NO20076363L - Fremgangsmate for fremstilling av vaksiner - Google Patents
Fremgangsmate for fremstilling av vaksinerInfo
- Publication number
- NO20076363L NO20076363L NO20076363A NO20076363A NO20076363L NO 20076363 L NO20076363 L NO 20076363L NO 20076363 A NO20076363 A NO 20076363A NO 20076363 A NO20076363 A NO 20076363A NO 20076363 L NO20076363 L NO 20076363L
- Authority
- NO
- Norway
- Prior art keywords
- saccharide
- protein
- vaccines
- procedures
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
- A61K39/0017—Combination vaccines based on whole cell diphtheria-tetanus-pertussis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
- A61K39/0018—Combination vaccines based on acellular diphtheria-tetanus-pertussis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16271—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Surgical Instruments (AREA)
Abstract
Foreliggende søknad beskriver en forbedret metode for utføring av sakkarid-protein konjugeringsreaksjoner ved anvendelse av karbodiimid kondenseringskjemi. Avhengig av typen av sakkarid eller proteinbærer involvert, kan kvaliteten av konjugatet forbedres ved tilsetning av én av reaksjonskomponentene langsomt til reaksjonsblandingen. Immunogene preparater er videre tilveiebragt, omfattende sakkarid-protein-konjugater fremstilt ved metodene beskrevet
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0513069.5A GB0513069D0 (en) | 2005-06-27 | 2005-06-27 | Immunogenic composition |
| GBGB0513071.1A GB0513071D0 (en) | 2005-06-27 | 2005-06-27 | Immunogenic composition |
| GB0515556A GB0515556D0 (en) | 2005-07-28 | 2005-07-28 | Immunogenic composition |
| GB0524204A GB0524204D0 (en) | 2005-11-28 | 2005-11-28 | Immunogenic composition |
| GB0526040A GB0526040D0 (en) | 2005-12-21 | 2005-12-21 | Immunogenic composition |
| GB0526041A GB0526041D0 (en) | 2005-12-21 | 2005-12-21 | Immunogenic composition |
| PCT/EP2006/006270 WO2007000343A2 (en) | 2005-06-27 | 2006-06-23 | Process for manufacturing vaccines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20076363L true NO20076363L (no) | 2008-03-26 |
| NO345305B1 NO345305B1 (no) | 2020-12-07 |
Family
ID=36716943
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20076343A NO345422B1 (no) | 2005-06-27 | 2006-06-23 | Immunogent preparat, vaksine omfattende immunogent preparat, fremgangsmåte for fremstilling av vaksinen og anvendelse av immunogent preparat for behandling eller forebygging av sykdom. |
| NO20076302A NO344452B1 (no) | 2005-06-27 | 2007-12-07 | Immunogent preparat, vaksine, vaksinesett samt fremgangsmåte for fremstilling av vaksinen. |
| NO20076350A NO342815B1 (no) | 2005-06-27 | 2007-12-11 | Immunogent preparat og fremgangsmåte for fremstilling av en vaksine. |
| NO20076363A NO345305B1 (no) | 2005-06-27 | 2007-12-12 | Metode for konjugering av et sakkarid til en proteinbærer ved anvendelse av karbodiimid kondenseringskjemi samt sakkarid-protein bærerkonjugat |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20076343A NO345422B1 (no) | 2005-06-27 | 2006-06-23 | Immunogent preparat, vaksine omfattende immunogent preparat, fremgangsmåte for fremstilling av vaksinen og anvendelse av immunogent preparat for behandling eller forebygging av sykdom. |
| NO20076302A NO344452B1 (no) | 2005-06-27 | 2007-12-07 | Immunogent preparat, vaksine, vaksinesett samt fremgangsmåte for fremstilling av vaksinen. |
| NO20076350A NO342815B1 (no) | 2005-06-27 | 2007-12-11 | Immunogent preparat og fremgangsmåte for fremstilling av en vaksine. |
Country Status (36)
| Country | Link |
|---|---|
| US (13) | US9789179B2 (no) |
| EP (11) | EP1896065B2 (no) |
| JP (9) | JP2008543907A (no) |
| KR (7) | KR101351870B1 (no) |
| CN (3) | CN102526723B (no) |
| AP (1) | AP2436A (no) |
| AR (3) | AR056397A1 (no) |
| AT (3) | ATE516816T1 (no) |
| AU (7) | AU2006263963B2 (no) |
| BE (1) | BE2012C042I2 (no) |
| BR (5) | BRPI0612655B1 (no) |
| CA (5) | CA2612980C (no) |
| CY (5) | CY1109996T1 (no) |
| DE (1) | DE602006013313D1 (no) |
| DK (7) | DK1896063T3 (no) |
| EA (4) | EA013374B1 (no) |
| ES (9) | ES2377075T5 (no) |
| FR (1) | FR22C1008I2 (no) |
| HR (4) | HRP20110567T4 (no) |
| HU (7) | HUE031380T2 (no) |
| IL (8) | IL187924A (no) |
| LT (2) | LT2351578T (no) |
| LU (2) | LU92085I2 (no) |
| MA (4) | MA29602B1 (no) |
| MX (5) | MX2007016405A (no) |
| MY (3) | MY147490A (no) |
| NL (2) | NL300549I2 (no) |
| NO (4) | NO345422B1 (no) |
| NZ (6) | NZ564607A (no) |
| PE (6) | PE20070163A1 (no) |
| PL (8) | PL1896061T3 (no) |
| PT (8) | PT1896065E (no) |
| SI (8) | SI2283857T1 (no) |
| TW (5) | TWI407970B (no) |
| UA (2) | UA95238C2 (no) |
| WO (6) | WO2007000327A1 (no) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1296715T4 (en) * | 2000-06-29 | 2016-03-07 | Smithkline Beecham Biolog | Multivalent vaccine composition. |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| ES2461350T3 (es) | 2003-01-30 | 2014-05-19 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| LT2351578T (lt) * | 2005-06-27 | 2017-04-10 | Glaxosmithkline Biologicals S.A. | Vakcinų gavimo būdas |
| EP2308504A3 (en) | 2005-09-01 | 2011-11-30 | Novartis Vaccines and Diagnostics GmbH | Multiple vaccines including serogroup C meningococcus |
| AU2012261764B2 (en) * | 2005-09-01 | 2016-09-08 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | Multiple vaccination including serogroup C meningococcus |
| BRPI0620460B8 (pt) | 2005-12-22 | 2021-05-25 | Glaxosmithkline Biologicals Sa | uso de composição imunogênica para bebês, e, processo para produzir uma vacina |
| US10828361B2 (en) * | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| ES2383209T3 (es) | 2006-03-22 | 2012-06-19 | Novartis Ag | Regímenes para la inmunización con conjugados meningococicos |
| GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
| EA015964B1 (ru) | 2006-09-07 | 2012-01-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700136D0 (en) | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| GB0700135D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Vaccine |
