NO324528B1 - Kopolymer-1-fraksjon, fremgangsmate for fremstilling av denne, anvendelse, sammensetning og fremfangsmate for fremstilling av et preparat for behandling av multippel sklerose samt kopolymer-1-preparat - Google Patents

Kopolymer-1-fraksjon, fremgangsmate for fremstilling av denne, anvendelse, sammensetning og fremfangsmate for fremstilling av et preparat for behandling av multippel sklerose samt kopolymer-1-preparat Download PDF

Info

Publication number: NO324528B1
Authority: NO; Norway
Prior art keywords: copolymer; molecular weight; kilodaltons; mixture; preparation
Prior art date: 1994-05-24

Application number

NO19964976A

Other languages

English (en)

Norwegian (no)

Other versions

NO964976D0 (no

NO964976L (no

Inventor

Eliezer Konfino

Michael Sela

Dvora Teitelbaum

Ruth Arnon

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-24

Filing date

1996-11-22

Publication date

2007-11-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26939072&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO324528(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-11-22 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

1996-11-22 Publication of NO964976D0 publication Critical patent/NO964976D0/no

1997-01-23 Publication of NO964976L publication Critical patent/NO964976L/no

2007-11-12 Publication of NO324528B1 publication Critical patent/NO324528B1/no

Links

239000000203 mixture Substances 0.000 title claims abstract description 44
238000002360 preparation method Methods 0.000 title claims description 46
238000000034 method Methods 0.000 title claims description 24
201000006417 multiple sclerosis Diseases 0.000 title claims description 20
239000002516 radical scavenger Substances 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 claims description 28
102000004196 processed proteins & peptides Human genes 0.000 claims description 27
229920001184 polypeptide Polymers 0.000 claims description 26
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 14
238000006243 chemical reaction Methods 0.000 claims description 13
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims description 13
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 9
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 9
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 9
235000004279 alanine Nutrition 0.000 claims description 9
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 9
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims description 8
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 8
239000004472 Lysine Substances 0.000 claims description 8
235000018977 lysine Nutrition 0.000 claims description 8
238000004519 manufacturing process Methods 0.000 claims description 8
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 6
235000013922 glutamic acid Nutrition 0.000 claims description 6
239000004220 glutamic acid Substances 0.000 claims description 6
235000002374 tyrosine Nutrition 0.000 claims description 6
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 5
KNCHTBNNSQSLRV-YFKPBYRVSA-N (2s)-6-amino-2-[(2,2,2-trifluoroacetyl)amino]hexanoic acid Chemical group NCCCC[C@@H](C(O)=O)NC(=O)C(F)(F)F KNCHTBNNSQSLRV-YFKPBYRVSA-N 0.000 claims description 4
239000003814 drug Substances 0.000 claims description 4
229940079593 drug Drugs 0.000 claims description 4
238000006116 polymerization reaction Methods 0.000 claims description 4
231100000419 toxicity Toxicity 0.000 claims description 4
230000001988 toxicity Effects 0.000 claims description 4
238000009826 distribution Methods 0.000 claims description 3
229920001577 copolymer Polymers 0.000 claims description 2
239000000825 pharmaceutical preparation Substances 0.000 claims description 2
238000000746 purification Methods 0.000 claims description 2
238000010512 small scale reaction Methods 0.000 claims description 2
229930195712 glutamate Natural products 0.000 claims 4
238000010511 deprotection reaction Methods 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 10
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 8
239000000243 solution Substances 0.000 description 6
229940076279 serotonin Drugs 0.000 description 5
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 4
241000699670 Mus sp. Species 0.000 description 4
229960000583 acetic acid Drugs 0.000 description 4
210000004027 cell Anatomy 0.000 description 4
238000004587 chromatography analysis Methods 0.000 description 4
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 3
201000002491 encephalomyelitis Diseases 0.000 description 3
KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical class C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
239000005695 Ammonium acetate Substances 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
102000006386 Myelin Proteins Human genes 0.000 description 2
108010083674 Myelin Proteins Proteins 0.000 description 2
238000002835 absorbance Methods 0.000 description 2
235000001014 amino acid Nutrition 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
229940043376 ammonium acetate Drugs 0.000 description 2
235000019257 ammonium acetate Nutrition 0.000 description 2
210000003651 basophil Anatomy 0.000 description 2
238000000502 dialysis Methods 0.000 description 2
238000002523 gelfiltration Methods 0.000 description 2
239000012362 glacial acetic acid Substances 0.000 description 2
WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 description 2
229960001340 histamine Drugs 0.000 description 2
229910000042 hydrogen bromide Inorganic materials 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
231100000053 low toxicity Toxicity 0.000 description 2
230000001404 mediated effect Effects 0.000 description 2
210000005012 myelin Anatomy 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
OFCNTYBPPAQCRE-UHFFFAOYSA-N 3-(2-aminoethyl)-3h-indol-5-ol Chemical compound C1=C(O)C=C2C(CCN)C=NC2=C1 OFCNTYBPPAQCRE-UHFFFAOYSA-N 0.000 description 1
208000016557 Acute basophilic leukemia Diseases 0.000 description 1
208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
208000001718 Immediate Hypersensitivity Diseases 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
102000047918 Myelin Basic Human genes 0.000 description 1
101710107068 Myelin basic protein Proteins 0.000 description 1
108010039918 Polylysine Proteins 0.000 description 1
206010045240 Type I hypersensitivity Diseases 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
OQIQSTLJSLGHID-WNWIJWBNSA-N aflatoxin B1 Chemical compound C=1([C@@H]2C=CO[C@@H]2OC=1C=C(C1=2)OC)C=2OC(=O)C2=C1CCC2=O OQIQSTLJSLGHID-WNWIJWBNSA-N 0.000 description 1
VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000000427 antigen Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
208000010216 atopic IgE responsiveness Diseases 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000007071 enzymatic hydrolysis Effects 0.000 description 1
238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
230000005713 exacerbation Effects 0.000 description 1
208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 description 1
230000014509 gene expression Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
238000009169 immunotherapy Methods 0.000 description 1
238000010874 in vitro model Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000003999 initiator Substances 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229920000656 polylysine Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229940124606 potential therapeutic agent Drugs 0.000 description 1
238000000926 separation method Methods 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
238000010998 test method Methods 0.000 description 1
239000012085 test solution Substances 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
210000003462 vein Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rehabilitation Therapy (AREA)
Biophysics (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Polymers & Plastics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Marine Sciences & Fisheries (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compositions Of Macromolecular Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Polyamides (AREA)

