ECSP088466A - Compuesto de cinamida biciclico - Google Patents

Compuesto de cinamida biciclico

Info

Publication number
ECSP088466A
ECSP088466A EC2008008466A ECSP088466A ECSP088466A EC SP088466 A ECSP088466 A EC SP088466A EC 2008008466 A EC2008008466 A EC 2008008466A EC SP088466 A ECSP088466 A EC SP088466A EC SP088466 A ECSP088466 A EC SP088466A
Authority
EC
Ecuador
Prior art keywords
group
optionally substituted
cinamide
bicycle
composite
Prior art date
Application number
EC2008008466A
Other languages
English (en)
Inventor
Teiji Kimura
Koki Kawano
Eriko Doi
Noritaka Kitazawa
Mamoru Takaishi
Koichi Ito
Toshihiko Kaneko
Takeo Sasaki
Takehiko Miyagawa
Hiroaki Hagiwara
Yu Yoshida
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of ECSP088466A publication Critical patent/ECSP088466A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto de cinamida bicíclico representado por la Fórmula general (I):en donde ---- representa un enlace sencillo o un enlace doble; Ar1 representa un grupo fenilo o grupo piridinilo opcionalmente substituido por uno hasta tres substituyentes; R1 y R2 cada uno representa un grupo alquilo C1-6, un grupo hidroxilo, etc.; Z1 representa un grupo metileno opcionalmente substituido o grupo vinileno, un átomo de oxígeno, o un grupo imino opcionalmente substituido por un grupo alquilo C1-6 o un grupo acilo C1-6; y p, q, y r cada uno es un entero de 0 hasta 2. Funciona para reducir Ab40 y Ab42. Por lo tanto útil especialmente como una prevención o remedio para enfermedades neurodegenerativas de las cuales Ab es el causante, tal como enfermedad de Alzheimer y síndrome de Down.
EC2008008466A 2005-11-24 2008-05-22 Compuesto de cinamida biciclico ECSP088466A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005337963 2005-11-24
JP2006205538 2006-07-28

Publications (1)

Publication Number Publication Date
ECSP088466A true ECSP088466A (es) 2008-08-29

Family

ID=38067057

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008466A ECSP088466A (es) 2005-11-24 2008-05-22 Compuesto de cinamida biciclico

Country Status (25)

