NO20061766L - 1,1,1-trifluor-4-fenyl-4-metyl-2-(1H-Pyrrolo'2,3-Cl Pyridin-2-ylmetyl)pentan-2-ol derivater og beslektede forbindelser som glukokortikoidligander for behandling av inflammatoriske sykdommer og diabetes - Google Patents
1,1,1-trifluor-4-fenyl-4-metyl-2-(1H-Pyrrolo'2,3-Cl Pyridin-2-ylmetyl)pentan-2-ol derivater og beslektede forbindelser som glukokortikoidligander for behandling av inflammatoriske sykdommer og diabetesInfo
- Publication number
- NO20061766L NO20061766L NO20061766A NO20061766A NO20061766L NO 20061766 L NO20061766 L NO 20061766L NO 20061766 A NO20061766 A NO 20061766A NO 20061766 A NO20061766 A NO 20061766A NO 20061766 L NO20061766 L NO 20061766L
- Authority
- NO
- Norway
- Prior art keywords
- pentan
- pyrrolo
- ylmethyl
- trifluoro
- pyridin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 239000003862 glucocorticoid Substances 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- JYVLIDXNZAXMDK-UHFFFAOYSA-N pentan-2-ol Chemical class CCCC(C)O JYVLIDXNZAXMDK-UHFFFAOYSA-N 0.000 title 1
- 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 title 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 2
- 108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Applications Claiming Priority (3)
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| US50545603P | 2003-09-24 | 2003-09-24 | |
| US50707903P | 2003-09-29 | 2003-09-29 | |
| PCT/US2004/031009 WO2005030213A1 (fr) | 2003-09-24 | 2004-09-22 | Derives de 1,1,1-trifluoro-4-phenyl-4-methyl-2-(1h-pyrrolo-2,3-c pyridin-2-ylmethyl)pentan-2-ole et composes associes en tant que ligands de glucocorticoides pour le traitement de maladies inflammatoires et de diabete |
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| BR (1) | BRPI0414591A (fr) |
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| EP1730145A1 (fr) * | 2004-03-22 | 2006-12-13 | Boehringer Ingelheim Pharmaceuticals Inc. | Amines ou alcools alpha-trifluoromethyliques mimetiques de glucocorticoides |
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| PL2061444T3 (pl) * | 2006-09-11 | 2011-09-30 | Bausch & Lomb | Kompozycje i sposoby leczenia, traktowania, kontrolowania, redukowania, łagodzenia lub zapobiegania alergii |
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-
2004
- 2004-09-20 UY UY28526A patent/UY28526A1/es not_active Application Discontinuation
- 2004-09-21 PE PE2004000917A patent/PE20050951A1/es not_active Application Discontinuation
- 2004-09-21 PE PE2008001805A patent/PE20090217A1/es not_active Application Discontinuation
- 2004-09-21 PE PE2008001807A patent/PE20090219A1/es not_active Application Discontinuation
- 2004-09-21 PE PE2008001806A patent/PE20090218A1/es not_active Application Discontinuation
- 2004-09-22 SG SG200807363-7A patent/SG146694A1/en unknown
- 2004-09-22 RS YUP-2006/0201A patent/RS20060201A/sr unknown
- 2004-09-22 US US10/947,420 patent/US8741897B2/en active Active
- 2004-09-22 CN CN2010102426640A patent/CN101948425A/zh active Pending
- 2004-09-22 MX MXPA06002880A patent/MXPA06002880A/es not_active Application Discontinuation
- 2004-09-22 CA CA2539909A patent/CA2539909C/fr not_active Expired - Fee Related
- 2004-09-22 WO PCT/US2004/031009 patent/WO2005030213A1/fr not_active Ceased
- 2004-09-22 AU AU2004275757A patent/AU2004275757B2/en not_active Ceased
- 2004-09-22 TW TW093128656A patent/TWI340138B/zh not_active IP Right Cessation
- 2004-09-22 BR BRPI0414591-7A patent/BRPI0414591A/pt not_active IP Right Cessation
- 2004-09-22 KR KR1020067007921A patent/KR101152690B1/ko not_active Expired - Fee Related
- 2004-09-22 JP JP2006528127A patent/JP4778430B2/ja not_active Expired - Fee Related
- 2004-09-22 NZ NZ546666A patent/NZ546666A/en not_active IP Right Cessation
- 2004-09-22 RU RU2006113696/04A patent/RU2006113696A/ru not_active Application Discontinuation
- 2004-09-22 EP EP04788894A patent/EP1673088A1/fr not_active Withdrawn
- 2004-09-23 AR ARP040103429A patent/AR046020A1/es not_active Application Discontinuation
-
2006
- 2006-03-21 IL IL174475A patent/IL174475A0/en unknown
- 2006-03-24 EC EC2006006459A patent/ECSP066459A/es unknown
- 2006-04-21 NO NO20061766A patent/NO20061766L/no not_active Application Discontinuation
-
2010
- 2010-05-06 JP JP2010106594A patent/JP2010209100A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2006113696A (ru) | 2007-11-20 |
| EP1673088A1 (fr) | 2006-06-28 |
| UY28526A1 (es) | 2005-04-29 |
| JP2007506750A (ja) | 2007-03-22 |
| AU2004275757A1 (en) | 2005-04-07 |
| PE20090219A1 (es) | 2009-03-26 |
| PE20090217A1 (es) | 2009-03-26 |
| PE20090218A1 (es) | 2009-03-28 |
| CA2539909A1 (fr) | 2005-04-07 |
| KR20060115858A (ko) | 2006-11-10 |
| CA2539909C (fr) | 2012-07-31 |
| US8741897B2 (en) | 2014-06-03 |
| US20050176706A1 (en) | 2005-08-11 |
| BRPI0414591A (pt) | 2006-11-07 |
| ECSP066459A (es) | 2006-09-18 |
| SG146694A1 (en) | 2008-10-30 |
| WO2005030213A1 (fr) | 2005-04-07 |
| TWI340138B (en) | 2011-04-11 |
| AU2004275757B2 (en) | 2011-03-24 |
| AR046020A1 (es) | 2005-11-23 |
| PE20050951A1 (es) | 2005-12-12 |
| JP4778430B2 (ja) | 2011-09-21 |
| IL174475A0 (en) | 2006-08-01 |
| CN101948425A (zh) | 2011-01-19 |
| NZ546666A (en) | 2010-02-26 |
| MXPA06002880A (es) | 2006-06-05 |
| TW200526655A (en) | 2005-08-16 |
| JP2010209100A (ja) | 2010-09-24 |
| RS20060201A (sr) | 2008-08-07 |
| KR101152690B1 (ko) | 2012-07-05 |
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