NO19964976A 1994-05-24 1996-11-22 Kopolymer-1-fraksjon, fremgangsmate for fremstilling av denne, anvendelse, sammensetning og fremfangsmate for fremstilling av et preparat for behandling av multippel sklerose samt kopolymer-1-preparat NO324528B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US24803794A	1994-05-24	1994-05-24
US34424894A	1994-11-23	1994-11-23
PCT/US1995/006551 WO1995031990A1 (fr)	1994-05-24	1995-05-23	Ameliorations apportees a des compositions de copolymeres contenant du copolymere-1

Publications (3)

Publication Number	Publication Date
NO964976D0 NO964976D0 (no)	1996-11-22
NO964976L NO964976L (no)	1997-01-23
NO324528B1 true NO324528B1 (no)	2007-11-12

Family

ID=26939072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19964976A NO324528B1 (no)	1994-05-24	1996-11-22	Kopolymer-1-fraksjon, fremgangsmate for fremstilling av denne, anvendelse, sammensetning og fremfangsmate for fremstilling av et preparat for behandling av multippel sklerose samt kopolymer-1-preparat

Country Status (30)

Country	Link
US (11)	US5800808A (fr)
EP (1)	EP0762888B1 (fr)
JP (2)	JPH10500955A (fr)
KR (1)	KR100403750B1 (fr)
CN (2)	CN1310673C (fr)
AT (1)	ATE212857T1 (fr)
AU (1)	AU2602195A (fr)
BR (2)	BR9507758A (fr)
CA (1)	CA2191088C (fr)
CZ (1)	CZ292247B6 (fr)
DE (2)	DE69525340T2 (fr)
DK (1)	DK0762888T3 (fr)
EE (1)	EE03423B1 (fr)
ES (1)	ES2172586T3 (fr)
FI (1)	FI120236B (fr)
GE (1)	GEP20002205B (fr)
HU (1)	HU223473B1 (fr)
IL (2)	IL113812A (fr)
LU (1)	LU90987I2 (fr)
MD (1)	MD1443G2 (fr)
NL (1)	NL300096I2 (fr)
NO (1)	NO324528B1 (fr)
NZ (1)	NZ287335A (fr)
PL (1)	PL181026B1 (fr)
PT (1)	PT762888E (fr)
SI (1)	SI0762888T1 (fr)
SK (1)	SK283699B6 (fr)
TJ (1)	TJ392B (fr)
UA (1)	UA62908C2 (fr)
WO (1)	WO1995031990A1 (fr)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6077509A (en) *	1990-03-30	2000-06-20	Autoimmune, Inc.	Peptide fragments of myelin basic protein
US6252040B1 (en)	1991-10-22	2001-06-26	The Governors Of The University Of Alberta	Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US7090982B2 (en)	1991-10-22	2006-08-15	The Governors Of The University Of Alberta	Methods of predicting therapeutic efficacy of treatment of a multiple sclerosis patient
IL113812A (en) *	1994-05-24	2000-06-29	Yeda Res & Dev	Copolymer-1 pharmaceutical compositions containing it and its use
US5858964A (en) *	1995-04-14	1999-01-12	Yeda Research And Development Co. Ltd.	Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD
IL119989A0 (en) *	1997-01-10	1997-04-15	Yeda Res & Dev	Pharmaceutical compositions for oral treatment of multiple sclerosis
AU2868699A (en) *	1998-02-13	1999-08-30	Autoimmune, Inc.	Treatment of multiple sclerosis using cop-1 and th2-enhancing cytokines
ES2527760T3 (es) *	1998-07-23	2015-01-29	Yeda Research And Development Co., Ltd.	Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