| BRPI0813644B8 (pt) * | 2007-06-26 | 2021-05-25 | Glaxosmithkline Biologicals Sa | composição imunogênica, vacina, processo para fabricar a mesma, e, uso da composição imunogênica ou vacina |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| US20160228500A9 (en) * | 2007-07-23 | 2016-08-11 | Martina Ochs | Immunogenic Polypeptides and Monoclonal Antibodies |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| BR122016015627A2 (pt) | 2007-10-19 | 2018-10-30 | Novartis Ag | kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica |
| MX2011002267A (es) * | 2008-08-28 | 2011-03-30 | Glaxosmithkline Biolog Sa | Vacuna. |
| CN102264444B (zh) | 2008-10-27 | 2015-08-05 | 诺华股份有限公司 | 纯化方法 |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| WO2010070453A2 (en) | 2008-12-17 | 2010-06-24 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| US20120064103A1 (en) | 2009-03-24 | 2012-03-15 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| PL2411048T3 (pl) | 2009-03-24 | 2020-11-16 | Glaxosmithkline Biologicals Sa | Adjuwantowe meningokokowe białko wiążące czynnik h |
| JP5593626B2 (ja) * | 2009-03-31 | 2014-09-24 | 凸版印刷株式会社 | 計量スプーン |
| NZ612315A (en) | 2009-04-14 | 2014-10-31 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| WO2010125480A1 (en) * | 2009-04-30 | 2010-11-04 | Coley Pharmaceutical Group, Inc. | Pneumococcal vaccine and uses thereof |
| GB0910046D0 (en) * | 2009-06-10 | 2009-07-22 | Glaxosmithkline Biolog Sa | Novel compositions |
| CN102481352A (zh) | 2009-06-22 | 2012-05-30 | 惠氏有限责任公司 | 金黄色葡萄球菌抗原的免疫原性组合物 |
| SA114350400B1 (ar) * | 2009-06-22 | 2016-05-26 | ويث ال ال سي | تركيبات وطرق لتحضير تركيبات مولدة للمناعة لمقترن بولي سكاريد كبسولي للنمط المصلي 5 و 8 من المكورات العنقودية الذهبية |
| AU2010290896B2 (en) | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
| WO2011030218A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| PL2493498T3 (pl) * | 2009-10-30 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Oczyszczanie sacharydów otoczkowych staphylococcus aureus typu 5 i typu 8 |
| GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
| US9173954B2 (en) | 2009-12-30 | 2015-11-03 | Glaxosmithkline Biologicals Sa | Polysaccharide immunogens conjugated to E. coli carrier proteins |
| TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| GB201003333D0 (en) | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
| GB201003924D0 (en) * | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB201003922D0 (en) * | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| GB201005625D0 (en) | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
| CA2803239A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
| RU2580620C2 (ru) | 2010-08-23 | 2016-04-10 | ВАЙЕТ ЭлЭлСи | СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086 |
| MX343914B (es) | 2010-09-01 | 2016-11-18 | Glaxosmithkline Biologicals Sa | Adsorcion de inmunopotenciadores en sales metalicas insolubles. |
| BR112013005626B1 (pt) | 2010-09-10 | 2022-07-26 | Glaxosmithkline Biologicals Sa | Meningococo, processo para a preparação de uma cepa meningocócica, vesículas de membrana externa, composição farmacêutica imunogênica, e, uso de uma composição |
| WO2012032489A1 (en) | 2010-09-10 | 2012-03-15 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
| US20140112950A1 (en) | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| GB201114923D0 (en) | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
| WO2013068949A1 (en) | 2011-11-07 | 2013-05-16 | Novartis Ag | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| JP2013112653A (ja) * | 2011-11-30 | 2013-06-10 | Jnc Corp | 新規重合体およびその製造方法 |
| GB201121301D0 (en) | 2011-12-12 | 2012-01-25 | Novartis Ag | Method |
| AU2011384634A1 (en) | 2011-12-29 | 2014-06-19 | Novartis Ag | Adjuvanted combinations of meningococcal factor H binding proteins |
| MX354103B (es) * | 2012-01-30 | 2018-02-13 | Serum Inst India Ltd | Composicion inmunogenica. |
| MX2014008988A (es) | 2012-02-02 | 2014-08-27 | Novartis Ag | Promotores para aumento de expresion de proteinas en meningococo. |
| CN102569723A (zh) * | 2012-02-13 | 2012-07-11 | 华为技术有限公司 | 锂离子电池正极材料及其制备方法、正极及锂离子电池 |
| CN104519910B (zh) | 2012-03-07 | 2017-05-03 | 诺华股份有限公司 | 肺炎链球菌抗原的含佐剂制剂 |
| JP2015509963A (ja) | 2012-03-08 | 2015-04-02 | ノバルティス アーゲー | Tlr4アゴニストを含む混合ワクチン |
| JP6345603B2 (ja) | 2012-03-08 | 2018-06-20 | ノバルティス アーゲー | 追加免疫ワクチンのアジュバント化された処方物 |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CA2865745C (en) | 2012-03-09 | 2018-01-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| KR102057217B1 (ko) * | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| EP2892553A1 (en) | 2012-09-06 | 2015-07-15 | Novartis AG | Combination vaccines with serogroup b meningococcus and d/t/p |
| ITMI20121597A1 (it) * | 2012-09-25 | 2014-03-26 | Beta Pharma S A | Coniugato tra frammento di parete cellulare batterica ed un veicolo mucopolisaccaridico e suoi usi in ambito medico |
| CA2885625A1 (en) | 2012-10-02 | 2014-04-10 | Glaxosmithkline Biologicals S.A. | Nonlinear saccharide conjugates |
| US9987344B2 (en) | 2012-11-30 | 2018-06-05 | Glaxosmithkline Biologicals Sa | Pseudomonas antigens and antigen combinations |
| KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| US20150320852A1 (en) | 2012-12-18 | 2015-11-12 | Glaxosmithkline Biologicals Sa | Conjugates for protecting against diphtheria and/or tetanus |
| TR201807340T4 (tr) | 2013-02-01 | 2018-06-21 | Glaxosmithkline Biologicals Sa | Çan benzeri reseptör agonistleri içeren immünolojik kompozisyonların intradermal yoldan verilmesi. |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| SI2976101T1 (sl) * | 2013-03-18 | 2021-01-29 | Glaxosmithkline Biologicals S.A. | Metoda zdravljenja |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| IN2014DE02450A (no) | 2013-09-25 | 2015-06-26 | Suzuki Motor Corp | |
| RU2535122C1 (ru) * | 2013-11-06 | 2014-12-10 | Федеральное казенное учреждение здравоохранения "Российский научно-исследовательский противочумный институт "Микроб" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека ("РосНИПЧИ "Микроб") | Способ получения холерогена-анатоксина |
