキシカルボニル−８−メチルインドリジノ〔１，２−ｂ〕キノリン−９（１１Ｈ）−オンの製法
JPS58435B2 (ja) *	1975-12-23	1983-01-06	カメタニテツジ	ルテカルピンノセイホウ
GB8513460D0 (en) *	1985-05-29	1985-07-03	Glaxo Group Ltd	Chemical compounds
US4939255A (en) *	1987-06-24	1990-07-03	Daiichi Pharmaceutical Co., Ltd.	Hexa-cyclic camptothecin derivatives
US5004758A (en) *	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
AU2428092A (en) *	1991-07-22	1993-02-23	Abbott Laboratories	Reagent handling system for automated clinical analyzer apparatus
US5391745A (en) *	1992-07-23	1995-02-21	Sloan-Kettering Institute For Cancer Research	Methods of preparation of camptothecin analogs
MX9710228A (es) *	1995-06-21	1998-03-31	Sod Conseils Rech Applic	Nuevos analogos de camptotecina, procedimientos de preparacion, su aplicacion como medicinas y las composiciones farmaceuticas que los comprenden.
UA57757C2 (uk) *	1996-12-20	2003-07-15	Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.)	Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
DE19815812A1 (de) *	1998-04-08	1999-10-14	Bayer Ag	Modifizierte Cytostatika
US6043367A (en) *	1998-09-30	2000-03-28	Roffler; Steve	Proactive antitumor compounds

1999
- 1999-11-18 FR FR9914499A patent/FR2801309B1/fr not_active Expired - Fee Related
2000
- 2000-11-09 PT PT00403108T patent/PT1101765E/pt unknown
- 2000-11-09 SI SI200030016T patent/SI1101765T1/xx unknown
- 2000-11-09 AT AT00403108T patent/ATE222253T1/de active
- 2000-11-09 DK DK00403108T patent/DK1101765T3/da active
- 2000-11-09 EP EP00403108A patent/EP1101765B1/fr not_active Expired - Lifetime
- 2000-11-09 ES ES00403108T patent/ES2180501T3/es not_active Expired - Lifetime
- 2000-11-09 DE DE60000328T patent/DE60000328T2/de not_active Expired - Lifetime
- 2000-11-15 MX MXPA00011238A patent/MXPA00011238A/es unknown
- 2000-11-16 JP JP2000348947A patent/JP3545332B2/ja not_active Expired - Fee Related
- 2000-11-17 NO NO20005807A patent/NO318464B1/no not_active IP Right Cessation
- 2000-11-17 KR KR10-2000-0068441A patent/KR100460785B1/ko not_active Expired - Fee Related
- 2000-11-17 PL PL343949A patent/PL202231B1/pl not_active IP Right Cessation
- 2000-11-17 AU AU71683/00A patent/AU772609B2/en not_active Ceased
- 2000-11-17 HU HU0004573A patent/HUP0004573A3/hu unknown
- 2000-11-17 CA CA002325776A patent/CA2325776C/fr not_active Expired - Fee Related
- 2000-11-17 CN CNB001284606A patent/CN1158282C/zh not_active Expired - Fee Related
- 2000-11-17 EA EA200001084A patent/EA003206B1/ru not_active IP Right Cessation
- 2000-11-17 ZA ZA200006730A patent/ZA200006730B/xx unknown
- 2000-11-17 NZ NZ508248A patent/NZ508248A/en not_active IP Right Cessation
- 2000-11-17 CN CNB200410045949XA patent/CN1304395C/zh not_active Expired - Fee Related
- 2000-11-21 BR BR0005486-0A patent/BR0005486A/pt not_active IP Right Cessation
2001
- 2001-11-05 US US10/010,380 patent/US6509345B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EA200001084A1 (ru)	2001-06-25
HUP0004573A2 (hu)	2001-09-28
PL343949A1 (en)	2001-05-21
CA2325776C (fr)	2007-02-20
CN1304395C (zh)	2007-03-14
HUP0004573A3 (en)	2002-06-28
DK1101765T3 (da)	2002-12-16
CN1158282C (zh)	2004-07-21
JP3545332B2 (ja)	2004-07-21
EP1101765B1 (fr)	2002-08-14
FR2801309A1 (fr)	2001-05-25
BR0005486A (pt)	2001-08-07
CN1301701A (zh)	2001-07-04
DE60000328T2 (de)	2003-04-17
US20020077325A1 (en)	2002-06-20
EP1101765A3 (fr)	2001-10-04
AU772609B2 (en)	2004-05-06
MXPA00011238A (es)	2002-05-23
PT1101765E (pt)	2002-11-29
US6509345B2 (en)	2003-01-21
CN1552712A (zh)	2004-12-08
AU7168300A (en)	2001-05-24
HK1071892A1 (en)	2005-08-05
ATE222253T1 (de)	2002-08-15
JP2001151776A (ja)	2001-06-05
DE60000328D1 (de)	2002-09-19
ZA200006730B (en)	2001-05-31
KR100460785B1 (ko)	2004-12-09
NO20005807D0 (no)	2000-11-17
NO318464B1 (no)	2005-03-21
KR20010051779A (ko)	2001-06-25
ES2180501T3 (es)	2003-02-16
PL202231B1 (pl)	2009-06-30
FR2801309B1 (fr)	2002-01-04
EA003206B1 (ru)	2003-02-27
HU0004573D0 (no)	2001-02-28
NZ508248A (en)	2001-08-31
HK1036803A1 (en)	2002-01-18
SI1101765T1 (en)	2002-12-31
EP1101765A2 (fr)	2001-05-23
CA2325776A1 (fr)	2001-05-18