WO2000005250A1 (fr)	1998-07-23	2000-02-03	Yeda Research And Development Co., Ltd	Traitement de maladies auto-immunes a l'aide du copolymere 1 et des copolymeres et peptides apparentes
JP2003521448A (ja)	1998-07-23	2003-07-15	ザ・プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ	合成ペプチドおよび自己免疫疾患治療のための使用方法
US6514938B1 (en)	1998-09-25	2003-02-04	Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science	Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
EP2090583B1 (fr)	1998-09-25	2011-07-13	Yeda Research And Development Co., Ltd.	Polypeptides associés au copolymère 1 à utiliser en tant que marqueurs de poids moléculaire et à utilisation thérapeutique
US6800287B2 (en) *	1998-09-25	2004-10-05	Yeda Research And Development Co., Ltd.	Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
AU6281599A (en) *	1998-10-02	2000-04-26	Yeda Research And Development Co. Ltd.	Alternate day administration of copolymer 1 for treating autoimmune diseases
US7083777B1 (en)	1999-04-02	2006-08-01	The Brigham And Women's Hospital, Inc.	Immunomodulating polymers
EP1248643B1 (fr) *	2000-01-20	2005-08-17	YEDA RESEARCH AND DEVELOPMENT Co. LTD.	Utilisation de copolymere 1 et de peptides et polypeptides connexes et cellules t traitees a l'aide de ces produits en therapie neuroprotective
JP2003522799A (ja) *	2000-02-18	2003-07-29	イエダ・リサーチ・アンド・ディベロップメント・カンパニー・リミテッド・アット・ザ・ウェイズマン・インスティテュート・オブ・サイエンス	コポリマー１の経口、経鼻および経肺投与製剤
ZA200206457B (en) *	2000-02-18	2003-08-13	Yeda Res & Dev	Oral, nasal and pulmonary dosage formulations of copolymer 1.
US20020077278A1 (en) *	2000-06-05	2002-06-20	Yong V. Wee	Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
PL363431A1 (en) *	2000-06-05	2004-11-15	Teva Pharmaceuticals Industries, Ltd.	The use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
DE60116467T2 (de) *	2000-06-07	2006-11-02	Yeda Research And Development Co., Ltd.	Verwendung des Copolymer-1 Peptids sowie von damit verwandten Peptiden und Polypeptiden und von damit behandelten T-Zellen zur Neuroprotektion gegen die Toxizität von Glutamat
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- 2001-12-14 US US10/014,477 patent/US6620847B2/en not_active Expired - Lifetime
2002
- 2002-07-29 NL NL300096C patent/NL300096I2/nl unknown
- 2002-08-05 LU LU90987C patent/LU90987I2/fr unknown
- 2002-08-09 JP JP2002233094A patent/JP3715600B2/ja not_active Expired - Lifetime
2003
- 2003-07-10 US US10/615,865 patent/US6939539B2/en not_active Expired - Lifetime
2005
- 2005-04-05 US US11/098,432 patent/US7199098B2/en not_active Expired - Fee Related
2007
- 2007-01-23 US US11/656,505 patent/US7625861B2/en not_active Expired - Fee Related
2011
- 2011-09-26 US US13/244,737 patent/US8367605B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR9507758A (pt)	1997-09-23
