NO303449B1 - Stereoselektiv syntese av nukleosidanaloger samt bicyklisk forbindelse - Google Patents

Stereoselektiv syntese av nukleosidanaloger samt bicyklisk forbindelse

Info

Publication number: NO303449B1
Authority: NO; Norway
Prior art keywords: pct; formula; image; nucleoside analogues; well
Prior art date: 1993-06-07

Application number

NO950432A

Other languages

English (en)

Norwegian (no)

Other versions

NO950432L (no

NO950432D0 (no

Inventor

Tarek S Mansour

Colleen A Evans

Haolun Jin

Arshad M Siddiqui

Allan H L Tse

Original Assignee

Iaf Biochem Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-07

Filing date

1995-02-06

Publication date

1998-07-13

1995-02-06 Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int

1995-02-06 Publication of NO950432D0 publication Critical patent/NO950432D0/no

1995-03-13 Publication of NO950432L publication Critical patent/NO950432L/no

1998-07-13 Publication of NO303449B1 publication Critical patent/NO303449B1/no

Links

229940127073 nucleoside analogue Drugs 0.000 title abstract 2
-1 bicyclic compound Chemical class 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
230000000707 stereoselective effect Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
239000002841 Lewis acid Substances 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
229910052736 halogen Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 abstract 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NO950432A 1993-06-07 1995-02-06 Stereoselektiv syntese av nukleosidanaloger samt bicyklisk forbindelse NO303449B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939311709A GB9311709D0 (en)	1993-06-07	1993-06-07	Stereoselective synthesis of nucleoside analogues using bicycle intermediate
PCT/CA1994/000311 WO1994029301A1 (en)	1993-06-07	1994-06-07	Stereoselective synthesis of nucleoside analogues using bicyclic intermediate

Publications (3)

Publication Number	Publication Date
NO950432D0 NO950432D0 (no)	1995-02-06
NO950432L NO950432L (no)	1995-03-13
NO303449B1 true NO303449B1 (no)	1998-07-13

Family

ID=10736757

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO950432A NO303449B1 (no)	1993-06-07	1995-02-06	Stereoselektiv syntese av nukleosidanaloger samt bicyklisk forbindelse

Country Status (21)

Country	Link
US (1)	US5763606A (pl)
EP (1)	EP0654031B1 (pl)
JP (1)	JP3110461B2 (pl)
KR (1)	KR100304072B1 (pl)
CN (1)	CN1046720C (pl)
AT (1)	ATE188215T1 (pl)
AU (1)	AU668829B2 (pl)
BR (1)	BR9405423A (pl)
CA (1)	CA2141029C (pl)
DE (1)	DE69422374T2 (pl)
DK (1)	DK0654031T3 (pl)
ES (1)	ES2139744T3 (pl)
FI (1)	FI112078B (pl)
GB (1)	GB9311709D0 (pl)
HU (1)	HU219199B (pl)
NO (1)	NO303449B1 (pl)
NZ (1)	NZ267379A (pl)
OA (1)	OA10349A (pl)
PL (1)	PL180870B1 (pl)
RU (1)	RU2139870C1 (pl)
WO (1)	WO1994029301A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6175008B1 (en) *	1988-04-11	2001-01-16	Biochem Pharma Inc.	Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
AU3710395A (en) *	1994-10-22	1996-05-15	Chong Kun Dang Corporation	Nucleoside derivatives and process for preparing thereof
ATE292631T1 (de)	1998-08-12	2005-04-15	Gilead Sciences Inc	Verfahren zu herstellung von 1,3-oxathiolane nukleosiden
US6979561B1 (en) *	1998-10-09	2005-12-27	Gilead Sciences, Inc.	Non-homogeneous systems for the resolution of enantiomeric mixtures
CA2308559C (en)	2000-05-16	2005-07-26	Brantford Chemicals Inc.	1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues
CN102942563A (zh)	2001-03-01	2013-02-27	基利得科学公司	顺-ftc的多晶型物及其它晶型
DK1583542T3 (da)	2003-01-14	2008-09-22	Gilead Sciences Inc	Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
CA2554782C (en)	2004-02-03	2013-08-13	Emory University	Methods to manufacture 1,3-dioxolane nucleosides
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047407A (en) *	1989-02-08	1991-09-10	Iaf Biochem International, Inc.	2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) *	1990-05-02	1990-06-27	Glaxo Group Ltd	Chemical compounds
WO1992010496A1 (en) *	1990-12-05	1992-06-25	University Of Georgia Research Foundation, Inc.	ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES
ZA923640B (en) *	1991-05-21	1993-02-24	Iaf Biochem Int	Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) *	1991-08-01	1991-09-18	Iaf Biochem Int	1,3-oxathiolane nucleoside analogues
US5332814A (en) *	1991-11-12	1994-07-26	Ciba-Geigy Corporation	Process for the preparation of carbacyclic nucleosides, and intermediates