Country Link
US (1) US8048878B2 (es)
EP (1) EP1953158B1 (es)
JP (1) JP5178203B2 (es)
KR (1) KR101296239B1 (es)
AR (1) AR057915A1 (es)
AU (1) AU2006317468B2 (es)
BR (1) BRPI0618890A2 (es)
CA (1) CA2629512C (es)
CR (1) CR9983A (es)
EA (1) EA014427B1 (es)
EC (1) ECSP088466A (es)
ES (1) ES2394364T3 (es)
GE (1) GEP20115172B (es)
HN (1) HN2008000792A (es)
MA (1) MA29968B1 (es)
ME (1) ME00040B (es)
MY (1) MY144596A (es)
NO (1) NO20082805L (es)
NZ (1) NZ568422A (es)
PE (1) PE20071029A1 (es)
PL (1) PL1953158T3 (es)
RS (1) RS20080242A (es)
SA (1) SA06270432B1 (es)
TW (1) TWI370130B (es)
WO (1) WO2007060821A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2566094A1 (en) 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Cinnamide compound
AU2005297966B2 (en) 2004-10-26 2010-12-23 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
BRPI0618814A2 (pt) 2005-11-24 2014-04-29 Eisai R&D Man Co Ltd Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico
US7482345B2 (en) * 2005-12-05 2009-01-27 Meng-Hsin Chen P38 kinase inhibiting agents
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
US7737141B2 (en) 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
CL2008000582A1 (es) * 2007-02-28 2008-06-27 Eisai R&D Man Co Ltd Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis.
EP2152695A2 (en) * 2007-06-01 2010-02-17 Schering Corporation Gamma secretase modulators
JP5121346B2 (ja) * 2007-08-07 2013-01-16 国立大学法人 長崎大学 光学活性プロリンエステル誘導体およびｎ−ホルミル光学活性プロリン誘導体の製造方法
CA2694401C (en) 2007-08-31 2012-12-04 Eisai R&D Management Co., Ltd. Polycyclic compound
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
JPWO2009081959A1 (ja) * 2007-12-26 2011-05-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 ４−（置換フェニル）ヘキサヒドロピリド［２，１−ｃ］［１，４］オキサジン−６−オンの製造方法
KR101247840B1 (ko) 2008-02-22 2013-03-26 에프. 호프만-라 로슈 아게 아밀로이드 베타 조절제
JP5502089B2 (ja) 2008-10-09 2014-05-28 エフ．ホフマン−ラ ロシュ アーゲー アミロイドβのモジュレーター
WO2010054064A1 (en) * 2008-11-06 2010-05-14 Schering Corporation Gamma secretase modulators
WO2010054067A1 (en) * 2008-11-06 2010-05-14 Schering Corporation Gamma secretase modulators
WO2010052199A1 (en) 2008-11-10 2010-05-14 F. Hoffmann-La Roche Ag Heterocyclic gamma secretase modulators
AU2009314049B2 (en) * 2008-11-13 2015-03-05 Merck Sharp & Dohme Corp. Gamma secretase modulators
AU2010218714A1 (en) 2009-02-26 2011-09-08 Eisai R&D Management Co., Ltd. Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
KR20110118626A (ko) 2009-02-26 2011-10-31 에자이 알앤드디 매니지먼트 가부시키가이샤 테트라하이드로트리아졸로피리딘 유도체의 염과 이의 결정
JP2012176901A (ja) 2009-09-25 2012-09-13 Eisai R & D Management Co Ltd 新規ベンゾニトリル化合物およびその製造方法
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
KR20130121076A (ko) * 2010-06-15 2013-11-05 에자이 알앤드디 매니지먼트 가부시키가이샤 Ｈｃｖ 감염증 치료제
JP6095208B2 (ja) * 2012-12-04 2017-03-15 学校法人慶應義塾 環化化合物の製造方法、及び、環化化合物を含有する溶液の発光方法
HUE058802T2 (hu) * 2016-12-09 2022-09-28 Denali Therapeutics Inc RIPK1 inhibitorokként alkalmas vegyületek
EP3625234B1 (en) * 2017-05-17 2023-09-20 Denali Therapeutics Inc. Hexahydropyrazolo [1,2-a] diazepinones and related heterocycles as inhibitors of rip-1 kinase
CN114828963A (zh) * 2019-10-07 2022-07-29 D·E·萧尔研究有限责任公司 作为Kv1.3钾SHAKER通道阻滞剂的芳基杂二环化合物