| US12616744B2 (en) | 2014-01-21 | 2026-05-05 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| PT3096785T (pt) * | 2014-01-21 | 2020-10-13 | Pfizer | Composições imunogénicas que compreendem antigénios de sacáridos capsulares conjugados e utilizações das mesmas |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| EP2921856B1 (en) | 2014-03-18 | 2016-09-14 | Serum Institute Of India Private Limited | A quantitative assay for 4-pyrrolidinopyridine (4-ppy) in polysaccharide-protein conjugate vaccines |
| EP3131576B1 (en) | 2014-04-17 | 2021-06-30 | Medizinische Hochschule Hannover | Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity |
| AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| KR102225282B1 (ko) | 2015-07-21 | 2021-03-10 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| US20170333546A1 (en) * | 2015-12-08 | 2017-11-23 | Jl Medical Corporation | Method for Producing and Vaccine Composition of Neisseria Meningitidis Serogroups A, C, Y, and W-135 Oligosaccharides Conjugated to Glycan-Free Carrier Protein |
| RU2758090C2 (ru) * | 2016-03-15 | 2021-10-26 | Мсд Уэлком Траст Хиллеман Лабораторис Пвт. Лтд. | Новые конъюгаты полисахарида с белком и способ их получения |
| RS65362B1 (sr) | 2016-09-02 | 2024-04-30 | Sanofi Pasteur Inc | Vakcina protiv neisseria meningitidis |
| WO2018042015A1 (en) | 2016-09-02 | 2018-03-08 | Glaxosmithkline Biologicals Sa | Vaccines for neisseria gonorrhoeae |
| IL265109B2 (en) | 2016-09-13 | 2024-05-01 | Allergan Inc | Stabilized non-protein clostridial toxin compositions |
| EP3530285B1 (en) * | 2016-10-20 | 2023-08-09 | KM Biologics Co., Ltd. | METHOD FOR PRODUCING HIB CONJUGATE VACCINE USING PRP WITH
LOWERED MOLECULAR WEIGHT |
| MX2019007910A (es) | 2016-12-30 | 2019-12-05 | Sutrovax Inc | Conjugados de polipeptido-antigeno con aminoacidos no naturales. |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| US10183070B2 (en) | 2017-01-31 | 2019-01-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US11389540B2 (en) | 2017-09-07 | 2022-07-19 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| US20200353064A1 (en) * | 2018-01-29 | 2020-11-12 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Novel meningococcal vaccine composition and process thereof |
| WO2019198096A1 (en) * | 2018-04-11 | 2019-10-17 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Tetravalent meningococcal vaccine composition and process to prepare thereof |
| JOP20200214A1 (ar) | 2019-09-03 | 2021-03-03 | Serum Institute Of India Pvt Ltd | تركيبات مولدة للمناعة ضد الأمراض المعوية وطرق لتحضيرها |
| EP4034157A1 (en) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| BR112022008761A2 (pt) | 2019-11-22 | 2022-07-26 | Glaxosmithkline Biologicals Sa | Dosagem e administração de uma vacina de glicoconjugado de sacarídeo |
| CN116847879A (zh) | 2020-11-13 | 2023-10-03 | 葛兰素史密丝克莱恩生物有限公司 | 细菌蛋白载体和缀合方法 |
| RU2770877C1 (ru) * | 2021-04-08 | 2022-04-22 | Федеральное бюджетное учреждение науки "Ростовский научно-исследовательский институт микробиологии и паразитологии" | Способ получения антигенной конъюгированной субстанции гемофильного типа b микроба для создания вакцинных препаратов |
| GB202215414D0 (en) | 2022-10-18 | 2022-11-30 | Glaxosmithkline Biologicals Sa | Vaccine |
| WO2025021710A1 (en) | 2023-07-21 | 2025-01-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (184)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB513069A (en) | 1937-04-24 | 1939-10-03 | Linde Air Prod Co | Improvements in method of and apparatus for the treatment of metallic bodies by oxidising gas |
| GB505518A (en) † | 1938-02-03 | 1939-05-12 | Daniel Morgan Skeins | Improvements in or relating to envelopes |
| US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| US4123520A (en) * | 1977-08-01 | 1978-10-31 | Merck & Co., Inc. | Method for preparing high molecular weight meningococcal Group C vaccine |
| DE2748132A1 (de) * | 1977-10-27 | 1979-05-03 | Behringwerke Ag | Stabilisator fuer polysaccharid |
| US4235994A (en) * | 1978-06-26 | 1980-11-25 | Merck & Co., Inc. | High molecular weight meningococcal group C vaccine and method for preparation thereof |
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| EP0027888B1 (en) | 1979-09-21 | 1986-04-16 | Hitachi, Ltd. | Semiconductor switch |
| DE3040825A1 (de) * | 1980-10-30 | 1982-09-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neues tridekapeptid, verfahren zu seiner herstellung und verwendung |
| US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
| HU193083B (en) * | 1984-02-22 | 1987-08-28 | Sandoz Ag | Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds |
| US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| US4709017A (en) | 1985-06-07 | 1987-11-24 | President And Fellows Of Harvard College | Modified toxic vaccines |
| IT1187753B (it) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| DE3526940A1 (de) | 1985-07-27 | 1987-02-12 | Siegfried Fricker | Anker zum einbetonieren in schwere lasten |
| IL78929A0 (en) | 1985-07-29 | 1986-09-30 | Abbott Lab | Microemulsion compositions for parenteral administration |
| US4727136A (en) | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| US4950740A (en) | 1987-03-17 | 1990-08-21 | Cetus Corporation | Recombinant diphtheria vaccines |
| JPH01125328A (ja) | 1987-07-30 | 1989-05-17 | Centro Natl De Biopreparados | 髄膜炎菌ワクチン |
| US5180815A (en) * | 1988-04-13 | 1993-01-19 | Fuji Photo Film Co., Ltd. | Modified protein for carrying hapten |
| US5115924A (en) | 1988-05-31 | 1992-05-26 | Beatrice Konig-Haug | Shelf system |
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| DE68907045T2 (de) | 1989-01-17 | 1993-12-02 | Eniricerche Spa | Synthetische Peptide und deren Verwendung als allgemeine Träger für die Herstellung von immunogenischen Konjugaten, die für die Entwicklung von synthetischen Impfstoffen geeignet sind. |
| JPH04506662A (ja) | 1989-07-14 | 1992-11-19 | アメリカン・サイアナミド・カンパニー | 接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| ATE121947T1 (de) | 1989-12-14 | 1995-05-15 | Ca Nat Research Council | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| DE69113564T2 (de) | 1990-08-13 | 1996-05-30 | American Cyanamid Co | Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff. |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| GB2264352A (en) | 1992-01-31 | 1993-08-25 | Richards Eng Ltd | Incineration apparatus |