1993
- 1993-06-07 GB GB939311709A patent/GB9311709D0/en active Pending
- 1993-11-19 OA OA60438A patent/OA10349A/en unknown
1994
- 1994-06-07 EP EP94918252A patent/EP0654031B1/en not_active Expired - Lifetime
- 1994-06-07 CA CA002141029A patent/CA2141029C/en not_active Expired - Fee Related
- 1994-06-07 CN CN94190356A patent/CN1046720C/zh not_active Expired - Fee Related
- 1994-06-07 US US08/379,644 patent/US5763606A/en not_active Expired - Fee Related
- 1994-06-07 HU HU9500364A patent/HU219199B/hu not_active IP Right Cessation
- 1994-06-07 RU RU95108553A patent/RU2139870C1/ru not_active IP Right Cessation
- 1994-06-07 DE DE69422374T patent/DE69422374T2/de not_active Expired - Fee Related
- 1994-06-07 AT AT94918252T patent/ATE188215T1/de not_active IP Right Cessation
- 1994-06-07 BR BR9405423A patent/BR9405423A/pt not_active Application Discontinuation
- 1994-06-07 ES ES94918252T patent/ES2139744T3/es not_active Expired - Lifetime
- 1994-06-07 NZ NZ267379A patent/NZ267379A/en not_active IP Right Cessation
- 1994-06-07 KR KR1019950700453A patent/KR100304072B1/ko not_active Expired - Fee Related
- 1994-06-07 WO PCT/CA1994/000311 patent/WO1994029301A1/en not_active Ceased
- 1994-06-07 AU AU69667/94A patent/AU668829B2/en not_active Ceased
- 1994-06-07 DK DK94918252T patent/DK0654031T3/da active
- 1994-06-07 JP JP07501139A patent/JP3110461B2/ja not_active Expired - Fee Related
- 1994-06-07 PL PL94307350A patent/PL180870B1/pl not_active IP Right Cessation
1995
- 1995-02-06 NO NO950432A patent/NO303449B1/no unknown
- 1995-02-07 FI FI950535A patent/FI112078B/fi active