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508718A (en) 1984-01-16 1985-04-02 Warner-Lambert Company Cardiotonic and antihypertensive oxadiazinone compounds
EP0219756B1 (de) 1985-10-09 1994-01-05 Shell Internationale Researchmaatschappij B.V. Neue Acrylsäureamide
US4783463A (en) 1985-10-23 1988-11-08 Rorer Pharmaceutical Corporation Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure
DE3541716A1 (de) 1985-11-26 1987-05-27 Celamerck Gmbh & Co Kg Neue acrylsaeureamide
FI91754C (fi) 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
IT1205834B (it) * 1987-04-22 1989-03-31 Elbart Derivati tiodiossolanici ad attivita' mucolitica a procedimento per la loro preparazione
FI902321A7 (fi) 1989-05-19 1990-11-20 Eisai Co Ltd Buteenihappojohdannaiset
JPH03206042A (ja) 1990-01-06 1991-09-09 Takeda Chem Ind Ltd 降圧剤
WO1991012237A1 (en) 1990-02-08 1991-08-22 Eisai Co., Ltd. Benzenesulfonamide derivative
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
GB9402807D0 (en) 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
EP0784612A1 (en) 1994-10-04 1997-07-23 Fujisawa Pharmaceutical Co., Ltd. Urea derivatives and their use as acat-inhibitors
JPH08283219A (ja) 1995-04-07 1996-10-29 Eisai Co Ltd アラルキルアミノアルキルアミド誘導体
EE9800390A (et) * 1996-05-10 1999-06-15 Icos Corporation Karboliini derivaadid
JP2000515153A (ja) 1996-07-22 2000-11-14 モンサント カンパニー チオールスルホンアミド メタロプロテアーゼインヒビター
WO1998024785A1 (en) 1996-12-02 1998-06-11 Fujisawa Pharmaceutical Co., Ltd. Indole-urea derivatives with 5-ht antagonist properties
JP3108997B2 (ja) 1997-03-31 2000-11-13 武田薬品工業株式会社 アゾール化合物、その製造法および用途
AU6520098A (en) 1997-03-31 1998-10-22 Takeda Chemical Industries Ltd. Azole compounds, their production and their use
TW379224B (en) 1997-12-02 2000-01-11 Fujisawa Pharmaceutical Co Urea derivatives
JP2001527083A (ja) 1997-12-31 2001-12-25 ザ・ユニバーシティ・オブ・カンザス 第二級および第三級アミン含有薬剤の水溶性プロドラッグおよびその製造方法
GB9816984D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
US6235728B1 (en) * 1999-02-19 2001-05-22 Bristol-Myers Squibb Company Water-soluble prodrugs of azole compounds
EP1159263A1 (en) 1999-02-26 2001-12-05 Merck & Co., Inc. Novel sulfonamide compounds and uses thereof
AU2899400A (en) 1999-03-04 2000-09-21 Nortran Pharmaceuticals Inc. Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics
WO2001068585A1 (en) 2000-03-14 2001-09-20 Fujisawa Pharmaceutical Co., Ltd. Novel amide compounds
US20010051642A1 (en) * 2000-04-17 2001-12-13 Kyunghye Ahn Method for treating Alzheimer's disease
WO2001081312A2 (en) 2000-04-24 2001-11-01 Merck Frosst Canada & Co. Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
ATE288898T1 (de) * 2000-12-04 2005-02-15 Hoffmann La Roche Phenylethenyl- oder phenylethinylderivate als glutamatrezeptorantagonisten
GB0108770D0 (en) * 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
CA2458029A1 (en) 2001-09-13 2003-03-20 Boehringer Ingelheim Pharmaceuticals, Inc. Methods of treating cytokine mediated diseases
HUP0401492A3 (en) 2001-09-14 2008-05-28 Novo Nordisk As Novel ligands for the hisb10 zn2+ sites of r-state insulin hexa
AU2002364549B2 (en) 2001-12-10 2007-11-22 Amgen, Inc Vanilloid receptor ligands and their use in treatments
GEP20063920B (en) * 2001-12-20 2006-09-11 Bristol Myers Squibb Co Alpha-(n-sulphonamido) acetamide derivatives as beta-amyloid inhibitors
JP2003206280A (ja) 2001-12-28 2003-07-22 Takeda Chem Ind Ltd ビアリール化合物およびその用途
WO2003062206A2 (en) 2002-01-23 2003-07-31 Arena Pharmaceuticals, Inc. Small molecule modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
GB0207436D0 (en) 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
JP2005531574A (ja) * 2002-05-22 2005-10-20 アムジエン・インコーポレーテツド 痛みの治療にバニロイド受容体リガンドとして使用するためのアミノ−ピリジン、−ピリジンおよびピリダジン誘導体
SI1511710T1 (sl) 2002-05-31 2014-04-30 Proteotech, Inc. Spojine, sestavki in postopki za zdravljenje amiloidnih bolezni in sinukleinopatij, kot je Alzheimerjeva bolezen, diabetes tipa 2 in Parkinsova bolezen
WO2004002478A1 (en) 2002-06-27 2004-01-08 Elan Pharmaceuticals, Inc. Methods for treating alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
DE50312261D1 (de) * 2002-07-12 2010-02-04 Sanofi Aventis Deutschland Heterozyklisch substituierte benzoylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US6900354B2 (en) 2002-07-15 2005-05-31 Hoffman-La Roche Inc. 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives
CN1747936A (zh) 2003-02-12 2006-03-15 特兰斯泰克制药公司 作为治疗试剂的取代吡咯衍生物
EP1628666B1 (en) * 2003-05-14 2015-09-23 NeuroGenetic Pharmaceuticals, Inc. Compouds and uses thereof in modulating amyloid beta
CA2536954C (en) * 2003-08-29 2012-11-27 Exelixis, Inc. C-kit modulators and methods of use
BRPI0417267A (pt) 2003-12-22 2007-04-17 Pfizer derivados de triazol como antagonistas de vasopressina
WO2005072731A1 (en) 2004-01-29 2005-08-11 X-Ceptor Therapeutics, Inc. 3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders
NZ548208A (en) 2004-02-12 2010-09-30 Transtech Pharma Inc Substituted azole derivatives, compositions, and methods of use
CA2566094A1 (en) 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Cinnamide compound
JP2008509982A (ja) 2004-08-16 2008-04-03 プロシディオン・リミテッド アリール尿素誘導体
AU2005297966B2 (en) 2004-10-26 2010-12-23 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
US20060241038A1 (en) 2005-04-20 2006-10-26 Eisai Co., Ltd. Therapeutic agent for Abeta related disorders
WO2007034282A2 (en) 2005-09-19 2007-03-29 Pfizer Products Inc. Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists
EP1953151A4 (en) 2005-11-18 2010-06-02 Eisai R&D Man Co Ltd SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF
CN101309916A (zh) * 2005-11-18 2008-11-19 卫材R&D管理有限公司 制备肉桂酰胺衍生物的方法
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
BRPI0618814A2 (pt) 2005-11-24 2014-04-29 Eisai R&D Man Co Ltd Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico
TWI378091B (en) * 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
PL1992618T3 (pl) 2006-03-09 2012-06-29 Eisai R&D Man Co Ltd Policykliczna pochodna cynamidowa
US7737141B2 (en) * 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
CA2677296A1 (en) 2007-02-08 2008-08-14 Merck & Co., Inc. Therapeutic agents
WO2008137102A2 (en) 2007-05-04 2008-11-13 Torreypines Therapeutics, Inc. Methods of modulating amyloid beta and compounds useful therefor
WO2008137139A1 (en) 2007-05-07 2008-11-13 Schering Corporation Gamma secretase modulators
DE602008004769D1 (en) * 2007-05-11 2011-03-10 Hoffmann La Roche Hetarylaniline als modulatoren für amyloid beta
US8242150B2 (en) 2007-06-13 2012-08-14 Merck Sharp & Dohme Corp. Triazole derivatives for treating alzheimer'S disease and related conditions
PE20090957A1 (es) 2007-08-06 2009-07-13 Schering Corp Moduladores de gamma secretasa