| AU685047B2 (en) | 1992-02-11 | 1998-01-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Dual carrier immunogenic construct |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| ATE178907T1 (de) | 1992-05-06 | 1999-04-15 | Harvard College | Rezeptorbindende region des diphtherietoxius |
| DE69319728T2 (de) | 1992-05-23 | 1999-02-04 | Smithkline Beecham Biologicals S.A., Rixensart | Kombinierte Impfstoffe, die Hepatitis B oberfläche Antigen und andere Antigenen enthalten |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| ES2126616T3 (es) | 1992-10-27 | 1999-04-01 | American Cyanamid Co | Vacuna pediatrica combinada, con una inmunogenecidad aumentada de cada componente de la vacuna. |
| AU5951894A (en) | 1992-12-14 | 1994-07-04 | Western Atlas International, Inc. | Removable piston bore liner for hydraulically actuated seismic vibrator |
| ES2210262T3 (es) | 1993-09-22 | 2004-07-01 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Procedimiento que permite activar un glucido soluble con la ayuda de nuevos reactivos cianilantes para producir estructuras inmunogenas. |
| US5849301A (en) | 1993-09-22 | 1998-12-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents |
| DE4416166C2 (de) * | 1994-05-06 | 1997-11-20 | Immuno Ag | Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen |
| US5869058A (en) * | 1994-05-25 | 1999-02-09 | Yeda Research And Development Co. Ltd. | Peptides used as carriers in immunogenic constructs suitable for development of synthetic vaccines |
| US6455673B1 (en) | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
| US5917017A (en) | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
| GB9422096D0 (en) | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
| AU712981B2 (en) | 1995-03-22 | 1999-11-18 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents |
| NZ311000A (en) | 1995-06-07 | 1999-04-29 | Smithkline Beecham Biolog | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and a free carrier protein |
| IL122588A (en) | 1995-06-23 | 2001-12-23 | Smithkline Beecham Biolog | A combination vaccine containing a polysaccharide conjugated antigen attached to a phosphate aluminum and one or more additional antibodies |
| SE9601158D0 (sv) | 1996-03-26 | 1996-03-26 | Stefan Svenson | Method of producing immunogenic products and vaccines |
| EP1271490B1 (en) | 1996-10-23 | 2011-12-21 | Panasonic Corporation | Optical disk |
| CA2271720A1 (en) | 1996-10-31 | 1998-05-07 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
| WO1998026799A1 (en) | 1996-12-18 | 1998-06-25 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Conjugate vaccine for salmonella paratyphi a |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| FR2763244B1 (fr) | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
| AU4707097A (en) | 1997-09-15 | 1999-04-05 | Pasteur Merieux Serums Et Vaccins | Multivalent vaccines |
| WO1999013905A1 (en) | 1997-09-18 | 1999-03-25 | The Trustees Of The University Of Pennsylvania | Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery |
| US5965714A (en) | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
| US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| CA2264970A1 (en) | 1998-03-10 | 1999-09-10 | American Cyanamid Company | Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria |
| GB9806456D0 (en) | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| WO1999055715A2 (en) * | 1998-04-28 | 1999-11-04 | Galenica Pharmaceuticals, Inc. | Polysaccharide-antigen conjugates |
| CN1263510C (zh) | 1998-08-19 | 2006-07-12 | 巴克斯特健康护理股份有限公司 | 多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用 |
| AU1626199A (en) † | 1998-12-04 | 2000-06-26 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | A vi-repa conjugate vaccine for immunization against salmonella typhi |
| DE69940439D1 (de) | 1998-12-21 | 2009-04-02 | Medimmune Inc | Streptococcus pneumoniae proteine und immunogene fragmente für impstoffe |
| US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| EP2286792A1 (en) | 1999-02-26 | 2011-02-23 | Novartis Vaccines and Diagnostics, Inc. | Microemulsions with an adsorbent surface, comprising a microdroplet emulsion |
| JP2002539273A (ja) * | 1999-03-19 | 2002-11-19 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ワクチン |
| CA2365914A1 (en) | 1999-04-09 | 2000-10-19 | Techlab, Inc. | Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines |
| ES2343304T3 (es) * | 1999-06-25 | 2010-07-28 | Wyeth Holdings Corporation | Produccion de la forma lipidada de las lipoproteinas asociadas a peptidoglicano de bacterias gram-negativas. |
| GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| GB9925559D0 (en) | 1999-10-28 | 1999-12-29 | Smithkline Beecham Biolog | Novel method |
| DK1233784T3 (da) | 1999-12-02 | 2008-09-01 | Novartis Vaccines & Diagnostic | Præparater og fremgangsmåder til stabilisering af biologiske molekyler efter lyofilisering |
| FR2806304B1 (fr) * | 2000-03-17 | 2002-05-10 | Aventis Pasteur | Conjugues polysaccharidiques du pneumocoque a usage vaccinal contre le tetanos et la diphterie |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| DK1296715T4 (en) | 2000-06-29 | 2016-03-07 | Smithkline Beecham Biolog | Multivalent vaccine composition. |
| KR20030024811A (ko) * | 2000-07-27 | 2003-03-26 | 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 | 나이세리아 메닌지티디스에 의하여 유발되는 질병에 대한광범위하게 유효한 보호를 위한 백신 |
| GB0103170D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| ATE439372T1 (de) * | 2000-10-27 | 2009-08-15 | Novartis Vaccines & Diagnostic | Nukleinsäuren und proteine von gruppen a und b- streptokokken |
| PT2332581E (pt) * | 2001-01-23 | 2015-10-16 | Sanofi Pasteur Inc | Vacina meningocócica tri- ou tetravalente de conjugados de polissacárido e crm-197 |
| GB0107661D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| US20030035806A1 (en) | 2001-05-11 | 2003-02-20 | D'ambra Anello J. | Novel meningitis conjugate vaccine |