Legal Events

Date	Code	Title	Description
2013-06-24	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
CO5540307A2 (es)	2005-07-29	Derivados de piperidina utiles como moduladores de la activi dad del receptor de quimoquina
IL190713A0 (en)	2008-11-03	Pyrimidin-4-yl-3,4-dihydro-2h-pyrrol0[1,2a]
AR037907A1 (es)	2004-12-22	Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6
AR035235A1 (es)	2004-05-05	Derivados heterocicliloxi-,-tioxi- y -aminobenzazol como ligandos de 5-hidroxitriptamina-6, un procedimiento para su preparacion, composicion farmaceutica, y el uso de dichos derivados para la manufactura de un medicamento
AR019190A1 (es)	2001-12-26	Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
CO5031250A1 (es)	2001-04-27	Compuesto farmaceutico
AR033879A1 (es)	2004-01-07	Compuesto sulfonamida, composicion farmaceutica que lo comprende, su uso para preparar dicha composicion y procedimiento para la obtencion de dicho compuesto
ATE311378T1 (de)	2005-12-15	Benzopyran derivate
NO20005807D0 (no)	2000-11-17	Nye kamptotekinanaloge forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
ATE227712T1 (de)	2002-11-15	Flavone-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammenstellungen
AR030239A1 (es)	2003-08-13	Fta lidas substituidas, un procedimiento para su preparacion y composiciones farmaceuticas que contienen las mismas
ATE344230T1 (de)	2006-11-15	Triphenylbutenderivate zur behandlung von neurologischen störungen
DK1092717T3 (da)	2003-04-14	Polycykliske azaindolforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske tilberedninger indeholdende disse
ATE291577T1 (de)	2005-04-15	Cyanoindol-derivate als inhibitoren der wiederaufnahme von serotonin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
AR041877A1 (es)	2005-06-01	Procedimiento para la preparacion de compuestos de pirrolidiniletilamina mediante una aminacion de arilo mediada por cobre
AR040276A1 (es)	2005-03-23	Derivados de 3-(4-oxo-4h-cromen-2-il)-(1h)-quinolein-4-onas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
AR034287A1 (es)	2004-02-18	Compuestos azepan , procedimiento para su preparacion y composiciones farmaceuticas que los contienen
DK0820985T3 (da)	2000-12-18	Bis-imidderivater, fremgangsmåde til deres fremstilling og farmaceutiske præparater indeholdende dem
DE69706206D1 (de)	2001-09-27	Von Neurokininen abgeleitete Pseudopeptide, Verfahren für ihre Herstellung und sie enthaltende pharmazeutische Zubereitungen
AR034004A1 (es)	2004-01-21	Derivados de amidoalquil-piperidina y amidoalquil-piperazina y su uso en la fabricacion de medicamentos
AR035800A1 (es)	2004-07-14	Pirimidin-2,4,6-trionas 5,5-disustituidas, composiciones farmaceuticas que las comprenden, y el uso de dichos compuestos en la preparacion de medicamentos
HUP9903319A3 (en)	2001-02-28	2-hetaroylcyclohexane-1,3-dione derivatives, use thereof and herbicide compositions containing these compounds
ECSP034870A (es)	2004-01-28	Nuevos derivados de indol con afinidad por el receptor 5-ht6
MX9703112A (es)	1997-07-31	Nitro-benzamidas utiles como agentes antiarritmicos.
ECSP961783A (es)	1997-11-20	Derivados de pirimidindiona pirimidintriona triacindiona tetrahidro- quinazolindion como antagonistas adrenoceptores case ran 4013/26