Also Published As

Publication number	Publication date
BR9405423A (pt)	1999-05-25
RU2139870C1 (ru)	1999-10-20
RU95108553A (ru)	1996-11-20
NO950432L (no)	1995-03-13
EP0654031B1 (en)	1999-12-29
PL307350A1 (en)	1995-05-15
GB9311709D0 (en)	1993-07-21
CA2141029C (en)	2000-07-25
ES2139744T3 (es)	2000-02-16
FI112078B (fi)	2003-10-31
DK0654031T3 (da)	2000-06-13
HU219199B (en)	2001-03-28
DE69422374T2 (de)	2000-06-29
CA2141029A1 (en)	1994-12-22
AU668829B2 (en)	1996-05-16
FI950535A0 (fi)	1995-02-07
NZ267379A (en)	1997-04-24
FI950535L (fi)	1995-02-07
ATE188215T1 (de)	2000-01-15
HK1008673A1 (en)	1999-05-14
AU6966794A (en)	1995-01-03
HU9500364D0 (en)	1995-05-29
JPH08505643A (ja)	1996-06-18
US5763606A (en)	1998-06-09
DE69422374D1 (de)	2000-02-03
HUT73630A (en)	1996-08-28
CN1046720C (zh)	1999-11-24
CN1110479A (zh)	1995-10-18
PL180870B1 (pl)	2001-04-30
KR100304072B1 (ko)	2001-11-22
JP3110461B2 (ja)	2000-11-20
EP0654031A1 (en)	1995-05-24
WO1994029301A1 (en)	1994-12-22
NO950432D0 (no)	1995-02-06
OA10349A (en)	2001-10-18

Publication	Publication Date	Title
TW262474B (pl)	1995-11-11
GR3024420T3 (en)	1997-11-28	Process for the preparation of oxetanones
NO303449B1 (no)	1998-07-13	Stereoselektiv syntese av nukleosidanaloger samt bicyklisk forbindelse
ATE198479T1 (de)	2001-01-15	Verfahren zur herstellung von purinderivaten
PL263885A1 (en)	1988-09-15	Method of obtaining novel derivatives of dihydrobenzofurane and chromate carbonamide
IT1289904B1 (it)	1998-10-19	Composizione cristallina mesoporosa ad alta area superficiale di un metallo tetravalente utile come catalizzatore
SE9101482D0 (sv)	1991-05-16	Foerfarande foer framstaellning av mellanprodukter anvaendbara foer syntes av bensotiazepiner
KR910006288A (ko)	1991-04-29	신규 제조방법
AU2139792A (en)	1993-05-27	Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
SE9300455D0 (sv)	1993-02-11	Mellanprodukt vid framstaellning av histamin h2-antagonister
ATE207908T1 (de)	2001-11-15	Verfahren zur herstellung von 2-alkoxy-6- (trifluormethyl)-pyrimidin-4-ol
HUT48260A (en)	1989-05-29	New process for producing 6-/d-/-alpha-/4-ethyl2,3-dioxo-1-piperazin-carboxamido/-phenyl-acetamido/-penicillanic acid
GB8907008D0 (en)	1989-05-10	Intermediates useful for the synthesis for delphinidin chloride
HU896057D0 (en)	1991-07-29	(15,25,3r,5r)-2-[(3s)]-2-halogen-3-hydroxy-1-alkene-inyl]-3-trialkyl-silyl-oxy-7,7-(2,2-dimethyl-trimethylene-dioxy)-bicyclo(3.3.0) octane derivatives and process for producing them
HU9202679D0 (en)	1992-12-28	Method for producing uracyl derivatives
ES2138535A1 (es)	2000-01-01	Procedimiento para la preparacion de los compuestos antivirales penciclovir y famciclovir.
Zhuk et al.	1978	2-/5-Substituted uracil-1-yl/tetrahydrofuran-5-carboxylic acids as pyrimidine nucleotide analogues
ES8606368A1 (es)	1986-04-01	Un procedimiento para producir un derivado de bencil-fosfi- nato etilico
JPS6429390A (en)	1989-01-31	Production of pentofuranoside derivative
DE3462035D1 (en)	1987-02-19	Process for the preparation of 4-quinolinones
ES2017864A6 (es)	1991-03-01	Procedimiento para la preparacion de n-ciclopropilquinolonas.
KR970042487A (ko)	1997-07-24	알칼리 금속을 촉매로 이용한 아크릴산 에스테르 화합물의 제조방법
MX9705481A (es)	1998-08-30	Farmacos.
AR005042A1 (es)	1999-04-07	Procedimiento para la preparacion de un antagonista endotelin.