Also Published As

Publication number Publication date
RS20080242A (sr) 2009-09-08
EP1953158A4 (en) 2010-09-01
HN2008000792A (es) 2010-09-17
EP1953158A1 (en) 2008-08-06
ES2394364T3 (es) 2013-01-31
JP5178203B2 (ja) 2013-04-10
US8048878B2 (en) 2011-11-01
PE20071029A1 (es) 2007-11-17
CA2629512C (en) 2014-04-22
US20090181945A1 (en) 2009-07-16
WO2007060821A1 (ja) 2007-05-31
MY144596A (en) 2011-10-14
HK1122806A1 (en) 2009-05-29
TW200804372A (en) 2008-01-16
AR057915A1 (es) 2007-12-26
EA014427B1 (ru) 2010-12-30
MA29968B1 (fr) 2008-11-03
AU2006317468A1 (en) 2007-05-31
ME00040B (me) 2010-06-10
NO20082805L (no) 2008-08-20
KR20080072057A (ko) 2008-08-05
KR101296239B1 (ko) 2013-08-13
CA2629512A1 (en) 2007-05-31
NZ568422A (en) 2010-09-30
EA200801417A1 (ru) 2009-02-27
JPWO2007060821A1 (ja) 2009-05-07
GEP20115172B (en) 2011-03-10
BRPI0618890A2 (pt) 2013-01-08
CR9983A (es) 2008-08-21
EP1953158B1 (en) 2012-09-12
PL1953158T3 (pl) 2013-02-28
AU2006317468B2 (en) 2011-10-13
TWI370130B (en) 2012-08-11
SA06270432B1 (ar) 2011-06-22

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