ECSP088466A - Compuesto de cinamida biciclico - Google Patents

Compuesto de cinamida biciclico

Info

Publication number
ECSP088466A
ECSP088466A EC2008008466A ECSP088466A ECSP088466A EC SP088466 A ECSP088466 A EC SP088466A EC 2008008466 A EC2008008466 A EC 2008008466A EC SP088466 A ECSP088466 A EC SP088466A EC SP088466 A ECSP088466 A EC SP088466A
Authority
EC
Ecuador
Prior art keywords
group
optionally substituted
cinamide
bicycle
composite
Prior art date
Application number
EC2008008466A
Other languages
English (en)
Inventor
Teiji Kimura
Koki Kawano
Eriko Doi
Noritaka Kitazawa
Mamoru Takaishi
Koichi Ito
Toshihiko Kaneko
Takeo Sasaki
Takehiko Miyagawa
Hiroaki Hagiwara
Yu Yoshida
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of ECSP088466A publication Critical patent/ECSP088466A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto de cinamida bicíclico representado por la Fórmula general (I):en donde ---- representa un enlace sencillo o un enlace doble; Ar1 representa un grupo fenilo o grupo piridinilo opcionalmente substituido por uno hasta tres substituyentes; R1 y R2 cada uno representa un grupo alquilo C1-6, un grupo hidroxilo, etc.; Z1 representa un grupo metileno opcionalmente substituido o grupo vinileno, un átomo de oxígeno, o un grupo imino opcionalmente substituido por un grupo alquilo C1-6 o un grupo acilo C1-6; y p, q, y r cada uno es un entero de 0 hasta 2. Funciona para reducir Ab40 y Ab42. Por lo tanto útil especialmente como una prevención o remedio para enfermedades neurodegenerativas de las cuales Ab es el causante, tal como enfermedad de Alzheimer y síndrome de Down.
EC2008008466A 2005-11-24 2008-05-22 Compuesto de cinamida biciclico ECSP088466A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005337963 2005-11-24
JP2006205538 2006-07-28

Publications (1)

Publication Number Publication Date
ECSP088466A true ECSP088466A (es) 2008-08-29

Family

ID=38067057

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008466A ECSP088466A (es) 2005-11-24 2008-05-22 Compuesto de cinamida biciclico

Country Status (25)

Country Link
US (1) US8048878B2 (es)
EP (1) EP1953158B1 (es)
JP (1) JP5178203B2 (es)
KR (1) KR101296239B1 (es)
AR (1) AR057915A1 (es)
AU (1) AU2006317468B2 (es)
BR (1) BRPI0618890A2 (es)
CA (1) CA2629512C (es)
CR (1) CR9983A (es)
EA (1) EA014427B1 (es)
EC (1) ECSP088466A (es)
ES (1) ES2394364T3 (es)
GE (1) GEP20115172B (es)
HN (1) HN2008000792A (es)
MA (1) MA29968B1 (es)
ME (1) ME00040B (es)
MY (1) MY144596A (es)
NO (1) NO20082805L (es)
NZ (1) NZ568422A (es)
PE (1) PE20071029A1 (es)
PL (1) PL1953158T3 (es)
RS (1) RS20080242A (es)
SA (1) SA06270432B1 (es)
TW (1) TWI370130B (es)
WO (1) WO2007060821A1 (es)

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Also Published As

Publication number Publication date
NO20082805L (no) 2008-08-20
PE20071029A1 (es) 2007-11-17
JP5178203B2 (ja) 2013-04-10
EP1953158A1 (en) 2008-08-06
ES2394364T3 (es) 2013-01-31
SA06270432B1 (ar) 2011-06-22
US20090181945A1 (en) 2009-07-16
JPWO2007060821A1 (ja) 2009-05-07
MY144596A (en) 2011-10-14
MA29968B1 (fr) 2008-11-03
CA2629512C (en) 2014-04-22
PL1953158T3 (pl) 2013-02-28
EA014427B1 (ru) 2010-12-30
TWI370130B (en) 2012-08-11
EP1953158B1 (en) 2012-09-12
AU2006317468B2 (en) 2011-10-13
BRPI0618890A2 (pt) 2013-01-08
EP1953158A4 (en) 2010-09-01
CR9983A (es) 2008-08-21
GEP20115172B (en) 2011-03-10
NZ568422A (en) 2010-09-30
US8048878B2 (en) 2011-11-01
RS20080242A (sr) 2009-09-08
HK1122806A1 (en) 2009-05-29
ME00040B (me) 2010-06-10
KR101296239B1 (ko) 2013-08-13
KR20080072057A (ko) 2008-08-05
EA200801417A1 (ru) 2009-02-27
TW200804372A (en) 2008-01-16
WO2007060821A1 (ja) 2007-05-31
AR057915A1 (es) 2007-12-26
CA2629512A1 (en) 2007-05-31
HN2008000792A (es) 2010-09-17
AU2006317468A1 (en) 2007-05-31

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