| US6615062B2 (en) | 2001-05-31 | 2003-09-02 | Infraredx, Inc. | Referencing optical catheters |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0118249D0 (en) * | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| CU23031A1 (es) | 2002-01-24 | 2005-02-23 | Ct Ingenieria Genetica Biotech | Antigeno de superficie del virus de la hepatitis b como inmunopotenciador mucosal, formulaciones resultantes |
| MXPA04008890A (es) | 2002-03-15 | 2005-10-18 | Wyeth Corp | Mutantes de la proteina p4 de haemophilus influenzae no tipicable con actividad enzimatica reducida. |
| DK1777236T3 (en) * | 2002-03-26 | 2017-02-27 | Glaxosmithkline Biologicals Sa | MODIFIED SUCCARIDES WHICH IMPROVED WATER STABILITY FOR USE AS A MEDICINE |
| GB0210128D0 (en) * | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
| GB0302218D0 (en) | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| CN1816350B (zh) | 2002-05-14 | 2010-11-10 | 莱顿大学 | 带有几丁聚糖佐剂和/或脑膜炎抗原的粘膜疫苗 |
| DE60328481D1 (de) * | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält |
| GB0211118D0 (en) * | 2002-05-15 | 2002-06-26 | Polonelli Luciano | Vaccines |
| US20040096461A1 (en) | 2002-07-30 | 2004-05-20 | Baxter Healthcare Corporation | Chimeric multivalent polysaccharide conjugate vaccines |
| CA2493124C (en) | 2002-08-02 | 2014-04-29 | Glaxosmithkline Biologicals S.A. | Vaccine |
| GB0220199D0 (en) | 2002-08-30 | 2002-10-09 | Univ Utrecht | Mutant protein and refolding method |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| CN1809380B (zh) * | 2002-10-11 | 2010-05-12 | 启龙有限公司 | 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 |
| CN1401328A (zh) * | 2002-10-18 | 2003-03-12 | 北京绿竹生物技术有限责任公司 | 流行性脑脊髓膜炎多糖-蛋白结合疫苗 |
| MXPA05004528A (es) | 2002-11-01 | 2005-07-26 | Glaxosmithkline Biolog Sa | Composicion inmunogenica. |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| CN1168501C (zh) | 2002-12-27 | 2004-09-29 | 北京绿竹生物技术有限责任公司 | 一种多糖-蛋白结合疫苗 |
| ES2461350T3 (es) * | 2003-01-30 | 2014-05-19 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| PT1601689E (pt) * | 2003-03-13 | 2008-01-04 | Glaxosmithkline Biolog Sa | Processo de purificação para citolisina bacteriana |
| US20060251675A1 (en) | 2003-03-17 | 2006-11-09 | Michael Hagen | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
| JP2006528936A (ja) * | 2003-05-07 | 2006-12-28 | アヴェンティス パストゥール インコーポレイテッド | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
| JP5557415B2 (ja) | 2003-06-02 | 2014-07-23 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物 |
| GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| CA2530434A1 (en) | 2003-06-23 | 2005-01-06 | Aventis Pasteur, Inc. | Immunization method against neisseria meningitidis serogroups a and c |
| KR101034055B1 (ko) | 2003-07-18 | 2011-05-12 | 엘지이노텍 주식회사 | 발광 다이오드 및 그 제조방법 |
| US8048432B2 (en) * | 2003-08-06 | 2011-11-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Polysaccharide-protein conjugate vaccines |
| CA2844154C (en) * | 2003-08-06 | 2016-12-20 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Polysaccharide-protein conjugate vaccines |
| US6995363B2 (en) * | 2003-08-21 | 2006-02-07 | Applera Corporation | Reduction of matrix interference for MALDI mass spectrometry analysis |
| ATE474595T1 (de) * | 2003-10-02 | 2010-08-15 | Glaxosmithkline Biolog Sa | B. pertussis antigene und ihre verwendung bei der vakzinierung |
| NZ546430A (en) * | 2003-10-02 | 2009-04-30 | Novartis Vaccines & Diagnostic | Liquid vaccines for multiple meningococcal serogroups |
| JP5173194B2 (ja) | 2003-12-23 | 2013-03-27 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| GB0405787D0 (en) * | 2004-03-15 | 2004-04-21 | Chiron Srl | Low dose vaccines |
| JP5393978B2 (ja) | 2004-04-05 | 2014-01-22 | ゾエティス・ピー・エルエルシー | マイクロ流動化された水中油型乳剤及びワクチン組成物 |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| US9402915B2 (en) | 2004-04-30 | 2016-08-02 | Glaxosmithkline Biologicals Sa | Integration of meningococcal conjugate vaccination |
| GB0409745D0 (en) * | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0413868D0 (en) * | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| EP2298340B1 (en) * | 2004-09-22 | 2014-04-16 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition for use in vaccination against staphylococcei |
| US20060121055A1 (en) * | 2004-12-06 | 2006-06-08 | Becton, Dickinson And Company, Inc. | Compositions with enhanced immunogenicity |
| GB0428394D0 (en) * | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
| GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| SI2351772T1 (sl) | 2005-02-18 | 2016-11-30 | Glaxosmithkline Biologicals Sa | Proteini in nukleinske kisline iz Escherichia coli povezane z meningitisom/sepso |
| GB0505518D0 (en) | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| EP2425853A1 (en) * | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent Pneumococcal Polysaccharide-Protein Conjugate Composition |
| US20070184072A1 (en) * | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| BRPI0611447A2 (pt) | 2005-05-06 | 2010-09-08 | Stockholm University | imunógenos para vacinas contra meningite a |
| LT2351578T (lt) * | 2005-06-27 | 2017-04-10 | Glaxosmithkline Biologicals S.A. | Vakcinų gavimo būdas |
| CN1709505B (zh) | 2005-07-13 | 2010-06-16 | 北京绿竹生物制药有限公司 | 多价细菌荚膜多糖-蛋白质结合物联合疫苗 |
| EP2308504A3 (en) | 2005-09-01 | 2011-11-30 | Novartis Vaccines and Diagnostics GmbH | Multiple vaccines including serogroup C meningococcus |
| ES2407683T3 (es) * | 2005-09-05 | 2013-06-13 | Glaxosmithkline Biologicals S.A. | Ensayo bactericida del suero para antisuero específico de N. Meningitidis |
| GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
| BRPI0620460B8 (pt) | 2005-12-22 | 2021-05-25 | Glaxosmithkline Biologicals Sa | uso de composição imunogênica para bebês, e, processo para produzir uma vacina |
| GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| WO2007071786A2 (en) * | 2005-12-23 | 2007-06-28 | Glaxosmithkline Biologicals Sa | Conjugate vaccines |