HK1008657A1 (en)	1999-05-14
US5800808A (en)	1998-09-01
US8367605B2 (en)	2013-02-05
KR970703154A (ko)	1997-07-03
JPH10500955A (ja)	1998-01-27
CN1152874A (zh)	1997-06-25
IL113812A (en)	2000-06-29
US5981589A (en)	1999-11-09
NL300096I1 (nl)	2002-10-01
CZ292247B6 (cs)	2003-08-13
GEP20002205B (en)	2000-08-25
US7625861B2 (en)	2009-12-01
HU9603243D0 (en)	1997-01-28
TJ392B (en)	2004-10-13
NO964976D0 (no)	1996-11-22
HU223473B1 (hu)	2004-07-28
PL181026B1 (pl)	2001-05-31
JP3715600B2 (ja)	2005-11-09
FI964600L (fi)	1996-12-05
MD1443G2 (ro)	2000-11-30
CN1174753C (zh)	2004-11-10
EP0762888A1 (fr)	1997-03-19
US20070117757A1 (en)	2007-05-24
CA2191088A1 (fr)	1995-11-30
PT762888E (pt)	2002-07-31
UA62908C2 (uk)	2004-01-15
EE9600170A (et)	1997-06-16
EE03423B1 (et)	2001-06-15
SI0762888T1 (en)	2002-08-31
US20030064914A1 (en)	2003-04-03
EP0762888A4 (fr)	1997-04-16
LU90987I2 (fr)	2003-02-25
DE69525340T2 (de)	2002-09-19
ATE212857T1 (de)	2002-02-15
EP0762888B1 (fr)	2002-02-06
DE10299030I1 (de)	2003-01-23
US6048898A (en)	2000-04-11
CZ341096A3 (en)	1997-06-11
CN1626238A (zh)	2005-06-15
CN1310673C (zh)	2007-04-18
US6620847B2 (en)	2003-09-16
AU2602195A (en)	1995-12-18
CA2191088C (fr)	2004-09-28
PL317331A1 (en)	1997-04-01
KR100403750B1 (ko)	2006-02-13
US6342476B1 (en)	2002-01-29
US6362161B1 (en)	2002-03-26
US6939539B2 (en)	2005-09-06
SK149396A3 (en)	1997-08-06
IL133890A0 (en)	2001-04-30
US7199098B2 (en)	2007-04-03
DE69525340D1 (de)	2002-03-21
NZ287335A (en)	1999-02-25
HUT75672A (en)	1997-05-28
FI964600A0 (fi)	1996-11-15
NL300096I2 (nl)	2003-02-03
DK0762888T3 (da)	2002-05-27
WO1995031990A1 (fr)	1995-11-30
US20050171286A1 (en)	2005-08-04
BRPI9507758B1 (pt)	2021-03-16
IL113812A0 (en)	1995-08-31
NO964976L (no)	1997-01-23
MD1443F1 (en)	2000-04-30
JP2003105000A (ja)	2003-04-09
US20120077754A1 (en)	2012-03-29
FI120236B (fi)	2009-08-14
US6054430A (en)	2000-04-25
SK283699B6 (sk)	2003-12-02
US20040106554A1 (en)	2004-06-03
ES2172586T3 (es)	2002-10-01

Legal Events

Date	Code	Title	Description
2015-06-01	MK1K	Patent expired

Publication	Publication Date	Title
US8367605B2 (en)	2013-02-05	Copolymer-1 improvements in compositions of copolymers
ZA200100366B (en)	2002-01-14	Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides.
RU2198900C2 (ru)	2003-02-20	Усовершенствованный сополимер-1 и способ его получения
US20060039918A1 (en)	2006-02-23	Stress proteins and peptides and methods of use thereof
AU741590B2 (en)	2001-12-06	Copolymer-1 improvements in compositions of copolymers
AU2004202245B2 (en)	2006-06-15	Copolymer-1 Improvements in Compositions of Copolymers
AU775214B2 (en)	2004-07-22	Copolymer-1 improvements in compositions of copolymers
HK1008657B (en)	2002-08-30	Copolymer-1 improvements in compositions of copolymers
AU2005263205A1 (en)	2006-01-26	Therapeutic and diagnostic agents