| CN101405028B (zh) * | 2006-03-17 | 2015-08-19 | 美国政府健康及人类服务部 | 制备复合的多价免疫原性结合物的方法 |
| MY148405A (en) * | 2006-03-30 | 2013-04-30 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| AR060187A1 (es) | 2006-03-30 | 2008-05-28 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
| CN101479293A (zh) | 2006-06-29 | 2009-07-08 | 诺华有限公司 | 脑膜炎奈瑟球菌多肽 |
| US7491517B2 (en) * | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
| WO2008011120A2 (en) | 2006-07-21 | 2008-01-24 | The Regents Of The University Of California | Human endogenous retrovirus polypeptide compositions and methods of use thereof |
| EA015964B1 (ru) * | 2006-09-07 | 2012-01-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
| GB0700135D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Vaccine |
| GB0700136D0 (en) | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| WO2008111374A1 (ja) * | 2007-03-14 | 2008-09-18 | Konica Minolta Business Technologies, Inc. | 情報埋め込み方法、そのプログラムおよび情報埋め込み装置 |
| EA201490303A1 (ru) | 2007-05-02 | 2014-05-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
| JP5637848B2 (ja) * | 2007-06-04 | 2014-12-10 | ノバルティス アーゲー | 髄膜炎ワクチンの製剤化 |
| BRPI0813644B8 (pt) | 2007-06-26 | 2021-05-25 | Glaxosmithkline Biologicals Sa | composição imunogênica, vacina, processo para fabricar a mesma, e, uso da composição imunogênica ou vacina |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| MX2011002267A (es) * | 2008-08-28 | 2011-03-30 | Glaxosmithkline Biolog Sa | Vacuna. |
| GB0816447D0 (en) * | 2008-09-08 | 2008-10-15 | Glaxosmithkline Biolog Sa | Vaccine |
| US8259461B2 (en) * | 2008-11-25 | 2012-09-04 | Micron Technology, Inc. | Apparatus for bypassing faulty connections |
| EP2493510B1 (en) * | 2009-09-30 | 2020-07-08 | GlaxoSmithKline Biologicals SA | Conjugation of staphylococcus aureus type 5 and type 8 capsular polysaccharides |
| TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| GB201003922D0 (en) * | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| BR112012022800A2 (pt) * | 2010-03-11 | 2018-05-15 | Glaxosmithkline Biologicals Sa | composição imunogênica ou vacina, cepa bacteriana gram-negativa geneticamente engenheirada, métodos para o tratamento ou prevenção de infecção ou doença, para produzir uma composição imunogênica ou uma vacina, e para preparar uma imunoglobulina, preparação da imunoglobulina, e, preparação farmacêutica |
| JP5144836B2 (ja) * | 2010-06-11 | 2013-02-13 | パナソニック株式会社 | 語音聴取の評価システム、その方法およびそのプログラム |
| WO2013068949A1 (en) * | 2011-11-07 | 2013-05-16 | Novartis Ag | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| GB2495341B (en) | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| MX354103B (es) * | 2012-01-30 | 2018-02-13 | Serum Inst India Ltd | Composicion inmunogenica. |
| RU2014151567A (ru) * | 2012-05-22 | 2016-07-10 | Новартис Аг | Конъюгат менингококка серогруппы х |
| WO2014001328A1 (en) | 2012-06-25 | 2014-01-03 | Nadiro A/S | A lifeboat deployment unit |
| HRP20230359T1 (hr) * | 2012-12-05 | 2023-06-09 | Glaxosmithkline Biologicals Sa | Imunogeni pripravak |
| GB201310008D0 (en) * | 2013-06-05 | 2013-07-17 | Glaxosmithkline Biolog Sa | Immunogenic composition for use in therapy |
| US10245310B2 (en) * | 2014-08-05 | 2019-04-02 | Glaxosmithkline Biologicals Sa | Carrier molecule for antigens |
| TWI715617B (zh) * | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
| GB201518684D0 (en) * | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| RS65362B1 (sr) * | 2016-09-02 | 2024-04-30 | Sanofi Pasteur Inc | Vakcina protiv neisseria meningitidis |
| US11951165B2 (en) * | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| US10183070B2 (en) * | 2017-01-31 | 2019-01-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| BR112020000999A2 (pt) * | 2017-07-18 | 2020-07-14 | Serum Institute Of India Pvt Ltd. | composição imunogênica tendo estabilidade aperfeiçoada, imunogenicidade melhorada e reatogenicidade reduzida e processo para a sua preparação |
-
2006
- 2006-06-23 LT LTEP10179820.5T patent/LT2351578T/lt unknown
- 2006-06-23 EP EP06754611.9A patent/EP1896065B2/en active Active
- 2006-06-23 PE PE2006000719A patent/PE20070163A1/es active IP Right Grant
- 2006-06-23 EP EP15189397.1A patent/EP3009146B1/en active Active
- 2006-06-23 US US11/917,610 patent/US9789179B2/en active Active
- 2006-06-23 AU AU2006263963A patent/AU2006263963B2/en active Active
- 2006-06-23 EP EP14198052.4A patent/EP2878307B1/en active Active
- 2006-06-23 PT PT06754611T patent/PT1896065E/pt unknown
- 2006-06-23 BR BRPI0612655-3A patent/BRPI0612655B1/pt active IP Right Grant
- 2006-06-23 SI SI200632356T patent/SI2283857T1/sl unknown
- 2006-06-23 US US11/917,569 patent/US8431136B2/en active Active
- 2006-06-23 US US11/917,702 patent/US9486515B2/en active Active
- 2006-06-23 DK DK06754599.6T patent/DK1896063T3/da active
- 2006-06-23 EP EP06754596A patent/EP1896062B1/en not_active Revoked
- 2006-06-23 PE PE2006000720A patent/PE20070499A1/es active IP Right Grant
- 2006-06-23 MX MX2007016405A patent/MX2007016405A/es active IP Right Grant
- 2006-06-23 HR HRP20110567TT patent/HRP20110567T4/hr unknown
- 2006-06-23 WO PCT/EP2006/006220 patent/WO2007000327A1/en not_active Ceased
- 2006-06-23 KR KR1020087002217A patent/KR101351870B1/ko active Active
- 2006-06-23 DK DK06754582.2T patent/DK1896061T3/da active
- 2006-06-23 JP JP2008517440A patent/JP2008543907A/ja active Pending
- 2006-06-23 ES ES06754599.6T patent/ES2377075T5/es active Active
- 2006-06-23 BR BRPI0612656-1A patent/BRPI0612656B1/pt active IP Right Grant
- 2006-06-23 WO PCT/EP2006/006210 patent/WO2007000322A1/en not_active Ceased
- 2006-06-23 AU AU2006263965A patent/AU2006263965B2/en active Active
- 2006-06-23 WO PCT/EP2006/006188 patent/WO2007000314A2/en not_active Ceased
- 2006-06-23 AT AT06754611T patent/ATE516816T1/de active
- 2006-06-23 PL PL06754582T patent/PL1896061T3/pl unknown
- 2006-06-23 MX MX2007016403A patent/MX2007016403A/es active IP Right Grant
- 2006-06-23 BR BRPI0612654A patent/BRPI0612654B8/pt active IP Right Grant
- 2006-06-23 DE DE602006013313T patent/DE602006013313D1/de active Active
- 2006-06-23 CN CN201210028358.6A patent/CN102526723B/zh active Active
- 2006-06-23 HU HUE10179820A patent/HUE031380T2/en unknown
- 2006-06-23 US US11/917,580 patent/US8329184B2/en active Active
- 2006-06-23 PL PL10177832T patent/PL2283857T3/pl unknown
- 2006-06-23 NZ NZ564607A patent/NZ564607A/en unknown
- 2006-06-23 JP JP2008517436A patent/JP5280199B2/ja active Active
- 2006-06-23 UA UAA200714086A patent/UA95238C2/uk unknown
- 2006-06-23 CA CA2612980A patent/CA2612980C/en active Active
- 2006-06-23 SI SI200632415T patent/SI3009146T1/sl unknown
- 2006-06-23 PL PL10179820T patent/PL2351578T3/pl unknown
- 2006-06-23 PL PL06754596T patent/PL1896062T3/pl unknown
- 2006-06-23 WO PCT/EP2006/006269 patent/WO2007000342A2/en not_active Ceased
- 2006-06-23 ES ES06754596T patent/ES2340711T3/es active Active
- 2006-06-23 KR KR1020077031058A patent/KR101351873B1/ko not_active Expired - Fee Related
- 2006-06-23 DK DK06754596.2T patent/DK1896062T3/da active
- 2006-06-23 PL PL06754611T patent/PL1896065T5/pl unknown
- 2006-06-23 KR KR1020087002312A patent/KR101408113B1/ko active Active
- 2006-06-23 US US11/917,726 patent/US8398983B2/en active Active
- 2006-06-23 WO PCT/EP2006/006270 patent/WO2007000343A2/en not_active Ceased
- 2006-06-23 PT PT06754596T patent/PT1896062E/pt unknown
- 2006-06-23 ES ES10158046.2T patent/ES2662651T3/es active Active
- 2006-06-23 EA EA200702577A patent/EA013374B1/ru not_active IP Right Cessation
- 2006-06-23 CN CN2011101438611A patent/CN102218138A/zh active Pending
- 2006-06-23 HU HUE10177832A patent/HUE047211T2/hu unknown
- 2006-06-23 DK DK10177832T patent/DK2283857T3/da active
- 2006-06-23 SI SI200632352T patent/SI2878307T1/sl unknown
- 2006-06-23 CA CA2611964A patent/CA2611964C/en active Active
- 2006-06-23 MX MX2007016402A patent/MX2007016402A/es active IP Right Grant
- 2006-06-23 PT PT101778322T patent/PT2283857T/pt unknown
- 2006-06-23 HR HR20120102T patent/HRP20120102T1/hr unknown
- 2006-06-23 AR ARP060102724A patent/AR056397A1/es not_active Application Discontinuation
- 2006-06-23 BR BRPI0612670A patent/BRPI0612670B8/pt active IP Right Grant
- 2006-06-23 DK DK14198052.4T patent/DK2878307T3/da active
- 2006-06-23 KR KR1020077030683A patent/KR101359953B1/ko active Active
- 2006-06-23 AU AU2006263944A patent/AU2006263944B2/en active Active
- 2006-06-23 EA EA200702575A patent/EA012528B1/ru not_active IP Right Cessation
- 2006-06-23 EP EP06754610A patent/EP1896064A2/en not_active Ceased
- 2006-06-23 HU HUE15189397A patent/HUE056842T2/hu unknown
- 2006-06-23 SI SI200632159A patent/SI2351578T1/sl unknown
- 2006-06-23 ES ES14198052T patent/ES2747025T3/es active Active
- 2006-06-23 PT PT06754599T patent/PT1896063E/pt unknown
- 2006-06-23 SI SI200631247T patent/SI1896063T1/sl unknown
- 2006-06-23 PT PT141980524T patent/PT2878307T/pt unknown
- 2006-06-23 ES ES06762248T patent/ES2901378T3/es active Active
- 2006-06-23 SI SI200631109T patent/SI1896065T2/sl unknown
- 2006-06-23 DK DK10179820.5T patent/DK2351578T3/en active
- 2006-06-23 ES ES15189397T patent/ES2898451T3/es active Active
- 2006-06-23 US US11/917,709 patent/US9931397B2/en active Active
- 2006-06-23 AU AU2006263964A patent/AU2006263964B2/en active Active
- 2006-06-23 EA EA200702574A patent/EA012214B1/ru not_active IP Right Cessation
- 2006-06-23 AT AT06754596T patent/ATE462444T1/de active
- 2006-06-23 PL PL15189397T patent/PL3009146T3/pl unknown
- 2006-06-23 AU AU2006263936A patent/AU2006263936B2/en active Active
- 2006-06-23 JP JP2008517441A patent/JP5297800B2/ja active Active
- 2006-06-23 PT PT101798205T patent/PT2351578T/pt unknown
- 2006-06-23 NZ NZ564606A patent/NZ564606A/en unknown
- 2006-06-23 HU HUE14198052A patent/HUE046905T2/hu unknown
- 2006-06-23 CA CA2612963A patent/CA2612963C/en active Active
- 2006-06-23 SI SI200630681T patent/SI1896062T1/sl unknown
- 2006-06-23 AP AP2007004274A patent/AP2436A/xx active
- 2006-06-23 NO NO20076343A patent/NO345422B1/no active Protection Beyond IP Right Term
- 2006-06-23 PT PT06754582T patent/PT1896061T/pt unknown
- 2006-06-23 WO PCT/EP2006/006268 patent/WO2007000341A2/en not_active Ceased
- 2006-06-23 EA EA200702576A patent/EA012506B1/ru not_active IP Right Cessation
- 2006-06-23 EP EP10158046.2A patent/EP2201961B1/en active Active
- 2006-06-23 CA CA2611960A patent/CA2611960C/en active Active
- 2006-06-23 NZ NZ590204A patent/NZ590204A/en unknown
- 2006-06-23 KR KR1020077030681A patent/KR101321056B1/ko active Active
- 2006-06-23 PE PE2010000444A patent/PE20110096A1/es active IP Right Grant
- 2006-06-23 CA CA2612957A patent/CA2612957C/en active Active
- 2006-06-23 EP EP06762248.0A patent/EP1896066B8/en active Active
- 2006-06-23 EP EP10179820.5A patent/EP2351578B1/en active Active
- 2006-06-23 EP EP06754582.2A patent/EP1896061B1/en active Active
- 2006-06-23 PL PL06754599T patent/PL1896063T3/pl unknown
- 2006-06-23 HR HR20100211T patent/HRP20100211T1/hr unknown
- 2006-06-23 MX MX2007016236A patent/MX2007016236A/es active IP Right Grant
- 2006-06-23 SI SI200632346T patent/SI1896061T1/sl unknown
- 2006-06-23 EP EP06754599.6A patent/EP1896063B2/en active Active
- 2006-06-23 EP EP10177832.2A patent/EP2283857B1/en active Active
- 2006-06-23 KR KR1020137018446A patent/KR101532068B1/ko active Active
- 2006-06-23 AR ARP060102725A patent/AR053935A1/es not_active Application Discontinuation
- 2006-06-23 PT PT151893971T patent/PT3009146T/pt unknown
- 2006-06-23 PE PE2006000718A patent/PE20070123A1/es not_active Application Discontinuation
- 2006-06-23 JP JP2008517437A patent/JP5037503B2/ja active Active
- 2006-06-23 JP JP2008517442A patent/JP5731737B2/ja active Active
- 2006-06-23 PE PE2010000450A patent/PE20110072A1/es not_active Application Discontinuation
- 2006-06-23 BR BRPI0612669A patent/BRPI0612669B8/pt active IP Right Grant
- 2006-06-23 UA UAA200714084A patent/UA95237C2/uk unknown
- 2006-06-23 PE PE2014001334A patent/PE20142165A1/es active IP Right Grant
- 2006-06-23 ES ES10179820.5T patent/ES2621780T3/es active Active
- 2006-06-23 NZ NZ564370A patent/NZ564370A/en unknown
- 2006-06-23 KR KR1020137028209A patent/KR20130122810A/ko not_active Ceased
- 2006-06-23 CN CN201310023297.9A patent/CN103083657B/zh active Active
- 2006-06-23 NZ NZ564605A patent/NZ564605A/en unknown
- 2006-06-23 ES ES10177832T patent/ES2750243T3/es active Active
- 2006-06-23 MX MX2007016237A patent/MX2007016237A/es active IP Right Grant
- 2006-06-23 AR ARP060102723A patent/AR056396A1/es not_active Application Discontinuation
- 2006-06-23 PL PL14198052T patent/PL2878307T3/pl unknown
- 2006-06-23 HU HUE06754582A patent/HUE045482T2/hu unknown
- 2006-06-23 AT AT06754599T patent/ATE536884T1/de active
- 2006-06-23 NZ NZ564371A patent/NZ564371A/en not_active IP Right Cessation
- 2006-06-23 DK DK06754611.9T patent/DK1896065T4/da active
- 2006-06-23 ES ES06754582T patent/ES2741529T3/es active Active
- 2006-06-26 TW TW095122979A patent/TWI407970B/zh active
- 2006-06-26 TW TW102118476A patent/TW201336507A/zh unknown
- 2006-06-26 TW TW095122993A patent/TWI477283B/zh active
- 2006-06-26 MY MYPI20063025A patent/MY147490A/en unknown
- 2006-06-26 MY MYPI20063023A patent/MY148110A/en unknown
- 2006-06-26 TW TW102148542A patent/TWI537001B/zh active
- 2006-06-26 TW TW095122969A patent/TWI422386B/zh active
- 2006-06-26 MY MYPI20063024A patent/MY147783A/en unknown
-
2007
- 2007-12-06 IL IL187924A patent/IL187924A/en active IP Right Grant
- 2007-12-07 NO NO20076302A patent/NO344452B1/no unknown
- 2007-12-11 IL IL188046A patent/IL188046A/en active IP Right Grant
- 2007-12-11 IL IL188045A patent/IL188045A0/en active IP Right Grant
- 2007-12-11 NO NO20076350A patent/NO342815B1/no unknown
- 2007-12-12 NO NO20076363A patent/NO345305B1/no unknown
- 2007-12-12 IL IL188072A patent/IL188072A/en active IP Right Grant
- 2007-12-26 MA MA30511A patent/MA29602B1/fr unknown
- 2007-12-26 MA MA30512A patent/MA29603B1/fr unknown
- 2007-12-27 MA MA30521A patent/MA29569B1/fr unknown
- 2007-12-27 MA MA30522A patent/MA29993B1/fr unknown
-
2010
- 2010-04-30 CY CY20101100387T patent/CY1109996T1/el unknown
- 2010-07-21 AU AU2010203115A patent/AU2010203115C1/en active Active
- 2010-08-18 AU AU2010212417A patent/AU2010212417A1/en not_active Abandoned
-
2011
- 2011-06-22 IL IL213718A patent/IL213718A/en active IP Right Grant
- 2011-06-28 IL IL213795A patent/IL213795A/en active IP Right Grant
- 2011-08-15 IL IL214657A patent/IL214657A0/en unknown
- 2011-09-15 CY CY20111100883T patent/CY1111827T1/el unknown
-
2012
- 2012-02-21 CY CY20121100175T patent/CY1112698T1/el unknown
- 2012-04-27 US US13/457,891 patent/US8846049B2/en active Active
- 2012-10-11 IL IL222346A patent/IL222346A/en active IP Right Grant
- 2012-10-16 CY CY2012027C patent/CY2012027I1/el unknown
- 2012-10-16 LT LTPA2012019C patent/LTC1896065I2/lt unknown
- 2012-10-18 BE BE2012C042C patent/BE2012C042I2/fr unknown
- 2012-10-19 LU LU92085C patent/LU92085I2/fr unknown
- 2012-10-19 HU HUS1200023C patent/HUS1200023I1/hu unknown
- 2012-10-19 NL NL300549C patent/NL300549I2/nl unknown
- 2012-11-01 JP JP2012241817A patent/JP5769688B2/ja active Active
-
2013
- 2013-02-27 US US13/778,633 patent/US8883163B2/en active Active
- 2013-03-13 JP JP2013050333A patent/JP5718960B2/ja active Active
- 2013-05-14 JP JP2013102249A patent/JP2013209395A/ja active Pending
-
2014
- 2014-10-28 US US14/525,883 patent/US9358279B2/en active Active
-
2015
- 2015-04-28 JP JP2015091394A patent/JP5965512B2/ja active Active
-
2016
- 2016-09-14 US US15/265,597 patent/US10245317B2/en active Active
-
2017
- 2017-02-21 CY CY20171100234T patent/CY1118646T1/el unknown
- 2017-03-20 HR HRP20170457TT patent/HRP20170457T1/hr unknown
- 2017-08-30 US US15/691,440 patent/US10166287B2/en active Active
-
2018
- 2018-11-02 US US16/179,476 patent/US11241495B2/en active Active
-
2019
- 2019-02-05 US US16/268,287 patent/US20200000911A1/en not_active Abandoned
-
2021
- 2021-12-07 NL NL301151C patent/NL301151I2/nl unknown
- 2021-12-29 LU LU00247C patent/LUC00247I2/fr unknown
-
2022
- 2022-01-13 HU HUS2200002C patent/HUS2200002I1/hu unknown
- 2022-02-21 FR FR22C1008C patent/FR22C1008I2/fr active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2007000343A3 (en) | Process for manufacturing vaccines | |
| WO2008081014A3 (en) | Process for manufacturing vaccines | |
| Detz et al. | Enantioselective Copper‐Catalysed Propargylic Substitution: Synthetic Scope Study and Application in Formal Total Syntheses of (+)‐Anisomycin and (−)‐Cytoxazone | |
| CY1119416T1 (el) | Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ' αυτων | |
| WO2006031560A3 (en) | Process for concentration of antibodies and therapeutic products thereof | |
| CR8765A (es) | Preparacion de pregabalina y compuestos relacionados | |
| NO20083062L (no) | Humane monoklonale antistoffer mot fukosyl-GM1 og fremgangsmater for anvendelse av anti-fukosyl-GM1 | |
| EA200702278A1 (ru) | Антитела, специфичные в отношении tgf-бета 1 | |
| WO2006005074A3 (en) | Novel hot start nucleic acid amplification | |
| WO2006089230A3 (en) | Human monoclonal antibodies to prostate specific membrane antigen (psma) | |
| NO20080590L (no) | Humane, monoklonale antistoffer mot programmert dodsligand (PD-L1) | |
| PH12015501848A1 (en) | Binding agents | |
| EA200801571A1 (ru) | Композиции, содержащие молекулы ctl4-ig, и способы их получения | |
| MX348432B (es) | Epitopes. | |
| NO20081987L (no) | Humane, monoklonale antistoffer mot CD70 | |
| NO20083053L (no) | Humane monoklonale antistoffer mot O8E | |
| TW200732346A (en) | Chimeric hepatitis C virus antigens for eliciting an immune response | |
| WO2008139206A3 (en) | Optical imaging agents | |
| MX2010001723A (es) | Formulaciones de anticuerpos y moleculas de fusion-fc usando policationes. | |
| DE602004031368D1 (de) | Universelle vervielfältigung von fragmentierter rns | |
| WO2006116181A3 (en) | Regulatory t cell mediator proteins and uses thereof | |
| BRPI0412916A (pt) | formulações liofilizadas de cci-779 | |
| WO2008046232A8 (en) | Aziridine aldehydes, aziridine-conjugated amino derivatives, aziridine-conjugated biomolecules and processes for their preparation | |
| Thedy et al. | Exploring Metallaphotoredox Catalysis: A Synergistic Approach to Biomolecule Functionalization | |
| WO2006015370A3 (en) | Site specific system for generating diversity protein sequences |